Thank you for the wonderful lecture Nwanyioma,I have been able to grab more insight about the Lewis blood group. At the end of the lecture I was able to understand that the Lewis blood group system differs from all other blood group systems and more so,the Lewis antigens are not actually red cell antigens absorbed onto the red cells from the plasma…the Lewis blood group is unique
You have not really said what is unique about Lewis blood group system. You said Lewis antigens are not red cell antigens absorbed from the plasma. This got me confused. I am not sure that you really watched the lecture video
@@ifyokaforOkay ma!,what makes it the Lewis blood group unique and different from the other blood groups is that the antigen is present in soluble form in the blood and the saliva!
Thank you for this insightful discussion, Ma. I gained a lot of valuable knowledge about the Lewis blood group system, which I found very impactful. To summarize, the Lewis blood group system is unique compared to other blood group systems because it involves soluble antigens found in bodily fluids like secretions and plasma rather than being intrinsic to red blood cells. This system includes six antigens, with the primary ones being Le(a) and Le(b). Le(a) was first discovered by A.E. Mourant in 1946, and Le(b) followed in 1948, discovered by Andersen. Other variants include Le(ab), Le(BH), Ale(b), and BLe(b). It's also important to note that the A and B antigens correspond to the ABO blood group system. The gene FUT3, located on chromosome 19, is responsible for the production of these antigens. In saliva and plasma, Lewis antigens are primarily glycoproteins and glycolipids, and they are absorbed into the red blood cell membrane, forming the Lewis phenotype. At birth, Lewis antigens are not well-developed, and newborns typically have Le(a-b-) red blood cells, with these antigens only becoming present 12-15 months after birth. Therefore, newborns usually do not have Le(a) or Le(b) antigens. Clinically, the Lewis blood group system is significant in transfusion medicine and the context of hemolytic disease of the fetus and newborn.
@@ifyokaforLewis antibodies, primarily IgM in nature, are naturally occurring and target Lewis antigens, which are not directly part of red blood cells but are absorbed from plasma. They rarely cause severe transfusion reactions because they are neutralized by soluble Lewis antigens in the plasma, exhibit weak reactions at body temperature, and do not cause significant red blood cell destruction. As a result, Lewis antibodies are considered clinically insignificant in most transfusion settings.
This is a very impactful lecture!!! I’ve been able to have a broad knowledge about the Lewis Blood Group. The History, the number of antigens involved, it’s biosynthesis and lot more. I have learnt that without the presence of the Le gene, neither the LeA or LeB will be produced and this will result to the Le (a-b-) phenotype.
Thank you for this lecture Ma I learnt so much about the Lewis blood group system, i learnt that the Lewis blood group system is different from other blood group system, it is primarily a system of soluble antigens present in secretion and in plasma. I also learnt about the development of Lewis antigens on red blood cells. Finally, i learnt about the reactions of antibodies in the blood group system and also the biosynthesis in the Lewis group system.
Thank you so much ma for the great lectures i learnt that Lewish antigen are a group of antigens present on red blood cells and also learnt that the biosynthesis of the lewish blood group system involves a series of enzymes catalysed reaction that modify carbohydrates structures on glycoprotein and glycolipids
Thank you ma for this lecture I learnt that lewis blood group system is differnt from other blood groups because it is a system of soluble antigens,constant presence of plasma is needed to maintain Lewis antigen on the red cells Also,the lewis antigens on red xells are absorbed passively from the plasma.The Lewis blood group antigens are carbohydrates moities attached to lipids and glycoproteins. Lewis structures also appear on other cell surfaces and have functions in embryogenesis and also tissue differentiation.
Thank you ma for this lecture,I got a lot from it. First of all,I learnt about the history of Lewis blood group system. I learnt that the Lewis blood group system differs from all other blood group systems in that it is primarily a system of soluble antigens present in secretions and in plasma.The Lewis blood group antigens are carbohydrate moieties attached to lipids and glycoproteins,and the antigens are not resident of the red blood cells. I also learnt the Lewis blood group system has 6 known antigens I learnt about the biosynthesis of Lewis antigens that when you inherit the Lewis gene you’re able to produce the enzyme fucosyltransferase 3 and the enzyme produced reacts with one of the two possible substance either the H gene substrate or Se gene substrate. I learnt about the absorption on red cells. Also I learnt about the Development that Lewis antigens are poorly developed at birth and the red cell Lewis antigens only develop during the first 12-15 month after birth. Also the clinical significance of it,I learnt they do not cause transfusion reactions,patients with anti-Lea and anti-Leb which reacts at 37°C can be transfused with cross math compatible blood.
@@ifyokaforthis is cause the Lewis antigen are weakly expressed on red blood cells compared to other blood group antigens. This means they are less likely to provoke a strong immune response
Such a really impactful Teaching and i learnt the biosynthesis of the Lewis antigens are dependent on the FUT3 gene that encodes the Alpha(1,4) fucosyltransferase protein which catalysis the addition of fucose to a precursor polysaccharides
This is educating ma Ive learnt alot about the lewis blood system which contains soluble antigens present in secretions and in plasma and also about lewis antigens and the major lewis antigens are the LEa and LEb antigen which is not redcell antigen but absorbed into red cell from the plasma Ive learnt also about its history, its antigens, its biosynthesis and its adsorption
Greetings ma. Thank you for the interesting lecture. I learnt that The Lewis blood group antigens Lea and Leb have been found on red blood cells (RBCs), in secretions and fluids such as saliva, alimentary tract juice, and urine, and in various tissues including renal tubular cells, collecting ducts, urothelium, and ductal or mucosal epithelium of the sweat glands, salivary glands, gastrointestinal tract, pancreas, uterus, cervix, and breast. Hepatic bile duct epithelium also contains Lewis antigens.bLewis antigens in secretions are glycoproteins. RBC Lewis antigens are glycolipids acquired from plasma and are not intrinsic to the RBCs. Transfused RBCs have been found to assume the recipient’s Lewis phenotype by absorption or loss of antigens within two to seven days, and bone marrow transplant patients retain their own RBC Lewis phenotype, not that of their donors. The site of origin of Lewis plasma glycolipids is uncertain. Crookston suggested that the study of RBC Lewis phenotypes in liver transplants would shed light on this issue. Lewis antibodies are generally clinically insignificant in RBC compatibility, in part because of the shift of transfused RBCs to the recipient’s phenotype. However, in renal transplantation, Lewis incompatibility has been reported to adversely affect graft survival. Some Lewis antibodies are lymphocytotoxic1 and others are not detected by routine hemagglutination techniques.In one case an anti-host Lewis antibody of bone marrow graft origin was associated with renal failure in the recipient.However, other clinical studies have not found a significant adverse effect of Lewis incompatibility in renal transplantation.
Thanks for this wonderful and interesting topic Ma. I really learnt alot from lewis Blood group system which was quite impacting. In summary,the Lewis blood group system differs from all other blood group system,it is primarily a system of soluble antigens present in secretion and in plasma. The Lewis blood group system is made up of 6 antigens but the basic or main antigens are Le(a) and Le(b). Le(a) was the first antigen which was discovered in 1946 by A.E Mourant and Le(b) was the second lewis antigen which was discovered in 1948 by Andersen. Variations are: Le(ab),Le(BH),Ale(b),BLe(b). I also came to understand that A is (A) Blood group system,B is (B) Blood group system. The gene responsible for the production of this antigens is FUT3 (Fucosyl transfares 3) found in (chromosome 19). Lewis antigen in saliva and plasma are mostly glycoprotein and glycolipid.these antigens are not intrinsic to red blood cells instead they are absorbed into the red cell membrane giving rise to the Lewis phenotype. The Lewis antigens are poorly developed at birth and red cells from cord blood are usually Le(a-b-) .it only develop during the 12-15 months after birth,and it is made known and clear to me that new born dies not have lewis A or L(b) antigen they are mostly Le(a-b-) red cells. Clinical significance are -Transfusion -Hemolytic disease of the fetus and new born.
Thank you ma After the lectures I learnt about the antigens associated with the Lewis blood group system and also the reactions of the antibodies in the blood group system and also the biosynthesis in the Lewis group system
Thank you ma for the lecture. At the end of the lecture I learnt alot about lewis blood system and it's rich history. Lewis blood system have 6 antigens: LEa,LEb,LEab, LEbh,ALEb and BLEb but we have two major antigens.The 1st lewis antigen LEa was discovered by A.E mourant in 1946 ,the 2nd LEb was discovered by Andersen in 1948. The lewis blood system is a complex system that involves soluble antigens present in secretions and plasma. I also learnt about it's biosynthesis and absorption. Thank you ma.
The Lewis blood group system is unique because it involves the presence or absence of specific antigens on the surface of red blood cells. The Lewis antigens are not considered problematic during transfusion because they are not typically involved in the immune response, unlike other blood group antigens. This means that individuals with Lewis antibodies do not typically produce antibodies against Lewis antigens, and therefore, transfusions involving Lewis antibodies are generally safe.
This is educating Ma I've learnt Alot about the Lewis blood system which contains soluble antigens present in secretions and in plasma and also about Lewis Antigens and the major Lewis Antigens are the LEa and LEb antigen which is not a red cell Antigens but absorbed into red cell from the plasma I've learnt also about it's History ,it's antigens ,it's biosynthesis and it's Absorption .
Can Lewis antibodies cause HDN . Are they to be considered in blood transfusion process. What is peculiar with transfusing a patient with blood with incompatible Lewis antigen. Just take note of Lewis antibody reactivity
Ma Lewis antibodies cannot cause HDN (Hemolytic disease of the newborn),because the Lewis blood group has no associations with HDN . Lewis antibodies can be considered in blood transfusion process because patients with Lewis antibodies may be transfered with RBC that are crossmatch compatible at 37oC when they are reactive. When a patient is transfused with blood with incompatible Lewis antigens , they are treated as foreigners in the blood of the receiver and are then acted upon by the immune system.
Thank you for the wonderful lecture ma, I now have a good knowledge on the biosynthesis and molecular basis of antigens on the Lewis blood group system and I also now know that the antigens are poorly developed at birth and red cells from cord blood and they’re usually Le(a-b)
The Lewis blood group system is unique compared to other blood group systems because it involves soluble antigens found in bodily fluids like secretions and plasma rather than being intrinsic to red blood cells. This system includes six antigens, with the primary ones being Le(a) and Le(b). The gene FUT3, located on chromosome 19, is responsible for the production of these antigens. In saliva and plasma, Lewis antigens are primarily glycoproteins and glycolipids, and they are absorbed into the red blood cell membrane, forming the Lewis phenotype. At birth, Lewis antigens are not well-developed, and newborns typically have Le(a-b-) red blood cells, with these antigens only becoming present 12-15 months after birth. Therefore, newborns usually do not have Le(a) or Le(b) antigens. Clinically, the Lewis blood group system is significant in transfusion medicine and the context of hemolytic disease of the fetus and newborn.
Thank you very much ma for this wonderful lecture on Diego blood group system. At the end of the video I learnt that these blood group system was first diagnose in a lady, Mrs. Diego, who had given birth to a child with hemolytic diseases of the new born in the year 1955. The RBCs of the baby were known to contain a gene that encodes for the anti- gene V12, Anti- Diego A and B (Anti-Di^a &Di^b and the serum of the mother contains antibodies which penetrate her placenta and react with the antigen on the RBC of the baby leading to a condition known as hemolytre disease of the new born. The Diego antigen is only expressed in the RBC and the distal and collecting the duet of the kidney. And also, the gene that codes for this antigen is founded on the long hand at chromosome 17. 7 also learned that the Diego anti gene are carriers that serves as chloride bio-carbonate exchanger that helps in the transport of carbon dioxide (Co2) from tissues to lungs. Diego: antigens are also involve in the exchange of ions across the kidney tubule. The band 3 protein that forms this antigen serves as an integral protein forming the membrane of RBC from my study of this blood group system I learnt that is very important in transfusion medicine, hemolytre diseases of the new born as well as serving as a structural protein to RBC membrane. Therefore mutation in the gene that codes for the protein that forms this anti-gene may results to transfusion reactions increase acidosis due to inability of the kidney to Febechang ions, and also alteration of the structure of RBC membrane. Oloko Karen chidera
Thank you ma for the impactful lecture I learnt about the development of Lewis antigens on red blood cells and I also learnt that the Lewis blood group system are based on the presence or absence of two antigens which are the Lewis antigens A and Lewis antigens B they are inherited in an autosomal recessive manner.
Thank you ma, I've learnt a lot about the Lewis blood group system it's different from others blood grouping system in that, it's primarily a system of soluble antigens present in secretion and in plasma. I have also learnt the brief history of antigen it's biosynthesis and it's absorption.
Thank you for the wonderful lecture Nwanyioma,I have been able to grab more insight about the Lewis blood group.
At the end of the lecture I was able to understand that the Lewis blood group system differs from all other blood group systems and more so,the Lewis antigens are not actually red cell antigens absorbed onto the red cells from the plasma…the Lewis blood group is unique
You have not really said what is unique about Lewis blood group system. You said Lewis antigens are not red cell antigens absorbed from the plasma. This got me confused. I am not sure that you really watched the lecture video
@@ifyokaforOkay ma!,what makes it the Lewis blood group unique and different from the other blood groups is that the antigen is present in soluble form in the blood and the saliva!
Thank you for this insightful discussion, Ma.
I gained a lot of valuable knowledge about the Lewis blood group system, which I found very impactful.
To summarize, the Lewis blood group system is unique compared to other blood group systems because it involves soluble antigens found in bodily fluids like secretions and plasma rather than being intrinsic to red blood cells. This system includes six antigens, with the primary ones being Le(a) and Le(b). Le(a) was first discovered by A.E. Mourant in 1946, and Le(b) followed in 1948, discovered by Andersen.
Other variants include Le(ab), Le(BH), Ale(b), and BLe(b). It's also important to note that the A and B antigens correspond to the ABO blood group system.
The gene FUT3, located on chromosome 19, is responsible for the production of these antigens. In saliva and plasma, Lewis antigens are primarily glycoproteins and glycolipids, and they are absorbed into the red blood cell membrane, forming the Lewis phenotype.
At birth, Lewis antigens are not well-developed, and newborns typically have Le(a-b-) red blood cells, with these antigens only becoming present 12-15 months after birth. Therefore, newborns usually do not have Le(a) or Le(b) antigens.
Clinically, the Lewis blood group system is significant in transfusion medicine and the context of hemolytic disease of the fetus and newborn.
Good. Well done 👍✅. Note the nature of Lewis antibodies and why they don't cause severe transfusion reaction
@@ifyokaforLewis antibodies, primarily IgM in nature, are naturally occurring and target Lewis antigens, which are not directly part of red blood cells but are absorbed from plasma. They rarely cause severe transfusion reactions because they are neutralized by soluble Lewis antigens in the plasma, exhibit weak reactions at body temperature, and do not cause significant red blood cell destruction. As a result, Lewis antibodies are considered clinically insignificant in most transfusion settings.
This is a very impactful lecture!!!
I’ve been able to have a broad knowledge about the Lewis Blood Group. The History, the number of antigens involved, it’s biosynthesis and lot more.
I have learnt that without the presence of the Le gene, neither the LeA or LeB will be produced and this will result to the Le (a-b-) phenotype.
You tried but you have not really said much about Lewis blood group system. I suggest that you watch the lecture video to the end to learn more
Thank you for this lecture Ma
I learnt so much about the Lewis blood group system, i learnt that the Lewis blood group system is different from other blood group system, it is primarily a system of soluble antigens present in secretion and in plasma.
I also learnt about the development of Lewis antigens on red blood cells.
Finally, i learnt about the reactions of antibodies in the blood group system and also the biosynthesis in the Lewis group system.
You tried but you have not really said much about Lewis blood group system. I will suggest that you watch the video to the end
Thank you so much ma for the great lectures i learnt that Lewish antigen are a group of antigens present on red blood cells and also learnt that the biosynthesis of the lewish blood group system involves a series of enzymes catalysed reaction that modify carbohydrates structures on glycoprotein and glycolipids
You tried but you need to learn more. Watch the video to the end
Thank you ma for this lecture
I learnt that lewis blood group system is differnt from other blood groups because it is a system of soluble antigens,constant presence of plasma is needed to maintain Lewis antigen on the red cells
Also,the lewis antigens on red xells are absorbed passively from the plasma.The Lewis blood group antigens are carbohydrates moities attached to lipids and glycoproteins.
Lewis structures also appear on other cell surfaces and have functions in embryogenesis and also tissue differentiation.
Good ✅. Note the nature of their antibodies and their reactivity
Thank you ma for this lecture,I got a lot from it.
First of all,I learnt about the history of Lewis blood group system.
I learnt that the Lewis blood group system differs from all other blood group systems in that it is primarily a system of soluble antigens present in secretions and in plasma.The Lewis blood group antigens are carbohydrate moieties attached to lipids and glycoproteins,and the antigens are not resident of the red blood cells.
I also learnt the Lewis blood group system has 6 known antigens
I learnt about the biosynthesis of Lewis antigens that when you inherit the Lewis gene you’re able to produce the enzyme fucosyltransferase 3 and the enzyme produced reacts with one of the two possible substance either the H gene substrate or Se gene substrate.
I learnt about the absorption on red cells.
Also I learnt about the Development that Lewis antigens are poorly developed at birth and the red cell Lewis antigens only develop during the first 12-15 month after birth.
Also the clinical significance of it,I learnt they do not cause transfusion reactions,patients with anti-Lea and anti-Leb which reacts at 37°C can be transfused with cross math compatible blood.
Good. Well done 👍✅. But can you give reasons why they don't cause severe transfusion reaction
@@ifyokaforthis is cause the Lewis antigen are weakly expressed on red blood cells compared to other blood group antigens. This means they are less likely to provoke a strong immune response
Such a really impactful Teaching and i learnt the biosynthesis of the Lewis antigens are dependent on the FUT3 gene that encodes the Alpha(1,4) fucosyltransferase protein which catalysis the addition of fucose to a precursor polysaccharides
You tried but you have not really said anything about Lewis blood group system. I suggest that you watch the video to the end
This is educating ma
Ive learnt alot about the lewis blood system which contains soluble antigens present in secretions and in plasma and also about lewis antigens and the major lewis antigens are the LEa and LEb antigen which is not redcell antigen but absorbed into red cell from the plasma
Ive learnt also about its history, its antigens, its biosynthesis and its adsorption
You tried but you need to learn more about the nature of their antibodies and their reactivity
Greetings ma. Thank you for the interesting lecture.
I learnt that The Lewis blood group antigens Lea and Leb have been found on red blood cells (RBCs), in secretions and fluids such as saliva, alimentary tract juice, and urine, and in various tissues including renal tubular cells, collecting ducts, urothelium, and ductal or mucosal epithelium of the sweat glands, salivary glands, gastrointestinal tract, pancreas, uterus, cervix, and breast. Hepatic bile duct epithelium also contains Lewis antigens.bLewis antigens in secretions are glycoproteins. RBC Lewis antigens are glycolipids acquired from plasma and are not intrinsic to the RBCs. Transfused RBCs have been found to assume the recipient’s Lewis phenotype by absorption or loss of antigens within two to seven days, and bone marrow transplant patients retain their own RBC Lewis phenotype, not that of their donors. The site of origin of Lewis plasma glycolipids is uncertain. Crookston suggested that the study of RBC Lewis phenotypes in liver transplants would shed light on this issue.
Lewis antibodies are generally clinically insignificant in RBC compatibility, in part because of the shift of transfused RBCs to the recipient’s phenotype. However, in renal transplantation, Lewis incompatibility has been reported to adversely affect graft survival. Some Lewis antibodies are lymphocytotoxic1 and others are not detected by routine hemagglutination techniques.In one case an anti-host Lewis antibody of bone marrow graft origin was associated with renal failure in the recipient.However, other clinical studies have not found a significant adverse effect of Lewis incompatibility in renal transplantation.
Good but I will advice you watch the video to learn more
Thanks for this wonderful and interesting topic Ma.
I really learnt alot from lewis Blood group system which was quite impacting.
In summary,the Lewis blood group system differs from all other blood group system,it is primarily a system of soluble antigens present in secretion and in plasma.
The Lewis blood group system is made up of 6 antigens but the basic or main antigens are Le(a) and Le(b). Le(a) was the first antigen which was discovered in 1946 by A.E Mourant and Le(b) was the second lewis antigen which was discovered in 1948 by Andersen.
Variations are: Le(ab),Le(BH),Ale(b),BLe(b). I also came to understand that A is (A) Blood group system,B is (B) Blood group system.
The gene responsible for the production of this antigens is FUT3 (Fucosyl transfares 3) found in (chromosome 19).
Lewis antigen in saliva and plasma are mostly glycoprotein and glycolipid.these antigens are not intrinsic to red blood cells instead they are absorbed into the red cell membrane giving rise to the Lewis phenotype.
The Lewis antigens are poorly developed at birth and red cells from cord blood are usually Le(a-b-) .it only develop during the 12-15 months after birth,and it is made known and clear to me that new born dies not have lewis A or L(b) antigen they are mostly Le(a-b-) red cells.
Clinical significance are
-Transfusion
-Hemolytic disease of the fetus and new born.
Very good. Well done ✅ ✅👍. But are Lewis antibodies not considered a threat in transfusion medicine
Thank you ma
After the lectures I learnt about the antigens associated with the Lewis blood group system and also the reactions of the antibodies in the blood group system and also the biosynthesis in the Lewis group system
Thank you ma for the lecture.
At the end of the lecture I learnt alot about lewis blood system and it's rich history.
Lewis blood system have 6 antigens: LEa,LEb,LEab, LEbh,ALEb and BLEb but we have two major antigens.The 1st lewis antigen LEa was discovered by A.E mourant in 1946 ,the 2nd LEb was discovered by Andersen in 1948. The lewis blood system is a complex system that involves soluble antigens present in secretions and plasma. I also learnt about it's biosynthesis and absorption.
Thank you ma.
Good. What is so unique about Lewis blood group system. Why are their antibodies not considered to be problematic during transfusion.
Well done 👍
The Lewis blood group system is unique because it involves the presence or absence of specific antigens on the surface of red blood cells. The Lewis antigens are not considered problematic during transfusion because they are not typically involved in the immune response, unlike other blood group antigens. This means that individuals with Lewis antibodies do not typically produce antibodies against Lewis antigens, and therefore, transfusions involving Lewis antibodies are generally safe.
This is educating Ma
I've learnt Alot about the Lewis blood system which contains soluble antigens present in secretions and in plasma and also about Lewis Antigens and the major Lewis Antigens are the LEa and LEb antigen which is not a red cell Antigens but absorbed into red cell from the plasma
I've learnt also about it's History ,it's antigens ,it's biosynthesis and it's Absorption .
Can Lewis antibodies cause HDN . Are they to be considered in blood transfusion process. What is peculiar with transfusing a patient with blood with incompatible Lewis antigen. Just take note of Lewis antibody reactivity
Ma
Lewis antibodies cannot cause HDN (Hemolytic disease of the newborn),because the Lewis blood group has no associations with HDN .
Lewis antibodies can be considered in blood transfusion process because patients with Lewis antibodies may be transfered with RBC that are crossmatch compatible at 37oC when they are reactive.
When a patient is transfused with blood with incompatible Lewis antigens , they are treated as foreigners in the blood of the receiver and are then acted upon by the immune system.
Thank you for the wonderful lecture ma,
I now have a good knowledge on the biosynthesis and molecular basis of antigens on the Lewis blood group system and I also now know that the antigens are poorly developed at birth and red cells from cord blood and they’re usually Le(a-b)
Thank you for the wonderful lecture Dr.
Thank you Dr.
The Lewis blood group system is unique compared to other blood group systems because it involves soluble antigens found in bodily fluids like secretions and plasma rather than being intrinsic to red blood cells. This system includes six antigens, with the primary ones being Le(a) and Le(b). The gene FUT3, located on chromosome 19, is responsible for the production of these antigens. In saliva and plasma, Lewis antigens are primarily glycoproteins and glycolipids, and they are absorbed into the red blood cell membrane, forming the Lewis phenotype. At birth, Lewis antigens are not well-developed, and newborns typically have Le(a-b-) red blood cells, with these antigens only becoming present 12-15 months after birth. Therefore, newborns usually do not have Le(a) or Le(b) antigens. Clinically, the Lewis blood group system is significant in transfusion medicine and the context of hemolytic disease of the fetus and newborn.
Good but you still need to learn more about the nature of their antibodies and their reactivity. Well done ✅
Thank you very much ma for this wonderful lecture on Diego blood group system.
At the end of the video I learnt that these blood group system was first diagnose in a lady, Mrs. Diego, who had given birth to a child with hemolytic diseases of the new born in the year 1955.
The RBCs of the baby were known to contain a gene that encodes for the anti- gene V12, Anti- Diego A and B (Anti-Di^a &Di^b and the serum of the mother contains antibodies which penetrate her placenta and react with the antigen on the RBC of the baby leading to a condition known as hemolytre disease of the new born.
The Diego antigen is only expressed in the RBC and the distal and collecting the duet of the kidney. And also, the gene that codes for this antigen is founded on the long hand at chromosome 17.
7 also learned that the Diego anti gene are carriers that serves as chloride bio-carbonate exchanger that helps in the transport of carbon dioxide (Co2) from tissues to lungs.
Diego: antigens are also involve in the exchange of ions across the kidney tubule.
The band 3 protein that forms this antigen serves as an integral protein forming the membrane of RBC from my study of this blood group system I learnt that is very important in transfusion medicine, hemolytre diseases of the new born as well as serving as a structural protein to RBC membrane.
Therefore mutation in the gene that codes for the protein that forms this anti-gene may results to transfusion reactions increase acidosis due to inability of the kidney to Febechang ions, and also alteration of the structure of RBC membrane.
Oloko Karen chidera
Are you talking about Lewis blood group system or Diego blood group system. The lecture video and write up do not match
Thank you ma for the impactful lecture I learnt about the development of Lewis antigens on red blood cells and I also learnt that the Lewis blood group system are based on the presence or absence of two antigens which are the Lewis antigens A and Lewis antigens B they are inherited in an autosomal recessive manner.
You tried but create time and watch the video to the end so that you can learn more. Thank you
Thank you ma, I've learnt a lot about the Lewis blood group system it's different from others blood grouping system in that, it's primarily a system of soluble antigens present in secretion and in plasma.
I have also learnt the brief history of antigen it's biosynthesis and it's absorption.
So what is the biosynthesis and absorption. Watch the video and learn something about Lewis blood group system