The smoothest clearest most amazing ever made video on this complicated topic!! I discovered after watching this video that I was just memorizing random numbers and definitions without really understanding, god bless your heart , keep doing such amazing video lectures , I'm writing this comment under the influence of amazement by your video
This is the most logical and lucid presentation of Helper T cell types. Thank you! It also perfectly follows and clarifies the material on this topic in my Parham The Immune System. Great job and I really appreciate and love the entire Frank Lecture series!!
Fantastic! Very clear and concise explanations. First time viewer converted to a subscriber. I will recommend to everyone I know who is interested in the topics. This is better than the Khan academy videos. Thanks for your hard work! :-)
Very informative video. Thank you soo much. Can you please answer my query please. - Intracellular antigens can be presented only by MHC CLASS 1 molecules which can present antigens to only CD8 cells, then how can an APC present intracellular antigen to a CD4+ cell?
3:50 sec..main function of th1 cells is to induce macrophages to fight against intracellular pathogens..? How can macrophage fight against intracellular pathogens?? It can engulf the bacteria but how can it kill pathogens inside cell? Please help
Type 1 T helper cells (TH1 cells) help in defense against the intracellular infection by secreting cytokines which induce phagocytosis and opsonization by macrophages.
How can dendritic cells play role in intracellular infections. They play role in extracellular infections in which they phagocytes extracellular pathogens, but how they can play role in intracellular infections
Since it is an intracellulr pathogn as said in 2:23 thn dendritc cel must hv reprsntd it via MHC-l...so how can CD4 cel respond to it???....MHC-l was supposd to b recognisd by CD8....i appologize fo raisng my qustn but i don undrstnd how can CD8 cells b activatd by CD4 cells, which can only respond to MHC-l
Bharti Paul, First of all, there is no need to apologize for asking whatever you don't understand. Keep posting your queries here anytime. Answer to your question is... Dendritic cell can present antigens both on MHC I and MHC II. Besides two main antigen presentation pathways, there is also a concept of cross-presentation and autophagy that explains this ability of Dendritic cells. And for activation of CD8 cells check out lecture no. 33 - " cytotoxic cells".
Nice video! Could return to his topic and make a comprehensive video about how immune system react to each type of infection (viral and bacterial ones are most important). I mean there are some unclear things. For instance, when virus infection occurs not only cytotoxic T cells and NK cells work to eliminate it, also the production of antibodies allows to do it faster. You have said that IFNg make B cells to produce antibodies, but how it happens? Does IFNg activate Tfh-cells, or it directly acts on B cells? So, it would be great, if you make 2 videos about viral and bacterial infections. Where you discuss all aspects, from the moment when pathogen get through theepithelium to the elimination, and tell about all cytokines that work there.
What dendritic cell presents to Th2 cell is the protein antigen derived from the cells of the parasite that are shed by parasite's body in the blood or other areas of infection.
So I have an undiagnosed Autoimmune disease that we are trying to get to the bottom of and I think it would be very beneficial to determine which part I is the driving factor of my issues. I have a frequently elevated ESR/CRP, elevated Eosinophils, elevated prostaglandins, tons of mucus production, several random autoantibodies _(AChR, SP1 and a few others) and some other nonspecific markers of inflammation. Would you say this sounds like a TH1, TH2 or TH17 issue?
I get it But so much papers and literature talk about other other interleukins For example IL -23 can activate T 17 to make IL-17 The variation on how people explain this drives me nuts because everyone teaches it differently
+seemab khan memory cells are long-lived cells which play main role in secondary immune response. Check out recently uploaded video on " primary and secondary immune response" on this channel. Thank you.
+do do Type 1 T helper cells (TH1 cells) help in defense against the intracellular infection by secreting cytokines which induce phagocytosis and opsonization by macrophages. It is Type 2 T helper cells (TH2 cells) that defend against extracellular infections.
OMG! That female voice is so extreeemly monotonous and boring just like a TTS (text-to-speak) engine. Do You really think You can attract attention with that voice??
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thank u sooo very much ma'm. .for such awesome video...very easily understood & easy to revise also...
+karishma shaik thank you.
Glad that these videos are useful to you.
Thank you for this suggestion. Will make these videos later.
Thank you
You're Welcome.
@@FrankLectures Hi, is there a way to download your .pptx or at least give it as a .PDF ?
Holy crap. THIS was the short and simple version I've been looking for for weeks. THANK YOU.
The smoothest clearest most amazing ever made video on this complicated topic!! I discovered after watching this video that I was just memorizing random numbers and definitions without really understanding, god bless your heart , keep doing such amazing video lectures , I'm writing this comment under the influence of amazement by your video
This is the most logical and lucid presentation of Helper T cell types. Thank you! It also perfectly follows and clarifies the material on this topic in my Parham The Immune System. Great job and I really appreciate and love the entire Frank Lecture series!!
You teach WAY better than my online professor at Berkeley!! You should be proud! :) Thank you so much!
Glad to know this. Thank you for your feedback.
Thank you, this was exactly what I needed. Very clear and understandable
Thank you for your valuable feedback
Wonderful. Short simple straight forward clear.
This has been very helpful.
Thank you for making immune response with cytokines easy to understand
the computed voice makes me nervous, and make it hard to understand, please change it
Great video, at first I was like Oh no... a robot voice but, it did very well in helping me listen very carefully.
Many thanks for your work ! You have made it crystal clear
Thank you….i was stuck on this topic for a week 😢
Wow. Agree with all the other comments more info here in 10mins then I could find with hours else where. Thank you
Concise and clear explanation. Thank you!
very beautiful video one of the best, it is difficult to present a clear scheme and avoid confusion about this topic
Wow what a nice video! I really like the summary in the end aswell. Very well done =)
Fantastic! Very clear and concise explanations. First time viewer converted to a subscriber. I will recommend to everyone I know who is interested in the topics. This is better than the Khan academy videos. Thanks for your hard work! :-)
Thank you for your valuable feedback. Glad to know that these videos are helpful to you all.
Ironic! As if you were paying n got nothing to watch free youtube videos! Bro pls be thankful.
You're the best, please keep doing these videos.
thanks for clear explanation
very nice summary and explanation. especially the diagram at the end!
Beautifully explained.. excellent 👍
Wowwww what a osm vdo ... 1 lecture all confusion durr 🥰😍🤩🤩😍
Very informative video.
Thank you soo much.
Can you please answer my query please. -
Intracellular antigens can be presented only by MHC CLASS 1 molecules which can present antigens to only CD8 cells, then how can an APC present intracellular antigen to a CD4+ cell?
Maybe because APC have MHC class 2, which it uses to show to CD4 cells.
your motivational voice drives me crazy, love it
Thank you for your feedback.
Amazing video!
Your videos are great... Ty....... It help me lot to clear concept for exams...... Ty
Thank you so much for your feedback. Glad to know this.
This is a godsend!! Thank you so much ❤❤
You're welcome.
yes monotonous but very informative and simplified things. Great video. Thanks.
+Mohsin Fareed thank you.
Very informative. Keep up the good work.
+alvin trieu thank you
Which interleukins differentiate helper t cells to T reg and T fh cells ?
Thank you so much. Helpful video.
Beautiful lecture
Thank you!! Great explanation!
Well done! :) Thank you so much!!
Thanks
3:50 sec..main function of th1 cells is to induce macrophages to fight against intracellular pathogens..? How can macrophage fight against intracellular pathogens?? It can engulf the bacteria but how can it kill pathogens inside cell? Please help
I have the same question...
Type 1 T helper cells (TH1 cells) help in defense against the intracellular infection by secreting cytokines which induce phagocytosis and opsonization by macrophages.
@@FrankLectures Translation = the infected cells will be exterminated.
THANK YOU SOO MUCH.. VERY HELPFUL VIDEO.. TO THE POINT INFORMATION
Very clear🖤
Excellent 👌
i can't thank you enough madam ❤😊
So helpful! Thanks so much :D
Y antigen presentation only dendritic cells.. what about b cells and other antigen presenting cells.. pls clarify.. or related videos..
We want whole life science CSIR NET covered as soon as possible
Pls do that
Very nice analysis
thanks
According to prescott TH1,TH2,TH9,TH17 but very thanks you mam and your team 👍👍👏😊
Why no discussion of plasmid variants? The interactions with T sub h lymphocytes and antibiotic resistance. Maybe another TH-cam video?
It's so helpful thank u
You're welcome.
🎉awesome
very informative !
thank you !
+Kais Maiza thank you for your feedback.
Very informative video
This is really helpful. Thannk you
What would high levels of CD4+/CD8+ ratio levels indicate about the marker being used?
Is effector t cells and helper t cells are same
Very informative
at 2:30 how does the macrophage know that there is intracellular infection ? macrophage can't enter into other cells then how ?
How would dendritic cell activate T cells to differentiate into TH2. WHEN they can't ingest the parasite and process the antigen.
How can dendritic cells play role in intracellular infections. They play role in extracellular infections in which they phagocytes extracellular pathogens, but how they can play role in intracellular infections
Since it is an intracellulr pathogn as said in 2:23 thn dendritc cel must hv reprsntd it via MHC-l...so how can CD4 cel respond to it???....MHC-l was supposd to b recognisd by CD8....i appologize fo raisng my qustn but i don undrstnd how can CD8 cells b activatd by CD4 cells, which can only respond to MHC-l
Bharti Paul, First of all, there is no need to apologize for asking whatever you don't understand.
Keep posting your queries here anytime.
Answer to your question is...
Dendritic cell can present antigens both on MHC I and MHC II.
Besides two main antigen presentation pathways, there is also a concept of cross-presentation and autophagy that explains this ability of Dendritic cells.
And for activation of CD8 cells check out lecture no. 33 - " cytotoxic cells".
Frank Lectures ......wow❤❤❤.....ths is s new thng i came knw😊😊😊😊thank you so much....
@@FrankLectures Thank you for your answer! I had the same question
What
a method to differentiate between T helper 1 and T helper 2 lymphocytess
Nice video! Could return to his topic and make a comprehensive video about how immune system react to each type of infection (viral and bacterial ones are most important). I mean there are some unclear things. For instance, when virus infection occurs not only cytotoxic T cells and NK cells work to eliminate it, also the production of antibodies allows to do it faster. You have said that IFNg make B cells to produce antibodies, but how it happens? Does IFNg activate Tfh-cells, or it directly acts on B cells?
So, it would be great, if you make 2 videos about viral and bacterial infections. Where you discuss all aspects, from the moment when pathogen get through theepithelium to the elimination, and tell about all cytokines that work there.
Please, could you answer my question
Awesome 👏👏👏
thank you so much!
You're Welcome.
4:15 How can dendritic cell present part of parasite to Th2 cell, if the parasite is too big for dendritic cell to digest it?
What dendritic cell presents to Th2 cell is the protein antigen derived from the cells of the parasite that are shed by parasite's body in the blood or other areas of infection.
@@FrankLectures
I had the same question during the lecture
It make sense now
Thanks your for clarifying that
Regards
You're welcome :)
Thanks 😊
Video about immunoelectrophorosis
I have no T3 cells. How can I heal? Thank you.
Awesome ❤️
WOW THANK U VERY MUCH
So I have an undiagnosed Autoimmune disease that we are trying to get to the bottom of and I think it would be very beneficial to determine which part I is the driving factor of my issues.
I have a frequently elevated ESR/CRP, elevated Eosinophils, elevated prostaglandins, tons of mucus production, several random autoantibodies _(AChR, SP1 and a few others) and some other nonspecific markers of inflammation.
Would you say this sounds like a TH1, TH2 or TH17 issue?
Not an expert but the eosiniphil and mucous profuction sounds like a Th2 cell thing.
Th2.
Nice
what activates Treg
Great .....niCe viDeo
+Mustajab Alam thank you.
I get it
But so much papers and literature talk about other other interleukins
For example IL -23 can activate T 17 to make IL-17
The variation on how people explain this drives me nuts because everyone teaches it differently
Thanks. Where is the role of memory cell in lmmunity?
+seemab khan memory cells are long-lived cells which play main role in secondary immune response.
Check out recently uploaded video on " primary and secondary immune response" on this channel.
Thank you.
❤perfect....
as i know ..T helper for extracellular infection why you say intracellular infection at 2:26
+do do Type 1 T helper cells (TH1 cells) help in defense against the intracellular infection by secreting cytokines which induce phagocytosis and opsonization by macrophages.
It is Type 2 T helper cells (TH2 cells) that defend against extracellular infections.
thanks for explain
ما في ترجمها جماعه
can you kindly add some references to your knowledge ...
just google!
the sounds scaring me so bad
478 Fisher Center
Delta card
Very bad nervous sound
When the AI teaches you to...either fall aslepp or click away. Next time, please use a HUMAN voice...thanks...
Why are creepy voices used for these videos???? It's so distracting!
Were there no human in reach to narrate this?
Why ffing everyone resist on using this translator voice I hate it so much
OMG!
That female voice is so extreeemly monotonous and boring just like a TTS (text-to-speak) engine.
Do You really think You can attract attention with that voice??
+Maximilian Eberl thank you for your feedback.
Horrible computer voice