Lactate Metabolism Latest Updates - Exercise Physiology What You Need to Know

In this educational video, we provide the latest updates on exercise physiology and lactate metabolism. Learn about the recent research and discoveries regarding lactate, a molecule once thought to be a waste product of metabolism, but now known to play important roles in energy metabolism, brain function, and cancer. We'll explore the groundbreaking work of Dr. George Brooks and his lactate shuttle theory, and discuss the latest findings on lactate metabolism in exercise and health. Whether you're an exercise science major or just interested in optimizing your fitness and health, this video is for you! Stay up-to-date with the latest updates on exercise physiology and lactate metabolism by joining us in this informative video.
0:00 Introduction
0:30 The traditional view of lactate
1:15 Dr. George Brooks' groundbreaking research
2:00 Lactate as a fuel source and signaling molecule
2:45 The lactate shuttle theory
3:30 Lactate and brain function
4:15 The Warburg effect and cancer
5:00 Targeting lactate metabolism in cancer therapy
5:45 Conclusion and practical applications
6:30 Call-to-action and subscribe
References:
"Lactate shuttles in nature" by George A. Brooks (published in Biochemical Society Transactions in 2002)
"The lactate shuttle during exercise and recovery" by George A. Brooks (published in Medicine and Science in Sports and Exercise in 1986)
"The Science and Translation of Lactate Shuttle Theory" by George A. Brooks, et al. (published in Cell Metabolism in 2018)
Disrupting Lactate Transport and Glucose Uptake with Small-Molecule Inhibitors Synergistically Inhibits Cancer Cell Growth" by Shuai Jiang, et al. (published in the journal Cell on March 23, 2017)

[@mcbaldoviastarloa9593]

Great video, thanks for explaining this so clearly and in only 4 mins. I have a question, can the lactate that goes from muscles to the liver increase the growth of existing cancer cells in the liver in the case of a patient with liver metastasis? Thanks

[@Exscihub]

Thank you for the kind words on the video! That's a very good question, and one I don't feel equipped to properly answer as don't have specialization in cancer cells metabolism. Only a note here on the potential role of lactate in anaerobic "starvation" of cells to aid in its combat.

[@matt566]

Two things here: lactic acidosis is a common lethal endpoint for many disease processes. If the blood becomes acidic from too much lactic acid, then the cells and thus organs stop working.

[@Exscihub]

Yes, Matt the world of lactic acid production and consequences are fascinating and too vast for a short video! My goal is to focus on keeping them informative, complex made simple, in less than 5 min. Thank you for the added information!

[@paulallenscards]

Issss the person talking CG? The sound does not match his mouth movements at all

[@Exscihub]

Hi Paul, yes the narrator is electronic generated and i'm getting the hang of the software along with testing some functionalities. Thanks for checking us out and for the feedback!

[@Exscihub]

And, of course, important here for me to note that the narrator may be electronically generated, but not the content. All of it is orignally written ;)

[@paulallenscards]

That’s super cool! Just thought I was tripping bc I didn’t see any disclaimer about it being CG

[@tamer6893]

@@Exscihub yeah the head movements were weird lol