Alison Hill: Model-based evaluation of HIV treatment strategies

(30 avril 2024/April 30, 2024) CRM Distinguished Lectures in Applied Mathematics. . www.crmath.ca/en/activities/#...
Alison Hill: Model-based evaluation of HIV treatment strategies
Abstract: HIV/AIDS remains a major global health concern, with no vaccine or curative therapy. Current standard of care involves daily, lifelong adherence to combination antiretroviral drugs, which can be compromised by drug resistance. New therapies with diverse mechanisms of action are in the pipeline, but their potential costs and benefits must be carefully evaluated. In this talk I will discuss how mathematical models of HIV infection within individual patients can be used to understand disease dynamics and evaluate interventions. I will give examples where these models have provided critical guidance into the development and deployment of new therapeutics for HIV treatment, prevention, and cure.