At first I thought he was talking wayyy too slow, but then ... it allowed me to think about what he was talking about. OMG THIS VIDEO IS DA BOMB DOT COM PLS
i was so confused in class when my professor when over glycolysis which took all of 2 50min lectures this 11min video just created a new synapse and glycolysis will forever stay with me... thank you so much for providing this video... best video I've seen thus far!!!
Great video, the only you might want to mention somewhere is that only 3 of the steps are irreversible: -Glucose -> Glucose-6-Phosphate (rate limiting step) -Fructose-6-Phosphate -> Fructse-1,6-Bisphosphate (most important step) -Phosphyoenolpyruvate -> Pyruvate (substarte-level phosphorylation) Great video and definitely worth the watch. Thanks!
I am taking biochemistry as an undergraduate summer course. My professor, while smart, seems to have spent too long researching and not enough time teaching. Confusing! This video unraveled in 11 minutes what he spent a week running circles around me with. Perfect way to actually understand this material instead of base memorization. Thank you so much for making it!
Really like the way glycolysis was explained in a words that helped me understand this process a lot better. Can't wait to see all the other videos you produce/are producing on the various metabolic processes. Many thanks. I might actually pass my Chem exam next Tuesday! Viv :-)
That was just a well taught and presented video. It was the perfect video, at the level needed, to not have to study anything else but your video to cover the glycolysis portion of my test tomorrow. Great job. Hoping you have a Krebs video.
Simple clue, ALL kinases involved in glycolysis involve ATP (Hexokinase/glucokinase, PFK-1, phosphoglycerate kinase, pyruvate kinase), and ALL dehydrogenases reduce/oxidize NAD+ to NADH (glyceraldehyde 3-P dehydrogenase, Lactate dehydrogenase for anaerobic). 1. ALL kinases in glycolysis use ATP 2. ALL dehydrogenases involve NAD That is only good until pyruvate, once pyruvate enters the mitochondria, it gets slightly different (pyruvate carboxylase uses ATP) but it's a quick way to remember (hope it helps)
thank you medical school it helps me to understand glycolysis cycle....because so many times i tried to by heart this cycle but i never remembered....but after watching your video it help me out....to understand this cycle....:)
fantastic video, got a test tomorrow on this tomorrow and I didn't have a clue about anything on glycolysis but I have a good understanding after watching this.
well it's pretty good .When did you graduate?I'm in the English section.I heard Constata is a good uni but the city is a little expensive coz its near the sea ,esp. in summer.
I was studying for a test and this really helped me better understand glycolysis. This was actually the essay question and now after watching this video, I feel I am more prepared for my test. Thank you! :)
This is great! The layout of your videos is awesome - a more detailed description followed by a brief synopsis with the important points highlighted. Thank you thank you!
This is so awesome! It is my first year in medschool and I needed simple explanations SO BADLY! And then I watched your videos. Funny thing is,even though I'm in college in France (so I guess our systems are quite different from each other), they are still very helpful! so THANK YOU! Really!
How is medical school so far? I'm in my last year of high school and I'm considering becoming a physician but I'm horrible at biology. What degree did you get because you started medical school?
+sydney yendys if the school doesn't offer premed then usually biological science or similar majors will be fine. Just make sure to take all the required classes.
it is really helpful. i've been studying glycolysis from the past 3 months. but didnt had clear idea, but this video helped me a lot especially in remebering the enzymes and their concerned step. :)
in 9th grade honors biology were learning cellular respiration. We don't go in depth into how or why everything happens to the atomic level, although that is the only way to truly understand it. Instead we are only taught the major things that happen, like Glucose takes 2 atp and becomes two pyruvate molecules, producing 4 Atp. This video helps to understand how everything happens.
in the US, it doesn't advance much, until you reach higher level college courses. I'm just now required to know each step. even in general biology, it was simplified to not much more than you mention.
I guess a lot of people already thank you for that but Man!! I'm in the first year of med school (in France, even tho how program might be completely different we still have the same basis) also and this helped me a lot just to see how does it works, what each molecules require to work. Thanks :) I aint gonna forget it: a Kinase enzymes infers the moving of an inorganic phosphate. :)
I think there was a small error at 9:09 - The oxygen that is single bonded to the second carbon on pyruvate should sport a negative charge. Other than that, I think this a wonderful video for Glycolysis. It's clean-cut, organized, and really breaks it down!
Your video is crystal clear, it simplifies things a lot, thank you very much ! :-) However, be careful with the first G6P, I think you're missing an O in the formula on the 6th carbon (Should have been CH2OPO3(2-) instead of CH2PO3(2-)), but it's completely understandable, and also corrected afterwards ;-)
Not a bad presentation. It's pretty clean, and I'm sure it has helped a ton of people with the concepts. I think it would have been nice to see a mention of the glycogen phosphorylase step that occurs when the source is coming directly from glycogen instead of free glucose. This step bypasses the hexokinase step and as such skips the first ATP investment. Under higher intensity scenarios, phosphorylase activity increases, and I would argue that more glycolysis is resulting from a glycogen source instead of free glucose. That said, all of the steps afterward are explained rather well, and I don't want to take away from that. Please continue the good work :) [My Background -- Exercise Physiology grad student and metabolism junkie]
The first release of water isn’t in the enolase step. Note that in the aldolase step, an acid in the active site and a free-flowing H+ ion interact with the carbonyl to produce a water. While it is quickly recycled and used to convert DHAP to G3P under a majority of physiologic conditions, a water is still synthesized, potentially remaining as such until Le Chatelier’s principle necessitates the isomerization. Beyond that, the rest of the video is great!
At first I thought he was talking wayyy too slow, but then ... it allowed me to think about what he was talking about. OMG THIS VIDEO IS DA BOMB DOT COM PLS
I learned more from this video than 4 lectures at University that I'm paying thousands of bucks for.. thank you thank you thank you
i was so confused in class when my professor when over glycolysis which took all of 2 50min lectures this 11min video just created a new synapse and glycolysis will forever stay with me... thank you so much for providing this video... best video I've seen thus far!!!
Great video, the only you might want to mention somewhere is that only 3 of the steps are irreversible:
-Glucose -> Glucose-6-Phosphate (rate limiting step)
-Fructose-6-Phosphate -> Fructse-1,6-Bisphosphate (most important step)
-Phosphyoenolpyruvate -> Pyruvate (substarte-level phosphorylation)
Great video and definitely worth the watch. Thanks!
I am taking biochemistry as an undergraduate summer course. My professor, while smart, seems to have spent too long researching and not enough time teaching. Confusing!
This video unraveled in 11 minutes what he spent a week running circles around me with. Perfect way to actually understand this material instead of base memorization.
Thank you so much for making it!
This is possibly the best glycolysis video on TH-cam!
Really like the way glycolysis was explained in a words that helped me understand this process a lot better. Can't wait to see all the other videos you produce/are producing on the various metabolic processes.
Many thanks. I might actually pass my Chem exam next Tuesday!
Viv :-)
In my opinion this is the best glycolysis video online.
That was just a well taught and presented video. It was the perfect video, at the level needed, to not have to study anything else but your video to cover the glycolysis portion of my test tomorrow. Great job. Hoping you have a Krebs video.
This is by far the best video I have seen and I plan to watch it a hundred times. Thank you for the help!
This was the BEST video that I found on glycolysis. I really appreciate the direct information of this video, and its step by step break-down.
Simple clue, ALL kinases involved in glycolysis involve ATP (Hexokinase/glucokinase, PFK-1, phosphoglycerate kinase, pyruvate kinase), and ALL dehydrogenases reduce/oxidize NAD+ to NADH (glyceraldehyde 3-P dehydrogenase, Lactate dehydrogenase for anaerobic).
1. ALL kinases in glycolysis use ATP
2. ALL dehydrogenases involve NAD
That is only good until pyruvate, once pyruvate enters the mitochondria, it gets slightly different (pyruvate carboxylase uses ATP) but it's a quick way to remember (hope it helps)
+Sean Chagani You are amazing, you just made this much easier to remember for me!
😊 good....
But ATP is also consumed when kinases act in some steps...right?
I mean ADP
OMG THANK YOU SO MUCH FOR THIS VIDEO. My bio midterm is tomorrow and I have to write about the enzymes of glycolysis. You're a life saver.
thank you medical school it helps me to understand glycolysis cycle....because so many times i tried to by heart this cycle but i never remembered....but after watching your video it help me out....to understand this cycle....:)
I've been trying to understand glycolysis and the role of ATP for 3 years and just learned it in 11 minutes.... amazing video, thank you!!!!
Thank you so much sir. You are my invisible teacher, next to my parents.
This is the best video of glycolysis I've seen on the net!!!!
This makes more sense than the lecture does!!! Love it man... Keep them coming!!!
Love the explanation, great speed and very understandable...makes much more sense.
I love you so much. I am taking cell biology and this was not broken down this well.
haha nice pun
This is exactly the level of depth necessary for me to study for my molecular bio exam next week. So glad I found this video, and thank you!
fantastic video, got a test tomorrow on this tomorrow and I didn't have a clue about anything on glycolysis but I have a good understanding after watching this.
after 3 days i have cabohydrate metabolism test....nd thnk GOD i got this video...
Thank u....tmrw my bio chem exam... it is usefull completed in 10 mins...... thank u
This is the best explanation I have seen so far.
Hi I'm a 1st yr med student in Craiova/Romania and I gotta say YOU ARE AWESOME
and i am a ex student of constanta howis in romania now?
well it's pretty good .When did you graduate?I'm in the English section.I heard Constata is a good uni but the city is a little expensive coz its near the sea ,esp. in summer.
Thank you so much for making this video. A valuable resource for nursing students as well.
Thank you so much my teachers are terrible at explaining my lecture to be honest you saved me a lot if time.
I was studying for a test and this really helped me better understand glycolysis. This was actually the essay question and now after watching this video, I feel I am more prepared for my test. Thank you! :)
Great video, current MS 1, works really well if you draw along with the video and follow with your own notes from lecture
Amazing video. Keep it up and thank you. Very good for refreshing your memory.
Regards, 2nd year MD.
Guys wish me luck tomorrow is my Carbohydrates biochemistry test!!!
Dave James Good luck bro!
good luck DJ!!!!
@@MrPridizzle lol
Gl Dave
This is beautiful. You saved my life. God bless.
soooo helpful! Followed my textbook as you spoke and you didn't miss a thing! Thanks a lot!
That was absolutely extraordinary presentation about Glycolysis . Much Much appreciated.
This is great! The layout of your videos is awesome - a more detailed description followed by a brief synopsis with the important points highlighted. Thank you thank you!
This is so awesome! It is my first year in medschool and I needed simple explanations SO BADLY! And then I watched your videos. Funny thing is,even though I'm in college in France (so I guess our systems are quite different from each other), they are still very helpful! so THANK YOU! Really!
How is medical school so far? I'm in my last year of high school and I'm considering becoming a physician but I'm horrible at biology. What degree did you get because you started medical school?
+sydney yendys if the school doesn't offer premed then usually biological science or similar majors will be fine. Just make sure to take all the required classes.
I thought khan was the best, until now! Thanks for making bio chemistry relaxing =) Keep it up man!!!!
This video is amazing!! You explain it so simply and clearly. Thank you!
it is really helpful. i've been studying glycolysis from the past 3 months. but didnt had clear idea, but this video helped me a lot especially in remebering the enzymes and their concerned step. :)
The best video about glycolysis I’ve ever seen
Thanks for the video. I'm taking physiology and this video is super helpful for understanding the basic steps of glycolysis.
in 9th grade honors biology were learning cellular respiration. We don't go in depth into how or why everything happens to the atomic level, although that is the only way to truly understand it. Instead we are only taught the major things that happen, like Glucose takes 2 atp and becomes two pyruvate molecules, producing 4 Atp. This video helps to understand how everything happens.
in the US, it doesn't advance much, until you reach higher level college courses. I'm just now required to know each step. even in general biology, it was simplified to not much more than you mention.
Random Internet Profile Last year when I posted this comment I was in honors biology. I live in the US too.
This is so helpful. Way better than the breezy metaphors my prof tried to use. Thank you!!
Clear, concise video that helped me understand Glycolysis.
this is one heck of an amazing video! my gosh thank you so much. solves much of my problems. keep uploading. God bless. thanks, mann!
Thank you very much, studying for a test about gycolysis and citric acid cycle. This really helped. Now to see if there's a good CAcycle video
That's so much easier to understand how my lecturer just described it! Thank you :)
Pedagogy at its finest - bravo.
This is the most helpful glycolysis video out there. Thanks!
Simple and straight forward explanation..thanks Doc.
really great vid! very easy to follow and very thorough.I'm required to do a vid review for a biochem project and I'm so glad I found this one :)
I guess a lot of people already thank you for that but Man!! I'm in the first year of med school (in France, even tho how program might be completely different we still have the same basis) also and this helped me a lot just to see how does it works, what each molecules require to work. Thanks :)
I aint gonna forget it: a Kinase enzymes infers the moving of an inorganic phosphate. :)
+Ritchy Emboulé our*
Thank you so much! This was incredibly easy to follow and extremely helpful!
Excellent video! This is going to help me so much on my exam lol. Thanks a million!
I love this!!!!!! keep it up; really broke it down for me and made me understand! :)
You have no idea how much you have helped me!
Really interesting n educative video, dis really makes glycolysis easier to commit to memory.
Thanks so much
you are a savior....Thanks alot, you just made my life better.
Great video!! I'm about to start medical school and this helps a lot. THANKS!!!
i really loved this one .......clear and precise
This video is a life saver!! The material is well explained and presented, thank you so much;-)
Thank you so much, it helps me alot to understand. and that key points were really nice.
this was so simple and easy to understand. amazing, thank you!
This was EXTREMELY helpful! Thank you!
thank you for explaining sooo well... im getting a head start for my metabolism class.. this video sure helped :)
I think there was a small error at 9:09 - The oxygen that is single bonded to the second carbon on pyruvate should sport a negative charge.
Other than that, I think this a wonderful video for Glycolysis. It's clean-cut, organized, and really breaks it down!
Thank you. I finally understand glycolysis properly.
Wow perfect explanation!!!👍🏻👏
Biochem test tomorrow. This helps a ton!!!
you are seriously the best! thank you! :D and thank you TH-cam! :D
Thanks for the great video! This is much better explained than the hideous diagram by my textbook lol.
Only request: Could you show the whole cycle in one picture after pyruvate is formed? This helped a lot thank you!
Thankyou this was so helpful for my Clinical life science Biochemistry !!
Awesome! Very clear and easy to understand. Thank you very much for sharing :)
thnx alot i found it very helpful
but i got a question in 5:50 the 1-3bisphosphoglycerate from where the second phosphate group came ?
BEST GLYCOLYSIS VIDEO EVER
GREAT VIDEO! EXCELLENT!!! Keep making more Biochem videos!!
Your video is crystal clear, it simplifies things a lot, thank you very much ! :-)
However, be careful with the first G6P, I think you're missing an O in the formula on the 6th carbon (Should have been CH2OPO3(2-) instead of CH2PO3(2-)), but it's completely understandable, and also corrected afterwards ;-)
This is amazing way to teach. Thank you for your work
This is really a helpful video 👌🏼
Thank you
Not a bad presentation. It's pretty clean, and I'm sure it has helped a ton of people with the concepts.
I think it would have been nice to see a mention of the glycogen phosphorylase step that occurs when the source is coming directly from glycogen instead of free glucose. This step bypasses the hexokinase step and as such skips the first ATP investment.
Under higher intensity scenarios, phosphorylase activity increases, and I would argue that more glycolysis is resulting from a glycogen source instead of free glucose. That said, all of the steps afterward are explained rather well, and I don't want to take away from that. Please continue the good work :)
[My Background -- Exercise Physiology grad student and metabolism junkie]
What happens to the hydrogen atom in carbon 6 when phosphate group replaces glucose at the beginning of glycolysis?pls reply 11:04 .
Thank you so much!This is much much easier to understand!
YOU SAVED MY EXISTENCE!
Very nice video. Really helped me visualize what is actually going on.
THANKYOU SO MUCH THIS HAS SAVED ME
You guys had my subscription as soon as the first song started lol.
Words cannot express how greatly this video has saved my Grade 10 Biology mark.
Just kidding I got a B- on the exam anyways *cries*
Now I've downgraded to AP and this video is going to save me again
Best video ever. Thanks a lot!
Thank you so much! You're much better than my prof.
This literally saved my life. Ty.
You are a great teacher. Thank you!
You are the shit :D I don't get why lecturers make it unnecessarily complicated. This video is amazing. Thanks :)
This video was extremely helpful.
The first release of water isn’t in the enolase step. Note that in the aldolase step, an acid in the active site and a free-flowing H+ ion interact with the carbonyl to produce a water. While it is quickly recycled and used to convert DHAP to G3P under a majority of physiologic conditions, a water is still synthesized, potentially remaining as such until Le Chatelier’s principle necessitates the isomerization.
Beyond that, the rest of the video is great!
A lot of info but super easy to follow!
I'm here because my professor failed to do his job... Thanks a million!
Great job thank you for making this stuff really helps with my studying
excellent job on making this easy to follow. thank you