ฝัง
- เผยแพร่เมื่อ 13 ส.ค. 2013
- 2013.psychedelicscience.org
maps.org
LSD Neuroscience
David E. Nichols, PhD
Abstract: This talk will provide a foundation for understanding the importance of 5-HT2A receptors in the brain, now widely believed to be the key brain target for psychedelics. The study of this G protein-coupled receptor (GPCR) has required research efforts across several disciplines. Although it was initially thought to couple only to Gq, leading to activation of phospholipase C, it is now known to couple to multiple intracellular signaling pathways. The unique psychopharmacological properties of psychedelics clearly demonstrate that this receptor has special importance as a critical component of sensory perception in humans, and by extension, may be a key player in mediating consciousness. This presentation will focus on current understanding of the structure-activity relationships of psychedelics at the 5-HT2A receptor from a molecular perspective that has included synthesis of libraries of compounds, in vitro effects on cloned wild-type and mutated receptors, in vivo studies in rats, and computational chemistry.
Until his retirement in June 2012, David E. Nichols, PhD, was the Robert C. and Charlotte P. Anderson Distinguished Chair in Pharmacology, and a Distinguished Professor of Medicinal Chemistry and Molecular Pharmacology at Purdue University. He also was an Adjunct Professor of Pharmacology and Toxicology at the Indiana University School of Medicine. He currently is an Adjunct Professor of Medicinal Chemistry at the University of North Carolina, Chapel Hill.
Nichols received his PhD from the University of Iowa in 1973, followed by a postdoctoral stint in Pharmacology. From his time as a graduate student, Nichols focused his research on the relationship between molecular structure and the action of substances that modify behavior. His research took him to Purdue University in 1974, where he remained until his retirement this year.
His research was funded by government agencies for more than three decades. Internationally recognized for his research on centrally active drugs, he is one of the world's foremost authorities on psychedelic agents, and founded the nonprofit Heffter Research Institute in 1993. He also was a pioneer in the study of the medicinal chemistry of dopamine D1 receptor agonists, and in 1991 he and his colleagues first showed that dopamine D1 agonists had remarkable efficacy in a primate model of Parkinson's disease. He consults for the pharmaceutical industry and has served on numerous committees and government review groups.
More videos available at 2013.psychedelicscience.org
At Psychedelic Science 2013, over 100 of the world's leading researchers and more than 1,900 international attendees gathered to share recent findings on the benefits and risks of LSD, psilocybin, MDMA, ayahuasca, ibogaine, 2C-B, ketamine, DMT, marijuana, and more, over three days of conference presentations, and two days of pre- and post-conference workshops.
"How does a receptor change consciousness ...."
"So this is where the hand-waving comes in."
LOL. David has some really great dry humor
daamn I just scrolled down, then he said that sentence and 1sec. later I readed that comment hahah
Every time i take LSD i feel the need to become more authentic and genuine. I feel like this worlds become too fake
Truth syrum
Do good, meet good.
I also think this but, if it wasn’t so fake there would be nothing. I hate hype but we actually need it to progress.
Every dose of LSD causes severe permanent cumulative brain damage. If you do not do advanced mathematics on a day-to-day basis, you will not notice the damage until it accumulates to severe levels and starts to affect your competence at day-to-day activity. There is no safe dosage, the damage is linear in the amount of drug ingested.
@@annaclarafenyo8185 have you experienced this yourself?
A student of mine proposed a fitting axiology, "make one drug illegal, and replacements are sure to appear"
nichols plays a mean harp too! seems like everyone involved share a passion for playing!
32:19 "Rats love cocaine" -- cannot unhear that.
+GreekAsTheGods shit needs to be sampled and put in a filthy dubstep track
+Dan Bayfield fuck yeah
no loop it into a industrial music song im rick james bitch ricky rat james splinter on glass
LOL, there's a huge truth in that. And I must confess I've met a good dozen of them in my freewheeling' youth.
It is a shame that you can't simply do research on psychedelics with the aim of studying the relationship between consciousness and the brain.
But feel free to smoke cigarettes and drink alcohol, Uncle Sam has no qualms with things that dumb you down.
I know right
There's no solid model of a consciousness to even talk about.
We haven't even invented the words to create a mental model of it yet.
Buuut
You can see what's not your own consciousness. What's progaganda, what's external influence, what's not your own personal idea.
I'd recommend that instead of ever considering the quantum mysticism route, you study George Pierce's semiotics and Dialectical and Historical materialism.
You start to see what shapes our thoughts, sense of self, sense of identity, of connection with the rest of the universe or the inner and outer universes, the physical to the abstract/metaphysical.
Psychedelics allow us to explore abstract space more freely, to literally make new connections and learn new ways, new things, new stuff.
So that you can see how Historical and Dialectical Materialism and semiotics are like dismounting the consciousness curtain of self awareness about one's own ideas and opens up a portal to think differently about everything.
The best psychedelic research is done by experiencing it. It is too subjective for science to directly measure anything metaphysically significant.
Science doesn't have the vocabulary to even begin to explain it scientifically. It's actually fundamentally impossible to do so.
At least not without someone to translate consciousness into data.
Through recalling/narrating their experiences, for example.
This is beyond modern science.
Great to hear Nichol's perspective. First learned of this man and his discoveries through research concerning 6-APB, a substance which I encountered and spent some time with, which was first created by David. I respect his attitude concerning the appropriation of his work by the research drug chemists and psychonaut enthusiasts, experiment responsibly and with the right caution so that men of his influence might not feel themselves responsible for the ill their life's work has the potential to cause. Glad MAPS has a YT Channel, thank you for all your work MAPS. Working with you folks would be my dream job! xD
We all owe a great deal of thanks to MAPS. Thank you!!!
The GI question was a good one, because I've always suspected that phsycadelics don't just affect the brain but the entire body. There are serotonin receptors in the stomach and intestins, and etc.
They actually feel very psychosomatic so I imagine those NT’s (serotonin) are effecting the somatosensory cortex
I think if you wanna know what LSD FEELS LIKE, as opposed to what it does in the brain, just ask an old hippie. LSD forces you to think in ways you never thought possible, which is why music and art influenced by LSD is so fantastic.
You can't be explained how it feels like to do psychedelics (i hate the word drugs). The only way to know, is to do it.
Lauren Houck .... no LSD does not force you to think in ways you never thought possible and asking an old hippie will just give you a person's subjective opinion on an individual experience. if you want to know what its like just go and do some.... its great fun :)
You should read more about David Nichols before making such abrasive comments. He is an absolute legend with the psychedelic research community. You can thank him down the road when you have the chance to use such substances legally due to the basic science research he carried out. Speaking of using these substances and growing, try your best to be supportive all all humans, especially those (Nichols) whose endeavors are looking to give so many others the chance for personal transformation.
i am glad to hear all of this.
15:24 hey hippie, what are you doing here.... that one cracked me up haha
nice vidéo mr Nichols,and R.i.P Alexender Shulgin
I love this man !!!
Congratulations. I wish I had the discipline and patients to go through something like that. I am more of an artist than an intellectual though and if I ever had the money, I would like to donate to non-profits like MAPS and get into rallying around the cause and the politics of the drug war. I dream of the day that I can walk into a psychedelic center and the great Rick Doblin will be my therapist or at least someone else great.
1:10:55 *drops the microphone and walks off stage*
Very interesting, thanks for uploading!
GREAT TALK THANK YOU!!!!
Great video and great advice. Research chems are tricky and safety comes first.
Incredible insights from the genius of pharmacology of psychedelics & stimulants 👍
thansks sasha! Very much love..
=R.I.P.-
so sick! thank you
Good job there buddy
1:03:50 I love that question because having had the experience of lsd, after reading the book called: The User Illusion: Cutting Consciousness Down to Size , I had realized thats kind of what lsd is like, lessening the filter on how we perceive reality. It was pretty eye opening I think
it would be interesting to see if we could make compounds that alter proteins that impact things that viruses connect too thus preventing them from binding.
thanks!!!!!!!!!!
Is his research still going on at Purdue? I mean, IK he's retired but is anyone at the university still a professor working on this stuff? That'd be simply amazing.
A moderate dose of LSD is estimated at 75-150 micrograms. Godspeed.
It would be awesome to see more data on LSD analogs like LSZ aka LA-SS-AZ. Which aren't controlled in some countries which are much more easier to research.
Trying AL LAD soon can't wait 😀
"The ones that mother gives you don't do anything, but the ones Sasha gives you may have some effect" I want this on my epitaph
most interesting document I came across in a long time! Why do people carry on with the K?there is an infinity of more interesting choices.
😢😢😢😢
LSD makes everything more fun. 😁👍
I hope Im not the only one having problems understanding almost half of the lecture, without any undergrad lvl of knowledge in chemistry and bio. The parts I went through though, are very educational nevertheless.
I understood quite a bit, but I'm particularily interested and read a lot.
FReeARouND1992 Like when you play language tapes for a baby, I'm just listening to glean what I may.
You either need background knowledge or a LOT of time and interest to understand most of his main points....its dense stuff
even as someone who took 4th year uni organic chem, a fair bit of this is not the most simplified; yet he's simplifying it enough to basically touch on a lot of the major high level concepts (ie the benzene ring receptor binding affinity changes, the "fit" of the chemicals into the binding receptors, etc). imagine actually doing the work they're doing. truly, *TRULY* cutting edge, and truly PURE science. stuff like this should be funded a LOT more than it is. This, imo, is akin to the discoveries of galileo and a lot of other scientific work throughout history that was often clamped down upon by the authorities of the time; ultimately, to the detriment of potentially significant gains to human understanding and scientific growth and advancement. humans are the only creature on the planet that has evolved not only the ability to think, but the ability to name and investigate the part of our biological bodies that allow us to think - we can investigate our own brains, we have the ability to think about why we have named the brain the brain, le cerveau, mozg, el cerebro, aldimagh, etc (the brain effectively naming itself). we should be giving the people that are working on these very complicated subjects more money, not less, and more awards and respect for their advancements to human understanding. maybe we'll understand more about why exactly we feel the way we feel about the things that happen in our lives; will be able to be far more introspective into the chemical reasons for why humans are the way we are. perhaps in the not so far flung future, just before the AI takes over or humanity hits the singularity, we'll be able to connect our brains to other people and share experiences with one another based partly on pure science like this.
@@SirIsaacMewtonIII ㅏ
If it weren't for him there probably wouldn't be nearly as many compounds to work with. And mice are the best to use because that's the most efficient way to determine how the shape of the molecule relates to the effect that it has.
haha... I was hoping someone else would mention Datura. Definitely a deliriant that should NEVER be taken recreational.
But, it is slightly peculiar how every trip report on datura is similar, which can lead one to believe they serve a function... but will we ever figure out what that function is? Probably not worth it.
want know more about future? must see
Where can you go to school to study this?
Once upon a time I loved and worshipped Elle Eshhh Deehh! 4:30 -See that charts, LSD is hitting all those brain receptors, it might be just coincidence or no relevance at all... or not...coincidence notwithstanding, Mescaline is primitive and simple by comparison, Tryptamines like Psilocybin and DMT less so, on the other hand, LSD is complex, intense, extreme in every way. It's the longest lasting (12 hours) of the classics and the one that probes potentially the most different qualities of layers of experience - Psychodynamic - Perinatal -Transpersonal, as Dr. Stan Grof would put it.
Anybody know if this powerpoint is available for download?
this guy can replicate the Sand patent Sunshine wish I was related to him but doubt he would lose his integrity of being a professional
Neat
Does anybody know how I could contact Dr. Nichols?
Tips for 600ug lsd? Looking for growth and perspective. But fearful. As I already know what areas are dragging me down.
Did you do it in the meantime?
Merlin Brennt no I held off. This weekend I partake on my journey
@@threelitelift1445 Which quantities did you already take before?
Merlin Brennt 100 3 times, 220 once. Multiple 100ug of one of the 2cs. 1 failed DPT trip. And a handful of high dose dxm/dph trips.
@@threelitelift1445 When you go on your trip I would suggest taking the tabs gradually, that always worked best for me. The time I took 440 all at once I felt like I was racing through some dimension and it overwhelmed me and I just felt like I would rather be on a 200 trip. You can always intensify the trip but once youre 600 youre there for the next few hours
What will happen if you give a hard criminal lsd or other? If it can turn on some part of their brain lacking
True, but for psychedelics to be safely implemented in treating people (therapy) or legally allowed it must be applied in the scientific model and tested innumerably before it's deemed safe for human consumption. Let's not forget that not everyone experiences these incredible components in a positive way brother.
He's trying to figure out how the drugs work. That's the way to make science GROW.
Hey, he uses the album cover from Muse, the 2nd law xD
Well, I think anyone who is researching the drugs should just focus on the neuroscience. As in, how do the drugs impact the functioning of the brain and does this correspond to much that can be described on a cognitive level. They shouldn't speak publicly about therapeutic properties.
What he say? I don't understand a word he say.
What does he mean by “whatever SASHA gives you it’s gonna have some effects”?
He is referring to Sasha Shulgin, a famous and prolific (legitimate) chemist of psychedelics. Shulgin also consumed most of the things he synthesized and wrote up hundreds if not thousands of trip reports.
the will of D
Drugs are brain candy, too much and it'll give you cavities.
I'm gonna be a brain dentist when I grow up to be an astronaut.
im going to be a archaic revivalist molarpscyhonautical capt of lunar colonization
I agree with what you said about the rats... but the rest is basically incoherent.
31:00
Someone should check out this idea that MDMA does a whole bunch of things while LSD just does one thing. You'd think it would be the other way around.
13:38
I do appreciate this. But i need Niel Degrasse Tyson to explain it.
Typical NASA fanboy.
They need they research chemicals to do the research. You shouldn't be against research.
Butler
I was watching sad drug abuse videos. Now i wanna drop some acid again
I wouldn't mind doing a trip again.the last one i had was in the 80's
The best thing is to keep away from ALL drugs, except tea, food, literature and music. Thanks for sharing this!
These people have NO idea.
I bet he makes that pure L
It would have been hilarious if he'd dropped a couple tabs at the end. I wish we still had it on sugar cubes like in the 60s rather than these shitty ink blotters.
No, they actually do have therapeutic properties, but those properties are NOT necessarilly scientific, as much as they are spiritual.
Timothy Leary put this research back 50 years by making the culture more important than the molecule and its many purposes. Timothy Leary was an egomaniac, but I think, if he knew the negative effect he'd have on research and acceptability of these molecules in society, he hopefully would have shut the fuck up... but he didn't and he marginalized it.
Holy-Terrorist:>*=* Impressive!
"I do not work with this reagent" (PCl_3). That is something you will not hear from someone who studied chemistry in the German speaking countries. If you are afraid of the stuff get an other job.
I really don't think he needs one...he's the international authority of LSD and one of the most knowledgeable psychedelic researchers on the planet. Oh, and he's retired.
I have no doubt about his contributions on psychedelic research but it just sounds odd to me to that his staff is not willing to perform standard chemistry that Albert Hofmann did and worked just fine.
Till West If you look at the MSDS for phosphoryl oxychloride there's no indication that he knows what he's talking about. Dr. Nichols that is. It's more akin to working with concentrated hydrochloric acid.
Haha, what an end.
Which animals does LSD work with? Rats, Cats, people, Cuttlefish?...
All of them?
What's the most 'basic' animal with a serotonin receptor?
Thomas Smith I don't personally know, but I do know that spiders make "perfect" geometric webs while exposed to LSD
+Joe Schmoe I had a chemistry instructor circa 76 who performed some of those experiments and had a portfolio of pics of the spiders' webs.
all of the above. LSD binds to most serotonin receptor subtypes (there are like 10 or more subtypes, forget exactly, H-HT2A, @B, HT1A, 1B, 1D, 5-HT6, HT7, alpha-adreno, beta1-adreno, D1->D5, H1, etc, etc. serotonin receptor subtypes diversified around the same time as vertebrates evolved/diverged from invertebrates (likely all related).
😅😅😅😅😅😅
They should on what the drugs do to the brain. The idea that they can be used for psychotherapy is just more Timothy Leary stuff.
I wouldn't like those pro hormone psychs