Michael Levin | Endogenous Bioelectrical Networks: An Interface to Regenerative Medicine
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Michael Levin | Endogenous Bioelectrical Networks: An Interface to Regenerative Medicine
Michael Levin is the Vannevar Bush Distinguished Professor of Biology at Tufts University, and associate faculty at Harvard’s Wyss Institute. He serves as the director of the Allen Discovery Center at Tufts and the co-director of the Institute for Computationally Designed Organisms at Tufts/UVM. He has published over 400 peer-reviewed publications across developmental biology, computer science, and philosophy of mind. Dr. Levin received dual B.S. degrees in computer science and biology, followed by a Ph.D. from Harvard with Clifford Tabin. His graduate work on the molecular basis of left-right asymmetry (Cell 1995) was chosen by the journal Nature as a “Milestone in Developmental Biology in the last century”. He did post-doctoral training at Harvard School of Medicine in cell biology, and started his independent lab in 2000, developing the first molecular tools to read and write bioelectric prepatterns in non-neural tissue. His group at Tufts works to understand information processing and problem-solving across scales, in a range of naturally evolved, synthetically engineered, and hybrid living systems. The Levin lab has pioneered approaches to organ regeneration, cancer reprogramming, non-genetic modification of the bodyplan, and the engineering of novel living proto-organisms. Using tools from behavioral and computer science, Dr. Levin seeks to understand the collective intelligence of cells and harness their problem-solving capacities for applications in birth defects, regeneration, cancer, and synthetic bioengineering.
as.tufts.edu/biology/people/f...
We all start life as a single cell, which self-assembles into a complex organism, simultaneously scaling up the emergence of both, body and mind. The journey through anatomical option space is not merely a mechanical process of generating complexity: it involves powerful navigational competencies to achieve its goal despite unexpected circumstances - a.k.a., problem-solving. In this talk, I will describe how the behavior of cellular swarms during development and regeneration can be analyzed and modulated as a collective intelligence. This framework allows powerful approaches to reprogramming growth and form which go far beyond the current emphasis on the genetically-specified molecular hardware. We have developed new tools to read and write non-neural bioelectric states - the cognitive glue that binds cells together to expand their cognitive light cone and enable them to cooperate toward specific complex anatomical outcomes. By re-writing these pattern memories, we have shown applications in the repair of complex birth defects, regeneration of limbs, and normalization of cancer. In this talk, I will sketch a roadmap that begins with an understanding of the plasticity and competencies of the agential substrate of evolution and aims toward a radical regenerative medicine in which we collaborate with the native intelligence of cells and tissues
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I'm a simple man, I see Mike Levin, I upvote.
Me too!
I see a simple man who upvotes Mike Levin, i upvote him.
👍
There are dozens of us!!
Im a simple man, I see Michael Levin, I upvote (and set the speed to 0.5x to really soak up what this genius trailblazer is putting down)
The question is not "if" but "when" Michael Levin gets honored with the nobel prize!
*assassinated
Not
"Michael Levin was born in Moscow, USSR, in 1969, in a Jewish family. His parents faced antisemitism in the Soviet Union, and in 1978 took advantage of a visa program for Soviet Jews and moved the family to Lynn, Massachusetts. Levin's father was a computer programmer and worked for the Soviet weather service; his mother was a concert pianist."
He is the Einstein of biology!
Dr. Michael Levin your research in bioelectricity and the extracellular matrix (ECM) has opened new doors for understanding cellular communication, regeneration, and intelligence. By exploring how these systems interact with each other and respond to various stimuli - including electromagnetic signals, glycobiome patterns, quantum effects within biological systems, and more - you are pushing the boundaries of our knowledge in biology, physics, chemistry, engineering, and computer science.
I'm thrilled by the prospect of seeing how your combined expertise will lead to breakthroughs that could revolutionize regenerative medicine, robotics, and even quantum computing applications inspired by nature. Together with other pioneers working at this intersection of disciplines - including experts in IR therapy, biophotonics, and other emerging fields - you are paving the way for a truly interdisciplinary approach to tackling complex problems related to health, technology, and our understanding of life itself.
Thank you both for your groundbreaking work, and I look forward to seeing what exciting discoveries await us in this rapidly evolving area of research!
Fantastic work thank you.
Wonderful, amazing, one of my favourite scientists right now and probably the one opening more new fields and exploring new ground. And the point is that he makes it sound as if the translational medical systems were easy to achieve"
The last question was amazing!❤😮
50:31 the most beautiful image.
Amazing talk
Wonderful!
I just think these ideas are beautiful. I have three kids, two whom have genetic mutations that eff with their body's ability to process salt, so this mucus gunk hampers multiple organs such that they struggle to absorb nutrition, to breathe, among other things. The gene modulator they take, we and our Drs suspect, is not targeted well given the drugs were designed with the most common mutation variant. So, we've started to see build-ups of mucus and scarring in organs. But these beautiful people in this community... I am just filled with awe. I wept when I saw that happy little anthrobot mend the wounded neuronal tissue. Because I felt an emotion I haven't for so long. Hope.
I feel desire to help in any way I can. I got a Ph.D. in the wrong field (health economics), perhaps. Do any of these teams need the perspectives of an empirical economist? I want to learn anything I can about these things.
Huge!
Chapters:
- Title: "Introduction to the Seminar"
Timestamp: 00:00 - 01:32
Summary:
- Michael Levin is introduced as a speaker in FET's biotech seminar series.
- Levin's past work and seminars, focusing on collective intelligence and regeneration in biological systems, are highlighted.
- His contributions to longevity and bio-angle research are acknowledged, sparking interest in AI applications.
- Title: "The Multiscale Competency Architecture of Bodies"
Timestamp: 01:32 - 05:07
Summary:
- Levin discusses the concept of bodies as multiscale competency architectures.
- He emphasizes problem-solving intelligence at every biological level, from molecular networks to organs.
- The argument is made that regenerative medicine requires exploiting collective cellular intelligence.
- Levin introduces the concept of endogenous bioelectric networks as a powerful interface for top-down control in regenerative medicine.
- Title: "Engineering with Agential Material"
Timestamp: 05:07 - 14:05
Summary:
- Levin compares traditional engineering with passive materials to bioengineering with agential materials.
- He explains the need for different approaches to problem-solving in biology, highlighting the importance of understanding material agency in regenerative medicine.
- The concept of anatomical homeostasis and regenerative capacity is discussed, illustrating how organisms adapt to changes.
- Title: "Bioelectric Networks and Regenerative Medicine"
Timestamp: 14:05 - 28:00
Summary:
- Levin focuses on bioelectric networks in tissues as a key to understanding and manipulating regenerative processes.
- He discusses various tools developed for reading and writing bioelectric patterns.
- Examples include inducing eye development in non-standard locations and leg regeneration in frogs.
- The potential for reshaping biological form and function through bioelectric manipulation is emphasized.
- Title: "Bioelectric Memory and Morphological Control"
Timestamp: 28:00 - 37:03
Summary:
- Levin explores the concept of bioelectric memory in cells, influencing morphology and regeneration.
- He demonstrates how manipulating bioelectric states can lead to the creation of two-headed planarians and species-specific head shapes.
- The implications of bioelectric memory for understanding cellular intelligence and regenerative capacities are discussed.
- Title: "Biomedical Applications and Future Directions"
Timestamp: 37:03 - 48:00
Summary:
- Levin outlines potential biomedical applications of bioelectric manipulation, including cancer treatment and brain repair.
- The future of medicine is envisioned as more aligned with cybernetics and behavioral science, utilizing top-down approaches.
- The concept of 'morphos cutical' is introduced, aiming to control tissue development through bioelectric signals.
- Title: "Anthrobots and Multiscale Biological Engineering"
Timestamp: 48:00 - 53:17
Summary:
- Levin introduces 'anthrobots,' self-motile biological constructs developed from human cells, showcasing their healing and repair capabilities.
- He discusses the potential for personalized medicine using such biological constructs.
- The future of bioengineering is envisioned, emphasizing the exploitation of cellular intelligence and collective problem-solving.
- Title: "Q&A Session"
Timestamp: 53:17 - 1:04:49
Summary:
- Levin answers questions on various topics, including aging theories, imaging bioelectric states, and challenges in bioengineering.
- He discusses the potential role of other forces like electromagnetism in biological processes.
- Levin highlights the importance of understanding higher-level information processing in cellular networks.
Legend
phrases like 'multiscale competency architecture' sound like they come from management gurus
re: bioelectric patterns can't be discerned in dead tissue
2 yrs ago there was a Nature journal YT video about a new type of microscope slide that could detect cancerous cells without staining - 'Cancer in nanocolour: a new type of microscope slide'. It was based on research in the paywalled article 'Colorimetric histology using plasmonically active microscope slides'. I'm still wondering about how this works. One of the suggested mechanisms was that it is picking up on differences in the cytoskeleton. There is bidirectional interaction between the cytoskeleton and ion channels which controls the gradient of ions across the cell membrane. This technique might be a way to indirectly discern bioelectric patterning at the time of preservation.
Dr. Bruce Lipton, Dr Joe Despensa ❤!
We are seeing reversal of a year of aging and degeneration with a related process developed out of electrophysiological measurements and biocommunication. We use only natural ingredients and stimuli... We've seen restoration of eye health and vision and other structures/functions.
Elaborate?
Wild what incredible amounts of knowledge in such novel fields Dr. Michael Levin has. This was an incredible watch, giving us grounding on what is currently possible and what are the limitations. Thank you all for pushing the boundaries of what's going to be possible, imagine conditioning human cells to restore their memory in order to avoid aging. Probably won't be available in our lifetime, if not for gigantic amounts of capital, but the upcoming generations might indeed hit escape velocity against aging in and of itself, maybe even at an affordable price.
I'm mind blown.
Thank You Michael Levin & Team. This is super exciting. What do You think drives our morphogenetic pattern memory (min 55:00)?
It makes Me wonder if the disintegration of cytoplasmic EZ (coherent) water has an impact on the ability to channel ions for maintaining this pattern.
What are Your thoughts here?
I had a pilonidal cyst removed and subcutaneous tissue removed, maybe fascia, would this be able to rebuild it ????? 😢😢😢😢😢😢😢
What fonts does he use in his PPT presentations?
Looks kind of like comic sans
One note - you say you are not using any EMF but, you are using light for optogenetics, which is, actually an em radiation. 😁
Re: competencies that enable cellular organization - my theory is that the virtues required for societies to form and prosper are also required for life itself to form and prosper. Specifically wisdom, courage, frugality, productivity, mercy, and generosity in order of descending importance
💥
Fascinating! Please put Michael Levin and Dr. Alexander Fedintsev in one (virtual) room and don't let them out too soon. There's no way on earth the ECM and the glycobiome isn't of relevance to the interviewees work. Also whoever else you can find on quantum biology, IR therapy, shouldn't be a bad idea.
do you consider Tesla thinking in energy, frequency and vibration❓
no
Ion Channels and Anthrobots. Incredible.
Wow, Amazing at around 33 minute mark they used mRNA to make an eye in a tadpole. Maybe Ai can help speed this along.
Only thing that can save us by now
Old he has said this many many time and it works yet how dose he know it can see like any other eye he dosnt
@supme7558 Maybe stimulate it with light, then it will react
So has Fauci called?
Ya he's out of work . Maybe we'll be OK NOW ! (?).
This technology only matters if they actually apply it to people. As far as i understand they havent even started animal trials, which makes the implementation of this like 2 decades away at the least.
Not according to Michael Levin , he has said in previous talks he expects positive real life transformations within humans within 10 years - remember , if he gets the automatic tools built and an A.I. to sift through the data , this could be an exponential growth rate ...watch this space!
@@elizabethwinsor5140
A scientist saying we're x years away doesnt ever really matter. Particle physicists and fusion reactors for example. His discoveries are world changing, species altering, but only after if is built apon and applied. It only matters once they start trials.
Whell the guy works with darpa...
...soo@@Will-fj9gy.
Totally. If this can't make humans more powerful in the next 28 days, it's useless science..
The key is to get the mainstream biology community to accept this theory, more people getting involved in researching this, better imaging techniques are needed (similar to nuclear magnetic resonance instead of dyes), better intervention techniques (better drugs or instruments) if we can develop this, then progress will be very fast
My dream WILL NOT be sold . ❤ Don't die !
The " GOD " of it ALL ! NATURE'S. " ONENESS" Source Code ❤ ! Ai is here now . ! ❤
All of our species, the 2nd. " Spliced" cromasome !
We are ALL ELECTRIC BE -INGS❤ ! LIGHT , WATER, MAGNETISM ❤ ! Eyes mind heart and soul wide open. NO FEAR !
Even beyond biology We've been needing a phenotypical model that will help young minds try and get a grip on emerging energetic actors of indirect lines of detection measured value or constant of nature that should be there on the smallest scales. It's not everything alive physicalism or dualism but clearly a feature Issac Newton and many others knew but got subverted ,detoured, by passed or whatever.
To scale this natural feature of info about anything and everything it can ever be is definable no matter what critical extreme states it will or can be ran through and phase changed.
This was detoured and deflected by the eclesatical input and perimeters set by a more European movement that America built coalition & accommodated but I'm fairly certain classical America's very reductionistic it wouldn't have rationalize the world through once upon a time evolutionary form and shape if not for allys proud heritage and wants to dictate terminologies this way. But this messes with sychosis and ignores known issues that Statitistical anylitic can't pair with .
He says the exaclty the same thing and adds 0 details in 25 years ...hes ether grifting or stuck