Is tretinoin better than adapalene? Every drug retinoid explained
ฝัง
- เผยแพร่เมื่อ 28 พ.ค. 2024
- Drug retinoids like tretinoin and adapalene are some of the most powerful skincare ingredients. But what's the difference between them, and which one works best for acne, anti-aging, or pigment? And what about the different formulations? I'm breaking it down in this video, and busting a bunch of retinoid myths too!
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0:00 Background
0:42 Tretinoin
3:32 Why newer retinoids? General benefits
4:19 Deep dive on receptors
7:45 Adapalene
8:34 Tazarotene
10:05 Trifarotene
11:16 Myths about choosing drug retinoids: receptors, studies, approvals, irritation
13:56 Which retinoid is best?
16:08 Converting between retinoid percentages
Blog post with more info here: labmuffin.com/ultimate-guide-...
Thanks to Dr Mara (dermomtology on IG) and Ruby (rubysresource) for helping me on this one!
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🙋🏻 I'm Michelle, a chemistry PhD, cosmetic chemist and science educator, here to explain how beauty products work, debunk myths, and help you make smarter decisions about your skincare, hair and makeup!
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"Scientists are bad at coming up with names. That is why my channel is called Lab Muffin."
Love it, Michelle.
Simp
Her deadpan delivery was chef’s kiss
I just started working in a cosmetics retail store and I'm watching your videos to get more educated and give my customers a good advice on skincare
👏🏻👏🏻 More workers like this! 😁
Kudos to you! You're doing more than most retail service people.
That’s awesome. I’ve met quite a few cosmetic retail workers that were telling me things I knew to be untrue. Glad you are educating yourself!
This is awesome! Too much skincare “information” being shared in retail stores is wrong because the actual science behind skincare has been limited to cosmetic chemists and dermatologists, and sometimes the dermatologists don’t get it right. Lab Muffin’s science and product nformation information has been very valuable to me and it’s great to see it getting shared.
You're doing very well! 😊
If I was infinitely rich I’d pay you anything to teach chem/orgo at universities. You have the best analogies to help make complex concepts tangible (i.e. using the boba reference for the tret/bpo formula to explain why it works), and to echo everyones sentiment, you are an exceptional teacher/communicator. I feel like I would’ve remained a chem major had I discovered your channel circa 2014!!
@@maalikserebryakov Why are all your comments on here so annoying
She would be an awesome high school teacher. She would be discriminated against at the university level
This is kind of bizarre, I was part of the final clinical trial for retinol for acne 40 years ago. It rocked I would like to say. It basically peeled my skin and all the craters and scars didn;t reform. And the acne kind of magically didn't come back. Now I use retinol to"fight the signs of aging" . Good old retinol!
I never realised how irritating tretinoin can be for most people - while my skin will freak the hell out at the slightest change of humidity, it's tolerated tretinoin incredibly well, never reacted poorly. And it has absolutely been a game changer! I'd been suffering from acne right from puberty, and it just never went away no matter what my routine. Tretinoin has been the only thing to clear up my skin long term
The delivery of the lab muffin joke got me
I’m a 44 year old male and I’ve been using Adapalene for 5 years.. I always get mistaken for looking in my late 20’s.. your videos have been so helpful for me immensely
@@maalikserebryakovthanks for your genetic assessment, Dr.Random Online
Bryakov stop being so bitter
@@maalikserebryakovyou’ve never used Tret and it shows…
@@maalikserebryakov I think you don't know what that word means
I was mistaken last month for 16, and I'm a week shy of 27. Adaptelene really is a miracle-worker. Never gonna stop lol
It's so amazing to finally understand how these acne treatments work! I suffered with acne throughout my entire adolescence and early adulthood, so I tried everything you can imagine, except for tretinoin - where I live doctors normally use it as a last resort thanks to the amount of side effects. Oddly enough not even adapalene worked in my case (I used Epiduo), so I decided to see another dermatologist to get a second opinion and as soon as she saw my acne she prescribed me antibiotics (Tetracycline) and topic azelaic acid.
I not only finally got rid of my acne, but my blemishes were pretty much gone in a matter of a couple of weeks as well, which was great since I am prone to hyperpigmentation (I have tan skin). After that, the few times I got a pimple benzoyl peroxide alone was enough to deal with it.
It's crazy and fascinating how our bodies respond differently to substances. I spent loads of money on expensive retinoids throughout the years, but the antibiotics which cost me under 10 bucks per box were the only thing to actually solve my problem.
That's so interesting! From speaking to derms who see a lot of acne like Dr Mara and Dr Anjali Mahto (I collaborated with her for my food and acne video), it's pretty common to have to try a few first-line treatments to tackle acne, and sometimes they'll work for a bit then fail and patients have to switch. Glad you found something that works so well for you!
@kayc . . .
Curious. Did u take Tetracycline topically or orally?
Where I live antibiotics are stndrd for acne. And they work very well for a lot of people. Only downside is that in most cases the acne comes back pretty much immediately when you stop taking them. Usually you can't take them for more than 3 months.
I took antibiotics too but it's not a long term solution since you have to stop it at some point. Enjoy it while it lasts. Because it will comeback soon.
I love adapalene, I use it for acne and overall skin texture and smoothness and it’s been amazing. Tretinoin was very irritating for me and caused more issues long term with post inflammatory erythema and random big breakouts. Now my skin is finally happy and glowy phew. Interesting how much of a difference changing the retinoids u use can make
I recently started using adapalene, and I'm also having good results with it. I'm older, so my problem isn't so much acne anymore, except that I get occasional pimples and a lot of closed comedones that are quite difficult to get rid of. The adapalene is taking care of them and my skin looks a lot smoother and healthier now.
Literally about to have an appointment with my doctor to discuss my retinoid options for my acne, so this could not have come at a more perfect time.
In Thailand, tretinoin is available OTC! It’s also super cheap, like 3-5 usd
Jealous!
@satoonneiei50 . . . .
Jealous, also.
$145 with Insurance!!!
$65 for Retrieve in Australia. Still much cheaper than the Retinaldehyde serum I was using!
Can you give me the brand name for Tretinoin sold in Thailand?
@@WithAshlyn04 The ones i’ve used are Acnetin-A and DermaKlares. They typically range from 80-150 THB for a 10-gram tube with a 0.05 concentration, depending on where you get them!
Can confirm that receptor selectivity does not necessarily translate to fewer side effects. I managed to get a prescription for trifarotene and my skin never adapted to it. I spent 6 weeks with my whole face stinging for no real benefit 😭
I really love my adapalene +Benzoyl peroxide formula! Works super well! I use a Retinal for anti-aging on my off days
I've had the opposite experience with tazarotene 0.1% cream. I was kinda scared of it but it's not irritating at all for me and some other people I know.
That's great! Which formula are you using?
I remember seeing a few things that really annoyed me on the Differin website.
They also had a table that claimed other OTC acne treatments don't effect cell differentiation, which… doesn't seem to be a claim they actually substantiated.
I've seen skin biopsy data that indicated salicylic acid _does_ influence cellular differentiation, however the sample size was quite small.
I didn't notice that! Definitely a sus claim...
i've been waiting for this video for my whole life
Thank you for this! As someone who has been on tazarotene since September, I’ve been dying to see more in depth videos on tazarotene!
queeeennnn 💪🏼 have a happy new year!
Wow...this was just amazing. Fantastic info!
Had a good chuckle on the team work hit.
Ohhh, this is right on time! My derm has been prescribing me Trifarotene, and it's been...a process. Sure there's technically no irritation, but the peeling is insane and even one year in not totally gone. I can also only use a handful of other skin care products because so much stuff makes my skin burn terribly (just as a sensation though, not actually burning happening). Before I've had an adapalene and benzoyl peroxide combo, which I hope to get back to, because I had almost zero issues with that 😅 Either way, that's the end of my rant, thank you for the video! The way you presented the advantages of the different retinoids pointing at scientific evidence/support is super helpful!
Trifarotene is one of the new ones drug companies have been pushing, particularly that one that developed epiduo.
It's far too expensive in my opinion. And they have been pushing it for the body.
Delighted to find you through Glam Girl Gabi’s referral! So good to hear actual science-based evaluations, comparisons and recommendations! 👏❤️ I’ve liked and subscribed and looking forward to cruising the backlog to catch up.
It’s so cool to find professors like you on TH-cam! Fellow Pharmacologist here! Did you abandon academia? I would consider moving to Australia if you were to supervise me! I’m a big fan of yours! Thanks for your insight!
I love your videos on retinoids! I would love to hear your points on newer ingredients like phytoretinols, granactive etc
I have to watch later without headphones because of the sound issues, but thanks ive been looking for exactly a breakdown like this!
Tazarotene is the best retinoid for me. It’s less irritating than tretinion for me, cleared my acne so fast, makes my skin texture so smooth and the glow it gives me is incredible!
As always, thank you for your work! Your channel is like a holy grail of skincare for me! So informative and well-explained, and science backed, simply amazing.
Thank you so much for your science based content, I'm pretty sure I learn something new every time I watch your videos :))
Hi Michelle, Thank you for recently mentioning the L'Oreal Bond Repair range... which I have now switched to. I purchased the shampoo, conditioner and the serum. I was previously using a hydrating shampoo and conditioner, which made my all-over blonded hair clean, soft & silky...but it also made it lank and "stringy" not too long afterwards. Because my hair is naturally oily, I was just thinking that this happened to my hair whenever I had more than 1mm of regrowth... when it was the shampoo & conditioner all along! So now I don't have to squirm every time I look at photos when I am wearing my (past shoulder length) hair down.
In fact, on the weekend I met up with a cousin (from Europe) that I had not seen in 40 years and wanted to look my best. Thanks to you, Mo (moskinlab) and Dr Dray, I actually went out socially for the first time in a million years without foundation or powder and just washed and dried my hair with hardly any styling. I felt more relaxed and looked better & younger than I usually do...both in real life and in photos. My boyfriend said that he has never seen me look more beautiful. I've always been a glam full-face make-up girl, but now realise that I don't have to cover the pimples or freckles/pigmentation that I used to have. It's OK for my skin to look like skin.
I still wore eye makeup; but no eyeshadow (except a subtle champagne liquid glitter on my lids) and petal pink lips. I admit I did have a trial run the previous day, just going to Bunnings, Chemist Warehouse & Aldi!
👱🏻♀️❤️
Thanks for this! I've always been wondering what the difference is. This is such a nice and clear explanation 😊
Beautiful video, very clear and very well explained .. thank you Michelle 👍
This video is great. I loved all of the chemistry and the way you show the chemical formulas, explain the functional groups and highlight why the molecules look different or similar.
Love your series on retinoids as I myself starting to introduce it into my skincare routine.
And THANK you for explaining about compromised skin barrier because now i know what to use and it saves me a lot of pain and itching.
Your channel is such a gem in general and endless source of useful info.
Happy New Year!
I really like the Superman analogy! It makes perfect sense to explain how a prodrug can be just as strong (or stronger!) than a drug.
Thanks! I spend a lot of my writing time thinking up nice analogies, I'm glad it's appreciated 😀
Thank you for new great video Michelle ❤
I love learning more about retinoids, started tretinoid year ago and after adjusting and finding good stable skin routine it really did wonders for me.
Thank you! Been waiting (patiently) for this video. I’ve been on Tazarotene for the past 10 years. It’s always worked quite well for me (aside from some irritation when I’m less diligent about skincare), but have always wondered about the differences to other retinoids!
Another banger of a video, love u always
Thank you!
This is a huge help!
This is exactly the video I needed
I eagerly await the video on cosmetic retinoids! I'm not using them on my face any time soon (too ADHD to use sunscreen consistently), but I'm interested in potentially using them on my body.
Thank you so much for this comparison! I don’t want to fall for myths. I can’t use tretanoin directly to bare skin without irritation. I used adapalene for years to treat acne, and I didn’t even know it was a retinoid.
Thank you so much for this information, Michelle! I'm 57, but brand new to Tretinoin, so need to learn more.
And I love your sweater. The color looks great on you! Did you crochet that yourself? Super cute.
Michelle, thank you for your wonderful work over the years. If you take video ideas from readers/ viewers, please consider these:
- The current state of innovation in the hair colour market. My particular interest is in why there are so few deposit only options, especially formulas based on dye precursors in henna and indigo; after all many people colour their hair for grey coverage and not fun/ fashion and these types of formulas could theoretically achieve that with limited colour options.
- How companies (especially big ones) develop the fragrances they use in products, both the chemistry side of things and the sensorial side (how do they test if people like a new fragrance etc.)
- As end users, what rules of thumb can stand us in good stead when choosing products and brands for maximum scientific soundness in formulation? I feel sometimes one can't just rely on the brands being big and international. Dove, for example, has stupidly gone "paraben-free" and many of their hair products in my country now contain MI.
Thank you again.
thank you for all that you do !
ugh you’re amazing
Love this video🥰 Thank you💖
You're very welcome!
This is fascinating. Thank you! I have super oily, sensitive and acne prone skin with melasma. I began my retinoid journey at the age of 42 with many over-the-counter gentle retinoids. My skin was always irritated for at least a year. So I tried differin, and that was less irritating than retinol. It also worked better for my acne. I used it for 2 years but I still had a small amount of acne, although it did help a little bit with fine lines. Finally got Tretinoin gel .025 percent. Hallelujah! Finally all my acne is gone. So is pigment! And my fine lines. In fact I look younger than I did 5 years ago. I'm blown away. I didn't believe the hype and I didn't think my sensitive skin could handle tret. But I do use the moisturizer sandwich method with niacinamide and centella toner first. Now my skin can't handle ascorbic acid any longer but I do use THD instead and I like it.
You are a godsend. Was just about to change my curology formula.
i also use curology. what formula changes are you planning to make after this video if you don’t mind me asking?
My first introduction to retinoids was tazarotene and it was awful, I stopped using it after 3 months and stopped using anything for my cystic acne. A year later I saw another derm who prescribed Epi-duo and that was a game changer. Three years later I am on tretinoin .05% and my skin is clear and healthy with minimal breakouts. Why a derm would start with that I do not know but your video is anecdotally accurate.
michelle you beautiful angel what a useful and wonderful present-video! happy holidays ❤
@sine40
She is an angel 😇 💖
Great video and very great detailed breakdown of everything retinoid. I personally found that the best retinoid is the maximum threshold your own skin can tolerate. For eg, if your skin can only tolerate adapalene 0.1 (given that you have experimented with different retinoid strengths), then that’s the best one for you at the given moment. If the higher ones irritate you, ofc you need to take a break because inflammation is the sure fire way for quicker aging. If the lower strength still doesn’t give you results after using it for a good while (ie. still have bumps or still dull, etc), then gradually increase to one level higher. That’s just my 2 cents.
You read my mind. This video popped up at the right time. I am turning 23 this month and am thinking about starting to use retinol products from now on. I always look up your recommendations before buying anything. I have dry skin without any skin problems. Can you please recommend some products for me or make a video about it. Tnx.
I used gel Adapalene and had wayyyyyy more irritation than Tretinoin in a cream base.
AMAZING! Thank youu.
And the Oscar goes to.... Dr. Michelle Wong for Retinoids and beyond. You're the best! Thanks for every video.
Thank you!!
This is like the best video I’ve watched in months!!! Thank you so much ☺️🧪💕
I have switched from Tretinoin to Tazarotene for last 3 months. Damm, I'm never going back to Tretnoin, Taz is less irritating than Tret as it does not bind to all RARs. Tazarotene helped me get that glass skin everyone talks about. What matters is going slow and steady.
Receptor selectivity doesn't seem to have much to do with irritation - see 4:19 onwards
What formula/strength are you on for Taz?
Please do a video about mica controversy, and how ti choose, and synthetic mica alternatives
Is the child labour controversy specific to mica, or is it a problem with all inorganic components of makeup?
I’ve been trying to figure out if I should stick with differin or start on a retinol instead. This is helpful, tyvm !
@AC-dz9yq
How about Adapalene. 3% Rx before going to Tret
I use a retinoid of some kind every day, and have fewer signs of aging than my peers, I still have acne. Done Acutane, lasers, tret, micro needling, and cortisone injections. Still have no fewer than 2/3 big cysts on my face at any given time. But I look real young, so… lol
Thank you for the helpful info! This is random, but would you share with us what's on your lips? The color is so beautiful and I'm so ready for glossy lips to be a thing again!
Thanks for the info!
Can you use tretinoin around the eyes? On the eyelids?
As a pharmacist, I'm very happy with this video. It is very complete and understandable ❤
You are the best
FINALLY, you have no idea how long i have waited for a video like this. When I originally watched your first videos on retinoids, I became so curious about how tretinoin works because its kinda vague just saying it goes on your skin and voila. I am still curious how the retinoic acid receptor being bound actually changes biological processes but from what I have researched, there just isn't much knowledge on it. Still this video really helped explain the papers I read on these forms of retinoids in simpler terms!
I really don't enjoy biochem so I generally blank out everything between receptor binding and biomarker/macroscopic impacts, but a very rough outline is: the RAR joins up with another type of receptor (RXR) and they mess around with the DNA of the cell, which then changes how the cell works.
Maybe try asking Dr Dray? I believe her PhD was on molecular biology, which is this kind of thing...
Thanks for the info! I guess I’ll stick with my 0.025% tretinoin! Been using it for 2 years and I’ve been seeing good result. It was irritating a first few months (using once every 3 days) as I have dry and sensitive skin, I even used sandwich moisturizing layering method.
For those who can't tolerate tretinoin cream or gel, give try to micro retin A it's so good, absolutely no irritation whatsoever no stinging at all, peeling still occurs though. I use tretinoin with benzoyl peroxide in wash form, i feel micro retina A can be used with wash off benzoyl peroxide as there isn't much irritation or dryness as with typical tretinoin, 'thats just my opinion not a fact though'.
Great video, but sadly a lot of these products are not available in EU. Could you do a video about retinoids available in Europe?
Just want to say your skin is gorgeous and you blush or blush/highlighter is 👌
Thank you!
@@LabMuffinBeautySciencelove to know what makeup products are you wearing! Looks so lovely!
Another great video- thanks, Michelle! I love how informative you are and how well you break down complicated topics, but when you randomly plug in your deadpan humor your content crosses over into epic territory for me lmao. "Scientists suck at naming things which is why my channel is named lab muffin"🤣💀
Rosacea sufferer here! I can handle adapalene once a week no problem (other nights i alternate soolantra or finacea), my skin is less inflamed and i get less and less rosacea "pimples" i love it! ❤
Thank you so much for this video! Just wanted to ask, how does Granactive retinoid compare? Many thanks
Thank you for this video. I hoped there will be more data about trifaroten. I'm using this retinoid and tried to find something about how it works for wrinkles and aging at all comparing to tretinoin, but I haven't found anything. :/
I will watch this later, but I just want to say you’ve taught me enough to feel more confident about my recent choice to switch from prescription tretinoin to adapalene (differin). I haven’t tried the differin yet, but I will say after about a month of my prescription, I have been left with some (sudden onset) chemical burns. I now know that otc retinoids aren’t useless (thanks to you) and found that research shows adapolene may be better for sensitive skin. Of course, I’m currently healing from the burns so won’t be starting differin for a while.
I love that top! do you have the pattern?
Been using Trentinoin 0.1, first time using and I know that’s a high starting point. I wanted fast results. I noticed a lot of peeling at first but now that I’ve been using it three times a week with an amazing moisturizer I’ve noticed the peeling is about gone, my skin texture is much better, and my break outs are not as long lasting. Though they still happen.
which moisturizer do you use?
@@Jessica-rp6yuasking the real questions
I’ve used both. Tretinoin has worked the best for me. I did have to apply it last after moisturizer to get results. But my skin has not been this clear since before adolescence.
My favorite retinoid, palovarotene, isn't here-probably because it isn't even a skin drug. It's a new treatment for FOP, the rare disease that turns people's soft tissue into bone, but its efficacy is extremely controversial. Still pretty cool any time a rare disease gets a new drug though. It's also a very selective RAR-gamma agonist, so it probably does work on skin, and some of its side effects are the same as the side effects from topical retinoids.
I love the explanations of what the different moieties are doing in the pharmacology of each retinoid, as someone who reads SAR papers for fun lol.
Adapalene is really good, and I can buy it OTC here in NZ.
Please make a video about moisturizer
So helpful! I’m happy with Tret but it’s good to know there are other options!
👏👏👏👏 thank You!
Please Review the brand naturium retinaldehyde
I have been on tretinoin for 3 years and it has done wonder for my skin. But I do need to be careful with my routine to prevent irritation. So was thinking about the new formulas as I've heard the claims of them being less irritating but now thx to you I will just continue my routine as it is. Tret is widely available and affordable where I am whereas the newer formulas not easy to find and double or triple the price. So tret it is until You make a video telling me there are evidence that says I would benefit from another formula.
On a side note, adapalene irritated my skin more than tret did. And for a long time I thought I wouldn't be able to handle tret but I'm doing just fine as long that I'm hydrating and looking after my skin barrier!
Adapalene irritated my skin too and i want to start tret. Do you use the gel or cream tret?
Thanks Michele! What are your thoughts on Retinaldehyde? I have seen dermatologists recommended this from Avene for people who cant tolerate retinoids?
Thank you so much Michelle! I've been on Adapalene 0.3 since the beginning of the year and I love it. Practically zero irritation on every day use. Might try to come back to tretinoin next year but in BR we only have two options. One with fragrance ;( and the other causes zero irritation in many of my followers. Not sure if it's really effective. Thanks again for the informative video!
Oi Edu! Quais são as opções que temos aqui no br de adapaleno ?
@@Amandaalmeida673 Oi! Temos Differin, Belpele e Deriva Micro.
@@belezacomdu Edu você sabe dizer se o adapaleno também promove efeito anti aging assim como a tretinoina?
@@Amandaalmeida673não promove tanto. Não tem tanta evidência ainda. É mais para acne, textura e poros.
I used adapalene and tretinoin. For me both were equal in irritation, mild in my case. Tazarotene discontinuation was approved by ANVISA (i dont know why) thus not avaliable for me to use. I still use tretinoin (mostly because is cheaper) and worked great for my acne
Thanks for the nice video. What do you think about the tretinoin microsphere? Is it true that it gets deactivated by moisturizers, and one shouldn't buffer? Is it proven for aging like the standard cream or gel formula? Thanks
Hello, love your video's as always. Could you explain about copper peptide. I saw some people say in comments in other video's (not yours) that it could grow hair on the face but i did not find any evidence. Also with age, women are more likely to produce hair on the face, so i don't think there is even a link or these people did read that on things like blogs etc. I guess more people concerned about aging will use these products because retinol can be irritating for some, so they make these links that aren't even connected
Thank you 💕
Re: Tretionoin studies... "A lot of people in these studies are teenage boys and men" ...
I wonder if this also accounts for this disconnect with doctors and female patients. Virtually all men I know have a MUCH higher threshold for irritation than women (obviously anecdotal). I was told to just push through the irritation and after 1 year of nonstop extreme breakouts with tretinoin, I stopped. I still have scarring 15 years later.
I have some topics of interest, if you think they are helpful to expend on:
- are Estradiol/ Estrogen creams safe to use on the skin? What if you take the pill? Is there an age related recommendation? Frequency? Etc.
- what do you think of Phenol peel? Is it the only way to penetrate deep into the skin to boost Collagen, or what other ways are there? Etc.
- what do you think about Ectoin? Combination of Ectoin with other ingredients? What products would you recommend? Etc.
Can you make a video on extreme cases of keratosis pilaris please
Ooh can you talk about Urea? I’m confused at whether it’s moisturizing or an exfoliant and how it depends on concentrations. It’s an NMF, but is it good for a damaged skin barrier?
Anecdotal but Tazarotene is actually less irritating for me than tretinoin. I couldn't put it on more than once everyday 5 days without severe irritation even with moisturizing. I can put on Tazarotene every other day with little issue besides dry skin and occasional slight redness. Maybe it was the formulation but no idea.
.3 adapalene is the game changer here.
As someone who has tried tret and tazarotene, I am definitely having more success with tazarotene but I also feel like derms are misleading when they tell you that you have to work up to using it daily. I have had the most success using it every second or third day because I have damaged my skin barrier before with tret and now I am treading lightly.
Thank you so much for making the science approachable and digestible for the lay person!
There is our girl, in all her beauty.
Now we just need more muffin science. Not enough muffin science on this channel.