The series of videos is so great! It gives comprehensive review of the topic and makes so many thing now sound logical and coherent that didn't make sense to me before! Thanks for a great job you have done😊
At 01:16 the virally infected dendritic cell presented the viral antigen attached to MHC I to naive CD8 + Tc to turn it into effector Tc . Did the dendritic cell present the viral antigen attached to MHC II to the naive CD4 + TH to turn it into TH1 ?
@@meenasharma9609 I can come up with an answer myself , but I wanted it to be clearly mentioned & thoroughly explained in that illustrated tutorial . I'd speculate that activation of CD4 TH0 to CD4 TH1 would produce memory TH1 cells roaming in the circulation ; eventually leading to rapid & potent immune response in any next encounter with viral antigens presented on the surface of virally infected cells along with dendritic cells & excessive flux / activation of naive CD8 Tc cells . But another reasonable speculation is activation of CD4 TH0 to CD4 TH2 ; initiating a HUMORAL immune response which is - no doubt - an integral component of the antiviral immune response ; along with the cell mediated Tc response . Thus producing neutralizing antiviral antibodies , memory B cells & memory TH2 cells We unanimously agree that developing antiviral antibodies either due to infections or vaccinations is a well known fact monitored by antiviral SEROCONVERSIONS , but little was mentioned about that in the tutorial .
@@meenasharma9609 I am NOT a short term memory learner , i.e : gulp & throw up ! I believe in the advantages of long term memory learning especially in the fields of cumulative knowledge & establishing reasonable scientific basis . Unfortunately , I can't disclose my identity to you for some security measures !
I liked the video, however, how do we make Tc cells active or able to kill something like a cold or flue or even cancel cells, naturally (no chems)? Thank you in advance.
Well, MHC 2 is expressed on antigen presenting cells (eg macrophage or dendrite cells). If macrophage engulfs some microbe or own infected cell, it destroys it with ferments in lysosome and transports some pieces to the MHC 2. Dendrite cells are able to present both of MHC - for T-helpers (MHC 2) and T-killers (MHC 1).
a little confusion . as you said intracellular viral infection that means the pathogen is inside the cell then how will dendritic cell get it and present it to other immune cell ? the virus also infect dendritic cells or the dendritic cells pick up the products of cells destroyed by virus . in short i feel like some detail is missing here . plz reply
First of all: Amazing content on FL !! Secondly, for my understanding: Tc need a second signal in order to kill a target cell right? E.g. the B7/CD28 signal. Is that correct?
![[UNCUT] The Loyal Pin ปิ่นภักดิ์ EP.15 (1/4)](http://i.ytimg.com/vi/TLBjiHvkKtE/mqdefault.jpg)
The series of videos is so great! It gives comprehensive review of the topic and makes so many thing now sound logical and coherent that didn't make sense to me before! Thanks for a great job you have done😊
Glad to know this. Thank you for your feedback.
~~~~p
@@FrankLectures ⁰0p
@@FrankLectures p
Brilliant descriptions! Your videos are very informative and easy to follow. Thanks!
+SCUBAelement Glad to know this. Thank you for your feedback.
I also appreciate it
VERY IMPRESSIVE VDO .THANKS O UPLOADING THE VDO.
I mostly like your all videos it's real very helpful.
Thanks
Very good video
it's excellent, thank you so much.
Thank you.
Very helpful thanks a lot
Thank you for your feedback.
At 01:16 the virally infected dendritic cell presented the viral antigen attached to MHC I to naive CD8 + Tc to turn it into effector Tc .
Did the dendritic cell present the viral antigen attached to MHC II to the naive CD4 + TH to turn it into TH1 ?
Same question 😔
Have you got the answer?
If yes, will you plz explain?
@@meenasharma9609 I can come up with an answer myself , but I wanted it to be clearly mentioned & thoroughly explained in that illustrated tutorial .
I'd speculate that activation of CD4 TH0 to CD4 TH1 would produce memory TH1 cells roaming in the circulation ; eventually leading to rapid & potent immune response in any next encounter with viral antigens presented on the surface of virally infected cells along with dendritic cells & excessive flux / activation of naive CD8 Tc cells .
But another reasonable speculation is activation of CD4 TH0 to CD4 TH2 ; initiating a HUMORAL immune response which is - no doubt - an integral component of the antiviral immune response ; along with the cell mediated Tc response . Thus producing neutralizing antiviral antibodies , memory B cells & memory TH2 cells
We unanimously agree that developing antiviral antibodies either due to infections or vaccinations is a well known fact monitored by antiviral SEROCONVERSIONS , but little was mentioned about that in the tutorial .
@@WhyNot-si4pj wooo!!! 🤗🤗🤗
Thank you soooo much.
I can't believe someone is replying to a comment he/she had posted 3 yrs ego.
Can i know your name?
@@meenasharma9609 I am NOT a short term memory learner , i.e : gulp & throw up !
I believe in the advantages of long term memory learning especially in the fields of cumulative knowledge & establishing reasonable scientific basis .
Unfortunately , I can't disclose my identity to you for some security measures !
@@WhyNot-si4pjokey!!!!
👍👍👍👍
what is the difference between killer T cells (which is the other name of cytotoxic T cell) and Natural killer cells? please respond
I liked the video, however, how do we make Tc cells active or able to kill something like a cold or flue or even cancel cells, naturally (no chems)? Thank you in advance.
Thank you!
Can denritic cells present to both the type of cells cd4 and cd8? ..
Does it possess both mhc1 and 2 molecules..
Yes, they do have both types of mhc molecules.
How come Intra-cellular antigen is presented to both, MHC 1 & MHC 2 ?
Well, MHC 2 is expressed on antigen presenting cells (eg macrophage or dendrite cells). If macrophage engulfs some microbe or own infected cell, it destroys it with ferments in lysosome and transports some pieces to the MHC 2. Dendrite cells are able to present both of MHC - for T-helpers (MHC 2) and T-killers (MHC 1).
@@iliatcymbal do macrophages
Also have the ability to release MHC1 and MHC2??
@@meenasharma9609 yes, macrophages present mhc 1 (as all cells) and mhc 2
@@iliatcymbal thanx🤗🤗🤗
@@iliatcymbal Is this what cross-presentation is?
a little confusion . as you said intracellular viral infection that means the pathogen is inside the cell then how will dendritic cell get it and present it to other immune cell ?
the virus also infect dendritic cells or the dendritic cells pick up the products of cells destroyed by virus .
in short i feel like some detail is missing here . plz reply
th-cam.com/video/aLejH4wsfuI/w-d-xo.html you can know that by this video
First of all: Amazing content on FL !! Secondly, for my understanding: Tc need a second signal in order to kill a target cell right? E.g. the B7/CD28 signal. Is that correct?
You have to add pdf in addition to the animated video is necessary
Thumbs up for content but the computer voice is horrible. Makes me want to turn it off.
But if she doesn't use the computer voice then the english subtitles will be incorrect, that's why computer voice is very important .
Get a Human Voice please.