Neuronal Migration Disorders: Embryology and Pathology

In this episode we review the molecular machinery and mechanisms that orchestrate neuronal migration during early fetal life. We then use this foundational knowledge to understand the mechanisms and neuropathological findings seen in a spectrum of neurodevelopmental disorders collectively referred to as neuronal migration disorders.

[@scottblakley9040]

Thank you. My daughter was just diagnosed with X-linked subcortical laminal
heterotopia she exhibits minor delays at 4 years old. We're still trying to wrap our heads around it and explain it to close friends and family. There is so little information out there. To all of you studying neuroscience, THANK YOU, we need more of you!

[@pramithanaveen]

finally! NMD making much sense to me. thank you for this detailed and very good video.

[@ArtisticlyAlexis]

My 3 y/o son has Periventricular Nodular Heterotopia, but it's *_not_* genetic so far as they can tell. We've done every genetic study possible through our amazing Harvard Medical School geneticist/neurologist at Boston Children's Hospital, but he doesn't have any genetic disorder that is known. He's our unique little guy!
Thanks so much for posting this lecture. It helps parents like me understand the science behind these rare & often overwhelming disorders. I'm a bit of a science nerd & really enjoyed learning how this abnormality was formed on a deeper level.

[@Fordsy_]

I have the condition myself and came here to learn more about it, and in a sense, myself. I've always just felt pretty out of place.. And it's been a bit difficult to grasp in utmost full sometimes- or so it feels like. I'm in my early 20s' and venturing down a deeper path of self discovery, including better understanding my mind for the enigma it is. My mother wasn't as dedicated to helping in my understanding. With that, I have high respect for you ma'am. I hope you and your son do take care! It makes me feel a little less mad of mind when met with the reminder i'm not alone.

[@ArtisticlyAlexis]

@@Fordsy_ You give me so much hope that one day my son will be able to live in the greater world, be able to do normal things like research his own complex disorder. May I ask if you are male or female & if you've had any genetic studies? I'm always eager to hear about males who have PVNH, because they're less likely to be brought to term & even less likely to be non-genetic based like my son.

[@Fordsy_]

@ArtisticAlexis And i'm elated to hear that. Knowing I can be of some aid means a lot, and I would be happy to answer your questions and chat further with you on the matter. Message me at my email: [e-mail]

[@TwoGrainsOfGold]

Subscribed! Thanks for doing this. I’m a doctoral student and I feel like you explained this better than my prof. Thank you 🙏🏼

[@NeuroscIQ]

Thanks Rochelle, glad this helped!

[@franzlutz5921]

Thanks a lot. Great work. Helps me immensely

[@jaimeteranrocha5875]

Very helpful, I appreciate the clinical correlation.

[@ast7173]

Brilliant 👏

[@NeuroscIQ]

Thanks! we are happy you enjoyed it

[@ast7173]

@@NeuroscIQ I can imagine the tremendous effort put to make it so lucid and comprehensive. Please try do more topics based on pediatric neuroscience.

[@k1278k]

My daughter is 24 and has neuronal migration disorder and global development delay and epilepsy,

[@gowthamsambasivam1476]

Neuronal migration disorder is curable or not?

[@pradiptater916]

Is this curable??

[@k1278k]

Sub conical band heprotopia

[@k1278k]

12 weeks this happened we were told we live in England