@Tinkerbell1554 :) Thank you! Glad you got something out of it. We have more Biology videos in the website, and more to be added so, please stay tuned for more!
I don't know what's his problem, but I love your voice :D I love how easily I can understand every word you say, even if english isn't my first language. If I have something I don't understand, I come to your channel, because you are my favorite biology teacher online :] I can't express how much you helped me, I have poor biology skills, but you actually made me understand it. I wish you were my teacher, not like it's possible or something. :D
I've been trying to understand this stupid dissociation curve for a year from a lot of different people but somehow i understood your explanation. Seriously you've helped me a lot!! :)
Thanks a lot for this, after 1 year of studying physiology this is the only tutorial actually opening my eyes on what's up with the curve! Your voice is so cool it would be insane if you wore dreadlocks as well hehe. Keep up with the great work! :)
You could've mentioned the change in the diffusion gradient when the haemoglobin molecule becomes more saturated. It'll be harder for an oxygen molecule to bind with a haem group when it's nearly completely saturated because it will be highly concentrated with oxygen so diffusion gradient changes. This explains the decrease in the gradient on the curve towards the end and explains why it's difficult for 100% saturation. Still a fantastic video though
This is an amazing video! Helped me with my A level biology.. You're better than my teachers.. And people keep saying you spelt Haemoglobin wrong, that's just how it's spelt in America
thank you. I was reading about partial pressure of gasses in blood and how that is related to H ions and bicarbonic ions but it was great to watch this now i know what they mean with conformational changes.
Is the haemoglobin inside the red blood cell or is it just floating inside the blood plasma, if its inside the red blood cell doesn't that lengthen the diffusion pathway making it less effective at picking up oxygen. Great video by the way it really helped.
wooooooow :) this is greaaaaaaaat vidoe man.. i ve biolgy exam in jan and i'm so glad to find such video >> i'm going to watch the rest :) thank u indeed mate
in effect the video is very simplistic and gives us a vision of elementary' hemoglobin and its operation that in reality is far more complicated .... luckily XD
someone please enlighten me because i am very confused... if it becomes easier for other O2 molecules to join the Hb the more there are, how comes the graphs are sigmoid? shouldn't they become steeper?
Does it really matter how haemoglobin is spelt? I'm American and have always spelt certain words the British way....not sure why but to me the British spelling has always seemed correct. Like if my professor writes "liters" on the board, without hesitation I write "litres", if he writes hemo- I write haemo- and so on....I know weird. Well anyway this video has been very helpful. Thank you very much! :-)
This is wrong? 1st oxygen molecule (OM), somewhat difficult, 2nd OM easier, 3rd, about the same as 2nd, and finally 4, very difficult to bind to the heme group. This is what I was taught? Even the graph supports my explanation, if it got easier, the graph wouldn't level off as such. Please correct me if I am wrong?
well the more oxygen binds the less is there to bind so it takes longer for oxygen to find a good haemoglobin to bind to but it is easier, so he did say it correct actually
Yikes, lots of y'all are so quick to correct his spelling, without realizing that hemoglobin is spelled two ways (Just like Color/Colour). All of my textbooks spell it Hemoglobin. Just look it up! Thanks for the great video!
Is it true about what you said at 05:16.... "As oxygen leaves, it makes it easier for more to leave, as oxygen binds it makes it easier for more oxygen to bind"?? Shouldn't it have been, " As oxygen leaves, it makes it difficult for more oxygen to leave and as oxygen binds it makes it easier for more oxygen to bind." No offense, just trying to reassure.
!!!! Remember everyone....pH can also be Hydrogen Ion. the arrows would just be the opposite. High pH = low H and vice versa !!!!!!! Just in case your exam comes out tricky like that.
I'm sorry for english I'm an Italian student the curve is a sigmoidal curve because it is' the result of an average between 2 other curves: the curve of high affinity (hyperbolic) that we get when hemoglobin binds O2 in the lungs....and the curve with low affinity (hyperbolic) that we get when hemoglobin leaves the 'O2 in the tissues. by union of the two curves you obtain the sigmoid as you see in the video. XD
@eddieyou1018 Oh, you poor guy. Having to listen to my annoying voice, lol. It's really easy though. All you have to do is not watch the videos, and everything will be ok. You won't have to deal with such an annoying voice. All the best :D
+Anna Zhukova He wrote it correct. There are two types in spelling haemoglobin which the other is hemoglobin. Its like colour and color, one american and one english
THANK YOU. Fantastic voice, nice speed, good use of language, no umming or ahhing. Don't know what people are complaining about.
@teddyasok Glad to know it helps. All the best with your studies. Many more coming, so stay tuned!
You know this guy is good when you understand exactly what he is saying at 3 in the morning. Thank you Leslie!
@Tinkerbell1554 :) Thank you! Glad you got something out of it. We have more Biology videos in the website, and more to be added so, please stay tuned for more!
These videos are amazing! Please dont ever stop, you are helping my whole class learn this difficult subject!
@Anna32071 You're very much welcome :) Stay tuned for more Biology videos!
Finally! A video that fills in the blanks for me. You explained this perfectly. I've read and watched but something was missing until now!! Thank you!
@kakaonkaka Glad it helped. Stay tuned for more :)
Thank you s to much. I'm a nursing student and I just could not wrap my head around this concept.
@Zendiya1 That's awesome. Glad it helped. Stay tuned for MANY more :D
I don't know what's his problem, but I love your voice :D I love how easily I can understand every word you say, even if english isn't my first language. If I have something I don't understand, I come to your channel, because you are my favorite biology teacher online :] I can't express how much you helped me, I have poor biology skills, but you actually made me understand it. I wish you were my teacher, not like it's possible or something. :D
THIS SAVED MY GRADE!!!!!! Thank you so much Leslie!
I've been trying to understand this stupid dissociation curve for a year from a lot of different people but somehow i understood your explanation.
Seriously you've helped me a lot!! :)
Above all, thank you for the help Leslie. It helps me a lot. God bless!
Thanks a lot for this, after 1 year of studying physiology this is the only tutorial actually opening my eyes on what's up with the curve! Your voice is so cool it would be insane if you wore dreadlocks as well hehe.
Keep up with the great work! :)
You could've mentioned the change in the diffusion gradient when the haemoglobin molecule becomes more saturated. It'll be harder for an oxygen molecule to bind with a haem group when it's nearly completely saturated because it will be highly concentrated with oxygen so diffusion gradient changes. This explains the decrease in the gradient on the curve towards the end and explains why it's difficult for 100% saturation. Still a fantastic video though
This is an amazing video! Helped me with my A level biology.. You're better than my teachers.. And people keep saying you spelt Haemoglobin wrong, that's just how it's spelt in America
Thanks, this stuff actually makes sense now. it's explained at a nice pace. Thanks
Great video. Really helped me understand this concept.
really great video. thank you so much for taking the time to do this. you are a great teacher!!!
thank you. I was reading about partial pressure of gasses in blood and how that is related to H ions and bicarbonic ions but it was great to watch this now i know what they mean with conformational changes.
Is the haemoglobin inside the red blood cell or is it just floating inside the blood plasma, if its inside the red blood cell doesn't that lengthen the diffusion pathway making it less effective at picking up oxygen. Great video by the way it really helped.
wooooooow :) this is greaaaaaaaat vidoe man.. i ve biolgy exam in jan and i'm so glad to find such video >> i'm going to watch the rest :) thank u indeed mate
Thank you so much!!
This is so easy to understand compared to my AS book!
Doesn't the 3rd conformational change make it harder for the 4th O2 do associate?
your videos really are too helpful... thanks a lot... may god bless you...
you just make everything so easy ..thank youuuuuuuuuuuuuuuuuuuuu!
nice comprehensive resp physio review for me! thx a lot!
in effect the video is very simplistic and gives us a vision of elementary' hemoglobin and its operation that in reality is far more complicated .... luckily XD
thank you so much Lesile..it helped a lot.
someone please enlighten me because i am very confused... if it becomes easier for other O2 molecules to join the Hb the more there are, how comes the graphs are sigmoid? shouldn't they become steeper?
this is life saving. thank you a lot
Thanks, hopefully this comes up in my exam tomorrow hehe
this is great!!!!!!!!!!!!!!!!!!! It's so easy!!!! although I'm german I can understand you better than my teacher.
Your videos have helped me so much! Thank you :) xxx
You put Lauralee Sherwood (the author of my textbook) to shame. Thanks for making complex things simple!
Actually, it is very difficult for the fourth oxygen molecule to diffuse in and associate with the last available haem group.
That really helps me , Thanks Leslie :)
thank you thats much easier to understand now!!! thank you
Excellent video!!
Does it really matter how haemoglobin is spelt? I'm American and have always spelt certain words the British way....not sure why but to me the British spelling has always seemed correct. Like if my professor writes "liters" on the board, without hesitation I write "litres", if he writes hemo- I write haemo- and so on....I know weird.
Well anyway this video has been very helpful. Thank you very much! :-)
This is wrong? 1st oxygen molecule (OM), somewhat difficult, 2nd OM easier, 3rd, about the same as 2nd, and finally 4, very difficult to bind to the heme group.
This is what I was taught? Even the graph supports my explanation, if it got easier, the graph wouldn't level off as such.
Please correct me if I am wrong?
well the more oxygen binds the less is there to bind so it takes longer for oxygen to find a good haemoglobin to bind to but it is easier, so he did say it correct actually
but yeah what he says at 5.27 is wrong he said it correct before tho
Yikes, lots of y'all are so quick to correct his spelling, without realizing that hemoglobin is spelled two ways (Just like Color/Colour). All of my textbooks spell it Hemoglobin. Just look it up!
Thanks for the great video!
Is it true about what you said at 05:16.... "As oxygen leaves, it makes it easier for more to leave, as oxygen binds it makes it easier for more oxygen to bind"??
Shouldn't it have been, " As oxygen leaves, it makes it difficult for more oxygen to leave and as oxygen binds it makes it easier for more oxygen to bind."
No offense, just trying to reassure.
the first statement :"As oxygen leaves, it makes it easier for more to leave, as oxygen binds it makes it easier for more oxygen to bind"??; is true
ok then
!!!! Remember everyone....pH can also be Hydrogen Ion. the arrows would just be the opposite. High pH = low H and vice versa !!!!!!!
Just in case your exam comes out tricky like that.
Sorry if I'm wrong, but is it not "haemoglobin"?
Am i wrong? or does it change for different countries?
gareth davies I’m Australian and we spell
It Haemoglobin. And we also spell Oestrogen not Estrogen
Thank you, I love your videos!
Spelt 'Haemoglobin' not 'Hemeglobin' apart from that very helpful :)
I'm sorry for english I'm an Italian student
the curve is a sigmoidal curve because it is' the result of an average between 2 other curves: the curve of high affinity (hyperbolic) that we get when hemoglobin binds O2 in the lungs....and the curve with low affinity (hyperbolic) that we get when hemoglobin leaves the 'O2 in the tissues. by union of the two curves you obtain the sigmoid as you see in the video. XD
what is DPG
Diphosphoglycerate
Iron is necessary to make hemoglobin. Don't forget Iron in your diet.
AMAZING. Thank you.
you are amazing 👍👍
haemoglobin*
+E.L.F. Idk haemoglobin is english, hemoglobin is american
Where does the CO2 bind?
It doesnt, CO2 is transported in the blood plasma, not red blood cells, only O2 is transported in them
@olb852 Hey, everyone's entitled to their own opinions :)
So good!
Yoooo😮😮 I just understood this than my teacher I was like please teach teacher we can hear you.😎😎
U r the BEST ! thank u
haemoglobin and haem groups good video though
thank you so much
Thank you!
love your accent!
lol he sounds so happy!
Thank you!!!!
@eddieyou1018 Oh, you poor guy. Having to listen to my annoying voice, lol. It's really easy though. All you have to do is not watch the videos, and everything will be ok. You won't have to deal with such an annoying voice. All the best :D
You spelt Haemoglobin wrong.
@eddieyou1018 Fasc-austic lol
thankssss
its heam group
A-HA! Thank you!
I hate American spelling... sheesh, imagine if I write that in my exam
Haha yeah.
*haemoglobin
americans spell it as hemoglobin... not haemo as english spelling.
you cant spell haemoglobin
You're an idiot haemoglobin is the original spelling and is still taught and accepted in the medical community.
you can't spell lol
+Anna Zhukova He wrote it correct. There are two types in spelling haemoglobin which the other is hemoglobin. Its like colour and color, one american and one english
Americans can't spell 👌🏻
Thank you !