I'm still a bit confused about the difference in the reactivity of the C2, C4, and C6 positions of trichloropyrimidine toward SNAr @1:06:00. Is there a way to rationalize why the C4/C6 position would be first to react? Based on the Handy method, the C2 position is more electrophilic than C4/C6.
I checked the 13C NMR of 2,4,6-trichloropyrimidine, C4, C6: 162.9 ppm (predicted 166.2); C2: 160.4 ppm (predicted 157.5). Not sure how to rationalize but it's supported by NMR data!
I'm still a bit confused about the difference in the reactivity of the C2, C4, and C6 positions of trichloropyrimidine toward SNAr @1:06:00. Is there a way to rationalize why the C4/C6 position would be first to react? Based on the Handy method, the C2 position is more electrophilic than C4/C6.
I checked the 13C NMR of 2,4,6-trichloropyrimidine, C4, C6: 162.9 ppm (predicted 166.2); C2: 160.4 ppm (predicted 157.5). Not sure how to rationalize but it's supported by NMR data!
Many thanks 👍
Great lecture, benefit a lot~
Great lecture, many thanks.
Heterocyclic chemistry