Why are "regular doctors" so ignorant of pernicious anemia? General practitioners do not seem to know about intrinsic factor, about the test for intrinsic factor. General practitioners do not seem to know best practice for treating a person with pernicious anemia. I had a pharmacist tell me, with absolute confidence, that sublingual B12 is no more effective in absorption than taking a swallowed pill form of B12. Doctors still test only for B12 levels and with that test assume no pernicious anemia. My doctor has never discussed how I should also be taking methylated B9 and/or SAM-E. My doctor has never tested for parietal cell factor antibodies or homocysteine. General practitioners seem to treat pernicious anemia as if it was a minor, passing issue. Why is this?
Agree. Its an Ego check for all in the medical field... Discovering that my mothers HRT has likey caused my PCOS, excessive bleeding + other conditions to be exacerbated. For a long time, I thought it was all about iron. The things we wish we new 10, 15, 20 yrs ago! Regards and love to all 🩵
Cus they are stupid……they know little about a lot of stuff. Specialists know a lot about 1 condition. A real comprehensive blood panel from anaemia/pernicious anaemia is expensive and very detained :) They misdiagnose you for MS or something serious as they are so stupid not to run blood tests to save your life. Pernicious anaemia is serious.
And it’s important to note that the intrinsic factor test is only 40-60 percent accurate so as this amazing doctor has said you need to put all, the other factor s together . I had a level of 180 then 130 4 yrs later, before I was treated .My folate was 2 . All my M tests were high .. and I also have every symptom listed. I truly believe if I hadn’t started on daily b12 shots 18 months ago I would have died. Thank you so much to this amazing doctor who if you missed it very lightly also touched on the mylene sheath being affected by b12 deficiency decline in the sheath is also major factor in MS..
Thank you so much for this! At times, it was a little dense and difficult to work through, especially when you used abbreviations that hadn’t been priorly explained, but most of it I got. I have AIG and am receiving monthly B12 injections (in the first 4 weeks on a weekly basis. Have improved but still quite sick, not sure I am properly utilizing the B12 yet. If you are interested in doing research, I am one of nine siblings, many of whom suffer from PA and related symptoms (as yet I am the only one with a formal diagnosis of autoimmune atrophic gastritis type A), whereby my mother and my maternal grandfather were also treated for PA with monthly injections for all of the time that I knew them until they died, we would be more than happy to accommodate that research in any way we can. Please let me know. Again, thank you so much for your video!
Thank you so much. Is it possible for you to provide a link to the physiology diagram in the description at 11mins...? Fascinating learning this for the first time. My Gps always thought I had a mild iron deficiency. I was deteriorating also due to a Candida overgrowth, robbing nutrients. Sublingal B12 has improved my symptoms dramatically within 24hrs. Cheers! Keep up the good work and sincere thanks for putting this up for us on TH-cam 😊 Molly
My son doesn't have IF, so he can't absorb B12. He has been diagnosed with pernicious anemia. We get him.B12 shots regularly methy and sometimes hydroxyl. Should he also be supplementing with B9, folate, or folic acid? I hear so much debate on all thing pernicious anemia. It gets confusing. It took years before finally getting a correct diagnosis. At first, they thought he had MS. This has been a long journey he's on, and it has taken its tole on him physically. He still struggles with his health quite a bit, but he is a lot better than he was 5 years ago. Can he absorb B9 without intrinsic factor? And is there a way to supplement with intrinsic factor 🤷♀️
I'm wondering that as well. In my case, I've got high MCV confirmed by peripheral blood smear, positive IFA, high serum B12 (I've always taken an oral B-complex), and normal B9, MMA and homocysteine. Yet, I've experienced all the severe PA symptoms (neurologic included) and they're resolving very slowly with high dose injections of methylcobalamin. I've injected daily for 2 months now and am still making tiny improvements.
Intrinsic factor antibodies interfere with the B12 serum levels. A normal/high B12 can be seen with the IF antibodies. So you have to either test for IF antibodies or look at other areas of the blood which might indicate a B12 deficiency. I have elevated folate which apparently indicates a B12 deficiency (as you need B12 to process folate).
Yes. PA is closely linked to Hashimotos, as is a B12 deficiency. Some people believe that it’s the B12 deficiency that causes Hashimotos which is interesting as I showed symptoms of anemia and then low stomach acid before I was diagnosed with Hashimotos. I’m trying to get my doctor to test me for PA at the moment and have been supplementing with a high b complex methylated supplement which has made me feel semi normal. Trying to get my gp to do anything is hard work so I might have to do a private test 😢
Why are "regular doctors" so ignorant of pernicious anemia? General practitioners do not seem to know about intrinsic factor, about the test for intrinsic factor. General practitioners do not seem to know best practice for treating a person with pernicious anemia. I had a pharmacist tell me, with absolute confidence, that sublingual B12 is no more effective in absorption than taking a swallowed pill form of B12. Doctors still test only for B12 levels and with that test assume no pernicious anemia. My doctor has never discussed how I should also be taking methylated B9 and/or SAM-E. My doctor has never tested for parietal cell factor antibodies or homocysteine. General practitioners seem to treat pernicious anemia as if it was a minor, passing issue. Why is this?
Agree. Its an Ego check for all in the medical field...
Discovering that my mothers HRT has likey caused my PCOS, excessive bleeding + other conditions to be exacerbated. For a long time, I thought it was all about iron.
The things we wish we new 10, 15, 20 yrs ago!
Regards and love to all 🩵
Cus they are stupid……they know little about a lot of stuff. Specialists know a lot about 1 condition. A real comprehensive blood panel from anaemia/pernicious anaemia is expensive and very detained :) They misdiagnose you for MS or something serious as they are so stupid not to run blood tests to save your life. Pernicious anaemia is serious.
Thank you!
And it’s important to note that the intrinsic factor test is only 40-60 percent accurate so as this amazing doctor has said you need to put all, the other factor s together . I had a level of 180 then 130 4 yrs later, before I was treated .My folate was 2 . All my M tests were high .. and I also have every symptom listed. I truly believe if I hadn’t started on daily b12 shots 18 months ago I would have died. Thank you so much to this amazing doctor who if you missed it very lightly also touched on the mylene sheath being affected by b12 deficiency decline in the sheath is also major factor in MS..
Thank you so much for this! At times, it was a little dense and difficult to work through, especially when you used abbreviations that hadn’t been priorly explained, but most of it I got. I have AIG and am receiving monthly B12 injections (in the first 4 weeks on a weekly basis. Have improved but still quite sick, not sure I am properly utilizing the B12 yet. If you are interested in doing research, I am one of nine siblings, many of whom suffer from PA and related symptoms (as yet I am the only one with a formal diagnosis of autoimmune atrophic gastritis type A), whereby my mother and my maternal grandfather were also treated for PA with monthly injections for all of the time that I knew them until they died, we would be more than happy to accommodate that research in any way we can. Please let me know. Again, thank you so much for your video!
Impressive amount of info! Thank you!
Amazing video this was such an in depth look at the topic, Thankyou
Thank-you for the lesson in biochemistry. My doctor would never understand this. But I do.
P.S. I forgot to say that one sister who had pernicious anemia subsequently died of a neuroendocrine tumour…
What is the word at 10:00, “ A lot of discussion about…“ what? Thank you so much for this video!!🙏🏼❤️
"A lot of discussion about bismuth."
Thank you so much. Is it possible for you to provide a link to the physiology diagram in the description at 11mins...? Fascinating learning this for the first time.
My Gps always thought I had a mild iron deficiency. I was deteriorating also due to a Candida overgrowth, robbing nutrients.
Sublingal B12 has improved my symptoms dramatically within 24hrs.
Cheers! Keep up the good work and sincere thanks for putting this up for us on TH-cam 😊
Molly
Hi! I posted the link to the article in the description. Thank you for your comments.
@@gatesbrainhealth2639 Thank you 😊 wonderful info
Wow! Thank you I'll definitely check into this.
I received a B12 shot 2 days ago. I have been able to get caught up on my chores! Tears of joy! I still suffer from PPPD; but my fatigue is gone.
16:03 can you confirm what you said about the binding of B12
Thanks
I think h-pylori cause it in me. What if you test positive for IF but not positive partial cell antibodies?
Dr, do you work one on one with individuals? I would be interested. Thank you.
Hi, I do, my office’s email is info@gatesbrainhealth.com, and phone is (775) 507-2000.
My son doesn't have IF, so he can't absorb B12. He has been diagnosed with pernicious anemia. We get him.B12 shots regularly methy and sometimes hydroxyl. Should he also be supplementing with B9, folate, or folic acid? I hear so much debate on all thing pernicious anemia. It gets confusing. It took years before finally getting a correct diagnosis. At first, they thought he had MS. This has been a long journey he's on, and it has taken its tole on him physically. He still struggles with his health quite a bit, but he is a lot better than he was 5 years ago. Can he absorb B9 without intrinsic factor? And is there a way to supplement with intrinsic factor 🤷♀️
I have heard that low MMA can also be seen in B12 deficiency. What is your take on this?
Dr. Ralph Green 👏👏👏
What would you conclude if one has pernicious anemia but has high serum levels of B12 ( without any supplements)?
Thank you
I'm wondering that as well. In my case, I've got high MCV confirmed by peripheral blood smear, positive IFA, high serum B12 (I've always taken an oral B-complex), and normal B9, MMA and homocysteine. Yet, I've experienced all the severe PA symptoms (neurologic included) and they're resolving very slowly with high dose injections of methylcobalamin. I've injected daily for 2 months now and am still making tiny improvements.
Intrinsic factor antibodies interfere with the B12 serum levels. A normal/high B12 can be seen with the IF antibodies. So you have to either test for IF antibodies or look at other areas of the blood which might indicate a B12 deficiency. I have elevated folate which apparently indicates a B12 deficiency (as you need B12 to process folate).
Overlap between autoimmune gastritis & Hashimoto's thyroiditis. ?
Yes. PA is closely linked to Hashimotos, as is a B12 deficiency. Some people believe that it’s the B12 deficiency that causes Hashimotos which is interesting as I showed symptoms of anemia and then low stomach acid before I was diagnosed with Hashimotos. I’m trying to get my doctor to test me for PA at the moment and have been supplementing with a high b complex methylated supplement which has made me feel semi normal. Trying to get my gp to do anything is hard work so I might have to do a private test 😢
What if you homeo isn’t high but test positive for IF
.