*ONE AMENDMENT (READ BELOW)* Videos on Studies: GlyNAC (Full Analysis): th-cam.com/video/6Lmc-mmqxyQ/w-d-xo.html Collagen (Full Analysis): th-cam.com/video/pM5LdJkjy9Q/w-d-xo.html OMAD (Full Analysis): th-cam.com/video/JKwC8sHEEjY/w-d-xo.html Reversing Aging/TRIIM Study: th-cam.com/video/rVoxfABoHh4/w-d-xo.html Obese & Autophagy: th-cam.com/video/F8arfpKri0M/w-d-xo.html Insulin vs Calories: th-cam.com/video/wJh98sNrBzM/w-d-xo.html LDL on Heart Disease (Full Analysis): th-cam.com/video/1t8rqfG1CMA/w-d-xo.html Urolithin A: th-cam.com/video/cJdAlp2new4/w-d-xo.html Omega-3 on Cognition (Full Analysis): th-cam.com/video/51sTitaUzJ8/w-d-xo.html Reversing Heart Disease (Full Analysis): th-cam.com/video/obD1GBU8gik/w-d-xo.html AMENDMENT: At 19:19, I say that there are a vocal minority of people who argue LDL is a cause of heart disease risk - that is reversed, it should be "a vocal minority of people who argue LDL is NOT a cause of heart disease risk" - thanks to @mkvalor for pointing it out.
I love your channel but I'm disappointed that you did not include research on nattokinase around its ability to remove arterial plaque. Also, berberine has been shown to remove arterial plaque. These are very important supplements to help people who can't exercise due to physical limitations or simply to help people who really struggle to get in shape. Many supplements can help people have an advantage until they can reshape all the other lifestyle factors needed for optimal health. They just give you an advantage even if you are healthy but you're older.
@@brianwnc8168 The evidence that berberine removes plaque is very early and needs more research - double blinded, case controlled study with enough participants. I do take it for that reason and it also does seems to lower blood sugar, BUT the only reason I take it without more evidence is that it does not seem to do any harm. So, I am hoping we eventually do get more robust/solid data. Nattokinase - not sure the evidence is there ... can you point me to some high quality studies? I AM SURPRISED HE LEFT OUT CREATINE MONOHYDRATE.
This is great analysis - independent, evidence-based and with context and nuance that is absent from the influencers and supplement sellers who are everywhere on TH-cam. Much appreciated.
I am back in school finishing my Nursing degree at 50 partially because of this man. His videos help me stay fit by running to TH-cam every time he posts. He's had me print out and read studies he's mentioned on here. It's like he's our own personal TLDR superhero. I trust his analysis.
Glynac has definitely been my Grandmother is 88. She was starting to show signs of cognitive decline and becoming increasingly frail. Started her on glynac 2.5g and 1.5g taurine twice daily, and the results have been astonishing. Moves faster gets up better, and her cognitive capacity and memory have come back to baseline.
I've been taking glynac since last summer and taurine since the fall and I must say it has vastly improved my energy levels and I think it's actually improving the speed of my thinking, no small feat, despite being under 50. I also think NAC generally acts as a detoxifier which is beneficial.
Who wouldn't want to learn the 10 best tips for your health that a Ph.D. student has gleaned from reading 250 research reports? At the least, it can point up vitamins that you should look at more closely. Immense value in this channel!
I am 48 and have suffered from severe chronic depression and anxiety for years. I have used all of the drugs, psychological treatment modalities and nothing ever gave me much relief until a couple of years ago I hears about glycine and NAC. I had seen a study somewhere that chronically anxious people were often found to be depleted in glutathione. Obviously this can lead to all kinds of problems. At the time, I started taking about 2 grams of NAC along with 2 grams of TMG daily. I started noticing after a few weeks everything was changing. It was like reality was becoming brighter. I could also breathe more deeply and freely (nac also helps the lungs) On top of that, my blood pressure normalized and my energy increased 10x. It was like getting my life back. I just wanted to point this out because I think people who have generalized anxiety even in their 20s and 30s could recover using glycine and nac. I think this needs more attention!
@@shahzamanhaque I try to take it on an empty stomach. I usually take a NOW 1G NAC pill with a glass of water mixed with glycine powder. Lately I have added 3 grams of Taurine to the mix as well as 2.5 grams of creatine.
@@oolala53 I think what the glycine/nac combination did for me was end the constant exhaustion, depression and edginess I experienced every moment of every day. It has given me space to work on the critical thoughts and destructive thinking patterns. Self enquiry and meditation have been extremely useful. anything that brings circulation to the prefrontal cortex. I really like the meditation devices like the Muse 2 and the Mendi.
Your channel and nutrition made simple are the only 2 I trust. Independent non-biased clinical evaluation of data. and no products or gimmicks being sold to me! ❤
You should only get diet advice from a real Ph.D in nutritional biochemistry with awards and honors and or a Nobel Prize with a long term track record of being right such as Roger J. Williams, Frederick Gowland Hopkins, Fred Kummerow, George H. Whipple, William Parry Murphy, Edward Adelbert Doisy. All 6 would say the same that Linus Pauling said that meat, poultry, fish and eggs are good for you in moderation and that dairy is ok in small amounts if you like it and are not allergic to it. Gil Carvalho has zero experience in anything.
i used to eat once a day for years and was 140kgs and miserable when i started eating 3 to 5-6 times a day in an 10h interval since waking up with 14h pause i got down to 100kg and felt amazing, no gym or exercise, just doing basic stuff + work. for reference i am also 1.95m tall
I think it really depends. I can see the point in not eating for a long time as kind of exercise in restraint. But I lost 20 kg last year with frequent small meals. Often just a protein shake as snack at work. I feel that helped shrink down my stomach making me feel full being less full. Couldn't have happened with Giant 1-2 meals
Thank you @Physionic for being a voice of reason. I LOVE your videos! I'm so glad I found you and now I can stop wasting hours of my time watching all the others debate. Please never stop what you're doing! We need you!
RE: Human growth hormone ("Reversing Aging/TRIIM Study) Studies indicate that betaine [anhydrous] (aka, trimethylglycine (TMG)) at c. 3g a day (in split dosages, morning and evening, with meals) increases serum HGH naturally. (Glycine, in its various forms [like glynac], appears to be very actively important to maintaining/optimizing health.)
By day two of a water fast you will feel HGH in your body. So if you can do a 3 to 5 day water fast you will generate your own HGH. In my opinion the most efficient way to maximize water fasting is 7 days but it's not easy for a lot of people. The key here is that when you come off of the water fast your body will make up for the protein deficit by maximizing efficiency and rebuilding once you start adding protein as it leverages the HGH that was used to preserve muscle mass during the fast to build up even further; it might be 3 days of water fasting @ a minimum to see the HGH effect, I don't usually pay attention until I start feeling it in the morning and that's not until I'm already well into the fast.
The thing is can you produce any HGH when you're 50+ ? or Testosterone ? No... not really, the charts crash badly. You produce very little, there's not much to stimulate "naturally". You have to supplement.
NAC definitely has a difference for people above 60, based on my own experience. My joints are less achy, my slight pre diabetic signs disappeared, I’ve noticed more strength as well. I’ve also got Covid recently, and unlike all my previous flu and lung infections, I had the least symptoms, and lasted only 5 days, which is phenomenal based on how I suffered every time I get some kind of lung infection. Still working and learning as I go. My eyesight seems a bit better, although my optician said it’s no change from my last eye examination.
@@littlevoice_11 Initially I bought 600mg capsules and I had 1 in the morning and 1 in the evening. Now I have them as 400mg, and still trying 1 morning and 1 evening. I'm usually giving it a little break every 2 week cycle. 2 days off it every 2 weeks for now. I'm thinking of 3 times a day at the moment.
You might do a segment on the following relationship: Hruby A, O'Donnell CJ, Jacques PF, Meigs JB, Hoffmann U, McKeown NM. Magnesium intake is inversely associated with coronary artery calcification: the Framingham Heart Study. JACC Cardiovasc Imaging. 2014 Jan;7(1):59-69. doi: 10.1016/j.jcmg.2013.10.006. Epub 2013 Nov 27. PMID: 24290571; PMCID: PMC3957229.
You have so many views nowadays!! Awesome! I've not followed anything nutrition related in a while because I started working in politics lol! But I'm so glad to see your current success!
Wow. I don’t know why the algorithm suggested this video (though I suspect you do), but I am sure glad it did. Thank you for the wealth of trustworthy information.
I listen to my own body. Period. As we all should. My triglycerides went way up when I was eating more carbs and experiencing stress. And I became pre-diabetes. Now I’m none of those on a low carb diet. LDL is high, but HDL is higher. You did no talk on stress or herbs such as tumeric . Listen to your body people….and I’m an RD. I also exercise as well
Thanks so much for this, Nic! As a student I’m grateful for the lessons in research literacy, and I so appreciate the way you approach analysis with equal parts intelligence, tenacity and humility. From a student’s perspective that is rare in both academia and wellness communication spheres, and highly worthy of emulation. 🙏
Regarding the insulin versus total calorie argument, I would really like to see an explanation of the differences of efficiency of conversion of molecule type into body fat disposition. Meaning, for a given calorie content of carbs versus same calorie content of fats, which results in the greater amount of resultant body fat. Is there some % metric of conversion to body fat? There is an argument amongst keto participants that dietary fat is less efficient at creating body fat then the same calories ingested as carbs. Can of worms here perhaps? Invigorating to hear discussions about cell/molecular biology. Studied this way back in the day but never went into the field. You never lose the passion for the science. Great work.
Thank you Nic, I really appreciate your sharing all this info to me as an aging young person, keep them coming. Its definately helping to educate me making my decisions.
I remember when I first came to your site I think 3 years ago and if I recall yours was one of the only ones that was very heavy into statistical analysis and broader cross study analysis. But more importantly, a broader respect for the lack of information and or the oversimplification as well as just the general lack of respect for science and most of these style of youtube informationals. I'm really glad to see that you are blowing up as I really think that your style of information is really helpful as the granular detail on this type of stuff is really what makes a difference & what makes you different because real results are always made in margins of 2 to 5% if you're lucky and anything promising more than that needs to be taken with a massive, massive grain of salt!! Congratulations dude, good on you!! P.s I'm currently struggling with type 2 diabetes. As a result to get my blood sugar down, I massively reduced my carbs for the obvious reason. However, as a result of the initial diabetic cannibalization of my muscle mass as well as my fat, I went from 240 lb to 155 lb is less than ideal for the obvious reasons of not just being considerably less strong. But as we will continue to lose muscle mass over time, it will be an issue moving forward as I am 48 years old. I guess all that being said, is if you end up coming across anything about how to maintain or keep muscle mass as a aging type 2 diabetic I would super appreciate it. Mostly, because everything is geared towards losing weight, but I actually just stopped eating. I'm mostly carb diet and switch to primarily protein, greens that don't add any carbs and then low and glycemic index vegetarian carbs. Obviously this will need to be. How is the consideration overall? But I would love to hear some strategies on building if not, at least maintaining muscle mass as a type. 2. Diabetic. Everything I've read about building or maintaining muscle mass is about carb intake which is not going to work for me. No worries if this isn't anywhere close to your wheelhouse, but I couldn't help but shake the feeling that you might have ran across some research that would be relevant to my situation. I can't imagine but I'm the only skinny type 2 Diabetic!! We're not all fat, some of us got this way cuz you were either just lucky or drunks 😉
I recently came across something saying basically that if you are overweight and insulin resistant you have a hell of a time switching to fat burning(meaning that when you try to exercise to burn fat you end up out of energy because you cant make the switch and you feel like crap)...I experienced this when I started getting back in shape 3 years ago. I couldnt lose weight my old school way of training hard first then having my body ask for a better diet...Instead I had to eat once per day and go walking for my exercise. Once I dropped about 8 kilos in two months I was able to exercise normally and off I went. I can now eat reasonably and train hard....like a psycho. To me eating once a day is a good way to get the weight lose going but once you are in decent shape you can expand the window..and have to in order to build some muscle and train properly. Just my experience and thoughts
Hi. For the Thymus rejuvenation, have you seen Brian Johnson talk about him trying this? He mentioned on Dr Mike’s podcast that it had the most negative health effects of anything he’s done due to the human growth hormone because of increased intracranial pressure and maybe some other negative health effects that I’ve forgot.
Thanks for the Roundup! .. Maybe when you get time maybe you could analyze the literature on Aspirin/Salicylic Acid's benefit for CVD & Cancer treatment
I took Omega 3 for the advertised reasons for years (and still do). What kept me taking it was how much it calmed my psoriasis. I had no idea that it could do that. I suppose it calms the inflammation down? It's the only reason I keep taking it.
This is an awesome analysis. I wish you could update this once a year and make it an event we look forward to. Then the title needs a bit adjustment: It needs an edition marker, such as "2024 Edition".
Wow I just saw a video you did 3 years ago on that old anecdote of a carnivore guy in GB a hundred years ago. You appear much heathier now in weight and confidence. However now you appear pasty white and puffy under the eyes. maybe dial back the sodium and creatine intake and ingest more potassium for less water retention and get more sleep. It could be the lights/lighting but I do recommend getting more sun, sleep and a little less sodium/creatine. Also eating more carotenoids will give your skin more pigmentation and UV protection. Great info BTW and thanks for the synopsis of your due diligence. I commend your efforts. We need more people like you as influencers.
the dose and form of zinc in this study was "50mg of elemental zinc" and I am wondering about safety and feasibility of getting this dose IRL- from what I am reading, over the counter zinc contains only a fraction of elemental zinc- eg 50 mg of zinc gluconate contains 7.14 mg of elemental zinc, and 50mg of zinc picolinate contains 10mg of elemental zinc. how should we think about this?
Love your humor (and you too), my good young man! Stay well, stay healthy, stay wise, and keep sharing the goodness of your heart! May the universe bless your good life!
I am a lean mass hyper responder whose LDL cholesterol went through the roof when I stopped eating crap processed food and started eating natural food. I lost 10% body mass, almost all of it visceral fat that was hiding out behind my abdominal muscles. I am very much looking forward to release of data from ongoing studies on LMHRs. I have a hard time believing that the increase in LDL that accompanies all the beneficial changes from eating a diet much closer to what humans evolved eating is anything but a natural normal phenomenon.
Hi Nicholas, I really enjoy your videos and learned a lot. One question: I’ve heard many times the most important information in a study is, who provided the funding. 😉 What’s your take on that? Thx from Germany 👍
I cover funding in my analyses. I agree that funding is important, but it's often overblown in importance as if it is *the* deciding factor to believe or not believe a study, and I disagree with that notion.
Great video! New sub here! I’ve been feeling defeated by post menopausal hashi hypo 25 lbs. Im not sure where I go next as I feel I’ve tried sooo many diets, coaches, purchased food, FMD, omad, keto, vegan, it’s been exhausting! I think I could seriously become a nutritionist which it shouldn’t be that hard. I’m going to give low carb, adding macadamia nuts for good fat, sardines and see how that works. Thank you ❤
As part of my preferred lifestyle, I eat just one largish meal a day, at the end of the day. I find eating (at any time of day) saps my energy, mood and motivation, thus brings an end to my useful day.
But what about the Rotterdam data that shows that people with higher cholesterol live 2 years longer? Is it just that older people need more cholesterol?
Found this: LDL cholesterol still a problem in old age? A Mendelian randomization study. Iris Postmus, Joris Deelen, Sanaz Sedaghat, Stella Trompet, Anton J M de Craen, Bastiaan T Heijmans, Oscar H Franco, Albert Hofman, Abbas Dehghan, P Eline Slagboom, Rudi G J Westendorp, J Wouter Jukema Author Information PMID: 25855712 DOI: 10.1093/ije/dyv031 BACKGROUND: Observational studies in older subjects have shown no or inverse associations between cholesterol levels and mortality. However, in old age plasma low-density lipoprotein cholesterol (LDL-C) may not reflect the lifetime level due to reverse causality, and hence the risk may be underestimated. In the current study, we used an LDL genetic risk score (GRS) to overcome this problem. METHODS: A weighted GRS was created using 51 single nucleotide polymorphisms associated with LDL-C levels. The LDL GRS was calculated in three Dutch cohorts: the Leiden Longevity Study (LLS) (n = 3270), the Leiden 85-plus study (n = 316) and the Rotterdam Study (n = 4035). We assessed the association between the LDL GRS and LDL-C levels, chronological age, familial longevity and mortality. RESULTS: Up to 90 years of age, in each age stratum individuals with high LDL GRS had higher LDL-C levels (P = 0.010 to P = 1.1 x 10(-16)). The frequency of LDL-increasing alleles decreased with increasing age [β = -0.021 (SE = 0.01) per year, P = 0.018]. Moreover, individuals with a genetic predisposition for longevity had significantly lower LDL GRS compared with age-matched individuals of the general population [LLS nonagenarians vs > 90 years: β = 0.73 (SE = 0.33), P = 0.029, LLS offspring vs partners: β = 0.66 (SE = 0.23), P = 0.005]. In longitudinal analysis, high GRS was associated with increased all-cause mortality in individuals > 90 years, with a 13% increased risk in individuals with the highest LDL GRS (P-trend = 0.043). CONCLUSION: Results of the current study indicate that a genetic predisposition to high LDL-C levels contributes to mortality throughout life, including in the oldest old, and a beneficial LDL genetic risk profile is associated with familial longevity.
Absolutely brilliant! the only thing I'm not sure about is calorie model vs insulin model as a mean to weight loss. It should be simple to decide, just put two groups on same calorie load and make a difference in insulin level. There shouldn't be any ambiguity cause none - I think - argues against that calorie restriction do not cause weight loss, it does. If the only parameter you change will be less calorie, than you will loose weight. The claim of minority is that eating food causing high insulin causes: 1. More energy from food will be stored as fat or less fat will be used for energy. 2. You will feel more hungry, and than you will eat more, in effect, in normal life, you will gain weigth.
I would be curious if there are any studIes on the effects of autophagy on plaque cleanup. Also, since glycine appears to have 10 calories, is it useful to take with extended water fasting or does it disrupt the autophagic process?
I am considering adding Glynac to my regimen. My goal is to slow down the symptoms of aging. I am a 34 year old man with a background in business so my understanding of this is extremely limited, but here is my idea: My antioxidant capacity is probably still high. I am fit, healthy and rarely ever sick, maybe a cold once a year. People in my family typically live to around the age of 90. Levels of Glutathione will decline with age so rather than waiting until they are low before I start supplementing I want to start supplementing now so that the reduction in Glutathione will be less over the coming years and decades allowing me to maintain higher levels as I age. Does this make sense or am I way off?
LMAO on your charming sense of humor. Yes Nick your charming. Thanks for sharing your research with us & most important explaining it for the non nerdy tribe.
I wonder if any of these learnings in terms of supplements can be translated into dietary modifications, e.g., reduce a certain food that prevents absorption or use of xx. And foods high in the beneficial molecule.
Hello, thanks for the in-depth video. Can you do a supplement special on autoimmune diseases? I have Long Covid and am trying to figure out how to recover. Studies are few and far between, so it's tough to get your hands on useful information. Maybe some general strategies that work for autoimmune could work with LC? Who knows. I'm gonna try Glynac in any case, as LC is supposed to at least partly be due to oxidative stress
Another great video. Could you please do one on Lp(a). For those of us that suffer very high numbers, we really need your take on the subject. Worry/don’t worry? Niacin/no niacin? Carbs/no carbs? Thanks.
I’ll be counting down the days. Thanks so much. Just for your info, I’ve been taking niacin in large doses (1000mg) and it has dropped my Lp(a) significantly. But of course I can’t be sure that lowering it alone will actually reduce my risk of atherosclerosis.
I've personally had great results on keto so I don't believe it's complete BS but it's also used as a way to regulate my calories and help me not overeat so I'm sure that's part of it I think the issue is that both thermodynamics and hormonal balance are equally important instead of the two fighting each other for dominance most should incorporate both eating a low carbohydrate diet in a slight calorie deficit and then increasing that calorie deficit with exercise seems to be the best at least when it comes to weight loss
I guess my point is you can't eat 3000 calories of butter and expect to lose weight just because you're on keto but then an 800 calorie a day diet consisting of Donuts probably isn't gonna be healthy either it doesn't have to be 1 extreme or the other there is a middle ground but diet influencers pick a side and rage about it never seemed to have any common sense
I have a question regarding creatine, if you are in the so called "20% of unresponders" when it comes to using it for muscle growth/strength does that mean you are exempt from all its benefits? (Cognitive function etc...)
My concern with NAC and Glutathione supplementation after reading How to Starve Cancer is the role it plays in Cancer proliferation. Once somebody had a tumor of some kind gaining traction you'd want to avoid it hardcore. The issue is, how to be sure you don't have developing cancer.
When you say "High LDL" as causal in CVD, maybe emphasize we are talking about LDL-Cholesterol and ApoB tagged particles and not Low Density Lipoproteins?
The lipid energy model shows increased cholesterol and minimal atherosclerotic plaque. This study shows that cholesterol regulates TRPV4 and recall the transcriptome of active atherosclerosis includes TRPV4 and klf4. 2021: Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension 2020: Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis carbohydrates stimulate glp-1 TRPV1, TRPA1 through the neurolymphocrine axis, 2020: Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves TRPV1 causes hyponatremia and hypoosmolality that stimulates the osmosensor TRPV4 2014: Transient Receptor Potential Vanilloid 1 Activation by Dietary Capsaicin Promotes Urinary Sodium Excretion by Inhibiting Epithelial Sodium Channel α Subunit-Mediated Sodium Reabsorption Lastly, in 1 year and 5 months I significantly reduced my atherosclerotic plaque and calcification on the low carb diet, estrogen patch and mineral supplements. My rate of recovery increased by 150% when I also stopped oxcarbazepine that up-regulated TRPV1 and TRPV4. The above includes recovery of bone mineral density at the same time. Glp-1 semaglutide that I did not take but I was on a normal carbohydrate diet, causes osteoporosis. 2023: The Effect of Semaglutide on Bone Turnover in Adults with Increased Fracture Risk: A Randomised, Double-Blinded, Placebo-Controlled Trial TRPV4 plays a significant role in osteoporosis too as it increases osteoclasts differentiation. Children on oxcarbazepine suffer from broken bones too. It’s all related to too much TRPV1 and too much TRPV4.
14:50 I think that calories matter the most to loose fat, but a low carb diet with low insulin levels makes it easier since you do not starve as you would a regular high carb diet in a calorie deficit. Also, protein and fat is like 🪵 for our body, it takes more time and energy to burn. On the other hand carbs are like hay, they burn fast and easy and you need more right away to keep moving.
Love all the content you put up, been following for a while and the sheer amount of work you put into your videos is astounding. Keep it up, we really appreciate you! Lum S.
I like that you say LDL is one among many factors relating to heart disease. Right, and so what do we do with studies showing heart attacks and strokes (roughly 50% of all) in people with low LDL and others studies showing people living to 100 with high LDL? One thing I will be critical of in your video is how you present the idea that higher amounts of LDL leads (seemingly automatically) to more in the walls of the vessels. I'm not convinced this has been proven to be a "automatic" mechanism. Thank you!
Science isn't perfect, some idea can become 'scientific dogma' and then the idea just gets propagated throughout the literature, and results interpreted within that framework.
From what I've read, a person's LDL will drop after they have a heart attack. Kind of like a person with high blood pressure will have low blood pressure after they pass out. The bloodpressure at the time of passing out isn't a good indicator of what it was months or years before that. That's the case with LDL and heart attacks. The person likely had high LDL before the heart attack. Now I don't know if this is correct but it's what I'm reading. I hope Physionic sees this and comments. 😀
Also, high LDL is just ONE risk factor. The people who have heart attacks with low LDL likely also had other risk factors that caused the heart attack. It's frustrating because I have high LDL yet all of my other numbers are good. BMI, blood pressure. I'd love to believe that my high LDL isn't an issue but now that I'm over 50 it does scare me.
Please study Protandim nfr1 and 2. Also a 20 year study from Japan has determined that low cholesterol has a direct correlation to shorter life expectancy. Sam-e and Milk Thistle or Dandelion root cleans liver. Studies in Italy have found people living five years longer with terminal liver disease than in America just with Sam-e alone. I’m almost 68 and have taken Same-e liquid (only) for 30 years now. I keep my D levels at 80 to 90 without dips and Never ever take any flu vaccinations (personal choice)
Fish oil is interesting.. I started taking regular fish oil with breakfast. The first thing I noticed was a significant increase in libido and on doing a spot on research I found various studies that talked about fish oils affect on libido. I'm 61 fyi. When you discussed memory, I found reducing sugar was incredibly effective at improving memory. I experienced head trauma when I was 3yo due to opening a moving cars door and landing on my head! So my memory has always been a bit crap.
fish oil or the omega threes? cuz my libido is already debilitatingly high and i just started increasing my omega three intake and i dont want to ruin myself
I have MCI caused by repetitive head trauma. Was able to get off a very expensive drug, Nudexta, by replacing it with Fish Oil + curcumin supplementation.
Anecdotally speaking only,,I lost a ton of fat free mass doing “text book” keto. On the positive, it did help me break a fat loss plateau, all things being equal(equal calories and exercise). On the very negative most of that free fat mass ended up being more lean mass than overall body fat. No real change in my already very low visceral fat as assessed via Dexxa Scan before and after ny N of 1 self experimentaion over 6 months. So what’s wrong with that, it takes a lot of effort to recover hard earned muscle than to lose body fat. Plus, I didn’t want to fast forward myself to a life of a sarcopenic elderly frail person at the expense of low body fat and some arguably positive cardiometabolic markers. My long term goal is to have a healthy balance of both without engaging in some dietary intervention or restriction that pushes the needle in a major way to one extreme or another.
Nac solved some problems but made me lazy. Over 60. I now take dhea and quit sugar as much as possible. Energy level is great. Nac got me over long covid like a champ but drained my get up and go.
It's hard to imagine that CVD would be as significant a disease as it currently is if people all had a healthy endothelium. Lowering LDL seems to be a strategy that is effectively masking the most significant risk factor for atherosclerosis. If someone can't or won't implement lifestyle changes to improve their metabolic health then sure, give them statins. But statins only marginally reduce risk, for this to be a first line defense promoted by doctors seems to be unethical.
Regarding LMHR, what I have learned is the the distribution of risk of ASCVD is not normal. Some lucky people are just genetically immune and will not get plaques even if their LDL-c/ApoB are way of of range to 1 out of a million extreme, as shown by their CCTA and CAC at age 50+. One model based on LDL doesn't fit all.
![Taurine: Aging Backwards? [Study 193 Analysis]](http://i.ytimg.com/vi/PNJpM0ac0GU/mqdefault.jpg)
![Taurine: Aging Backwards? [Study 193 Analysis]](/img/tr.png)
*ONE AMENDMENT (READ BELOW)*
Videos on Studies:
GlyNAC (Full Analysis): th-cam.com/video/6Lmc-mmqxyQ/w-d-xo.html
Collagen (Full Analysis): th-cam.com/video/pM5LdJkjy9Q/w-d-xo.html
OMAD (Full Analysis): th-cam.com/video/JKwC8sHEEjY/w-d-xo.html
Reversing Aging/TRIIM Study: th-cam.com/video/rVoxfABoHh4/w-d-xo.html
Obese & Autophagy: th-cam.com/video/F8arfpKri0M/w-d-xo.html
Insulin vs Calories: th-cam.com/video/wJh98sNrBzM/w-d-xo.html
LDL on Heart Disease (Full Analysis): th-cam.com/video/1t8rqfG1CMA/w-d-xo.html
Urolithin A: th-cam.com/video/cJdAlp2new4/w-d-xo.html
Omega-3 on Cognition (Full Analysis): th-cam.com/video/51sTitaUzJ8/w-d-xo.html
Reversing Heart Disease (Full Analysis): th-cam.com/video/obD1GBU8gik/w-d-xo.html
AMENDMENT: At 19:19, I say that there are a vocal minority of people who argue LDL is a cause of heart disease risk - that is reversed, it should be "a vocal minority of people who argue LDL is NOT a cause of heart disease risk" - thanks to @mkvalor for pointing it out.
I love your channel but I'm disappointed that you did not include research on nattokinase around its ability to remove arterial plaque. Also, berberine has been shown to remove arterial plaque. These are very important supplements to help people who can't exercise due to physical limitations or simply to help people who really struggle to get in shape. Many supplements can help people have an advantage until they can reshape all the other lifestyle factors needed for optimal health. They just give you an advantage even if you are healthy but you're older.
@@brianwnc8168 The evidence that berberine removes plaque is very early and needs more research - double blinded, case controlled study with enough participants. I do take it for that reason and it also does seems to lower blood sugar, BUT the only reason I take it without more evidence is that it does not seem to do any harm. So, I am hoping we eventually do get more robust/solid data. Nattokinase - not sure the evidence is there ... can you point me to some high quality studies? I AM SURPRISED HE LEFT OUT CREATINE MONOHYDRATE.
New subscriber. Just found your channel. Love it!🙂
This is great analysis - independent, evidence-based and with context and nuance that is absent from the influencers and supplement sellers who are everywhere on TH-cam. Much appreciated.
Thanks, Mark
I second this.
I third this.
He’s buying the lipid hypothesis, but hiding behind “one of the contributors…”, otherwise excellent summary.
A minority also thinks that males can be females, and females can be males. So take that with a grain of soy😂
I am back in school finishing my Nursing degree at 50 partially because of this man. His videos help me stay fit by running to TH-cam every time he posts. He's had me print out and read studies he's mentioned on here. It's like he's our own personal TLDR superhero. I trust his analysis.
Glynac has definitely been my Grandmother is 88. She was starting to show signs of cognitive decline and becoming increasingly frail. Started her on glynac 2.5g and 1.5g taurine twice daily, and the results have been astonishing. Moves faster gets up better, and her cognitive capacity and memory have come back to baseline.
I've been taking glynac since last summer and taurine since the fall and I must say it has vastly improved my energy levels and I think it's actually improving the speed of my thinking, no small feat, despite being under 50. I also think NAC generally acts as a detoxifier which is beneficial.
I have a 95 year old aunt who I am going to try this on.
let us know your anecdote @@SkyRiver1
@@SkyRiver1 Please let us know how it goes! Well wishes!
MDMA works wonders on pensioners too.
Who wouldn't want to learn the 10 best tips for your health that a Ph.D. student has gleaned from reading 250 research reports? At the least, it can point up vitamins that you should look at more closely. Immense value in this channel!
I am 48 and have suffered from severe chronic depression and anxiety for years. I have used all of the drugs, psychological treatment modalities and nothing ever gave me much relief until a couple of years ago I hears about glycine and NAC. I had seen a study somewhere that chronically anxious people were often found to be depleted in glutathione. Obviously this can lead to all kinds of problems.
At the time, I started taking about 2 grams of NAC along with 2 grams of TMG daily. I started noticing after a few weeks everything was changing. It was like reality was becoming brighter. I could also breathe more deeply and freely (nac also helps the lungs)
On top of that, my blood pressure normalized and my energy increased 10x. It was like getting my life back.
I just wanted to point this out because I think people who have generalized anxiety even in their 20s and 30s could recover using glycine and nac. I think this needs more attention!
Thank you for this. When you take this ? During or after meal ?
So you are now less bothered by critical thoughts about yourself and the world, past and future?
@@shahzamanhaque I try to take it on an empty stomach. I usually take a NOW 1G NAC pill with a glass of water mixed with glycine powder. Lately I have added 3 grams of Taurine to the mix as well as 2.5 grams of creatine.
@@oolala53 I think what the glycine/nac combination did for me was end the constant exhaustion, depression and edginess I experienced every moment of every day. It has given me space to work on the critical thoughts and destructive thinking patterns. Self enquiry and meditation have been extremely useful. anything that brings circulation to the prefrontal cortex. I really like the meditation devices like the Muse 2 and the Mendi.
Where did you buy it?
Your channel and nutrition made simple are the only 2 I trust. Independent non-biased clinical evaluation of data. and no products or gimmicks being sold to me! ❤
Gil is awesome. Humbled to be in his company.
You should only get diet advice from a real Ph.D in nutritional biochemistry with awards and honors and or a Nobel Prize with a long term track record of being right such as Roger J. Williams, Frederick Gowland Hopkins, Fred Kummerow, George H. Whipple, William Parry Murphy, Edward Adelbert Doisy. All 6 would say the same that Linus Pauling said that meat, poultry, fish and eggs are good for you in moderation and that dairy is ok in small amounts if you like it and are not allergic to it. Gil Carvalho has zero experience in anything.
An abundance of information using minimal words. No flashy intro, no yo yo music, just the facts and nothing but the facts. Information at it's best.
i used to eat once a day for years and was 140kgs and miserable
when i started eating 3 to 5-6 times a day in an 10h interval since waking up with 14h pause i got down to 100kg and felt amazing, no gym or exercise, just doing basic stuff + work. for reference i am also 1.95m tall
I think it really depends. I can see the point in not eating for a long time as kind of exercise in restraint. But I lost 20 kg last year with frequent small meals. Often just a protein shake as snack at work. I feel that helped shrink down my stomach making me feel full being less full. Couldn't have happened with Giant 1-2 meals
You are a gifted teacher. Great dissemination of useful information!
What a great video! The fact that people can get acces to this kind of useful knowledge for free and with so little effort is awesome
So take glynac and omega 3 if you are over 60 and do the usual (weight,exercise,whole foods) for heart health.
Toss in taurine and creatine monohydrate.
Thank you @Physionic for being a voice of reason. I LOVE your videos! I'm so glad I found you and now I can stop wasting hours of my time watching all the others debate. Please never stop what you're doing! We need you!
That’s some great stuff Nic, really proud to see how far you’ve come and happy to have been here since the start.
Keep up the awesome work…Richard
Thanks so much for the kind words, Richard. :)
RE: Human growth hormone ("Reversing Aging/TRIIM Study)
Studies indicate that betaine [anhydrous] (aka, trimethylglycine (TMG)) at c. 3g a day (in split dosages, morning and evening, with meals) increases serum HGH naturally. (Glycine, in its various forms [like glynac], appears to be very actively important to maintaining/optimizing health.)
By day two of a water fast you will feel HGH in your body. So if you can do a 3 to 5 day water fast you will generate your own HGH. In my opinion the most efficient way to maximize water fasting is 7 days but it's not easy for a lot of people.
The key here is that when you come off of the water fast your body will make up for the protein deficit by maximizing efficiency and rebuilding once you start adding protein as it leverages the HGH that was used to preserve muscle mass during the fast to build up even further; it might be 3 days of water fasting @ a minimum to see the HGH effect, I don't usually pay attention until I start feeling it in the morning and that's not until I'm already well into the fast.
I am going to check you on the TMG, but thanks in advance for the info if it checks out.
The thing is can you produce any HGH when you're 50+ ? or Testosterone ? No... not really, the charts crash badly. You produce very little, there's not much to stimulate "naturally". You have to supplement.
@@pavman42how does one feel HGH?
NAC definitely has a difference for people above 60, based on my own experience. My joints are less achy, my slight pre diabetic signs disappeared, I’ve noticed more strength as well. I’ve also got Covid recently, and unlike all my previous flu and lung infections, I had the least symptoms, and lasted only 5 days, which is phenomenal based on how I suffered every time I get some kind of lung infection. Still working and learning as I go. My eyesight seems a bit better, although my optician said it’s no change from my last eye examination.
How many grams per day do you use?
@@littlevoice_11 Initially I bought 600mg capsules and I had 1 in the morning and 1 in the evening. Now I have them as 400mg, and still trying 1 morning and 1 evening. I'm usually giving it a little break every 2 week cycle. 2 days off it every 2 weeks for now. I'm thinking of 3 times a day at the moment.
You might do a segment on the following relationship: Hruby A, O'Donnell CJ, Jacques PF, Meigs JB, Hoffmann U, McKeown NM. Magnesium intake is inversely associated with coronary artery calcification: the Framingham Heart Study. JACC Cardiovasc Imaging. 2014 Jan;7(1):59-69. doi: 10.1016/j.jcmg.2013.10.006. Epub 2013 Nov 27. PMID: 24290571; PMCID: PMC3957229.
You have so many views nowadays!! Awesome! I've not followed anything nutrition related in a while because I started working in politics lol! But I'm so glad to see your current success!
Hope things are going well on your end. :)
I was legitimately expecting you to discuss high dose Vitamin K2 and reversing atherosclerosis at the end.
And boron
Nattokinase can do that
Because it's high in k2, right? I've heard it is not tasty 😂
Glad to see how much your channel has grown and you are getting better and better each year with the delivery 👊 Brilliant vid bro🤙🔥
thank You. I always look forward to your monday-video but this 1 is another level, it's exceeded my expectations. regards.
Wow. I don’t know why the algorithm suggested this video (though I suspect you do), but I am sure glad it did. Thank you for the wealth of trustworthy information.
I listen to my own body. Period. As we all should. My triglycerides went way up when I was eating more carbs and experiencing stress. And I became pre-diabetes. Now I’m none of those on a low carb diet. LDL is high, but HDL is higher. You did no talk on stress or herbs such as tumeric . Listen to your body people….and I’m an RD. I also exercise as well
This is great! Thank you so much Nicholas! QUESTION: can you do (or, did you do) a video on CA-AKG?
Thanks so much for this, Nic! As a student I’m grateful for the lessons in research literacy, and I so appreciate the way you approach analysis with equal parts intelligence, tenacity and humility. From a student’s perspective that is rare in both academia and wellness communication spheres, and highly worthy of emulation. 🙏
Regarding the insulin versus total calorie argument, I would really like to see an explanation of the differences of efficiency of conversion of molecule type into body fat disposition. Meaning, for a given calorie content of carbs versus same calorie content of fats, which results in the greater amount of resultant body fat. Is there some % metric of conversion to body fat? There is an argument amongst keto participants that dietary fat is less efficient at creating body fat then the same calories ingested as carbs. Can of worms here perhaps? Invigorating to hear discussions about cell/molecular biology. Studied this way back in the day but never went into the field. You never lose the passion for the science. Great work.
Thank you Nic, I really appreciate your sharing all this info to me as an aging young person, keep them coming. Its definately helping to educate me making my decisions.
I remember when I first came to your site I think 3 years ago and if I recall yours was one of the only ones that was very heavy into statistical analysis and broader cross study analysis. But more importantly, a broader respect for the lack of information and or the oversimplification as well as just the general lack of respect for science and most of these style of youtube informationals. I'm really glad to see that you are blowing up as I really think that your style of information is really helpful as the granular detail on this type of stuff is really what makes a difference & what makes you different because real results are always made in margins of 2 to 5% if you're lucky and anything promising more than that needs to be taken with a massive, massive grain of salt!!
Congratulations dude, good on you!!
P.s I'm currently struggling with type 2 diabetes. As a result to get my blood sugar down, I massively reduced my carbs for the obvious reason. However, as a result of the initial diabetic cannibalization of my muscle mass as well as my fat, I went from 240 lb to 155 lb is less than ideal for the obvious reasons of not just being considerably less strong. But as we will continue to lose muscle mass over time, it will be an issue moving forward as I am 48 years old.
I guess all that being said, is if you end up coming across anything about how to maintain or keep muscle mass as a aging type 2 diabetic I would super appreciate it. Mostly, because everything is geared towards losing weight, but I actually just stopped eating. I'm mostly carb diet and switch to primarily protein, greens that don't add any carbs and then low and glycemic index vegetarian carbs. Obviously this will need to be. How is the consideration overall? But I would love to hear some strategies on building if not, at least maintaining muscle mass as a type. 2. Diabetic. Everything I've read about building or maintaining muscle mass is about carb intake which is not going to work for me.
No worries if this isn't anywhere close to your wheelhouse, but I couldn't help but shake the feeling that you might have ran across some research that would be relevant to my situation. I can't imagine but I'm the only skinny type 2 Diabetic!! We're not all fat, some of us got this way cuz you were either just lucky or drunks 😉
Do you have any idea what a suitable dose would be for GlyNAC? Thanks for your great videos!
3 gm/day(min)
I recently came across something saying basically that if you are overweight and insulin resistant you have a hell of a time switching to fat burning(meaning that when you try to exercise to burn fat you end up out of energy because you cant make the switch and you feel like crap)...I experienced this when I started getting back in shape 3 years ago. I couldnt lose weight my old school way of training hard first then having my body ask for a better diet...Instead I had to eat once per day and go walking for my exercise. Once I dropped about 8 kilos in two months I was able to exercise normally and off I went. I can now eat reasonably and train hard....like a psycho. To me eating once a day is a good way to get the weight lose going but once you are in decent shape you can expand the window..and have to in order to build some muscle and train properly. Just my experience and thoughts
Hi. For the Thymus rejuvenation, have you seen Brian Johnson talk about him trying this? He mentioned on Dr Mike’s podcast that it had the most negative health effects of anything he’s done due to the human growth hormone because of increased intracranial pressure and maybe some other negative health effects that I’ve forgot.
Thanks for the Roundup! .. Maybe when you get time maybe you could analyze the literature on Aspirin/Salicylic Acid's benefit for CVD & Cancer treatment
appreciate your insights and opinions. Good to see the science community come out on these hot topic items circulating today.
I took Omega 3 for the advertised reasons for years (and still do). What kept me taking it was how much it calmed my psoriasis. I had no idea that it could do that. I suppose it calms the inflammation down? It's the only reason I keep taking it.
Thanks for your summary. Terrific content as usual.
You should do a video on ellagic acid and osteoclast differentiation. If pomegranates can build bone, everyone needs to know about it!
This is an awesome analysis. I wish you could update this once a year and make it an event we look forward to. Then the title needs a bit adjustment: It needs an edition marker, such as "2024 Edition".
Wow I just saw a video you did 3 years ago on that old anecdote of a carnivore guy in GB a hundred years ago. You appear much heathier now in weight and confidence. However now you appear pasty white and puffy under the eyes. maybe dial back the sodium and creatine intake and ingest more potassium for less water retention and get more sleep. It could be the lights/lighting but I do recommend getting more sun, sleep and a little less sodium/creatine. Also eating more carotenoids will give your skin more pigmentation and UV protection. Great info BTW and thanks for the synopsis of your due diligence. I commend your efforts. We need more people like you as influencers.
the dose and form of zinc in this study was "50mg of elemental zinc" and I am wondering about safety and feasibility of getting this dose IRL- from what I am reading, over the counter zinc contains only a fraction of elemental zinc- eg 50 mg of zinc gluconate contains 7.14 mg of elemental zinc, and 50mg of zinc picolinate contains 10mg of elemental zinc. how should we think about this?
Love your humor (and you too), my good young man! Stay well, stay healthy, stay wise, and keep sharing the goodness of your heart! May the universe bless your good life!
I am a lean mass hyper responder whose LDL cholesterol went through the roof when I stopped eating crap processed food and started eating natural food. I lost 10% body mass, almost all of it visceral fat that was hiding out behind my abdominal muscles. I am very much looking forward to release of data from ongoing studies on LMHRs. I have a hard time believing that the increase in LDL that accompanies all the beneficial changes from eating a diet much closer to what humans evolved eating is anything but a natural normal phenomenon.
Could be, Ken. I'm not convinced, yet, but I'm open to the idea.
Hi Nicholas, I really enjoy your videos and learned a lot. One question: I’ve heard many times the most important information in a study is, who provided the funding. 😉 What’s your take on that? Thx from Germany 👍
I cover funding in my analyses. I agree that funding is important, but it's often overblown in importance as if it is *the* deciding factor to believe or not believe a study, and I disagree with that notion.
I love how this man embraces his nerd, and I am here for it!
That was a quick review of past videos. It was beneficial for me.
Great video! New sub here! I’ve been feeling defeated by post menopausal hashi hypo 25 lbs. Im not sure where I go next as I feel I’ve tried sooo many diets, coaches, purchased food, FMD, omad, keto, vegan, it’s been exhausting! I think I could seriously become a nutritionist which it shouldn’t be that hard. I’m going to give low carb, adding macadamia nuts for good fat, sardines and see how that works. Thank you ❤
Saw the title... clicked immediately! This is THE Physionics video I've been hoping for.
Thank you
Best health channel by far!
Can you share your workout & nutrition routine?
As part of my preferred lifestyle, I eat just one largish meal a day, at the end of the day. I find eating (at any time of day) saps my energy, mood and motivation, thus brings an end to my useful day.
But what about the Rotterdam data that shows that people with higher cholesterol live 2 years longer? Is it just that older people need more cholesterol?
Found this:
LDL cholesterol still a problem in old age? A Mendelian randomization study.
Iris Postmus, Joris Deelen, Sanaz Sedaghat, Stella Trompet, Anton J M de Craen, Bastiaan T Heijmans, Oscar H Franco, Albert Hofman, Abbas Dehghan, P Eline Slagboom, Rudi G J Westendorp, J Wouter Jukema
Author Information
PMID: 25855712 DOI: 10.1093/ije/dyv031
BACKGROUND: Observational studies in older subjects have shown no or inverse associations between cholesterol levels and mortality. However, in old age plasma low-density lipoprotein cholesterol (LDL-C) may not reflect the lifetime level due to reverse causality, and hence the risk may be underestimated. In the current study, we used an LDL genetic risk score (GRS) to overcome this problem.
METHODS: A weighted GRS was created using 51 single nucleotide polymorphisms associated with LDL-C levels. The LDL GRS was calculated in three Dutch cohorts: the Leiden Longevity Study (LLS) (n = 3270), the Leiden 85-plus study (n = 316) and the Rotterdam Study (n = 4035). We assessed the association between the LDL GRS and LDL-C levels, chronological age, familial longevity and mortality.
RESULTS: Up to 90 years of age, in each age stratum individuals with high LDL GRS had higher LDL-C levels (P = 0.010 to P = 1.1 x 10(-16)). The frequency of LDL-increasing alleles decreased with increasing age [β = -0.021 (SE = 0.01) per year, P = 0.018]. Moreover, individuals with a genetic predisposition for longevity had significantly lower LDL GRS compared with age-matched individuals of the general population [LLS nonagenarians vs > 90 years: β = 0.73 (SE = 0.33), P = 0.029, LLS offspring vs partners: β = 0.66 (SE = 0.23), P = 0.005]. In longitudinal analysis, high GRS was associated with increased all-cause mortality in individuals > 90 years, with a 13% increased risk in individuals with the highest LDL GRS (P-trend = 0.043).
CONCLUSION: Results of the current study indicate that a genetic predisposition to high LDL-C levels contributes to mortality throughout life, including in the oldest old, and a beneficial LDL genetic risk profile is associated with familial longevity.
Thank you! I appreciate your hard work and no BS approach.
I am 70 yrs of age and boy would I like to try some of these supplements !
I really like these recap videos you do, please keep doing them!
Absolutely brilliant! the only thing I'm not sure about is calorie model vs insulin model as a mean to weight loss. It should be simple to decide, just put two groups on same calorie load and make a difference in insulin level. There shouldn't be any ambiguity cause none - I think - argues against that calorie restriction do not cause weight loss, it does. If the only parameter you change will be less calorie, than you will loose weight.
The claim of minority is that eating food causing high insulin causes:
1. More energy from food will be stored as fat or less fat will be used for energy.
2. You will feel more hungry, and than you will eat more, in effect, in normal life, you will gain weigth.
It’s be super helpful to place your videos linked in a playlist so it just plays one after another. Thanks!!
Love your channel. Keep up the good work!
Thanks for your work.
Thank you for your hard work. I really enjoy your videos!
Humor with mild snark works great Nic. Never change.
I would be curious if there are any studIes on the effects of autophagy on plaque cleanup. Also, since glycine appears to have 10 calories, is it useful to take with extended water fasting or does it disrupt the autophagic process?
I am considering adding Glynac to my regimen. My goal is to slow down the symptoms of aging. I am a 34 year old man with a background in business so my understanding of this is extremely limited, but here is my idea:
My antioxidant capacity is probably still high. I am fit, healthy and rarely ever sick, maybe a cold once a year. People in my family typically live to around the age of 90. Levels of Glutathione will decline with age so rather than waiting until they are low before I start supplementing I want to start supplementing now so that the reduction in Glutathione will be less over the coming years and decades allowing me to maintain higher levels as I age.
Does this make sense or am I way off?
GlyNAC got me to ED in 3 mo. Stopped it so...
Watch his video on the studies.
This is so informative. Thank you very much. This is one of the best and most comprehensive videos out there.
LMAO on your charming sense of humor. Yes Nick your charming.
Thanks for sharing your research with us & most important explaining it for the non nerdy tribe.
I wonder if any of these learnings in terms of supplements can be translated into dietary modifications, e.g., reduce a certain food that prevents absorption or use of xx. And foods high in the beneficial molecule.
Have you become aware of the work of Ben Bikman on Insulin? Than ks for this video, very helpful!
Have videos on his work
Hello, thanks for the in-depth video. Can you do a supplement special on autoimmune diseases? I have Long Covid and am trying to figure out how to recover. Studies are few and far between, so it's tough to get your hands on useful information. Maybe some general strategies that work for autoimmune could work with LC? Who knows. I'm gonna try Glynac in any case, as LC is supposed to at least partly be due to oxidative stress
great analysis, mate! 🙌 thank you so much 🤩🤗
Really important video. Nic deserves Huberman level of audience.
Hope you will look at future research on LDL increases post-COVID infection. 21:31
Spiking glucose increases glocosolation of protein which is mechanism of aging.
Thx yet again, you are doing your fellow man a great service! Cheers, to our health, and to science!
Awesome. Thankyou for making me double check my routine.
Another great video. Could you please do one on Lp(a). For those of us that suffer very high numbers, we really need your take on the subject. Worry/don’t worry? Niacin/no niacin? Carbs/no carbs?
Thanks.
I’m on it. 3 months of work. I expect the video to release in 2 weeks.
I’ll be counting down the days. Thanks so much. Just for your info, I’ve been taking niacin in large doses (1000mg) and it has dropped my Lp(a) significantly. But of course I can’t be sure that lowering it alone will actually reduce my risk of atherosclerosis.
I've personally had great results on keto so I don't believe it's complete BS but it's also used as a way to regulate my calories and help me not overeat so I'm sure that's part of it I think the issue is that both thermodynamics and hormonal balance are equally important instead of the two fighting each other for dominance most should incorporate both eating a low carbohydrate diet in a slight calorie deficit and then increasing that calorie deficit with exercise seems to be the best at least when it comes to weight loss
I guess my point is you can't eat 3000 calories of butter and expect to lose weight just because you're on keto but then an 800 calorie a day diet consisting of Donuts probably isn't gonna be healthy either it doesn't have to be 1 extreme or the other there is a middle ground but diet influencers pick a side and rage about it never seemed to have any common sense
I have a question regarding creatine, if you are in the so called "20% of unresponders" when it comes to using it for muscle growth/strength does that mean you are exempt from all its benefits? (Cognitive function etc...)
Merci beaucoup pour cette synthèse.
De rien, Pierre.
My concern with NAC and Glutathione supplementation after reading How to Starve Cancer is the role it plays in Cancer proliferation. Once somebody had a tumor of some kind gaining traction you'd want to avoid it hardcore. The issue is, how to be sure you don't have developing cancer.
Nobody knows yet
Thanks I really appreciated all of your analysis . Looking forward to the one on CVD.
Dont you get enough NAC from meat etc no need to supplement it?
Nic is the best! LOVE this channel.
So clear and well explained…thank you 😊
You deserve way more subscribers ! !
When you say "High LDL" as causal in CVD, maybe emphasize we are talking about LDL-Cholesterol and ApoB tagged particles and not Low Density Lipoproteins?
The lipid energy model shows increased cholesterol and minimal atherosclerotic plaque.
This study shows that cholesterol regulates TRPV4 and recall the transcriptome of active atherosclerosis includes TRPV4 and klf4.
2021: Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension
2020: Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis
carbohydrates stimulate glp-1 TRPV1, TRPA1 through the neurolymphocrine axis, 2020: Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves
TRPV1 causes hyponatremia and hypoosmolality that stimulates the osmosensor TRPV4
2014: Transient Receptor Potential Vanilloid 1 Activation by Dietary Capsaicin Promotes Urinary Sodium Excretion by Inhibiting Epithelial Sodium Channel α Subunit-Mediated Sodium Reabsorption
Lastly, in 1 year and 5 months I significantly reduced my atherosclerotic plaque and calcification on the low carb diet, estrogen patch and mineral supplements. My rate of recovery increased by 150% when I also stopped oxcarbazepine that up-regulated TRPV1 and TRPV4.
The above includes recovery of bone mineral density at the same time.
Glp-1 semaglutide that I did not take but I was on a normal carbohydrate diet, causes osteoporosis.
2023: The Effect of Semaglutide on Bone Turnover in Adults with Increased Fracture Risk: A Randomised, Double-Blinded, Placebo-Controlled Trial
TRPV4 plays a significant role in osteoporosis too as it increases osteoclasts differentiation.
Children on oxcarbazepine suffer from broken bones too. It’s all related to too much TRPV1 and too much TRPV4.
Can you share with us the supplements routine and specific brand you use or would be greatly appreciated! Great video!
14:50 I think that calories matter the most to loose fat, but a low carb diet with low insulin levels makes it easier since you do not starve as you would a regular high carb diet in a calorie deficit.
Also, protein and fat is like 🪵 for our body, it takes more time and energy to burn. On the other hand carbs are like hay, they burn fast and easy and you need more right away to keep moving.
Quick question, where do you buy red t-shirts?
Love all the content you put up, been following for a while and the sheer amount of work you put into your videos is astounding. Keep it up, we really appreciate you!
Lum S.
I like that you say LDL is one among many factors relating to heart disease. Right, and so what do we do with studies showing heart attacks and strokes (roughly 50% of all) in people with low LDL and others studies showing people living to 100 with high LDL? One thing I will be critical of in your video is how you present the idea that higher amounts of LDL leads (seemingly automatically) to more in the walls of the vessels. I'm not convinced this has been proven to be a "automatic" mechanism. Thank you!
Science isn't perfect, some idea can become 'scientific dogma' and then the idea just gets propagated throughout the literature, and results interpreted within that framework.
I’ve commented on this further down
You must have High LDL lol
From what I've read, a person's LDL will drop after they have a heart attack. Kind of like a person with high blood pressure will have low blood pressure after they pass out. The bloodpressure at the time of passing out isn't a good indicator of what it was months or years before that. That's the case with LDL and heart attacks. The person likely had high LDL before the heart attack.
Now I don't know if this is correct but it's what I'm reading. I hope Physionic sees this and comments. 😀
Also, high LDL is just ONE risk factor. The people who have heart attacks with low LDL likely also had other risk factors that caused the heart attack.
It's frustrating because I have high LDL yet all of my other numbers are good. BMI, blood pressure. I'd love to believe that my high LDL isn't an issue but now that I'm over 50 it does scare me.
You remind me of a proto Huberman, keep up the good work!!
Please study Protandim nfr1 and 2.
Also a 20 year study from Japan has determined that low cholesterol has a direct correlation to shorter life expectancy.
Sam-e and Milk Thistle or Dandelion root cleans liver. Studies in Italy have found people living five years longer with terminal liver disease than in America just with Sam-e alone. I’m almost 68 and have taken Same-e liquid (only) for 30 years now. I keep my D levels at 80 to 90 without dips and Never ever take any flu vaccinations (personal choice)
Thank for putting in the hard work to make this easy to understand.
Thank you so much for your great content!!
Fish oil is interesting.. I started taking regular fish oil with breakfast. The first thing I noticed was a significant increase in libido and on doing a spot on research I found various studies that talked about fish oils affect on libido. I'm 61 fyi. When you discussed memory, I found reducing sugar was incredibly effective at improving memory. I experienced head trauma when I was 3yo due to opening a moving cars door and landing on my head! So my memory has always been a bit crap.
fish oil or the omega threes? cuz my libido is already debilitatingly high and i just started increasing my omega three intake and i dont want to ruin myself
I have MCI caused by repetitive head trauma. Was able to get off a very expensive drug, Nudexta, by replacing it with Fish Oil + curcumin supplementation.
Anecdotally speaking only,,I lost a ton of fat free mass doing “text book” keto. On the positive, it did help me break a fat loss plateau, all things being equal(equal calories and exercise). On the very negative most of that free fat mass ended up being more lean mass than overall body fat. No real change in my already very low visceral fat as assessed via Dexxa Scan before and after ny N of 1 self experimentaion over 6 months. So what’s wrong with that, it takes a lot of effort to recover hard earned muscle than to lose body fat. Plus, I didn’t want to fast forward myself to a life of a sarcopenic elderly frail person at the expense of low body fat and some arguably positive cardiometabolic markers. My long term goal is to have a healthy balance of both without engaging in some dietary intervention or restriction that pushes the needle in a major way to one extreme or another.
Nac solved some problems but made me lazy. Over 60. I now take dhea and quit sugar as much as possible. Energy level is great. Nac got me over long covid like a champ but drained my get up and go.
Top Drawer commentary - thanks!
It's hard to imagine that CVD would be as significant a disease as it currently is if people all had a healthy endothelium. Lowering LDL seems to be a strategy that is effectively masking the most significant risk factor for atherosclerosis. If someone can't or won't implement lifestyle changes to improve their metabolic health then sure, give them statins. But statins only marginally reduce risk, for this to be a first line defense promoted by doctors seems to be unethical.
Regarding LMHR, what I have learned is the the distribution of risk of ASCVD is not normal. Some lucky people are just genetically immune and will not get plaques even if their LDL-c/ApoB are way of of range to 1 out of a million extreme, as shown by their CCTA and CAC at age 50+. One model based on LDL doesn't fit all.