Transport inside the brain: The basic mechanisms of neuronal trafficking

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  • เผยแพร่เมื่อ 9 เม.ย. 2015
  • The primary aim of the Hoogenraad research lab at the University of Utrecht, the Netherlands, is to understand how intracellular transport underlies the development and function of nerve cells. During this animation, we will follow a presynaptic cargo during its journey through a nerve cell, illustrating the basic mechanisms, regulation and relevance of proper intracellular transport that occurs inside the cells of our brain.
    cellbiology.science.uu.nl
    dejongeakedemie.nl
    redrumbureau.nl
    Permission to use this video is not required. When you use our materials in print, on the Web or in a video or audio format, we simply request that you credit the "Hoogenraad lab at the Utrecht University" and refer to our website at cellbiology.science.uu.nl
  • วิทยาศาสตร์และเทคโนโลยี

ความคิดเห็น • 155

  • @revenger211
    @revenger211 11 หลายเดือนก่อน +13

    Actually insane. I'm learning neuroscience at the moment for the fun of it and wanted to actually see how it looks because I couldn't imagine it and oh boy this way crazier than I had imagined!

  • @Cozy.Mood.B
    @Cozy.Mood.B ปีที่แล้ว +8

    This is endlessly incredible. I have no words. Nature is out of this world!

  • @deadly.desai2
    @deadly.desai2 3 ปีที่แล้ว +23

    its only 1% related to my Studies,
    but damn! i just enjoyed watching the animation

  • @miramardream
    @miramardream 4 ปีที่แล้ว +138

    Wow, that trailer was amazing. When's the movie coming out?

    • @caseyalakwa5263
      @caseyalakwa5263 3 ปีที่แล้ว +4

      Hahaha

    • @quinattasneemrafique536
      @quinattasneemrafique536 2 ปีที่แล้ว +6

      Really want one movie on cell🥺

    • @ThomasConover
      @ThomasConover ปีที่แล้ว +6

      YOU are the movie bro.

    • @user-kv6vh5ug4i
      @user-kv6vh5ug4i 8 หลายเดือนก่อน +1

      I can sign now or you can wait till dead I me technically the gov marked me dead already 🎉

    • @user-kv6vh5ug4i
      @user-kv6vh5ug4i 8 หลายเดือนก่อน

      I dont mind

  • @anonymousplayer6378
    @anonymousplayer6378 ปีที่แล้ว +3

    Really a wonderful animation for a difficult topic to teach.

  • @goldengaming4911
    @goldengaming4911 6 ปีที่แล้ว +44

    Omg the 3D animation

  • @santrolli
    @santrolli ปีที่แล้ว +1

    Awesome visualisation! Thank you 🙏

  • @mshisha
    @mshisha 8 ปีที่แล้ว +12

    Great animation

  • @Neurosoul22.0
    @Neurosoul22.0 7 ปีที่แล้ว +58

    Dear Hoogenraad lab, thank you indebtedly for this animation - it is one of the most superb renditions of sci animation ive encountered... could i ask how the graphics were constructed/what software/which company etc.? Im a neuro graduate interested in getting into scie animating myself
    Many thanks!

  • @tonioverton9
    @tonioverton9 7 ปีที่แล้ว +23

    INCREDIBLE!!! Learning can be fun and interesting as well as educational. Thank you very much.

  • @bindasskanya3509
    @bindasskanya3509 3 ปีที่แล้ว +4

    I m an accountant but I m enjoying watching it,
    Beautiful

  • @CurtisLongkeep-uu3sm
    @CurtisLongkeep-uu3sm 2 หลายเดือนก่อน

    This was very fascinating to watch. Thank you for the upload. 10/10.

  • @im__Anonymous
    @im__Anonymous ปีที่แล้ว

    to make all this complicated mekanisme, is the soul

  • @quillclock
    @quillclock ปีที่แล้ว +1

    this one is way better than the one you did back in 2013. this is way more why and how than the other one that just covered what

  • @Ta3allamOnline
    @Ta3allamOnline 6 ปีที่แล้ว +2

    An Amazing video!

  • @ellios5734
    @ellios5734 2 ปีที่แล้ว

    Please upload more videos your animations are the best

  • @aboutstudies766
    @aboutstudies766 5 ปีที่แล้ว +1

    Thank you Madam/Sir!

  • @VLionV
    @VLionV 7 หลายเดือนก่อน

    What a great animation🔥🔥

  • @user-ff9hd9yw6x
    @user-ff9hd9yw6x 8 หลายเดือนก่อน

    How incredible it is!!!❤

  • @rossanaperrone3611
    @rossanaperrone3611 2 ปีที่แล้ว +4

    Hello! Thanks for this amazing video. I am a neuroscientist and a teacher in the School of Psychology in Uruguay. Can I use this video for teaching? Thank you very much.

  • @vitus008
    @vitus008 7 ปีที่แล้ว +1

    awesome video ....!!

  • @Dr.Zubair
    @Dr.Zubair 10 หลายเดือนก่อน

    Exactly what i was searching for

  • @nikitajangid1611
    @nikitajangid1611 ปีที่แล้ว +2

    This much clearity before 7 yrs

  • @seanotuleit
    @seanotuleit 3 หลายเดือนก่อน

    What a masterpiece in animation of the synapse. It is outstanding. Thank you.
    I still foster a doubt about which structures help neurotransmitters travel along the axone. Could you please point if those are the microtubles or the microfilaments? Cheers!

  • @AsiPtl
    @AsiPtl 23 วันที่ผ่านมา

    ASTONISHING!!

  • @abdulirhouma911
    @abdulirhouma911 4 ปีที่แล้ว +12

    3:26 yeeeeeet

  • @BlueUKLouis
    @BlueUKLouis 3 ปีที่แล้ว

    Amazing!!!

  • @paftaf
    @paftaf 5 ปีที่แล้ว +1

    Thanks!

  • @maimai-bd2iw
    @maimai-bd2iw ปีที่แล้ว

    More videos like this should be made

  • @michaelb1785
    @michaelb1785 5 ปีที่แล้ว +2

    What is the role of sleep and regulation of micro-tubules?

  • @BanginUKBeats01
    @BanginUKBeats01 6 หลายเดือนก่อน

    I get so excited watching this stuff. I'm like a kid in a sweet shop. 😂😊

  • @checkpointame
    @checkpointame 7 ปีที่แล้ว

    Hey we are making a school project about social media and how it affects the brain. Can I use short clips from your video to support the meaning? Looks amazing!

  • @12centuries
    @12centuries 4 ปีที่แล้ว +15

    This is so unbelievably, inconceivably complex. There's no way this wasn't designed.

    • @dhaneshtg8395
      @dhaneshtg8395 2 ปีที่แล้ว +2

      Ya true .. we are come from a rock it seems ..my ass..

    • @huntercurts9998
      @huntercurts9998 2 ปีที่แล้ว +6

      More like we have has literally billions of years to perfect this process

    • @12centuries
      @12centuries 2 ปีที่แล้ว +1

      @@huntercurts9998 With all respect, I think you might not be realizing the full complexity of what's happening here.

    • @iamBlackGambit
      @iamBlackGambit ปีที่แล้ว +4

      @@huntercurts9998 hey this animation video of the brain had no designer, it took a while for this video to make and order itself..but it did, all on its own.............

    • @aykoc2001
      @aykoc2001 ปีที่แล้ว

      @@huntercurts9998 literally billions of years are not enough to perfect such a process. Today's computers are capable of doing trillions of calculations per second. But no company on earth uses random and natural selection mechanism to create software that delivers value. Please try to do a probabilistic calculation and you will see that it is impossible that the life is the result of a random process. There is one God. It is obvious by the witness of every tiny little cell's processes.

  • @tanveerasarhadi8872
    @tanveerasarhadi8872 2 ปีที่แล้ว

    Never have I ever tripped so bad on an educational video before

  • @user-qu2qe2qy8c
    @user-qu2qe2qy8c 2 หลายเดือนก่อน +1

    Классно , молодцы. Побольше бы таких интересных видео.

  • @gosangel
    @gosangel 8 ปีที่แล้ว +3

    Buenos días, me gustaría saber si ustedes podrían subtitular todos los videos de este magnífico canal, pensando en las personas que NO hablamos inglés o poco lo entendemos.
    Gracias por su atención!!!

    • @ahntrjmpr
      @ahntrjmpr 6 ปีที่แล้ว

      Yo podria hacerlo si lo necesiten!!!

  • @Nonamelol.
    @Nonamelol. 2 หลายเดือนก่อน +1

    How exactly though does that entire process give me this experience??

  • @kikithepupper6774
    @kikithepupper6774 4 ปีที่แล้ว +1

    This is so beautiful.... WHo made this animation?

  • @isaiacaluza6712
    @isaiacaluza6712 8 หลายเดือนก่อน

    yall really ate with this, the microtubules popped off so dramatically lmao

  • @Nbokar
    @Nbokar 6 ปีที่แล้ว +2

    Need more videos

  • @jiahuiang1923
    @jiahuiang1923 5 ปีที่แล้ว +1

    I like your video

  • @chizauz
    @chizauz ปีที่แล้ว

    how many kinesin and dynein are moving through an axon?

  • @shadowsidesoamplified
    @shadowsidesoamplified 4 ปีที่แล้ว +3

    holy shit the graphics are mindblowing

  • @smurProductionz
    @smurProductionz 6 ปีที่แล้ว +16

    My god these types of animations are amazing!
    What sort of software do they use?

    • @noahwilliams8996
      @noahwilliams8996 6 ปีที่แล้ว +1

      David Murphy
      IDK about this video but if you're interested in 3D animation you can check out programs like blender, Maya, or 3D Max.

    • @ClaraWang32356
      @ClaraWang32356 5 ปีที่แล้ว

      I believe they use ray tracing to make it seem 3d -- you should check it out!

    • @iamBlackGambit
      @iamBlackGambit ปีที่แล้ว

      "My God" your exactly right! He made the brain

  • @RecoveryJimmy89
    @RecoveryJimmy89 7 หลายเดือนก่อน

    This stuff is so cool

  • @ninjatiger1163
    @ninjatiger1163 3 ปีที่แล้ว

    hey what is the name of the mucis when it transistion into the brain 0:19

  • @elviscaragea4433
    @elviscaragea4433 2 ปีที่แล้ว

    amazing

  • @DaddyBg69
    @DaddyBg69 3 ปีที่แล้ว

    Wow damn animation as well as damn sound..

  • @jinanarzary5677
    @jinanarzary5677 5 ปีที่แล้ว +2

    Wow!!

  • @Queen-fq4nk
    @Queen-fq4nk 21 วันที่ผ่านมา +1

    Lil bro is really strong

  • @vehicleboi5598
    @vehicleboi5598 ปีที่แล้ว

    realistic john

  • @chizauz
    @chizauz ปีที่แล้ว

    Ignore my previous comments and questions. I just watched a day in the life of John the walking motor protein. thanks for the video

  • @TheMraaqib
    @TheMraaqib 2 ปีที่แล้ว +4

    How Great the Creator would be. 🤯

  • @entisarnasser265
    @entisarnasser265 3 ปีที่แล้ว +3

    Why u are stop posting video ?? your video is too useful

  • @jamesl1014
    @jamesl1014 ปีที่แล้ว

    Intro song is Renascentiae, Sexually Assault. That is, some rendition of it I'd love to find an extended mix of- Hoogenrad sound persons I hope you're listening. 🙃

  • @anemari5809
    @anemari5809 3 ปีที่แล้ว +2

    It's like a suspense/thriller movie hahaha

  • @chizauz
    @chizauz ปีที่แล้ว +1

    how fast do the kinesin and dynein move? Do they move fast like the electrical light in the video moving fsat through the brain?

    • @flory6901
      @flory6901 ปีที่แล้ว +1

      250 steps per second

    • @flory6901
      @flory6901 ปีที่แล้ว +1

      Watch on utube A Day in the Life of a Motor Protein

  • @hajnalkakoller31
    @hajnalkakoller31 2 ปีที่แล้ว

    Danke GOTT

  • @petercareer439
    @petercareer439 5 ปีที่แล้ว

    Have you ever done a video of how estrogen receptor positive cancer cells find and feed off of the over produced estrogen in a man or a woman’s body?

  • @aaronj7081
    @aaronj7081 7 ปีที่แล้ว +21

    "The human brain, one of our most complex organs"
    Our most complex organ. The most complex organ in the animal kingdom. Why undermine the feat of understanding from the start, but ok.

    • @codyharrison771
      @codyharrison771 4 ปีที่แล้ว +3

      I've hear people say it's the most complex object in the known universe

  • @TARUN.2.2
    @TARUN.2.2 3 ปีที่แล้ว

    Best

  • @ifhtfilms
    @ifhtfilms 7 ปีที่แล้ว +8

    I'm only here for the shooting star meme loop

  • @siddharthannandhakumar6187
    @siddharthannandhakumar6187 2 ปีที่แล้ว +1

    Do the motor proteins really transport like walking?

    • @flory6901
      @flory6901 ปีที่แล้ว +1

      Yes this protein called Kinesin walks 250 steps per second

    • @flory6901
      @flory6901 ปีที่แล้ว

      If something goes wrong and there is traffic of this protein, it results in Brain Disease

  • @markopolofan5652
    @markopolofan5652 3 ปีที่แล้ว +1

    omg so cool

  • @bryzvyy1674
    @bryzvyy1674 3 ปีที่แล้ว +1

    This is one of the most Biopunk I have ever seen in my entire life.

  • @markshilhavy8326
    @markshilhavy8326 2 ปีที่แล้ว

    Brain diseases like what, I wonder. I've had several small brain injuries, one that left me unconscious for several minutes. Is depression or anxiety considered brain disease, I wonder. Cool video

  • @melissamiller8063
    @melissamiller8063 ปีที่แล้ว

    It is the universe inside.

  • @sulimansal2990
    @sulimansal2990 3 ปีที่แล้ว

    الله هو المهندس الأعظم.

  • @alphagonist4748
    @alphagonist4748 4 ปีที่แล้ว

    Damn

  • @DjDiDAS
    @DjDiDAS 2 ปีที่แล้ว +1

    Damn... definitely need to watch this on mushrooms or LSD trippie as FAh-Q! lol

  • @Mioochii
    @Mioochii 2 ปีที่แล้ว

    Now my brain knows how it looks like 😂

  • @ahmedkhaled2641
    @ahmedkhaled2641 2 ปีที่แล้ว +1

    that was better than breaking bad🥵

  • @ahmedtzaki4476
    @ahmedtzaki4476 ปีที่แล้ว

    AMAZING! It's very mind-blowing that reality is even more beautiful and complex and much faster than this! It's also unbelievable how there still atheists in the 21th century after all of these discoveries!

  • @SomaUlte
    @SomaUlte 2 ปีที่แล้ว +1

    Jimmy Neutron Intro hahahahaha

  • @kenconcepts
    @kenconcepts 3 ปีที่แล้ว

    damnnn who ever created us is a fucking genius. this some posthuman futuristic shit that we'd create in the future but as megastructures and dyson spheres.

  • @36yovan
    @36yovan 3 ปีที่แล้ว +7

    *Through the 3D animation video we are able to understand a little bit how marvelously and wonderfully we are formed in our mother's womb by our Creator ! Praise be to God 🙏*

  • @sitthuson
    @sitthuson 3 ปีที่แล้ว +1

    wow feels like I'm watching a horror movie

  • @protoborg
    @protoborg 5 ปีที่แล้ว

    Imagine if you managed to hack even a single neuron. The human brain is sooooo easy to hack if you control even just a few dozen neurons.

    • @kellogscornflakes2430
      @kellogscornflakes2430 5 ปีที่แล้ว

      Mind control

    • @paftaf
      @paftaf 5 ปีที่แล้ว +4

      Nope. It's a very stable system with many redundancy. Otherwise you'd fall from your bed on your head, and in the morning you'd be different person..

  • @JohnTepopo
    @JohnTepopo ปีที่แล้ว

    its like our brain is its own universe. and the universe we live in is someones synapses brain nerve and so on 😂

  • @BSin8413
    @BSin8413 3 ปีที่แล้ว +3

    God is amazing

  • @froggo7215
    @froggo7215 ปีที่แล้ว

    This is sureal. Like a protein stick figure walking on some kind of molecular thread carrying a gooey information. how all of them know how to do all of this?

  • @davehibbs9111
    @davehibbs9111 3 ปีที่แล้ว +1

    Thankless JOB 😂

  • @DENTiins
    @DENTiins ปีที่แล้ว

    It seems like i am watching the trailer of Neurons…

  • @DJSHaKa
    @DJSHaKa 3 ปีที่แล้ว

    Umm, what did i just watch, how did i get here - What has my life become? I did not search for this... HELP!

  • @higherresolution4490
    @higherresolution4490 5 ปีที่แล้ว +3

    Absolutely extraordinary 3D animation. Definitely produced by Europeans, and not North Americans. More detail is desirable (but probably too expensive).

    • @Novak2611
      @Novak2611 5 ปีที่แล้ว +1

      Are North Americans bad in 3D animation?

    • @wormhole331
      @wormhole331 5 ปีที่แล้ว +3

      @@Novak2611 No, I'd say Disney is pretty good with 3D animations, and many others. This guy is a typical pretentious European.

    • @coloradoing9172
      @coloradoing9172 8 หลายเดือนก่อน

      🤓

  • @silviaalexandrecordeiro8400
    @silviaalexandrecordeiro8400 ปีที่แล้ว

    🌹🌎🌍🌏🌹

  • @sportdutch
    @sportdutch 4 ปีที่แล้ว

    Don't have too much water on the brain.

  • @s.papadatos6711
    @s.papadatos6711 3 ปีที่แล้ว

    Movie directed by Zack Snyder...

  • @dhavalpandav4440
    @dhavalpandav4440 ปีที่แล้ว

    This theory 50% true but not expect protocol brain save in memory

  • @frankem4837
    @frankem4837 5 ปีที่แล้ว

    What did I just watch? 🤔😁

  • @mikekellerman4736
    @mikekellerman4736 3 หลายเดือนก่อน

    God the Almighty doesn't get his title from man. He gives that title to hiself. All praise and glory go to him for he is our lord and redeemer the master of the universe!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

  • @colerobison6916
    @colerobison6916 3 ปีที่แล้ว

    I didn't understand anything in this video.

  • @user-jv8ys8ju6p
    @user-jv8ys8ju6p ปีที่แล้ว

    سبحان الله العظيم ، كل من يقول لك أن كل هذا أتى بالعشوائية والصدفة فقط إضحك

  • @mahmouddridi386
    @mahmouddridi386 2 ปีที่แล้ว +1

    Quran "We will show them Our signs in the horizons and within themselves until it becomes clear to them that it is the truth. But is it not sufficient concerning your Lord that He is, over all things, a Witness?"
    Quran "Travel through the land and observe how He began creation. Then Allah will produce the final creation. Indeed Allah, over all things, is competent."
    Quran "Recite in the name of your Lord who created - Created man from a clinging substance. Recite, and your Lord is the most Generous - Who taught by the pen - Taught man that which he knew not.

    • @lostplanet1931
      @lostplanet1931 2 ปีที่แล้ว

      Muhammad is a false prophet

    • @lostplanet1931
      @lostplanet1931 2 ปีที่แล้ว

      He didn't get the Quran from God, he got it from the devil, he even choked him

  • @adamogilvie6951
    @adamogilvie6951 2 ปีที่แล้ว +1

    So based on the complexity and need I say design of systems like this, why do people still believe in Evelution? Something like this would simply not evolve. Glory to God!!!

    • @pietajunior3437
      @pietajunior3437 6 วันที่ผ่านมา +1

      Billions of years. Do you understand how much time that is?

    • @adamogilvie6951
      @adamogilvie6951 6 วันที่ผ่านมา

      ​@pietajunior3437 To be honest, not enough time. Look, if you're an evolutionist, that's cool, but I just don't see all these complex processes coming into existence randomly.

    • @pietajunior3437
      @pietajunior3437 6 วันที่ผ่านมา

      @@adamogilvie6951 It has been conclusively proven that a plethora of organic compounds can be abiotically synthesised on meteors, comets etc. People have demonstrated how to synthesise such compounds from simple chemicals. Those processes potentially happen all the time in the universe. If the building blocks of life are so readily created, then I don't see what stops them from forming yet even more complex structures on planets, which give them the opportunity to do so, like Earth.
      Things on the nanoscale aren't organised. It's constant chaos, atoms flying in every direction, hitting each other and potentially creating bonds, only for that bond to break a moment later. Now think about trillions of atoms participating in this chaos, and then think about a trillion trillions. That still isn't even close to the actual amount. Billions of years is a ton of time for these organic compounds to merge and modify and form strange chemical systems. Then one of such "systems" could reach a, more or less, stable form; for example, a lipid membrane, which then might work as a storage for other strange chemical systems, etc.

    • @pietajunior3437
      @pietajunior3437 5 วันที่ผ่านมา

      @@adamogilvie6951 It has been conclusively proven that a plethora of organic compounds can be abiotically synthesised on meteors, comets etc. People have demonstrated how to synthesise such compounds from simple chemicals. Those processes potentially happen all the time in the universe. If the building blocks of life are so readily created, then I don't see what stops them from forming yet even more complex structures on planets, which give them the opportunity to do so, like Earth.
      Things on the nanoscale aren't organised. It's constant chaos, atoms flying in every direction, hitting each other and potentially creating bonds, only for that bond to break a moment later. Now think about trillions of atoms participating in this chaos, and then think about a trillion trillions. That still isn't even close to the actual amount. Billions of years is a ton of time for these organic compounds to merge and modify and form strange chemical systems. Then one of such "systems" could reach a, more or less, stable form; for example, a lipid membrane, which then might work as a storage for other strange chemical systems, etc.

  • @mraravindbaku6338
    @mraravindbaku6338 3 ปีที่แล้ว +1

    *_stop procrastinating_*

  • @lacamendry1731
    @lacamendry1731 3 ปีที่แล้ว

    Supercomputer That God Made Is Human Brain.
    Think about it.
    Human can make a Car.
    Making A Rocket to fly around the Galaxy, Not really.
    Can make a Artificial Intelligence.

  • @akashbaiju6412
    @akashbaiju6412 3 ปีที่แล้ว

    Whoa. That white thing is walking he has no eyes so how is he know that this is the way.
    😂😂😂

  • @khirywidener7874
    @khirywidener7874 4 ปีที่แล้ว

    Allah Akbar

  • @patatavoladora3006
    @patatavoladora3006 2 ปีที่แล้ว +1

    bubu feo