You both are certainly making for a brighter future ahead. Thanks for all your hard work. For once it’s very refreshing seeing and watching a sincere discussion on TH-cam. I really like this style.
.....ironically, I've had the Life Extension brand of NAD+ sitting among my supplements collection for a year before yet taking it as I wanted to keep researching & get blood workup. It has an interesting formula I just again looked, but I can't yet understand the connection of NNM & NAD???? Also, i Sure wish you guys would review a new form of ionized? NAC called Augmented NAC. .... made in Switzerland which is I guess ionized & far more powerful. They have set up some kind of advocacy campaign called "zero spike Project", so I just don't know what to make about all this & sudden invention of Augmented NAC! It is directed to Long Covid & Covid infections. Been emailing back & forth with them to see if it could help ME/CFS EBV & if they have any studies, but nothing other than Dr's reports it helps to fully or partially resolve. Saw a vid or comment about this Augmented NAC few weeks ago, so they have a US distributor & will just try it. I've been taking Life Extension NAC 2 weeks now 600mg 2x daily & nothing yet. I saw "HIS" vid on spike protein protocol for NAC, Nattokinase, Bromelain, & doing the same also. I'd like to say I have "The Original Covid" of 18 yrs that started from noxious sewer gas poisoning from major sewer vent risers that collapsed behind our kitchen / bathroom walls in a plumbing chase way in my 28 story hi-rise here in Fl. Not only were we exposed to years of VOC H2S/SO2 , but serious viral, bacterial, & fungal load in this gas.....very similar to that hi-rise in Beijing with sewer plumbing problems that speaks SARS through the building many years back!!!!! Seems f'n hopeless. Maybe we can get him to do a vid about this Augmented NAC to help others then buy stock in the company! LoL.🤕🤔
Being a layman and only seeking to stay alive for as long as possible and remain vital while doing it, I appreciate the nerds' contribution to finding the facts. Unlearned people like me have to rely on the interpretation and discernment skills we have and take some chances. Thanks for taking the time to let us listen in on the discussion.
My mother recently passed at 100 years of age. During her lifetime many folks ridiculed her for being a "health food nut". They all died decades before mom!!! Also, she never had a doctor or took any prescription drugs, but DID take lots of Vitamin E and other vitamins!
At 73 I found that playing my guitar was becoming more difficult. For example - I Feel Fine by the Beatles starts with a bar chord with a pinky stretch. I was flubbing the pinky about 50% of the time. After supplementing with taurine for two weeks, I'm playing that chord with no problems. I didn't start taking taurine with any exceptions regarding guitar playing. Just an observation.
When you started taking taurine, did you make any other changes? (drinking more water, exercising more, new hobby with your hands, etc). Just wondering.
Sweet lord please make this a regular pod Nick. Your breakdown of collagen peptide metabolism was covered in a way that's not on TH-cam. It's MASSIVE for burn victims to observe and consider their options when recovering.
Two of my top three health(span) guides in a terrific discussion! I love your comparing notes and I hope you make this a regular feature on both your channels. Also, nice shout-out to the third of my favorites, Gil Carvalho. You all perform a terrific public service and I wish you more success into the New Year.
Where was the discussion on GlyNAC? That seems to be the real possibility of life extension through supplementation.Thank you though for the subjects discussed in this TH-cam.
To be fair, your source matters a lot. Renue is where I got mine. Originally got it from a source with no benefits. Secondly I suffered from terrible sleep quality. 3 weeks after NMN 1G a day I was getting 5-7 hours and feeling better than in my 20s. Can't be placebo. Started other supplements afterwards to ensure I knew what benefits I sustained. All that can be GUARANTEED is that your NAD+ is boosted. What that means to you individually is completely different than anyone else. The fact you didn't see any benefits shows you probably already have healthy cellular activity. It's worse for me that I got a benefit, because it shows I was unhealthy prior.
I’ve taken DNA’s NMN powder sublingually for almost two years. No impact that I can see. I work out more now that I’m retired so I’m in good shape but I attribute non of it to NMN. Creative is likely the one supplement that gave me results in just a few weeks. With the potential cognitive benefits, I’d suggest creatine is likely the most beneficial supplement that I take.
I listen to and watch both Dr. Stanfield and your videos. I stopped taking resveratrol and stick to blueberries and other berries now because of Brad. I also take collagen peptides now because of both of you. Thanks for being critical science based thinkers and distillers of scientific studies to spread knowledge in the age of not just misinformation but disinformation. Merry Christmas , you two are a gift of reason and sound judgement to the world.
This discussion It´s perfect example about what I ever thought about supplements. No sensationalism, no "marketing booms", no confirmation bias... Thank you both for your great job!!.
No placebo for my old dogs: One at age now 9, has been “lame” for about 3 years, a leg broken in puppyhood at age 4 weeks, and acting up on her every single day after noon, after morning activities (she’s a high energy vizsla). After a couple of months on NMN (powder sprinkled on her food) her lame leg is NORMAL and FULLY FUNCTIONAL, no more limping after noon. So then I decided to give it to my other 13 year old dog who was getting cranky (obviously pain or discomfort causing it) and going blind from cataracts. After 3 months for her, she’s stopped running into walls and furniture, and is behaving like she did 7 years ago! So I tried it for older age aches, and a 7-year shoulder injury has healed!! And those aches and pains are gone. It took a few months for full effect, 1g per day. If placebo, fine. Something worked. I’ll take it. I suspect NMN only works for older age with depletion of parts of the NAD cycle and cellular repair.
😊 Really awesome to see that you had Brad Stanfield on. You two have been my "go to" for the past year or two when I want to hear any analysis on a particular supplement or drug. Having had cancer, I read a multitude of studies trying to weed through all the b.s. things that people anecdotally try to throw out there regarding "curing" cancer. Luckily I had learned how to read and analyze studies at some point in college and I think it's an important skill for people to have to be able to recognize bias or confidence among other aspects to be able to analyze a study. I appreciate the knowledge and breakdown you provide in particular. I had found Brad's channel before finding your channel. It was somewhat angering to listen to some of the other "health advice" channels knowing that lots of what they were doing fed into clickbait sensationalist topics. Many of them aren't giving a full honest assessment of things. When I found Brad it was quite refreshing. He basically gave a very honest and accurate "cliff notes" assessment of any particular study or meta analysis on a subject. He doesn't get into the specifics a lot and gives enough information for the average layperson to get a grasp of the subject. Then when I found your channel I was so pumped to hear someone give the same kind of honest and unbiased assessment while getting more into the details of the mechanisms of what is going on. Brad's "cliff note" style will likely be more popular because I would bet the majority of people don't understand enough or don't care to understand enough to hear the more in depth analysis. But honestly I love it! I have noticed that you changed your format at some point to do both styles. Really smart move for the algorithm and people's attention span. But please keep the "in depth" stuff available like you have been. It's awesome! I expect that you both get a little boost in subscribers and views after this video since you both likely have viewers that never even knew about the other person. Keep up the awesome work! We need to get you and Brad on Rogan, Huberman, or Friedman's podcast to help amplify the accurate analysis of information. Thanks to you both!
@25:30- there are at least *ten* systematic reviews/meta-analyses of collagen supplementation, mostly for skin. All found benefit. There are also reviews of collagen for osteoarthritis, the best probably being Larder, Iskandar, and Kubow 2023.
Regarding collagen pepties - it contains quite a bit of glycine. The usual amounts of glycine in typical meat/whey protein cannot provide the amount provided in collagen. Personally, I just take glycine.
I started following Dr Sinclair's protocol a couple of years ago feel great look great 100 % had a huge difference in my health and life clearly the study's are missing something big for me the change has been huge 52 years old
Excellent video, I enjoy both of your TH-cam channels. I like that your information is backed by studies not hype. Too many channels make unrealistic claims on to the latest longevity supplements based on the most tentative of evidence.
In 1826 President John Adams was 90 and eating pretty good. What types of unregulated synthetic vitamins, supplements and fortified foods was he eating for his entire life? And how does the human body react to a synthetic unknown foreign supplement that it does not recognize? Which disease does the DNA instruct the body to promote?
@24:00- Dr. V. is correct about collagen peptides being bioavailable, and being signalling molecules for fibroblasts. But it's mostly di-peptides. Tri-peptides may get absorbed into serum, but the evidence is not as good. It's even possible that oligopeptides made up of 4 or more aminos make it into serum. But I haven't seen good evidence (e.g. radio tagging) of that.
I'm not sure if it says more about me or more about you (and your quirky humor I enjoy) but when Dr Brad said he had started taking hyaluronic acid "for skin health" I almost expected a quick camera cut to your face as you quipped "Foreskin health!" Yeah, it's probably more about me. You must admit it wouldn't be wholly inconsistent with your humor. :) Merry Christmas and thanks for all the videos this year! You've added a ton to my knowledge and I'm appreciative for it!
thank you so much to help us to know what seem to work and what is just "marketing". I follow both of your channel and the channel "Nutrition made simple!"
22:00 Just a small addition and a question on the discussion on collagen: The study on burn victims used soy flour in a porridge for the placebo group, not isolated soy protein or other more processed proteins. The texture (and possibly bio-availability) difference is huge because of the 20% fibre soy flour contains. Try to make porridge with collagen, soy protein and soy flour at home if you do not believe me. The recipe is in the study. Do collagen peptide receptors also respond to other peptides/amino acids? I mean, a collagen peptide can be cut in several ways and so it's shape can differ.
Had no fingerprints (not enough definition to use for ID screen scan). Decided to take collagen to "thicken" my skin when a short term factory job became impossible to do with my fairly shrivelled fingertip pads. Took collagen for a year. Now have well defined fingerprints and plumped up normal fingertip pads even after having stopped taking it for a year or two. Touch screens are doable also now. No employer ever looks at my hands and neither did docs here. Could never access the Omnicell drug machine at the hospital via fingerprint id while I still had that job before stupid COVID came around and we got benchmarked.
I would be interested in hearing you guys investigate and speak about Shilajit, Blackseed oil, supplementing with a couple tablespoons of Extra Virgin olive oil once or twice per day and certain other nutrients.
@33:00- N=1 study: I tried taking a larger dose of hyaluronic acid, about 500mg/day. I saw an unusual weight gain of about 5 lbs. I'm guessing it was water retention. But this would mean that the HA was getting absorbed... To Dr. Stanfield's point about bioavailability: there would not necessarily need to be a 'receptor' for HA bioavailability; it could be getting thru the small intestine via paracellular diffusion, transcellular passive diffusion, or transcytosis.
It's usually on the label or, if on Amazon, the Q&A section has someone asking and getting an answer from the brand. If no luck there, just calling/email the company will get you the answer, but most reputable companies will have this info on their label (or website).
Unless labelled, I think it's safe to assume it's low MW (as it's cheaper). Just like fish oil is typically in ethyl esther form unless it's labelled with "triglycerides". So far in US, I've only come across DoNotAge that labels its hayluronic acid as high MW.
Given our daily variations in energy based on sleep, diet, stress it can be very difficult to recognize the effects of a supplement. I find the best supplement to be a really good night sleep and a long walk in the fresh air. Nothing makes me feel better
I have not come a single Dr here in the good old US of A that will order a test for a potential change. It is ALWAYS after the fact. I think it makes it easier for them in terms of diagnosis and treatment.
That is what I thought - Dr Brad is a bog standard mainstream Doc imo. and Physionic is on the cutting edge of intra-cellular biology - strange collab.
I'm very lucky if I assimilate anything out of these discussions because I'm not work close to being on a level with you guys but from listening to you I trust your intellectual prowess and I do pull some tidbits out that may come together for me in the Long haul
It's not that people don't trust science; it's that they don't trust that the science was done with their best interests in mind. Like you mentioned in this video, meta-analyses can have two versions: one that is reliable and one that can be skewed to produce the desired results. The vocal minority is absolutely right to question the "science" behind everything, and that can be both good and bad. The good part is that people are researching more because of their distrust. The bad part is that they sometimes distrust everything without investigating it themselves or rely on someone they trust who might be wrong. Either way, there are plenty of bogus studies out there. This video looks like it took a lot of work---impressive and in-depth as always.
Please do a fair and honest review of Gary Brecka's comments on the Joe Rogan podcast. Knowing someone with an MD degree/background would have differing opinions, it just seems like you're more open to an honest review. And he has good results behind his claims with some of his "patients". Would love to hear your thoughts on gene specific therapy - methylation, celtic sea salt curing migraines, etc.
Yes, they make big claims like similar effects to Rapamycin on anti aging and I’ve only seen their own clinical study for their evidence (so possible bias)
So anecdotally collagen helps my arthritic (OA) joints a lot. My OA pain relieving concoction is daily collagen and turmeric with piperine - I was going out of town and realized I was out of collagen so for 3 days I only took the turmeric - day 2 my knees were sore and worse on day 3. My activity had not really changed - my trip was visiting my 31 yo son who is according to him too busy to cook and he is tired of eating fast food crap and could I come cook and freeze some real food for him. I cook at home so really no activity difference. I was surprised, I did not think the collagen was helping as much as it was!
things like magnesium chloride and other salt forms tend to cause digestive upset. they're the type that are used as a laxitive. forms like magnesium glycinate and others bonded to amino acids or things like orotic acid are tolerated better and are probably more bioavailable. @@Joe_C.
Collagen supplements work for avoiding skin problem at old age. I don't know about wrinkles, because I don't have anything which worries me in that regard. The reason why Whey Protein isn't enough when you are older is that you don't get enough of those amino acids which are most abundant in collagen. Glycine, proline, and hydroxyproline. Yes, the body can produce them to some degree from other amino acids. But, at least when older, that's not enough. I do supplement with about 12 g a day of hydrolyzed collagen, and with a lot of glycine. And it cured some skin problems I got at age 70 or so. But if I had known more when younger, I would have supplemented with collagen then too. The turn around of collagen slows down if you doesn't get what's needed to build it. And the quality of it in different parts of the body deteriorates. You just see it only in the skin!
thanks for the greetings. You guys spend more on supplements than most people have for food! lets have some studies comparing supplements and affordable food for pensioners. as in eating for $3 per day total.
I'm highly interested in the photomodulation effects of light at cellular level, nobody yet i think, researched narrowband spike light from IR LED light vs wideband noise light from filament light using only a red filter. Since a year I'm using wideband IR and bc i wasn't able yet to measure the amount of shorter wavelength content like UV, I use additional sunblocker cream to attenuate the UV part of the spectrum. Bc i think, the filter i have could still pass damaging UV radiation. And i use this light sometimes for hours. 500 Watt filament wideband.
I would still watch the 5 hrs of quilting..My experience with NMN is to pair it with Betaine to give my liver methyl groups and glycine to help methylate away the excess amount of it. The other aspect of it is that I take it only if I do a draining workout during cutting phases. I seem to tolerate it better than Niacin, I feel However, that this is because I have G6PD deficiency, and it has been seen that niacinamide and niacin tends to reduce the g6pd enzyme production.
Here my observasiin. I'm over 50 I first noticed my Hanmer toe could be bent 20 years after weight lifting accident Then my 2 torn rotator cuff quit hurting ( 25 year injury ) 12:5913:0513:12 .I'm more flexible I'm stronger Dose 1 .5 grams
a good argument for collagen peptides is the ratio of glycine, by taking collagen peptides along side whey protein, you get a much better balance of glycine to cysteine.
The problem with Creatine for many of us is it’s negative impact on sleep. I noticed significant cognitive benefits but had to stop as I wasn’t receiving adequate quality sleep. Very disappointing.
@@MajicFreeman Yes, I even tried it in the morning. (5mg) After performing some Reddit searches, I discovered that lots of people had experienced the same problem. It’s very common.
Have you considered taking glycine daily? It supposedly has some sleep improvement qualities but I’ve not seen a benefit there. I take 9 grams of glycine powder daily for general health.
Happy Holiday Seasons to you and all your viewers. In the era where everyone claims to be a doctor, skepticism arises when they say, "let me tell you …” I prefer, "let me show you with these stats, charts, and peer-reviewed studies …” Interestingly, there's a popular TH-cam “Doctor” with millions of views in various languages addressing health issues-a chiropractor, of all professions. I appreciate your channel. I used to follow Dr. Brad, a young physician yet to complete his residency. Although he underwent standard medical training(heavy course work), his research knowledge is limited. He references studies from China, raising concerns about reliability. Moreover, he takes personal digs at other research scientists like Dr. Sinclair, who holds a PhD, not an MD. This is just my perspective.
Skin health/wrinkles etc - Vita C/Ascorbic Acid has also has proven to work very well. Also, wherever possible it is best to heal from the inside as opposed to the outside.
Would be interested to know if either of you ever tried NMN/TMG/NR… personal experience makes me not care about these studies’ lack of findings on their selected endpoints.
I take collagen for bone 81 yrs do Taurine , l-leucine, creatinine . A Dexa pronounced osteoporosis after hit Greater Trochanter broke stem of femur had hip replacement in July had just done 9 miles step racing. I want improvement of bone doing therapy for walking without cane. Hair has thicken fingernails strong can’t see bones. Also on Alendronate prescription. Doing weight resistants upper and lower body with free weights and machines.
Merry Christmas to everyone who celebrates. Have a wonderful day.
Same to you brother. Have a Happy New year too. 🎉
Merry Christmas 🎄
This post lowkey made my day. 🙏🏼☺️ thank you!
Merry Christmas!
You both are certainly making for a brighter future ahead. Thanks for all your hard work. For once it’s very refreshing seeing and watching a sincere discussion on TH-cam. I really like this style.
Thanks for having me on your channel, Nic. Wishing you and everyone here a very Merry Christmas
Merry Christmas!
.....ironically, I've had the Life Extension brand of NAD+ sitting among my supplements collection for a year before yet taking it as I wanted to keep researching & get blood workup. It has an interesting formula I just again looked, but I can't yet understand the connection of NNM & NAD????
Also, i Sure wish you guys would review a new form of ionized? NAC called Augmented NAC.
....
made in Switzerland which is I guess ionized & far more powerful. They have set up some kind of advocacy campaign called "zero spike Project", so I just don't know what to make about all this & sudden invention of Augmented NAC!
It is directed to Long Covid & Covid infections. Been emailing back & forth with them to see if it could help ME/CFS EBV & if they have any studies, but nothing other than Dr's reports it helps to fully or partially resolve. Saw a vid or comment about this Augmented NAC few weeks ago, so they have a US distributor & will just try it. I've been taking Life Extension NAC 2 weeks now 600mg 2x daily & nothing yet. I saw "HIS" vid on spike protein protocol for NAC, Nattokinase, Bromelain, & doing the same also.
I'd like to say I have "The Original Covid" of 18 yrs that started from noxious sewer gas poisoning from major sewer vent risers that collapsed behind our kitchen / bathroom walls in a plumbing chase way in my 28 story hi-rise here in Fl. Not only were we exposed to years of VOC H2S/SO2 , but serious viral, bacterial, & fungal load in this gas.....very similar to that hi-rise in Beijing with sewer plumbing problems that speaks SARS through the building many years back!!!!! Seems f'n hopeless.
Maybe we can get him to do a vid about this Augmented NAC to help others then buy stock in the company! LoL.🤕🤔
Being a layman and only seeking to stay alive for as long as possible and remain vital while doing it, I appreciate the nerds' contribution to finding the facts. Unlearned people like me have to rely on the interpretation and discernment skills we have and take some chances. Thanks for taking the time to let us listen in on the discussion.
Nice to see both of you interact.
My mother recently passed at 100 years of age. During her lifetime many folks ridiculed her for being a "health food nut". They all died decades before mom!!! Also, she never had a doctor or took any prescription drugs, but DID take lots of Vitamin E and other vitamins!
At 73 I found that playing my guitar was becoming more difficult. For example - I Feel Fine by the Beatles starts with a bar chord with a pinky stretch. I was flubbing the pinky about 50% of the time. After supplementing with taurine for two weeks, I'm playing that chord with no problems. I didn't start taking taurine with any exceptions regarding guitar playing. Just an observation.
Very interesting!🤔
When you started taking taurine, did you make any other changes? (drinking more water, exercising more, new hobby with your hands, etc). Just wondering.
I'm also noticing unmistakable improvements with Taurine.
Thanks to both of you for coming together, I feel safe.
Sweet lord please make this a regular pod Nick. Your breakdown of collagen peptide metabolism was covered in a way that's not on TH-cam. It's MASSIVE for burn victims to observe and consider their options when recovering.
Dude, your humour is growing on me. It's so bad but you commit so well it works.
😜
His "humor" just makes me grimace.
Maybe he should have the deadpan look like. Pat Paulson
Two of my top three health(span) guides in a terrific discussion! I love your comparing notes and I hope you make this a regular feature on both your channels. Also, nice shout-out to the third of my favorites, Gil Carvalho. You all perform a terrific public service and I wish you more success into the New Year.
You two should have a regular podcast together. It would be a great pairing.
I didn't quite like Brad, but now I started to like him :) Thanks Nicolas for bringing him up into your channel
Where was the discussion on GlyNAC? That seems to be the real possibility of life extension through supplementation.Thank you though for the subjects discussed in this TH-cam.
Two of my favorites. Awesome. Merry Christmas!
My 2 favorite nutritioneers in the same video! What a gift! I’m 65 day 10 on nmn: a big 0 so far. And I was hoping for even just some placebo.
To be fair, your source matters a lot. Renue is where I got mine. Originally got it from a source with no benefits.
Secondly I suffered from terrible sleep quality. 3 weeks after NMN 1G a day I was getting 5-7 hours and feeling better than in my 20s. Can't be placebo. Started other supplements afterwards to ensure I knew what benefits I sustained.
All that can be GUARANTEED is that your NAD+ is boosted. What that means to you individually is completely different than anyone else.
The fact you didn't see any benefits shows you probably already have healthy cellular activity. It's worse for me that I got a benefit, because it shows I was unhealthy prior.
@@MajorCanadado you take capsules or powder? If powder, do you dissolve the powder under the tongue, or swallow it? Thanks
I’ve taken DNA’s NMN powder sublingually for almost two years. No impact that I can see. I work out more now that I’m retired so I’m in good shape but I attribute non of it to NMN. Creative is likely the one supplement that gave me results in just a few weeks. With the potential cognitive benefits, I’d suggest creatine is likely the most beneficial supplement that I take.
I taks two different NMN , thats very good,
I listen to and watch both Dr. Stanfield and your videos. I stopped taking resveratrol and stick to blueberries and other berries now because of Brad. I also take collagen peptides now because of both of you. Thanks for being critical science based thinkers and distillers of scientific studies to spread knowledge in the age of not just misinformation but disinformation. Merry Christmas , you two are a gift of reason and sound judgement to the world.
This discussion It´s perfect example about what I ever thought about supplements. No sensationalism, no "marketing booms", no confirmation bias... Thank you both for your great job!!.
two of my favorite TH-camrs together
As someone who has just turned 70, I believe NMN has made a difference.
No placebo for my old dogs:
One at age now 9, has been “lame” for about 3 years, a leg broken in puppyhood at age 4 weeks, and acting up on her every single day after noon, after morning activities (she’s a high energy vizsla). After a couple of months on NMN (powder sprinkled on her food) her lame leg is NORMAL and FULLY FUNCTIONAL, no more limping after noon.
So then I decided to give it to my other 13 year old dog who was getting cranky (obviously pain or discomfort causing it) and going blind from cataracts. After 3 months for her, she’s stopped running into walls and furniture, and is behaving like she did 7 years ago!
So I tried it for older age aches, and a 7-year shoulder injury has healed!! And those aches and pains are gone. It took a few months for full effect, 1g per day.
If placebo, fine. Something worked. I’ll take it.
I suspect NMN only works for older age with depletion of parts of the NAD cycle and cellular repair.
Excellent discussion! Thanks for bringing it!
😊 Really awesome to see that you had Brad Stanfield on. You two have been my "go to" for the past year or two when I want to hear any analysis on a particular supplement or drug. Having had cancer, I read a multitude of studies trying to weed through all the b.s. things that people anecdotally try to throw out there regarding "curing" cancer. Luckily I had learned how to read and analyze studies at some point in college and I think it's an important skill for people to have to be able to recognize bias or confidence among other aspects to be able to analyze a study. I appreciate the knowledge and breakdown you provide in particular. I had found Brad's channel before finding your channel. It was somewhat angering to listen to some of the other "health advice" channels knowing that lots of what they were doing fed into clickbait sensationalist topics. Many of them aren't giving a full honest assessment of things. When I found Brad it was quite refreshing. He basically gave a very honest and accurate "cliff notes" assessment of any particular study or meta analysis on a subject. He doesn't get into the specifics a lot and gives enough information for the average layperson to get a grasp of the subject. Then when I found your channel I was so pumped to hear someone give the same kind of honest and unbiased assessment while getting more into the details of the mechanisms of what is going on. Brad's "cliff note" style will likely be more popular because I would bet the majority of people don't understand enough or don't care to understand enough to hear the more in depth analysis. But honestly I love it! I have noticed that you changed your format at some point to do both styles. Really smart move for the algorithm and people's attention span. But please keep the "in depth" stuff available like you have been. It's awesome! I expect that you both get a little boost in subscribers and views after this video since you both likely have viewers that never even knew about the other person. Keep up the awesome work! We need to get you and Brad on Rogan, Huberman, or Friedman's podcast to help amplify the accurate analysis of information. Thanks to you both!
Subbed to both of you, very interesting podcast, thank you.
@25:30- there are at least *ten* systematic reviews/meta-analyses of collagen supplementation, mostly for skin. All found benefit.
There are also reviews of collagen for osteoarthritis, the best probably being Larder, Iskandar, and Kubow 2023.
NMN and exercise in those of us >60 is definitely a positive.
At 70 I agree. 500-750 mgs every morning with same of TMG. I work out daily, though lightly, and it does seem to have put a spring back in my step.
At 50 i do not se much benefit from 1000 mg of mnm. Creatine on the other hand has been much better.
YOU TWO ARE AMAZING .....resilience, discipline, creativity , critical thinking it's all here
Regarding collagen pepties - it contains quite a bit of glycine. The usual amounts of glycine in typical meat/whey protein cannot provide the amount provided in collagen. Personally, I just take glycine.
Excellent video. Nic, Gil, and Brad are the trifecta of sound nutritional/longevity information sources. 💠
So who is Gil?
I started following Dr Sinclair's protocol a couple of years ago feel great look great 100 % had a huge difference in my health and life clearly the study's are missing something big for me the change has been huge 52 years old
me too NMN+Collagen protein make my skin more health
Excellent video, I enjoy both of your TH-cam channels. I like that your information is backed by studies not hype. Too many channels make unrealistic claims on to the latest longevity supplements based on the most tentative of evidence.
In 1826 President John Adams was 90 and eating pretty good. What types of unregulated synthetic vitamins, supplements and fortified foods was he eating for his entire life? And how does the human body react to a synthetic unknown foreign supplement that it does not recognize? Which disease does the DNA instruct the body to promote?
Dr. Brad Stanfield needs to
have conversations with Dr. Ford Brewer.
Regarding cholesterol and other points of interest.
It would be very interesting.
thank you for posting this, normally Christmas youtube slows down. This is most welcomed. Merry Christmas also.
Great show thanks again!
@24:00- Dr. V. is correct about collagen peptides being bioavailable, and being signalling molecules for fibroblasts. But it's mostly di-peptides. Tri-peptides may get absorbed into serum, but the evidence is not as good. It's even possible that oligopeptides made up of 4 or more aminos make it into serum. But I haven't seen good evidence (e.g. radio tagging) of that.
I'm not sure if it says more about me or more about you (and your quirky humor I enjoy) but when Dr Brad said he had started taking hyaluronic acid "for skin health" I almost expected a quick camera cut to your face as you quipped "Foreskin health!"
Yeah, it's probably more about me. You must admit it wouldn't be wholly inconsistent with your humor. :)
Merry Christmas and thanks for all the videos this year! You've added a ton to my knowledge and I'm appreciative for it!
LOL Not just you I picked up on that pun too.
Great you do this together!
nice vibe between the two of you, thx!
thank you so much to help us to know what seem to work and what is just "marketing". I follow both of your channel and the channel "Nutrition made simple!"
Very good podcast. I follow both of you and i admire the most.
Nice talk!
Thanks
Solid episode, thanks for putting the info out there. Have either of you looked more into Amla for lowering LDL?
Great episode! Thanks for sharing your conversation with him!
Very interesting. Thank you. What about Astaxanthin, Urolithin A and sublingual Epitalon for longevity ? ❤
Have videos on 2 of those
Two great guys!!
I clicked on the video because it's Christmas morning and I wanted to give you the like. Will listen later.
Nic, watching your videos taps me into a constant stream of coordinated health information, a gift that keeps on giving.
I learn more from listening to your posts than any other on the internet! Thank you!
I’ve been taking NMN/NR for a few years and I’ve felt a benefit
How did I miss this!? My two favorite experts on TH-cam.
nice, looking forward to listening through this discussion
Merry Christmas! Hope you get a break but thanks for the regular uploads.
22:00
Just a small addition and a question on the discussion on collagen:
The study on burn victims used soy flour in a porridge for the placebo group, not isolated soy protein or other more processed proteins. The texture (and possibly bio-availability) difference is huge because of the 20% fibre soy flour contains. Try to make porridge with collagen, soy protein and soy flour at home if you do not believe me. The recipe is in the study.
Do collagen peptide receptors also respond to other peptides/amino acids? I mean, a collagen peptide can be cut in several ways and so it's shape can differ.
Had no fingerprints (not enough definition to use for ID screen scan). Decided to take collagen to "thicken" my skin when a short term factory job became impossible to do with my fairly shrivelled fingertip pads. Took collagen for a year. Now have well defined fingerprints and plumped up normal fingertip pads even after having stopped taking it for a year or two. Touch screens are doable also now. No employer ever looks at my hands and neither did docs here. Could never access the Omnicell drug machine at the hospital via fingerprint id while I still had that job before stupid COVID came around and we got benchmarked.
Great to see Dr. Brad in conversation rather than in presentation mode. It would be wonderful to see more of him in this format.
My two favs on a video together!! Made my day!!
I would be interested in hearing you guys investigate and speak about Shilajit, Blackseed oil, supplementing with a couple tablespoons of Extra Virgin olive oil once or twice per day and certain other nutrients.
I love you both, Brad and Nicolas. Thank you for all the valuable information.
I’ve really appreciated this video! Thank you very much 👍🏻
Im a nerd appreciating all the hard work you do, in fact I adore you for it!
This is fabulous!!!
❤❤❤❤❤
@33:00- N=1 study: I tried taking a larger dose of hyaluronic acid, about 500mg/day. I saw an unusual weight gain of about 5 lbs. I'm guessing it was water retention. But this would mean that the HA was getting absorbed... To Dr. Stanfield's point about bioavailability: there would not necessarily need to be a 'receptor' for HA bioavailability; it could be getting thru the small intestine via paracellular diffusion, transcellular passive diffusion, or transcytosis.
Wondering how you find out the molecular weight of a given hyaluronic supplement. Really enjoyed it; thank you both.
It's usually on the label or, if on Amazon, the Q&A section has someone asking and getting an answer from the brand. If no luck there, just calling/email the company will get you the answer, but most reputable companies will have this info on their label (or website).
Unless labelled, I think it's safe to assume it's low MW (as it's cheaper). Just like fish oil is typically in ethyl esther form unless it's labelled with "triglycerides". So far in US, I've only come across DoNotAge that labels its hayluronic acid as high MW.
This is an awesome collaboration. Thank you. 🙏 ❤
can honestly say that I have never noticed any improvement from any supplement I have taken..
Given our daily variations in energy based on sleep, diet, stress it can be very difficult to recognize the effects of a supplement. I find the best supplement to be a really good night sleep and a long walk in the fresh air. Nothing makes me feel better
Creatine for strength and mood has been my only benefits. The rest no difference (nmn included)
And then Olive oil for skin benefits.
I have not come a single Dr here in the good old US of A that will order a test for a potential change. It is ALWAYS after the fact. I think it makes it easier for them in terms of diagnosis and treatment.
Can you two make this a periodic meet up? I think it is very informative and worthwhile.
Great review, second time viewing it.
Wish Glynac was brought up.
Always look forward to your videos, keep up the great work!
Whoa! This is like two universes colliding❤
That is what I thought - Dr Brad is a bog standard mainstream Doc imo. and Physionic is on the cutting edge of intra-cellular biology - strange collab.
I really trust your reseaches and think you are a trustful source of information. I would like to hear your thoughts on spirulina and chlorella🙏
Great conversation between you two! Love this format❤
I'm very lucky if I assimilate anything out of these discussions because I'm not work close to being on a level with you guys but from listening to you I trust your intellectual prowess and I do pull some tidbits out that may come together for me in the Long haul
It's not that people don't trust science; it's that they don't trust that the science was done with their best interests in mind. Like you mentioned in this video, meta-analyses can have two versions: one that is reliable and one that can be skewed to produce the desired results. The vocal minority is absolutely right to question the "science" behind everything, and that can be both good and bad.
The good part is that people are researching more because of their distrust. The bad part is that they sometimes distrust everything without investigating it themselves or rely on someone they trust who might be wrong. Either way, there are plenty of bogus studies out there.
This video looks like it took a lot of work---impressive and in-depth as always.
Happy Christmas Nic 🎄
Please do a fair and honest review of Gary Brecka's comments on the Joe Rogan podcast. Knowing someone with an MD degree/background would have differing opinions, it just seems like you're more open to an honest review. And he has good results behind his claims with some of his "patients". Would love to hear your thoughts on gene specific therapy - methylation, celtic sea salt curing migraines, etc.
Excellent yt … thank you …
Thanks, informative. I would be interested in your evaluation of the C15:0 supplement Fatty 15.
Yes, they make big claims like similar effects to Rapamycin on anti aging and I’ve only seen their own clinical study for their evidence (so possible bias)
I would watch you knitting for 5 hours, no problems.
So anecdotally collagen helps my arthritic (OA) joints a lot. My OA pain relieving concoction is daily collagen and turmeric with piperine - I was going out of town and realized I was out of collagen so for 3 days I only took the turmeric - day 2 my knees were sore and worse on day 3. My activity had not really changed - my trip was visiting my 31 yo son who is according to him too busy to cook and he is tired of eating fast food crap and could I come cook and freeze some real food for him. I cook at home so really no activity difference. I was surprised, I did not think the collagen was helping as much as it was!
“I don’t know why you WOULDN’T take collagen peptides.” I do! Every time I take them I get a crashing migraine. 😢 It is very upsetting.
What is the best way to consume creatine?
Merry Christmas to you too
I have tried magnesium with taurine but had terrible stomach upset so now I take only taurine and have had no problems.
Maybe try a different form of magnesium. Several don't have gut effects like others
things like magnesium chloride and other salt forms tend to cause digestive upset. they're the type that are used as a laxitive. forms like magnesium glycinate and others bonded to amino acids or things like orotic acid are tolerated better and are probably more bioavailable. @@Joe_C.
Magnesium glycinate is a better form across the board
Collagen supplements work for avoiding skin problem at old age. I don't know about wrinkles, because I don't have anything which worries me in that regard.
The reason why Whey Protein isn't enough when you are older is that you don't get enough of those amino acids which are most abundant in collagen. Glycine, proline, and hydroxyproline.
Yes, the body can produce them to some degree from other amino acids. But, at least when older, that's not enough.
I do supplement with about 12 g a day of hydrolyzed collagen, and with a lot of glycine. And it cured some skin problems I got at age 70 or so.
But if I had known more when younger, I would have supplemented with collagen then too. The turn around of collagen slows down if you doesn't get what's needed to build it. And the quality of it in different parts of the body deteriorates. You just see it only in the skin!
Excellent stuff guys. I think I've definitely found my new source of reason and also wicked to see a fellow Kiwi on top of this!
Damn how did I not catch that one yet. That's great...would really love some more of these in terms of longevity supplements.
thanks for the greetings. You guys spend more on supplements than most people have for food!
lets have some studies comparing supplements and affordable food for pensioners. as in eating for $3 per day total.
I'm highly interested in the photomodulation effects of light at cellular level, nobody yet i think, researched narrowband spike light from IR LED light vs wideband noise light from filament light using only a red filter. Since a year I'm using wideband IR and bc i wasn't able yet to measure the amount of shorter wavelength content like UV, I use additional sunblocker cream to attenuate the UV part of the spectrum. Bc i think, the filter i have could still pass damaging UV radiation. And i use this light sometimes for hours.
500 Watt filament wideband.
I would still watch the 5 hrs of quilting..My experience with NMN is to pair it with Betaine to give my liver methyl groups and glycine to help methylate away the excess amount of it. The other aspect of it is that I take it only if I do a draining workout during cutting phases. I seem to tolerate it better than Niacin, I feel However, that this is because I have G6PD deficiency, and it has been seen that niacinamide and niacin tends to reduce the g6pd enzyme production.
I like garlic, green leaves, legumes, veggies and fish...
Interesting… I’ve always wondered if GlyNAC supplements would benefit someone who has a G6PD deficiency. Any thoughts?
2 awesome people in one video
Here my observasiin.
I'm over 50
I first noticed my Hanmer toe could be bent 20 years after weight lifting accident
Then my 2 torn rotator cuff quit hurting ( 25 year injury )
12:59 13:05 13:12
.I'm more flexible
I'm stronger
Dose 1 .5 grams
Merry Christmas! Did you ever look at research about red light therapy?
a good argument for collagen peptides is the ratio of glycine, by taking collagen peptides along side whey protein, you get a much better balance of glycine to cysteine.
The problem with Creatine for many of us is it’s negative impact on sleep. I noticed significant cognitive benefits but had to stop as I wasn’t receiving adequate quality sleep. Very disappointing.
never heard that or experienced it either. interesting. even if u take all of it in the morning?
@@MajicFreeman Yes, I even tried it in the morning. (5mg) After performing some Reddit searches, I discovered that lots of people had experienced the same problem. It’s very common.
Have you considered taking glycine daily? It supposedly has some sleep improvement qualities but I’ve not seen a benefit there. I take 9 grams of glycine powder daily for general health.
i take glycine as well, i want to take collagen too, but as i can only afford one i’m doing the glynac protocols
Haven't found that with creatine HCL
I just ran out of nicotinamid riboside and was wondering if I should order more
NMN does raise NAD levels though, you can test it yourself. Question is if there's any benefit to that
Happy Holiday Seasons to you and all your viewers.
In the era where everyone claims to be a doctor, skepticism arises when they say, "let me tell you …” I prefer, "let me show you with these stats, charts, and peer-reviewed studies …” Interestingly, there's a popular TH-cam “Doctor” with millions of views in various languages addressing health issues-a chiropractor, of all professions.
I appreciate your channel. I used to follow Dr. Brad, a young physician yet to complete his residency. Although he underwent standard medical training(heavy course work), his research knowledge is limited. He references studies from China, raising concerns about reliability. Moreover, he takes personal digs at other research scientists like Dr. Sinclair, who holds a PhD, not an MD. This is just my perspective.
Skin health/wrinkles etc - Vita C/Ascorbic Acid has also has proven to work very well. Also, wherever possible it is best to heal from the inside as opposed to the outside.
Would be interested to know if either of you ever tried NMN/TMG/NR… personal experience makes me not care about these studies’ lack of findings on their selected endpoints.
Thanks, great discussion. What about supplementation with red light?
I take collagen for bone 81 yrs do Taurine , l-leucine, creatinine . A Dexa pronounced osteoporosis after hit Greater Trochanter broke stem of femur had hip replacement in July had just done 9 miles step racing. I want improvement of bone doing therapy for walking without cane. Hair has thicken fingernails strong can’t see bones. Also on Alendronate prescription. Doing weight resistants upper and lower body with free weights and machines.