How to Optimize Fertility in Males & Females
ฝัง
- เผยแพร่เมื่อ 15 พ.ค. 2024
- In this episode, I discuss the mechanisms by which human eggs and sperm are generated, the ovulatory/menstrual cycle, the conception process and overall fertility in males and females. I also explain how, regardless of whether you seek to conceive children, optimizing egg and sperm health is directly related to vitality and longevity. I cover the nutrition-based, behavioral, supplement-based and prescription approaches to optimizing egg and sperm health, the ovulatory/menstrual cycle and fertility. In addition, I explain lifestyle choices that greatly assist or harm fertility-several of which are very surprising. I provide science-based protocols for those trying to conceive children. The tools and principles I discuss can also improve overall vitality and longevity in all people, regardless of age.
Note: At the timestamp related to cumulative probability of pregnancy (2:01:30), I misspoke, my apologies. The data in the following graph are correct but the “120%” is not.
The appropriate equation is 1-(1-p)^n where p is the probability of getting pregnant in a given cycle and n is the cycle number. Therefore the equation for this scenario is 1-(0.8^6).
Using the equation, cumulative probability over 6 cycles is 73.8% (rounded to 3 significant figures).
For a visual representation: bit.ly/4dxkfPA
Thank you to our sponsors
AG1 (Athletic Greens): athleticgreens.com/huberman
Maui Nui: mauinuivenison.com/huberman
Eight Sleep: eightsleep.com/huberman
InsideTracker: www.insidetracker.com/huberman
Momentous: www.livemomentous.com/huberman
Articles
Effects of mobile phone usage on sperm quality - No time-dependent relationship on usage: A systematic review and updated meta-analysis: bit.ly/3Horf39
Acupuncture and herbal medicine for female infertility: An overview of systematic reviews: bit.ly/3D6QyUW
Effect of Zinc Administration on Plasma Testosterone, Dihydrotestosterone, and Sperm Count: bit.ly/3XThteZ
Cannabis and Male Fertility: A Systematic Review: bit.ly/3iXAyOi
Tanner Stages: bit.ly/3HnYXpo
Link Between Body Fat and the Timing of Puberty: bit.ly/3Wz9nH8
Timestamps
00:00:00 Fertility, Vitality & Longevity
00:04:24 Maui Nui Venison, Eight Sleep, Momentous
00:08:20 Eggs & Sperm, Genes, Fertilization
00:18:28 Puberty: Gonadotropin Releasing Hormone (GnRH), Melatonin & Leptin
00:23:38 Onset Trends of Puberty, Odors Effects
00:31:24 Female Puberty, Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH)
00:35:25 AG1 (Athletic Greens)
00:36:34 Ovulatory & Menstrual Cycle
00:40:36 Follicular Phase: Egg Maturation & Ovulation, FSH & Estrogen
00:51:09 Luteal Phase: Progesterone & Estrogen, Menstruation
00:58:14 Ovulation & Libido; Luteal Phase & Malaise; Individual Variability
01:03:14 Inside Tracker
01:04:18 Sex Chromosomes, Sperm
01:11:40 Tool: Testicular Temperature & Fertility
01:17:22 Sperm Production, Seminal Fluid, Vasectomy
01:24:07 Sperm Cells, Mitochondria & Motility, Intercourse Frequency & Fertilization
01:28:31 Sperm Production, GnRH, FSH, LH & Testosterone
01:36:21 Ejaculate Quality, Sperm Counts, Fertilization, Ectopic Pregnancy
01:44:14 Tool: Sexual Intercourse Frequency & Fertilization
01:53:24 Tools: Tracking Ovulation, Libido, Lubricants
01:56:42 Fecundability: Egg Quality & Woman’s Age, Cumulative Pregnancy Rate
02:08:17 Miscarriages, Chromosomal Abnormalities
02:11:23 Female Fertility: Age, Follicle Testing & Anti-Mullerian Hormone (AMH) Testing
02:18:51 Male Fertility: Sperm Analysis, Age
02:24:52 Fertility & Hormone Analysis, Age
02:29:07 Fertility Effects of Sleep, Cortisol/Stress, Cannabis/Nicotine & Alcohol
02:42:40 Fertility, Sexually Transmitted Infections (STIs), Viral Infection & Cystic Fibrosis
02:47:42 Tool: Testicular Temperature & Fertility
02:51:26 Tool: Phones & Sperm Quality
02:58:06 Deliberate Cold Exposure & Fertility, Testicular Temperature, Cortisol/Stress
03:05:43 Fertility, Exercise & Mitochondrial Health; Intermittent Fasting
03:14:46 Testosterone Replacement Therapy & Sperm Production; Supplements
03:20:36 Sex Determination in Offspring, In Vitro Fertilization (IVF), Sperm Fractions
03:32:23 Postcoital Female Position & Fertilization, Sperm Quality
03:36:57 Cannabis & Sperm Motility, Libido, Pregnancy
03:42:33 Acupuncture, Fertility & Pregnancy
03:49:25 Fertility Supplements: L-Carnitine & Allicin, Coenzyme Q10
03:56:18 Fertility Supplements: Inositol, Omega 3 Fatty Acids
04:02:50 Supplements for Hormones: Tongkat Ali, Shilajit, Zinc
04:13:02 Fertility & Prescription Medications
04:16:44 Human Reproduction & Fertility
04:20:12 Zero-Cost Support, TH-cam Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter
Title Card Photo Credit: Mike Blabac - www.blabacphoto.com
Disclaimer: hubermanlab.com/disclaimer - วิทยาศาสตร์และเทคโนโลยี
Please note: at the timestamp related to cumulative probability of pregnancy (2:01:30), I misspoke, my apologies. The data in the following graph are correct but the “120%” is not.
The appropriate equation is 1-(1-p)^n where p is the probability of getting pregnant in a given cycle and n is the cycle number.
Therefore the equation for this scenario is
1-(0.8^6).
Using the equation, cumulative probability over 6 cycles is 73.8% (rounded to 3 significant figures).
For a visual representation: www.researchgate.net/figure/Cumulative-probability-distribution-of-conception-over-time-number-of-cycles-with_fig1_10610311
Anyone would’ve made this mistake
1 - 0.8^6
@@JakeDiMare Exactly.
The 20% chance isn't even actually accurate. The chances of pregnancy during the three days leading up to and including ovulation are higher - between 27-33,% and having sex multiple times during this time period - e.g. daily or multiple times a day - increases the probability of a sperm surviving to reach the ovum due to the increase in the overall amount of sperm in the vaginal canal. The 20% chance is nothing more than an average, and while averages are useful, they are only that - averages. Averages are just the mathematical values that have been adjusted to be less influenced by extremes and outliers (unlike using simply the mathematical mean itself, which is more heavily influenced by both.) There will always be people whose chances are below and above that average, and as such it's nothing more than a generalization.
The chance of someone getting pregnant within six months is NOT static. It's HIGHLY variable depending upon multiple factors, e.g. Their partner's sperm count and the quality and motility *of* said sperm, whether or not they have a hostile uterus due to hormonal issues, endometriosis, adenomyosis, or uterine fibroids, whether or not they actually ovulate during their predicted fertile period as things like ovarian cysts and conditions like PCOS can affect this, as well as irregular menstrual cycles, the frequency of intercourse during their fertile period, how accurate their predicted fertile window is, fertility treatments, et. al.
To suggest that the chance of pregnancy per ovulation is cumulative is just plain incorrect as that's just not how biology works. It's accurate in mathematics, yes, but not biology.
No, the majority of mathematically literate people would not have made this mistake
@@jadedimage :) It's not how it works in mathematics either. The assumption that the probability of one event having anything to do with another is a classic misunderstanding. See the "gambler's fallacy".
A note on the probability of success conception touched on in the middle of this video.
The probabilities are not cumulative. They are independent events, the rough equation is 1-(1-p)^n, where p is the probability of conception and n is the number of attempts. So if there is a 20% (or 0.2) chance of conception and there are 6 attempts the probability of conception is 1-(1-0.2)^6 or appropriately 74%.
Assuming a 20% conception rate, the cumulative odds of conception are as follows:
1 attempt: 20%
2 attempts: 36%
3 attempts: 49%
4 attempts: 59%
5 attempts: 67%
6 attempts: 74%
7 attempts: 79%
8 attempts: 83%
Exactly.
No, no, there is obviously a probability of 5*80=400% of *not* becoming pregnant... :)
He literally addresses it at the @2:02:10 mark onwards with Fecundibility
Maybe listen to the whole thing before you reply about basic stats to a researcher's podcast
@@Nachos4587 THat's not the problem with what he says. However, he just posted a reply correcting it, so all is fine.
Takeaways:
-Fertilization: The process by which sperm and egg cells come together to form an embryo.
-Menstrual cycle: The process in females that prepares the egg for fertilization and leads to the shedding of the uterus lining if fertilization does not occur.
-Spermatogenesis: The process of how sperm cells are produced.
-Embryogenesis: The development of the embryo after fertilization.
-Fertility: The ability to conceive a child.
-Hormones: Chemical messengers that play a key role in the onset of puberty, the menstrual cycle, and the production of hormones in the gonads.
-GnRH: A hormone that activates cells in the pituitary gland, leading to the release of LH and FSH.
-LH and FSH: Hormones that travel in the blood and affect the gonads, leading to the production of estrogen and testosterone in females and males respectively.
-Sexual differentiation: The development of female and male genitalia.
-Factors that affect fertility: Science-based tools, prescription drugs, acupuncture, and the presence of certain scents and odors.
-Hormones effects on cells and tissues: Different hormones can have different effects on different cells and tissues, such as testosterone stimulating hair growth and estrogen enlarging breast tissue.
-Ovulatory menstrual cycle: Triggered by FSH and to some extent luteinizing hormone.
-Medical conditions that affect the menstrual cycle: Polycystic ovary syndrome (PCOS).
-Understanding the biology of fertility and fertilization can help couples facing infertility issues.
It is important to consult with a healthcare professional for personalized recommendations
Sperm Survival and Fertilization
-sperm survival after ejaculation, timing of intercourse for successful fertilization, sperm quality and concentration in ejaculate, optimal strategy for fertilization
-Sperm can survive for a certain period of time after ejaculation, and couples should aim to have intercourse with ejaculation around the time of ovulation to increase the chances of fertilization. Ejaculate contains varying levels of sperm quality and concentration, and with each successive ejaculation, there is a decrease in the concentration of sperm per milliliter of semen. The optimal strategy for fertilization involves maximizing the concentration of healthy sperm within each ejaculate and timing intercourse around the day of ovulation. Factors such as the woman's age, health, and fertility also play a role in determining the best timing for intercourse.
Cumulative Pregnancy Rate
-probability of conception, cumulative pregnancy rate, independent probabilities, fecundability
-The probability of conceiving in one month is around 20% for women under 30 years old, but independent probabilities do not apply to fecundability as it is a cumulative pregnancy rate. Fertilization is not just about the egg, but also the sperm and multiple probability events are at play. The likelihood of pregnancy depends on the independent probabilities of the sperm and egg meeting and fertilizing. Women under 30 should try to conceive naturally for at least five or six months before seeing an OB GYN, and older women may need to try for longer periods before seeking help. It is important to understand the concept of cumulative pregnancy rate to understand the process of fertilization and the likelihood of getting pregnant.
AMH and AFC
-AMH, antral follicles, ovaries, age, probability of successful fertilization and pregnancy
-AMH (Anti-Mullerian Hormone) is a structural imaging measure of the antral follicles in the ovaries. The typical trend is for the number of antral follicles to decline over time. A woman in her 20s or 30s might have 20-40 antral follicles exiting the reserve each month, and the number of antral follicles and the levels of AMH will decline with age. It is a good idea for women interested in conceiving in the future to get their AMH levels or follicle count measured regularly. The earlier and more frequently a woman measures her AMH and follicle count, the higher the probability of successful fertilization and pregnancy.
Intermittent Fasting
Ovulation and Hormone Administration
In-vitro Fertilization (IVF)
-Egg and Follicle Collection
-Sperm Collection and Washing
-Embryo Creation and Implantation
-ICSI and Embryo Selection
-Sex Selection
Cannabis Use and Fertility
Behavioral Interventions and Fertility
Acupuncture and Fertility
Nutritional Supplements for Fertility
-Coenzyme Q10
-Inositol
-Myoinositol
-D-chiro Inositol
-Folic Acid
-Vitamin D
-Zinc
-Selenium
-Omega-3 Fatty Acids
-Antioxidants
Stress Management and Fertility
Zinc and Male Fertility
-Food Sources of Zinc
-Dosage and Supplementation Recommendations
Intermittent fasting is a dieting pattern where an individual alternates between periods of eating and fasting. It's important to consider whether or not you are overweight or lean when determining if intermittent fasting is right for you.
Ovulation can be suppressed through the administration of exogenous hormones. Under ultrasound guidance, an OB GYN can collect mature eggs and follicles and put them in a dish. Sperm can be delivered to the dish, either frozen sperm or live sperm collected that day. The sperm are washed through a straightforward procedure. The sperm compete for the eggs and fertilize them, allowing them to advance to the early embryo stage. The embryos can be frozen and later implanted into a woman for full term pregnancy.
In-vitro fertilization (IVF) is a medical procedure that involves collecting eggs from a woman and sperm from a man, fertilizing the eggs in a laboratory, and then implanting the resulting embryos in the woman's uterus. A specific sperm can be selected for fertilization through a process called ICSI. Multiple fertilized embryos can be obtained through this process. The genetic makeup and karyotype of the embryos can be examined, allowing for sex selection. Sex selection is only possible through IVF. Recent research suggests that sex selection is also possible at the sperm level before fertilization. Clinics outside of the United States have developed methods to separate sperm into fractions that give rise to male or female offspring, allowing for more reliable sex selection.
Cannabis use can negatively impact egg and sperm quality. Avoid using cannabis, whether smoked or vaped, when trying to conceive or during pregnancy. Behavioral interventions, such as pelvic tilt, can improve fertility. Acupuncture is a proven effective treatment for improving fertility and pregnancy outcomes. It has been shown to be effective in clinical trials funded by government agencies such as the National Institutes of Health. Acupuncture is no longer considered fringe science. Acupuncture can also be beneficial for hormone status, stress relief, and chronic illnesses. Acupuncture works by stimulating neural pathways that link different organs of the body.
Nutritional supplements such as Coenzyme Q10, Inositol, Myoinositol, D-chiro Inositol, Folic acid, Vitamin D, Zinc, Selenium, Omega-3 fatty acids, and antioxidants can improve egg and sperm quality and overall reproductive health for both men and women.
Stress management can improve overall reproductive health and increase chances of conception by reducing stress levels and improving overall well-being.
Zinc is a key nutrient for males to consider in terms of increasing fertility. Zinc can be found in foods such as oysters and can increase testosterone and dihydrotestosterone levels. A dosage of 120 milligrams of zinc twice per day with meals is recommended for maximum benefit. Zinc supplementation should be done with meals to avoid stomach discomfort.
-It is important to consult with a healthcare professional for personalized recommendations
Wow thx for this!
🤮
thanks
Thanks!
Thank you! his videos are just ridiculously long 😅
Been waiting for this one! I would also love an episode specifically about supporting healthy pregnancy/fetal brain development as well as infant/early child development.
I second this!
Yes, I was hoping for this as well!!! My wife is 4 months pregnant. I would love to optimize this pregnancy!
Yes please. Me too
@@badassdadscast1903 don’t you think that consulting a obstetrician gynaecologist or a neonatologist would work better? i mean huberman is nit an expert in eVeRyTHiNg
Yes please
Me and my husband were struggling to have children. After running some tests my husband sperm quality wasn't great. We sat down and watched the whole podcast and did the things recommended for male fertility. As mentioned in the podcast after 90 days we got a positive. We've now got our beautiful baby. Thank you Huberman for your time and podcasts ❤
Huberman should wear a cape.
Uberman
Not all heros wear capes.😉
@@lindaohanraha-hanrahan2817 You win TH-cam today, congratulations
Completely agree!
What manor of superhero is this?
The doctors told me I couldn't get pregnant but then I started to drink everyday pure concentration pomegranate juice within months I got pregnant with a beautiful healthy girl. Supposedly in the ancient times pomegranate was known for fertility.
After discussing so much about fertility and people wanting to have children we should definitely do deep dives on childhood development. It was adressed lightly in several episodes: attachment styles, trauma etc... but a deep dive into a child's brain development and the effects of the environment and interactions as he/she grows would be amazing.
You have demonstrated that solely the conception of children can be an enormous challenge. Parents probably don't squander all that effort on purpose by messing up their child. They probably just don't know what they and their child needs.
That would be amazing
There's a lot of debate but the good news is that the research pretty clearly shows that not being a terrible parent is much more impactful to childrens' outcomes than being a fantastic parent. That doesn't mean there aren't places to optimize but just generally trying to be a solid parent is likely to be the 80/20 solution to good parenting.
Right. The best thing parents can do for their children is work on their own issues. Deal with their own trauma, etc. So they don’t pass it on.
That's fine, but ppl who have no issues with having kids should Def do this.. I'm a teacher at an elementary school, and the behavior and paternal involvement is a mess.
I don’t have kids nor plan to have any but I know so many people who struggle with infertility and had to get IVF treatment. I know this information is greatly appreciated. Hormone health affects everything.
You can get a cat
Dear Huberman!
I'm listening from Hungary. My english is not the best, but you speak so well and explain the things clearly that I can understand most of what you say (automatically generated captions are also very helpful). I always learn a lot from your podcasts and this episode was extremly helpful for me. Your enthusiasm for science and to share knowledge with others shines through every minute of your videos. Thank you very much for the valuable content!
It is delighted to see that the words of Andrew Huberman were spreading into multiple countries. We live in a significant time in history when we can get any information at any time without any cost. Furthermore, it is so valuable that scientists (like Andrew and many others) digest, process and present the information in an easy-to-understand way.
Éljen Andrew és éljen a költségmentes információ minenki számára!
It’s leg day!!! Huberman’s podcast is my favourite podcast by far. He’s such a wonderful teacher. I think he was born to do it. The amount of content he put out every week is crazy. I’m a retired RN so science and medicine podcasts and lectures (nerd) make me feel like I’m still learning which I love. I’m in my early 50s and would love a show about hormonal changes as we age. Menopause has been a complete nightmare for me and I’m sure I’m not alone.
Look into vitex, or chasteberry and magnesium.
Legs and Huberman yes.
More power to you and us nerds!
You might like Dr. Barbie Taylor here on TH-cam.
In a world where it can be so difficult to get good information, it’s a blessing to have podcasts like Huberman Lab to turn to. Thank you for your contribution to the public Andrew!
I listen to huberman podcasts while exercising every morning to gain knowledge while improving my physical health.
Me too!!!
Neuroplasticity!! 💚
PLEASE do an episode on Women’s hormonal health issues like PCOS, insulin resistance, hashimotos and all!!! We women are tired of suffering and having so many conflicting opinions on these!!! Thank you Dr. Huberman!!
If you experience any of those, maybe waiting for an episode isn't the best thing to do and maybe you should talk to your gyno about it
@@Escalusfr Those of us with health issues do have doctors we talk to. We just want some general best practices because different doctors frequently give different advice and it can be hard to personally figure out who is giving the best information. Dr. Huberman isn't an expert in the field but he's better than me and he tends to focus on up to date research and discuss everything from lifestyle changes to supplements.
@@tiryaclearsong421 Yeah, I get that, but Pr Huberman isn't a gyno, so the best thing would be to find a reputable obgyn who actually reads new articles
@@Escalusfr doctors are generally not equipped to dealing with those problems. For example my friend has endometriosis; she suffers, a lot. Been to many doctors by now, seriously thinking about a full hysterectomy just to maybe stop the pain. Huberman would probably have more helpful information about dealing with this stuff than any of the doctors she has visited.
Only Andrew Huberman can make me sit over 4 hours and have my attention only on one thing: his podcast. Very informative ! Thank you for all that you do, it is a great benefit to all if us!
4 Hours ❤.
It’s Huberman and chill.
Wow😂😂
Netflix and chill😂
😂😂😂
♥️😂
Thank you so much for covering this topic! I'm a nurse midwife, women's health NP student and I know this topic will come up continually. I just wish I had the 4.5 hours to watch this instead of studying for my tests which won't give me a 10th of what you provide for free! A condensed version would be so so appreciated. Your are an amazing person and are changing health and wellness. Your podcasts should be required in all medical and nursing schools! Thank you!!
I would save it for later! Too much good to condense. I love that you are a midwife 🙂
fair point. Or maybe a summary statement at the end. But something.
I listen to it at 2x speed during meals or tasks lol
How much time did you need to record this 4 hr long episode Dr. Huberman?
Such dedication and efforts to bring zero cost information to general public. God bless you.
At least 4 hours I reckon
@@porto1st i never leave comments on a video or like a comment ever but this was the funniest comment I've seen in a long time
@@porto1st nah atleast 4.5 hours IMO
I was just wondering, how he can put out so much high-quality content within such a short period of time. He's constantly uploading new podcasts. Taking into account all the research he has to do for each one... I'm wowed!
@@AbhilashNairSpartnax I think he meant the research he's doing beforehand + the actual recording.
Me and my Mrs had our first set of IVF treatment fail yesterday, so I've made notes and hopefully something will work. This is a incredible indepth video, so thanks for all your hard work for getting it out there.
I hope it goes well for you and the Mrs!!
My doctors told me I couldn't get pregnant but I started drinking everyday pure concentration pomegranate juice. After few months I got pregnant with a beautiful healthy girl. Supposedly in ancient times the pomegranate was known for fertility
Congratulations
@@metaphysicalfractionals4509 Thank you
A key indicator of intelligence is being able to absorb mass amounts of information and repeat that information to another person in a way that is easily understandable and digestible. So grateful for your podcasts, I am amazed every time how you take all of this information and present it to us in a way that is engaging and actionable for the average person.
me too I am so amazed about his speech, how can he be so clear and speak so fluently about any subject. i admire this so much.,
Watched the whole episode (on regular speed too (I’m typically a 1.5X viewer)). Took me over a month to get through it all in a way I could digest and retain the info. Well worth it. What a great service being provided here. Thank you so much.
Thank you so much for taking the time to put together this fantastic resource. This is a topic that’s very close to my heart, and this episode is by far the most comprehensive overview of fertility that I’ve found. I’m looking forward to your future episode about embryonic development - I’d love to see you discuss chemical pregnancies and recurrent pregnancy loss.
Thank you from Germany to Prof. Huberman! Your podcasts are outstanding! Thank you for your expertise for everyone! Best wishes, Franziska 🙋🏼♀️
A fellow Neuro fan from Germany jippie! 🎉
Hey,Andrew, If you are reading this, please keep reading. Please don't skip. It's a request. You are the most wonderful human being running the most wonderful podcast ❤️ . I just want to tell you that till date you haven't covered a single podcast for STUDENTS(even if you are a professor,no pun intended 😃.)
I just want you to know that you should cover a whole podcast for students because you know we sometimes have a lot of issues regarding our studying. I have listened to many podcasts of you on other podcasts also (when you where a guest on other), but no one asked you a question about a student life. There are a few questions that I think every student will find helpful if they get an answer from you. I am sure there is a lot of literature out there regarding optimization of studying specifically.
Here are some questions that I think you should answer if possible through a podcast
1. How students can enable themselves to study long hours such as 9 to 10 hours or 11 to 12 if needed.
2. How to be focused during all those study hours and how to not get fatigued while studying.
3. Your thoughts on the famous Pomodoro technique and studying for long without a single break.
4. How workouts or meditation might affect student performance and which workouts to follow specifically for students ( you can even ask Andy Galpin 🥲, I love that guy ).
5. How to reduce stress which causes because of constant studying, and also during exams.
6. And please give some protocols and some tools on optimizing studying (recommended by you and by science of course),with Food and Supplements ( if needed ) for better performance as a student who wants to study whole day for some intense period like 3 to 4 months or as needed. ( not trying to be selfish, but yeah, it's ok I guess 😉)
So, Andrew If you have read this until now then I genuinely request you from the bottom of my heart to please record this podcast and to please reply to this comment and I am eagerly waiting for you to reply, also If you decide to do a podcast ( which I think you will ) please release that before 30 days or so from today because I have my most important exam in 3 to 4 months from now so if you release it in Feb, I will be very delighted. Thanks 😊 🫂 🙏
- A request from a student to a professor.
Hope you don't ignore this.
I think it's a really good idea
Hope he reply
It will be interesting podcast
@@mehanatking2635 yeah, it is
Hey Andrew will you make it ?
4 hours?! You are amazing. Thanks for taking the time to make this!!!
As someone who has studied this topic extensively, I am amazed to find that there were so many gaps in my knowledge about the process, that all were made clear with your amazing research
Amazing episode. Thank you
This episode couldn’t have come at a more perfect time. Thank you as always ❤
Your content is priceless...just to be able to receive such concise, science based information presented in such a way that a layperson can comprehend is incredible, a service to society. Thank you!
I'm addicted to this podcast 😎 I listen to it whenever and whereever I can. Thank you for this continuous flow of high-quality knowledge 🙏
I can’t believe all this information is free. This is so amazing. Thank you so much!
You've an expert on so many subjects, and can relay information at such impressive speed without pausing or stuttering, it's beyond comprehension. Very impressive specimen indeed.
Very useful information on this episode. I had hoped the female hormone episode would follow up and further expound on infertility approaches for women, however I found this episode much more informative. I've been patiently waiting for both episodes. Thanks for putting so much time and effort into compiling this information. I do hope to hear an infertility expert on your podcast as well someday. However, I think the Kyle Gellet episodes have been super helpful as well. I just didn't get as much out of the Sara Gottfried episode that I hoped for; it often felt off topic or opinion based. This one was great at providing guidance and ideas to bring up to my docs, Thanks again Huberman Lab.
Deserves a spot on the Top5 Huberman episodes list 🙌🏽 Thanks Doc.
A lot of the fertility information intended for laymen is directed at women and presented by women (e.g. Natalie Crawford and Mama Doctor Jones). I think that information is great, but it’s also an issue that men don’t tend to be interested in that content. Instead, their women relay the information to them and unless those women are professionals, men will naturally be skeptical about some of the things - especially things that need them to change practical habits (like having their phone in their pocket). The fact that Huberman presents this information in a way that I think is easy for men to be captured by and understand, makes it very valuable. When Huberman holds up a meta-analysis saying that having your phone near your testicles is bad for your sperm, I think men will understand that it’s not a myth. I was waiting for it while listening to this episode, because I knew it would come and when it did, I was so happy that you presented it in such a clear way. Thank you!
As always, an abundance of knowledge! I'm so thankful I came across your first posts over a year ago. Thank you for sharing!
I've been waiting for this topic, thank you. You are such a blessing for this world. Thank you for keeping this information free and accessible.
The best podcast in the world. I also have a question for the folks watching it - is there any podcast that makes you feel such a productive person than this one ? For me there isn`t. Watching something, whatever it is, often is associated with procrastination, but this one right here is like reading a book, or developing a skill. Keep up the good work Dr. Huberman, you and your team, standing behind that are amazing.
ive been waiting for so long for this episode to drop! over 4 hours of pure gold 😍😍😍😍
The explanations are so clear and accurate. This is amazing!
4 hours omg we are BLESSED 😭 Thank you so much!!!
I can feel ovulation, or better said i feel pain on the day of ovulation. I always record that day and when i start my period i look to my calendar and indeed, this pain always occurs 14 days prior to my period (+-0.5 days, depends on the time of the day). It’s pretty awesome to actually feel it. At first I didn’t understand it, thought it was maybe digestion or some inflammation issues, but i soon realised it’s actually ovulation.
I do to. Can even tell which side the egg is coming from. It is called Mittelschmerz
@@JasmineRenees me too. There were few times my annual obgyn appointment fall on ovulation and the doctor could confirm from what ovary I'm ovulating. Didn't know if has a name
that's amazing! I am definitely not interceptive enough to notice it ... perhaps a skill I could cultivate
@phnification don't worry, feeling it is very uncommon! And not even something I could ignore or not notice most months as the pain is awful for a couple hours! So it isn't a pleasant experience
I get this too - it's not so much painful, it's just... noticeable, kind of like a little spot of heat that waxes as that dominant follicle matures, and then wanes once ovulation actually happens.
Wow! Nearly 4.5 HOURS?! This much be a pretty comprehensive conversation on the topic. Looking forward to it!
I hope he’s drinking plenty of lemon/honey tea. I’d be so hoarse if I talked for so many hours!
Thank you so much for taking the time out of your day to share your knowledge and explain this topic with such great detail. 3 years of TTC, this video was a great watch.
Thank you Mr Huberman. I finally listened to the entire 4 hours over a week all while taking notes. This is a topic of interest to people trying to have children. The whole process is so complex, I wish the obgyns have a series of tests they can do to determine problem areas rather than recommend the standard, IVF. It'll be good if you can cover in more detail he various tests like the sperm test that one can do to determine their chances of getting pregnant naturally. Thank you again for sharing this wealth of knowledge.
Dr Andrew Huberman, I absolutely love your knowledge and your commitment to communicating science to us all. I work as a therapist and sometimes recommend your episodes to my patients :) I've been struggling with fertility and it was good to hear you talking on this subject, as always concrete and so interesting ... 🙏
Yay!!!!! In anticipation I’ve been telling everybody who will listen to me to keep a lookout for this lecture! I am so excited! Thank you, thank you, thank you!
Hallelujah! So happy to see this topic being discussed in depth. I think if society as a whole had these understandings there wouldn't be such confusion and conflict occurring around gender and identity. With the dropping of birth rates around the world, our younger generations particularly need to hear this and recognize the role they play in the survival of our species. Also our law makers need to learn this and recognize how their decisions with companies whose byproducts fatally disrupt our hormones negatively impact our future in all areas.
Couldn't agree more with you.
Sir, to go through this…is like the best lecture ever. You are a pure inspirational beast.
Thank you so much as always for the highly informative podcast! Always learn something new from each episode. Just a request, would you be able to do an episode on binge eating disorder please and ways to overcome it? It would be much appreciated and I think will help a lot of people 😊
This is so helpful, I had no interest in learning about this in high school but now that I am 40 and trying to conceive, it is so interesting! Thank you so much. You’re reaching so many more than you know!
This is so interesting! I’d love an episode about humans first food- breast milk and how it aids in neurocognitive development. Thank you as always, Andrew!
Thank you so much Dr Huberman for this explicit episode on fertility.
Best health podcast ever, always learn from you Dr. H
You truly are the highest quality educator that I know. I appreciate the depth of research and coherent presentation! My wife and I are trying to conceive and will try some of the behavioral and dietary changes.
I've been watching your podcasts for a few months now, and by far the biggest takeaway from everything I've heard is that our body is almost impossibly complexed and sophisticated, it's brilliant, and I regret not taking biology seriously and learning more tbh. I am learning now though, so thank you so much for opening my eyes!
00:00:00 - Maximizing fertility: The science and tools
00:04:37 - Sponsors: Maui NUI Meats
00:05:57 - How to Get a Great Night's Sleep
00:07:11 - Huberman Lab: Momentous Supplements
00:08:20 - Fertility and the germline
00:13:27 - Fertility and reproduction, from conception to fertilization
00:18:27 - The biology of fertility and fertilization
00:19:49 - The causes and physics of puberty
00:23:01 - The onset of puberty and its causes
00:24:44 - The onset of puberty has been accelerating
00:28:43 - Pheromone effects on the onset of puberty
00:35:25 - Athletic Greens
00:36:24 - Ovulation and the Cycle
00:39:18 - The menstrual cycle and the lunar cycle
00:40:36 - Ovulatory cycle 6, The follicular phase
00:51:59 - Ovulatory cycle 6, The luteal phase
00:59:08 - Malaise during the menstrual cycle
01:03:00 - Sperm Health
01:04:18 - Spermatogenesis, the generation of sperm
01:13:29 - If You're Trying to conceive in the Next 90 Days, Avoid
01:15:04 - Boxers vs Briefs
01:17:19 - Spermatogenesis 1, Introduction
01:22:31 - Vasectomies
01:24:04 - Sperm physiology, morphology, physiology
01:27:30 - How often should I have intercourse with my wife?
01:28:28 - Problems of spermatogenesis in males
01:36:16 - Probability of fertilization in a human pregnancy
01:41:12 - Sperm counts decline
01:44:12 - Fertility 6, Quality of sperm and frequency of ejaculation
01:46:45 - How Often Should Couples Have Sex?
01:52:15 - Can You Feel Your Ovulation?
01:53:21 - How to predict when you'll ovulate
01:54:35 - How to manage libido before ovulation and sperm health
01:56:39 - Choosing the optimal methods for conceiving a child
01:59:50 - How long should a couple try to conceive?
02:08:08 - Miscarriage 6, Women's experiences
02:11:14 - Ovarian fertility and fecundability
02:23:08 - Sperm Analysis, importance and cost
02:28:59 - How to Get Enough Sleep to Be Fertilized
02:31:12 - Five Don'ts to Do to Hurt Your Fertility
02:36:04 - Binge Drinking and fertility
02:41:46 - Alcohol and sexual health
02:44:02 - Viral Infection during pregnancy
02:45:44 - Cystic fibrosis affects the sperm
02:47:33 - 5 Tips for Increasing Your Fertility
02:51:18 - Does Phone Use Affect My Sperm?
02:59:02 - Cold Exposure for Fertilizer
03:05:27 - Fertility 6, Exercise and stress
03:07:20 - Intermittent Fasting and Time Restricted Feeding
03:09:13 - Intermittent Fasting During Pregnancy
03:11:46 - Is Intermittent Fasting Bad for Spermatogenesis
03:14:30 - Testosterone Replacement Therapy (TRT) and How to Help Your
03:24:07 - In vitro fertilization and sex selection
03:32:08 - Do pelvic positions affect the likelihood of pregnancy?
03:39:08 - Are cannabis users Aphrodisiacs?
03:41:12 - How to Improve Your Fertility?
03:49:09 - 3 ways to maximize your fertility
03:53:52 - Coenzyme Q 10
03:56:02 - Fertility Supplements
04:00:57 - Omega 3 fatty acids
04:03:47 - Two Options for Boosting Testosterone in Men and Women
04:05:37 - How to Increase Testosterone and FSH? Sheila Gee
04:09:45 - Fertility 6, Zinc
04:12:53 - Fertility drugs, pharmacology and surgery
04:17:40 - The Human Reproductive Axis
04:20:27 - Huberman Lab Podcast
Timestamps by Clippah
You dropped this 👑
@@aarrynz9721 🥰
Thank you sincerely my man
Omg thank you for this , I can't hold my attention span for 4hrs
Thank you !
59:08 Thank you SO MUCH for discussing the malaise that’s associated with the mid to second half of the luteal phase of the ovulatory menstrual cycle. I’ve gone decades thinking I’m just a terrible person who starts projects with high energy and then suddenly gets lazy at intervals for no apparent reason, and no amount of blaming and berating myself changes the pervasive feeling like I don’t want to do anything some days of the month. I’ve learned to just plod along and adjust my activities to more mundane work and make up for it when energy levels are higher.
Was about to skip this episode - no plans for having kids - but am glad I listened to the intro and then all throughout the discussion of the female reproductive cycle, this information is better than any lecture I recall in school or cycle-tracking app I’ve seen. Thank you, thank you.
It might be worth you checking out Mindy Pelz, who specialises in the menstrual cycle and safe fasting methods for women. She talks in detail about different phases of the cycle and the associated moods/feelings, healthy foods to eat, when to fast vs when not to etc. I've found her stuff really helpful so far, although still early days! Hope this helps in some way.
I don’t write reviews or comments. But, thank you Andrew for providing us with such incredible knowledge on a daily basis. The world is a healthier and better place because of you!
Amazing episode 😊 I am def an ongoing listener - thanks for the insight A!
Thank you for this! As a reproductive endocrinologist- I appreciate your thorough review. Incredibly detailed, accurate, but clear explanations- I’ll be sending my patients here to learn. Reach out if I can help you on fertility, IVF, miscarriage topics.
Prof. Huberman, thank you for another amazing episode, for the wealth of information, the level of depth and nuances discussed, and the manner in which you're presenting it - you can make anyone listen even to the most complex or boring subject! Thank you!
If you're planning future episodes on this topic, I would love it if you go deep into Bioidential Hormonal Replacement Therapy for women.
1) Types of BHRT
- What are different types of BHRT, and what are the potential long-term side effects from different forms of BHRT - oral vs. transdermal vs. vaginal, vs. sublingual, vs. pellets, other?
- T.S.Wiley protocol of BHRT - controversial among medical circles but makes sense as it tries to mimic the fluctuating levels of hormones in a normal cycle (rather than constant setady dose of hormones on standart HRT)
- BHRT for young women (20+ years of BHRT) vs. BHRT for menopausal women (much shorter treatment window). Currently there is one standard treatment for all.
2) Hormonal Testing on BHRT
- When you are on BHRT, what is the best way to test your hormonal levels - blood tests, vs. 24-urine test (DUTCH test), other?
- When is the best time to do the tests if you're on BHRT and therefore on a steady (same) dose of hormones (example: estradiol twice a week, and progesterone 12 days a month)? Does it make sense to test progesterone levels on the days you're off your progesterone supplementation for instance?
- Does it make sense to test the FSH if on BHRT, and will that give you a clue whether your hormonal levels are sufficient?
3) Optimal hormonal levels
- How do you know if your hormones are optimal, when you are on BHRT?
- What are optimal hormonal levels for your age, and when you are on BHRT? Reference ranges given by labs are so wide even within a cycle phase (Follicular vs. Luteal) that it is impossible to determine what is optimal. Most doctors will even refuse to test your hormones because according to them, if you are on HRT, we know your levels. That does not take into account however, the fact that HRT was designed for menopausal women, and if you are a young patient you may not get the optimal doses.
4) The different types of estrogen (estradiol, estriol, estrone) and how estrogen gets metabolized in the body - OH2 pathway, vs. OH8 pathway vs. OH16 pathway and how to fix suboptiaml metabolism?
5) In case of POI or loss of ovarian function, the standard HRT is estrogen + progesterone. However, other hormones are certainly impacted as the ovaries produce testosterone as well. What other hormones need to be tested and monitored in these cases?
6) As a subtopic, if possible, I would like to hear an expert talking about Premature Ovarian Insufficiency in which case, you have no choice but to be on HRT for 30+ years (if you're diagnosed in your teens). This is very different from being on HRT when you hit menopause.
There is very little research that I could find, concerning young girls with POI. They are being treated like women in menopause. However, I believe that the levels of estrogens and progesterone they need when they are in their 20s and 30s is way higher than the level of estrogen/progesterone women in their 50s need. I have heard from Dr. Sinclair and others anecdotal evidence that NMN supplentation can restore menstrual function? How does that compute with the theory that women are born with limited amount of eggs? Do you know of any human studies on NMN and ovarian function?
Apologies for the long list of questions, and thank you for your time!!
You are right Andrew- it’s amazing, we are wonderfully made 🙏🙌
55 and haven't started menopause yet. My OBGyn who delivered my 3rd took a looksie and said it's all looking like the average 35 yo woman today. That is sad for young women of today.
Really appreciate the time you spent on this. One request: could you include visuals as well? Helps a lot in these kinds of discussion!
An incredible service for humanity from an incredible scientist! You rock!
Just finished this podcast on Apple Podcasts.. probably my favourite listen so far as my wife & I have been trying for over a year. I promise one thing.. if these practices I will be implementing going forward work I will be name my son/daughter after you!
keep us updated :)
This is absolute gem of a podcast 💯 Greetings from Singapore🙏
Thank you for your effort and time, Sir. Sending more Love!
Perfect timing on this episode! I’ve been trying to get pregnant for 9 months while simultaneously nursing my first baby. Now that he is almost 2 and I’d really like to buckle down on optimizing fertility and balancing hormones after almost 3 years of feeling completely out of whack!
Have you considered the larger picture of our having destroyed most of our planet by over-breeding?
Thank you for using your platform to address this. Male Factor Infertility is on the rise - worldwide. And I love how you emphasize vitality through increasing fertility -even if a person doesn't want to have children.
Merci merci merci Andrew!! I was waiting since long for this one! Thank you for sharing.
Please one day a podcast with Adriene Mishler about yoga and neuroscience!! ❤
thank you so much for this precious clip i wanted this the most n searched for that everywhere
This was absolutely amazing, thank you, I love this!
As someone who has used IVF to conceive (mainly male factor, but also egg quality issues), I found this episode really interesting in terms of supplements. The infertility world seems to revolve around the supplements recommended in "It Starts with the Egg" by Rebecca Fett when it comes to egg quality. The list included in that book and the supplements discussed here are quite different with the only overlap being COQ10 and myo-inositol. I also have an acupuncturist who recommends supplements (mostly based on the book) and also includes some herbs. I had never heard of using l-carnitine from her or my RE or my OBGYN. Really interesting stuff that I will definitely check out before going into round 3 for a sibling!
Adding the odd image here and there to illustrate the concept while Dr. Huberman speaks would greatly help the understanding for some
Is it just me or the amazing Huberman podcasts are getting longer (4hours+!), earlier and more frequent👏 but HOW do you do all these ..
The complex beginning of life is not a 30 minute discourse. I could lecture for 4 hours of the complications causing infertility, and I am a retired chaplain who is a citizen scientist.
Well all of this seems to be maybe like just too much information how could you live your life that way life is supposed to be enjoyed and live not analyze at every single moment and molecule😱
I prefer Huberman's long-form topics.
I wish I had this podcast 15 years ago! Thank you Dr H!
A 4 hour long free podcast with so much information and tools about one of the most critical issues the world is facing right now. Thank you Dr. Huberman for your contribution to the world. You're very under-appreciated. I hope the world learns more about you and from you.
More than 7 billion people in the world and this is what you deem critical?
@@electrodynamicorb6548 oh...you should read about the rising infertility rates. 10% more increase compared to what it was 10 years ago.
@@alexkarakkal still don’t see an issue.
@@electrodynamicorb6548 you will if you try to retire in the next 20+ years
@@AtomeyNow be self sufficient don’t rely on the system
Andrew is a beast! Such a valuable content. Changing the game and raising the bar consistently.
We hear about overpopulation, but more than likely we might face or even already facing underpopulation crisis and I know some couples that struggle with conceiving. Also, pretty sure fertility health simply cannot be not linked with general health.
Andrew, any chance you are going to be doing an episode on the neurology of the developing mind? As a new father I would love to see this.
congrats bro
Until the episode comes out (I am awaiting as well) , your kids do as they see you do. So if they see you as a responsible human being and caring, they will be caring as well.
My parents were very big on my diet growing up and today I help the kids in our family in prioritizing eating fruits and veggies before chips. They can still have it, but after.
Congrats and may God grant us righteous children. Amen.
Thank you Dr. Huberman really informative as usual.
Impatient to see a discussion on Menopause- our risks of hormone therapy- maintaining our sexual health- our brain function-optimize bone density. You know, mature women stuff... Thank you in advance. btw love your podcast my brain insisted to write it down. 🤘
i'm a medical doctor and this video will be forwarded to many of my students
Thats a splendid explanation. It is how science is made. I also have an idea to strengthen the explanation the part of fertilization. If there could be an animation playing on the screen which is also showing very detailed in the maybe a microscopic level what is happening during, while Dr. Huberman is telling about it, that could help to imagine how it works. Beside this, I understood the processes very well. I really appreciate the podcast and I admire it, thank you so so much.
Amazing teacher , love the detailed science. From a Retired RN
Andrew Huberman? More like, Andrew Uberman! Thank you for this work of heart and to spread the scientific knowledge right as it is coming into consciousness. You are an inspiration and motivation, and responsible for changes in my life for the positive, by the power of knowledge. Thank you!
Thank you for this information Andrew you are the man!
Great episode! Could you please do an episode on hair loss, supplements. and treatment options?
Priceless! Thanks Andrew 🤠
When planning my family in the 90s I purchased a book which suggested Y sperm swam faster but lived shorter and X sperm swam slower and lived longer. I followed the method suggested and produced the son and daughter which was my ideal family. Sorry I haven’t details of the author as I lent it to my friend who also produced a daughter to complete her family after having two sons!! . Keep up the good work I’m learning so much. 🇬🇧
28 year old male, watching to learn more as my wife and I have been trying for a child for a while now. Done test and verified to be ok, just hoping to learn more with this video! Thank you in advance
Haven’t had a chance to go through all the comments to see if anyone has mentioned this, but I think that there is a big chunk of the woman’s fertility that was left out. There’s a huge conversation around cervical mucus and basal body temperature tracking and how these things are related to an Impact fertility. There is a super brief mention of how to identify ovulation that I think was misleading (I think referencing the rhythm method) but there is a much more accurate way to anticipate and confirm ovulation using the two biomarkers mentioned above. I would love to hear another episode that focuses on these things! I absolutely adore this podcast.
Hello Dr. Huberman! I wanted to thank you for all this info. Having two miscarriages in the past, I listened to this episode at the beginning of the year and my husband and I implemented many of the recommendations. We’re now happily pregnant! Thanks for always sharing such up to date and valuable science and research with us! ❤️ (He is also now back to his much-loved sauna protocol now that his guys have done their job 😆)
So much useful information. Thank you so much!
He really did focus on the mechanisms, like said in the description, but I was missing the psychological or let's just say humane part of conception in this talk.
There are so many people who are doing everything right, the eggs and semen are fine, they don't drink wine, don't keep phones in the front pocket and what not, but still it's not happening (as fast) as they'd like.
Huberman only mentioned it not happening quickly on statistical terms, but often the solution is to just live your live without limiting yourself in every step of the way for the fear of not doing it right.
E.g finally relaxing and having that wine that you graved could result in healthy pregnancy better than following all the do's and don'ts if that leads you to live a life where you're never relaxed or happy really
@hubermanlab what dose of L-Carnitine for IM injection (should it be Acetyl L-Carnitine or just L- Carnitine?) is equivocal to your PO recommendation for egg quality?
Thank you for your work 🙏 You have changed my family's life forever for the better ❤
Your podcasts are absolutely amazing. Please do a podcast on how to sustain a pregancy - the dos and donts.
Is there a summary. It's interesting but, it's pretty long for me .
Thank you for covering this topic.
Small suggestion: When you’re define words that you really want the audience to remember, like GNRH, it might be helpful to place the text on the screen for a short period. I think it would help “visual” and “reading” learners a bit more. But it also depends on how much editing you want done. Just a thought! Thank you for your continued commitment to shared science based knowledge!
Do an episode on long fasting and cancer treatment with Dr. Ernesto Prieto Gratacós plsss
4 hours of outstanding information