Medical School - Glycolysis Made Easy
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- เผยแพร่เมื่อ 30 ก.ย. 2024
- In today's video we discuss the steps of glycolysis. We take glycolysis step by step so you gain a true understanding and minimize the need for pure memorization. Remember to watch our other videos to help you understand important concepts that you will encounter in nursing school, medical school, and physician assistant school.
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iMedicalSchool is a channel dedicated to helping you understand complex medical topics in a simple manner. We want to make sure that you understand every topic presented. We are happy to answer questions and take suggestions. No matter if you are in medical school, nursing school or physician assistant school we are here to help you learn more.
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Brain just fucking exploded.
At first I thought he was talking wayyy too slow, but then ... it allowed me to think about what he was talking about. OMG THIS VIDEO IS DA BOMB DOT COM PLS
Guys wish me luck tomorrow is my Carbohydrates biochemistry test!!!
Dave James Good luck bro!
good luck DJ!!!!
@@MrPridizzle lol
Gl Dave
I learned more from this video than 4 lectures at University that I'm paying thousands of bucks for.. thank you thank you thank you
Ummm.... If this is to be taught in medical school why is this in my 11 th grade bio portions ?
hii
You will not need to know it in the same level of detail
Actually we did ... Hi Anil ! ;)
This a dumb down version of glycolysis. In medical school you will learn all the pathologies involved.
Glycolysis is taught in high school but in medical school you discuss glycolysis in terms of diseases and how defects in the cycle relate. Thanks for watching!
Simple clue, ALL kinases involved in glycolysis involve ATP (Hexokinase/glucokinase, PFK-1, phosphoglycerate kinase, pyruvate kinase), and ALL dehydrogenases reduce/oxidize NAD+ to NADH (glyceraldehyde 3-P dehydrogenase, Lactate dehydrogenase for anaerobic).
1. ALL kinases in glycolysis use ATP
2. ALL dehydrogenases involve NAD
That is only good until pyruvate, once pyruvate enters the mitochondria, it gets slightly different (pyruvate carboxylase uses ATP) but it's a quick way to remember (hope it helps)
+Sean Chagani You are amazing, you just made this much easier to remember for me!
😊 good....
But ATP is also consumed when kinases act in some steps...right?
I mean ADP
I'm laughing in sadness because I don't know where this video was when I was studying for my last biochem exam where I literally did the ini-mini-myni-mo game. hahaha T---T
i feel ya....
What. the. hell. ...I refuse to let this deter me away from my dream job though!!!
Uhmm... I think I know some of these words...
hahaha, I know how you feel
I'm here because my professor failed to do his job... Thanks a million!
You are the shit :D I don't get why lecturers make it unnecessarily complicated. This video is amazing. Thanks :)
That was just a well taught and presented video. It was the perfect video, at the level needed, to not have to study anything else but your video to cover the glycolysis portion of my test tomorrow. Great job. Hoping you have a Krebs video.
I love you so much. I am taking cell biology and this was not broken down this well.
haha nice pun
Where are the OH groups on the glucose and fructose?
The 6th carbon on the glucose-6-phosphate is missing an oxygen. It should be "CH2OPO3^2-" instead of "CH2PO3^2-". Great video, though!
+Shane Cronin Thank you, I was wondering why the number of Oxygens was changing when it was isomerized to F-6-P
Only request: Could you show the whole cycle in one picture after pyruvate is formed? This helped a lot thank you!
Wow perfect explanation!!!👍🏻👏
Amazing video. Keep it up and thank you. Very good for refreshing your memory.
Regards, 2nd year MD.
thank you medical school it helps me to understand glycolysis cycle....because so many times i tried to by heart this cycle but i never remembered....but after watching your video it help me out....to understand this cycle....:)
This is great!! But there are 10 steps and you have 9. You combined steps 4&5 into step 4 so it kind of throws some things off. Step 5 is where DHAP gets acted on by triose phosphate isomerase to produce glyceraldehyde-3-phosphate. Steps 6-10 are supposed to be energy producing steps that double their products. That was a little unclear here. But this is pretty great. Thank you!
Thanks for the video. I'm taking physiology and this video is super helpful for understanding the basic steps of glycolysis.
Great video, current MS 1, works really well if you draw along with the video and follow with your own notes from lecture
Thank you very much, studying for a test about gycolysis and citric acid cycle. This really helped. Now to see if there's a good CAcycle video
great video, for people who don't really understand the enzymes and reactions involved, google magic or read a biology book...cough
Don't you mean triosephosphate isomerase instead of triphosphate isomerase? I don't mean to be a critical prick but I was wondering if those two enzyme names are interchangeable!
you are seriously the best! thank you! :D and thank you TH-cam! :D
Thanks for the great video! This is much better explained than the hideous diagram by my textbook lol.
I really did like this video, however I do wish someone would make a cellular respiration video, that is slow enough to see where the carbons and hydrogens are coming and going. (nursing student).
THANK YOU VERY EDUCATIVE. SESHA
Really like the way glycolysis was explained in a words that helped me understand this process a lot better. Can't wait to see all the other videos you produce/are producing on the various metabolic processes.
Many thanks. I might actually pass my Chem exam next Tuesday!
Viv :-)
Thank you so much for making this video. A valuable resource for nursing students as well.
I love this!!!!!! keep it up; really broke it down for me and made me understand! :)
It would be great if you could zoom out so we could see the whole diagram and all the steps next to each other. But great video!!
Thank you so much sir. You are my invisible teacher, next to my parents.
Thank you so much my teachers are terrible at explaining my lecture to be honest you saved me a lot if time.
Is there any way that I could download this entire drawing?
You made a mistake it should be CH2OPO3-2 not CH2PO3-2
helped me a lot ! thanks
i would be dead without you
Very helpful video, thanks bro
How..is fermentation nd glycolysis is to be differentiate. .as we consider both r anaerobic??.
Plz sr ...can i have ans of this que...asked in my exam..thnx
Fermentation occurs at the end of glycolysis using up pyruvate IF oxygen is not present. On the other hand if oxygen is present pyruvate is shuttled into the pyruvate decarboxylation/Krebs cycle (aerobic respiration). The key difference is between fermentation and aerobic respiration as aerobic respiration produces significantly more ATP than fermentation. Hope that helps.
You dropped an necessary Oxygen when creating glucose-6-phosphate. The Phosphorus does not bond to the carbon. It bonds to the oxygen of the deprotonated hydroxyl group.
Thank you for explaining this to me! :D
The two G3P compounds only have 5 H, right? Then how is it that 2NADH and 2 H+ come from the production of 1,3BPG, which each have 4 H???
helped so much!
This video was extremely helpful.
This is really a helpful video 👌🏼
Thank you
i really loved this one .......clear and precise
Biochem test tomorrow. This helps a ton!!!
very helpful. thanks so much!
subscribed, loved this, tysmmm
Thank u....tmrw my bio chem exam... it is usefull completed in 10 mins...... thank u
you forgot the O in glucose 6 phosphate
wow this is perfect. thank you!
hey u did two mistakes at last and begining .. chech the formula of pyruvate man
thanks for the excellent information
Thank you, this helped a lot.
Thank you so much, it helps me alot to understand. and that key points were really nice.
TriOSE-phosphate isomerase?
This is better than my lecture section
really good video. It helped me a lot.
This made it more confusing
THANK YOOOOOOU
I cant thank you enough!
A lot of info but super easy to follow!
Best video ever. Thanks a lot!
Such a helpful video, thank youuuuu!
This is so awesome! It is my first year in medschool and I needed simple explanations SO BADLY! And then I watched your videos. Funny thing is,even though I'm in college in France (so I guess our systems are quite different from each other), they are still very helpful! so THANK YOU! Really!
How is medical school so far? I'm in my last year of high school and I'm considering becoming a physician but I'm horrible at biology. What degree did you get because you started medical school?
+sydney yendys if the school doesn't offer premed then usually biological science or similar majors will be fine. Just make sure to take all the required classes.
in 9th grade honors biology were learning cellular respiration. We don't go in depth into how or why everything happens to the atomic level, although that is the only way to truly understand it. Instead we are only taught the major things that happen, like Glucose takes 2 atp and becomes two pyruvate molecules, producing 4 Atp. This video helps to understand how everything happens.
in the US, it doesn't advance much, until you reach higher level college courses. I'm just now required to know each step. even in general biology, it was simplified to not much more than you mention.
Random Internet Profile Last year when I posted this comment I was in honors biology. I live in the US too.
Why aren't you taking about electron transport?????? That's the main point of glycolysis.
I mean nad+ didn't become nadh without getting electron and a hydrogen atom. It would be nice if u talk in terms of electrons.
riken maharjan I'm guessing that's because the main point of glycolysis is to produce pyruvates to be used for the Krebs cycle, the second step of cellular respiration, and finally the electron transport chain where most of the ATP is produced.
they have a separate video just for electron transport..
Wow, how much do I have to pay this guy to be my tutor?
Hi I'm a 1st yr med student in Craiova/Romania and I gotta say YOU ARE AWESOME
and i am a ex student of constanta howis in romania now?
well it's pretty good .When did you graduate?I'm in the English section.I heard Constata is a good uni but the city is a little expensive coz its near the sea ,esp. in summer.
thank you
thank you
thank you
Could you tell me what program this is made with?
This is super helpful thank you :)
Um, where is the O gone? The phosphate group is PO4, not PO3 (at 1.47), so shouldnt it be glucose+po4^2-?
GREAT VIDEO! EXCELLENT!!! Keep making more Biochem videos!!
I wish my Biochem teacher taught like this
That was absolutely extraordinary presentation about Glycolysis . Much Much appreciated.
Love the explanation, great speed and very understandable...makes much more sense.
Thanks! That really did make glycolysis simple, but needs error checking. Why did you write all the H₂ as H2? This is confusing, especially when the 3 oxygens in the phosphate group are written in subscript. Also, G-6-P (1:43) is missing an oxygen! The 6 carbon should read CH₂OPO₃²⁻. Finally, (9:01) Pyruvate should have a negative charge on the oxygen which is single bonded to the first carbon. These are great videos but are let down by silly mistakes. GIGO - garbage in, garbage out.
It should be noted that it is after aldolase where we see the 6 carbon molecule catalyzed into 2 (3 carbon molecules) where everything is consumed and produced 2X.
i.e: We resume with 2 Molecules Glyceradehyde 3 phosphate followed by enzyme Glyceraldehyde 3 Phosphate Dehydrogenase facilitates 2NAD + Pi(donated to Carbon 1) -> 2NADH etc...
Great video, the only you might want to mention somewhere is that only 3 of the steps are irreversible:
-Glucose -> Glucose-6-Phosphate (rate limiting step)
-Fructose-6-Phosphate -> Fructse-1,6-Bisphosphate (most important step)
-Phosphyoenolpyruvate -> Pyruvate (substarte-level phosphorylation)
Great video and definitely worth the watch. Thanks!
Your video is crystal clear, it simplifies things a lot, thank you very much ! :-)
However, be careful with the first G6P, I think you're missing an O in the formula on the 6th carbon (Should have been CH2OPO3(2-) instead of CH2PO3(2-)), but it's completely understandable, and also corrected afterwards ;-)
OH MY GOD!!! THANK YOU (subbed)
IVE BEEN SEARCHING FOR SOMETHIMG LIKE THIS FOR LIKE 2 HOURS
TEST TOMORROW 😥😥😥😥😥😥
Hi, first of all I would love to thank you for the video, it did make things clearer. However, I was just curious about something; when fructose - 1,6 - biphosphate changes to DHAP, you said that glycolysis terminates. Is this a form of end-product inhibition?
Hi.. I would like to ask something about this glycolysis.. In the 1st stage of energy paid-off phase, NAD+ accept H from 3-phosphoglyceraldehyde. Why there still a H+ into equation(NADH+H+)[where is the H+ Comes from]?
I was talking about NADH formed during glycolysis. Like how these reduced molecules are important. Pyruvate is the main product but he should also say NADH's job too. It'll be easy to follow.
Thank you so much for this!
What happens to the hydrogen atom in carbon 6 when phosphate group replaces glucose at the beginning of glycolysis?pls reply 11:04 .
Ok so I have a question: If there is an abundance of ATP in the body, then the triosephosphate isomerase will disconfigure the glyceraldehyde 3-phosphate (GADP) to dihydroxyacetone phosphate (DHAP) as a break mechanism. So is it possible that only one of the two triose sugars will be GADP and the other remains DHAP? Does this mean that there will be a net ATP of 0 and an NADH of 1 in this instance since there is only one triose sugar that can proceed with the process?
Hi, is bisphosphoglyceric acid same as bisphosphoglycerate?
Please help, thank you.
This was the BEST video that I found on glycolysis. I really appreciate the direct information of this video, and its step by step break-down.
i was so confused in class when my professor when over glycolysis which took all of 2 50min lectures this 11min video just created a new synapse and glycolysis will forever stay with me... thank you so much for providing this video... best video I've seen thus far!!!
THANKYOU SO MUCH THIS HAS SAVED ME
LOVE this video EXCEPT for the noisy intro... when trying to review biochem, the last thing i need is jarring dissonance. I very much appreciate the actual content tho.
thank you very much for this video is very useful for me. furthermore on 10/9, I have exam Biochem..so i'm ready to answer it.....thank a lot.
I think there was a small error at 9:09 - The oxygen that is single bonded to the second carbon on pyruvate should sport a negative charge.
Other than that, I think this a wonderful video for Glycolysis. It's clean-cut, organized, and really breaks it down!
man, after my first year in my bioscience program, i am really regretting choosing science.....theres too much information to take in (albeit easy to grasp concepts)
Not a bad presentation. It's pretty clean, and I'm sure it has helped a ton of people with the concepts.
I think it would have been nice to see a mention of the glycogen phosphorylase step that occurs when the source is coming directly from glycogen instead of free glucose. This step bypasses the hexokinase step and as such skips the first ATP investment.
Under higher intensity scenarios, phosphorylase activity increases, and I would argue that more glycolysis is resulting from a glycogen source instead of free glucose. That said, all of the steps afterward are explained rather well, and I don't want to take away from that. Please continue the good work :)
[My Background -- Exercise Physiology grad student and metabolism junkie]