Most benzos are simple single pot synthesis with necessary information to produce them widely available across the internet. That said I doubt many backyarders would be able to pull it off or bother. Especially making diazepam when you could just as easily make a much nicer, superior sedative hypnotic muscle and relaxant such as flunitrazepam with your knowledge and time.
I've been put in a situation where it's my only option, what exactly is cyclization? It would be great if this included a physically example of the synthesis!
Humour me, how much 2-amin-5choloro benzophenylone would I need to get a yield of 1 gram of nordiazepam. If I got that, i'd practice washing and refining it, with a hopeful yield of about .7gr pure nordiazepam.
Hello Sir, have you heard of this nordiazepam synth? Synthesis of 7-chloro-5-phenyl-1H benzo[e][1,4]diazepin2(3H)-one (nordiazepam) (1) To a vigorously stirred of 2-amino-5-chloro benzophenone (0.232 g, 1 mmol), chloro acetyl chloride (1.2 mL, 2 mmol) was added drop wise at room temperature under solvent-free conditions during 30 min and the progress of reaction was monitored by TLC. After completion of the reaction, NH4OAc (0.23 g, 3 mmol) and K2CO3 (0.42 g, 3 mmol) were added to the mixture at room temperature under solvent-free conditions and stirred for 2.5 h. When the reaction was completed, as it was shown by TLC, the water (30 mL) was added and the product was filtered off, washed with more water (2 9 100 mL) and dried. The product was obtained in high yield and purity (94 % yield) and was used in the next step without any purification. m.p = 212-214 C [217-218 C (Barthel et al., 2009) If i synth nordiazepam as shown above, can i follow YOUR last steps using methyl iodide for final reaction to diazepam or is it better to not use the NH4OAc / K2CO3 and just bubble NH3 then methyl iodide? Thank you, sir.
thank you so much for such a wonderful way of teaching and being so helpful... but you don't talk about the details such as the amount each ingredients... dpo you have a publication or recipe containing those details please?
Hi, i want to synth a small amount of nordiazepam to brush up on my lab skills etc. Can you see any problems with the following synth? Synthesis of 7-chloro-5-phenyl-1H benzo[e][1,4]diazepin2(3H)-one (nordiazepam) (1) To a vigorously stirred of 2-amino-5-chloro benzophenone (0.232 g, 1 mmol), chloro acetyl chloride (1.2 mL, 2 mmol) was added drop wise at room temperature under solvent-free conditions during 30 min and the progress of reaction was monitored by TLC. After completion of the reaction, NH4OAc (0.23 g, 3 mmol) and K2CO3 (0.42 g, 3 mmol) were added to the mixture at room temperature under solvent-free conditions and stirred for 2.5 h. When the reaction was completed, as it was shown by TLC, the water (30 mL) was added and the product was filtered off, washed with more water (2 9 100 mL) and dried. The product was obtained in high yield and purity (94 % yield) and was used in the next step without any purification. m.p = 212-214 C [217-218 C (Barthel et al., 2009) The first stage, is it just 1 mmol of 2 amino 5 chlorobenzophenone DRY reagent added to the CAC, or is it a solution of 1 mmol of chlorobenzophenone in eth/methanol etc, because after the addition of the other chems, it seems too viscous, or is that OK? Many thanks in advance Darren
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Now i can make diazepam at home, thanks
Most benzos are simple single pot synthesis with necessary information to produce them widely available across the internet. That said I doubt many backyarders would be able to pull it off or bother. Especially making diazepam when you could just as easily make a much nicer, superior sedative hypnotic muscle and relaxant such as flunitrazepam with your knowledge and time.
I've been put in a situation where it's my only option, what exactly is cyclization? It would be great if this included a physically example of the synthesis!
Humour me, how much 2-amin-5choloro benzophenylone would I need to get a yield of 1 gram of nordiazepam. If I got that, i'd practice washing and refining it, with a hopeful yield of about .7gr pure nordiazepam.
FYI: In the 1st scheme, (CH3)2SO4 is actually "dimethyl sulfate." In the 2nd scheme, C6H5C(O)Cl is "benzoyl chloride." C6H5CH2Cl is "benzyl chloride."
Not in India. 😅
Better than my class lectures 😀❣️🙏
Thank you sir for this classes
Thank you for your continuous support.
HAPPY LEARNING
Hello Sir, have you heard of this nordiazepam synth?
Synthesis of 7-chloro-5-phenyl-1H benzo[e][1,4]diazepin2(3H)-one (nordiazepam) (1) To a vigorously stirred of 2-amino-5-chloro benzophenone (0.232 g, 1 mmol), chloro
acetyl chloride (1.2 mL, 2 mmol) was added drop wise at room temperature under solvent-free conditions during 30 min and the progress of reaction was monitored by TLC. After completion of the reaction, NH4OAc (0.23 g, 3 mmol) and K2CO3 (0.42 g, 3 mmol) were added to the mixture at room temperature under solvent-free conditions and stirred for 2.5 h. When the reaction was completed, as it was shown by TLC, the water (30 mL) was added and the product was filtered off, washed with more water (2 9 100 mL) and dried. The product was obtained in high yield and purity (94 % yield) and was used in the next step without any purification. m.p = 212-214 C [217-218 C (Barthel et al., 2009)
If i synth nordiazepam as shown above, can i follow YOUR last steps using methyl iodide for final reaction to diazepam or is it better to not use the NH4OAc / K2CO3 and just bubble NH3 then methyl iodide?
Thank you, sir.
Did you ever get an answer to this?
@@tobenfarrell1334have seen this person asking the same question in different TH-cam channel lol! Nobody would even try to read this thing!
I want synthesis of haloperidol and alprazolam
Surely we will do it soon
You DO NOT WANT haloperidol. Trust me I've been on that stuff, nearly dislocated several joints and broke my teeth
Thats your own fault sir
@@GPATDISCUSSIONCENTER I'd love to see a simplified synthesis of Alprazolam tartrate, great video! Very informative!
Very useful..
Thnk you sirji
Thank you sir ,ur explanation is very helpful 🙏🙏
Sir in the last step do we need reduction so that o can taken out in form of h2o by adding h2 reduction proceess
So I know poppy's make morphine and weed makes thc were do I start with diazepam
If nuclear war kicks off how do I make this from scratch
Hi is there any step need to undergo under heat?
No, both reactions are organic.
Watching this for research only. Just in case I'm still being stalked
Can you please upload notes on sar of differnt drugs.
Can you please do a synthesis of benzodiazepines.
Yeah pls do!! I love your videos you are the best!!!
Diazepam is a benzo
Is there a reference for the first synthesis you describe (the one that involves the ethyl glycine ester)?
Did you find anything out?
Thanks for making sir
Thank you for your continuous support.
HAPPY LEARNING
sir that is the not structure of benzylchloride C6H5CH2CL this molecular formula
Very nice job
Thanks sir
Thank you for your continuous support.
HAPPY LEARNING
Thank you mr.I need application of benzodiazepines
I wont application benzodiazepines
Sar of barbiturates
great video
thank you so much for such a wonderful way of teaching and being so helpful... but you don't talk about the details such as the amount each ingredients... dpo you have a publication or recipe containing those details please?
I ❤ diazepm sooomuch mmmmmm
Thank u sir..
Hi, i want to synth a small amount of nordiazepam to brush up on my lab skills etc. Can you see any problems with the following synth?
Synthesis of 7-chloro-5-phenyl-1H benzo[e][1,4]diazepin2(3H)-one (nordiazepam) (1) To a vigorously stirred of 2-amino-5-chloro benzophenone (0.232 g, 1 mmol), chloro
acetyl chloride (1.2 mL, 2 mmol) was added drop wise at room temperature under solvent-free conditions during 30 min and the progress of reaction was monitored by TLC. After completion of the reaction, NH4OAc (0.23 g, 3 mmol) and K2CO3 (0.42 g, 3 mmol) were added to the mixture at room temperature under solvent-free conditions and stirred for 2.5 h. When the reaction was completed, as it was shown by TLC, the water (30 mL) was added and the product was filtered off, washed with more water (2 9 100 mL) and dried. The product was obtained in high yield and purity (94 % yield) and was used in the next step without any purification. m.p = 212-214 C [217-218 C (Barthel et al., 2009)
The first stage, is it just 1 mmol of 2 amino 5 chlorobenzophenone DRY reagent added to the CAC, or is it a solution of 1 mmol of chlorobenzophenone in eth/methanol etc, because after the addition of the other chems, it seems too viscous, or is that OK?
Many thanks in advance
Darren
Did u get it?
Thanks sir