Chemotherapy In
ฝัง
- เผยแพร่เมื่อ 25 มิ.ย. 2023
- Taxotere and Jevtana are the two most common chemotherapies used in prostate cancer. (They are both "taxane-based."). In this video, medical oncologist Mark Scholz, MD, discusses these two chemotherapies with emphasis on how the two are used in the advanced prostate cancer setting. (See our other videos on chemotherapy for more information about the use of chemotherapy in non-advanced settings.) He discusses how the side effects of these chemotherapies compare to those used in other cancers (lung cancer, for example), he discusses the differences between Taxotere and Jevtana, and the possibility of intermittent chemotherapy or adding other forms of chemotherapy if there is only a partial response to treatment.
0:07 How is PSA used to monitor the effectiveness of chemotherapy? Is chemotherapy for prostate cancer as intense as the chemotherapies used for other types of cancers?
3:37 How do you compare the two most common chemotherapy agents used in prostate cancer, Jevtana and Taxotere? How are they the same, and how are they different?
4:28 What are the other side effects of Jevtana and Taxotere? (fatigue and neuropathy are discussed in the question above.)
5:47 How does the use of ice help prevent hair loss, fingernail damage, etc.?
7:25 Are side effect mitigation techniques common in community hospital setting?
7:53 What kind of PSA response do you expect during and after chemotherapy?
9:18 Does a patient's PSA level at the initiation of chemotherapy determine how effective it will be, or does it affect the PSA response a doctor would expect if it was effective?
10:18 In what time frame do you expect a patient's PSA to nadir (reach its lowest point) during or after chemotherapy? What percentage of patients respond well to chemotherapy?
11:51 If a patient only has a partial response to chemotherapy, should their doctor consider adding other treatments?
13:46 What does it mean if a person has a stable PSA while on chemotherapy?
15:21 Where, in a patient's timeline, would you recommend PSMA PET scans?
16:13 If a patient's PSA is high, but stable after chemotherapy, could changing the type of chemotherapy potentially lower a patient's PSA?
18:12 How should patients speak with their doctors and medical professionals about any chemotherapy-related questions or concerns?
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I had my third round of chemo today , I'm also taking Nubeqa and Zoladex injection .
When I was first diagnosed with prostate cancer my PSA was 204 after my first treatment it went down to 83 , my Dr told me today after my second treatment I'm down to 8.
For now I'm happy with my chemo treatment I had hardly any side effects after my second treatment, I'll see how this 3rd one plays out .
My big concern that my prostate cancer mastesize to my liver and bones .
I feel good and have quality of life right now .
Fingers crossed and the best to everyone.
Thank you for this channel of sound questions and answers
Great information. 🙂
I am on cycle 5 of Jevtana and carboxytaxyl. My PSA has dropped from 850 to 32. The combination is being well tolerated and the last PSMA PET showed no new changes and a 3.5 cm shrinkage of an 8 cm tumor on my liver. Yahoo😊. Thanks for all you do.
I just finished 6 rounds of taxotere (every 3 weeks).
It wasn’t that bad an experience, but most of my body hair, my beard, mustache, eyebrows fell out. Oddly my scalp hair wasn’t affected.
My toenails turned black and still feel bruised. My fingernails didn’t turn black, but they’re separated from the mail needs and look horrible.
Quite a bit of fatigue, but I did go to the gym as often as I could.
Little nausea, but my taste buds were really impacted. Even water tasted gross.
I used ice in my mouth and ice gloves during infusion and still had those issues.
My PSA cut in half after every cycle, and reached 0.014 at the end.
My cancer was in my spine, hips, entire prostate, lymph nodes, and bladder. After chemo, PET scan showed the only active cancer left was a small amount in the seminal vesicles.
No regrets doing the chemo as my first line of defense (as part of triplet therapy with lupron and NUBEQA).
Good information in this video!
Your experience was very similar to my husband’s. Best wishes, you made the right decision.
Very similar experience with a family member, plus very annoying hot flushing, sunburned like of ears and face, like a mask. High photosensitivity. Strange rashes on palms of hands. Cold ice compresses on the face helped during the chemotherapeutic injection which significantly reduced the hot red face when it was started at the 3rd cycle. Also a white layer on the tongue, nystatin helped. Taste alterations and risk for weight loss were addressed with cooking novel foods, such as Indian and chinese dishes. Normally on a western healthy diet. That sort of food was tolerated and palatable. Still 2 cycles left. Prostate Cancer with bone mets in spine and pelvis. Congratulations on your results and stay well.
Best wishes, Dave, hope you’re doing well.
Hello Dave, are you exercising or walking?
I am a graduate of the college of dentistry at howard.i recall during pathology the prof. Had said if you get cancer get prostate cancer.i was diagnose stage four b .in 2018 and was introduced to your programme in 2021.i am extremely grateful to you mrs.sholtz for your guidance your encouragement esp. When you say you are not alone. I have listened to all available whats ap over and over.have had 56 sessions of radiation and 5 of chemo.for th last four years and 6 months my psa is 0.010 and i look forward to the 5 years yhat your husband had said that i can be consideref cured.may almight god bless you both and say to thamk you thank you and thank you
How to get rid of a psa pumb
Thank you so much. The help and guidance given has really helped me navigate thru this advanced prostate cancer..❤❤
I appreciate your dedication and concern. These videos are very helpful
Thanks to both of you for creating these wonderful videos.
Thank you folks so very much! You all are appreciated!
Thank you. I have been trying to find chemo information and it’s difficult given all the different individual situations. Y’all do,great work.
Thanks Dr. Scholz and Alex, could you comment on fasting before and after Chemotherapy treatments.
Thanks for another great one!
Do hormone blockers destroy metastatic lower abdominal lymph node cancer on their own?
Interesting interview. Thanks.
I did 6 cycles of Taxotere this winter, along with Nubeqa and Zoladex (triplet therapy). The chemo treatments really weren't that bad! The first week I generally felt gross and took my sick pills preventatively, and everything had a rusty taste. By the second week I could walk briskly on the treadmill for 30minutes every day, with weight training every 3 days. By the middle of the third week I felt fine. I lost my body hair and head hair, but kept eyelashes and brows. I did the ice thing on fingers and toes, and never got any nail bed problems (I DID get some numbness/neuropathy on the balls of my feet though, but this seems to be getting better 5 weeks out).
As for results, the ADT drugs had already taken my PSA to 1.4 from 104 two months earlier. After 18 weeks of Taxotere added it's undetectable at 0.0. My 8 soft tissue tumours (including the 6cm primary in my prostate) are gone, and my 5 bone tumours in my tailbone and spine are inert. Triplet therapy is very potent!
I should add that on my own (and with my oncologist's blessing) I added a tablespoon of black cumin seed oil to the protocol, as there's research out that shows the TMQ in it can help Docetaxel more effective. I also took 4g/day of a high quality turkey tail extract powder after reading that it's used as an adjuvant therapy with taxane-based chemotherapies in Japan.
Good luck to everyone reading this! Keep fighting the good fight
Did you do radiation too?
how many months (on average) does chemo extend life?
Please can you do a session on solitary bone metastasis, and the best possible treatment for a possible cure
In August 2007 I got a private health check and my PSA was 5.64.
Early this year 2023 I went ot the doctor for frequent visits to the toilet during the night and the doctor took a blood sample for a PSA test which was foun to be over 10 at 11.5.
So my PSA went from 5.64 to 11.5 over a period of 15 to 16 years during which I have been very healthy other than the frequent visits to the toilet during the night for a wee.
Anyway this was followed up from early this year ...scans, biopsy etc to find that I have Gleeson 4/3 and now I am on Hormone therapy for 6 months during which I will receive radiation therapy over 3 weeks.
My testostorone level is going down and I feel aged, body sweats and fatigued.
I read that my PSA should come down to near zero after Ratiation Therapy, but if it goes up slightly, I could be back to square one as it indictes that the cancer could still be present.
Is there no escape for this nightmare?
PSA is available for patients to SAEF-ORDER at Quest and LabCorp. But, insurance won’t pay for it without an order from a doctor or other provider. My Urologist set me up in September 2021 for a follow-up in March 2022. My PSA self-ordered and I paid for in December 2021 had jumped to 0.17, and kept climbing. I had Relugolix and IMRT a year ago. My Medical Oncologist retired earlier this year and the CRNP at the office has scheduled my next follow-up in November 2023. I have already bought a PSA to be done 7/7/23. I certainly don’t look forward to a SECOND BCR.
Hi, you were talking about the different dose and time frame for chemo when it comes to more sensitive seniors. Can you explain that to me again? Give an example again on what would be a more sensitive time/dose for seniors when it comes to chemo?
Hello. Thank you for another great video. I am left wondering if chemotherapy only given when the prostate cancer has metastasized, or would it be something to consider when the cancer is still localized. Thank you.
@pcri: Question for PCRI: is this true:"patients with a rapidly decreasing PSA level in the initial phase of ADT are more likely to progress to CRPC" and if yes why? If not please advise
I have asked this question before, but have not received an answer. An someone please tell me if a PSMA-PET is worthwhile when the PSA is undetectable? This PSA is down due to chemotherapy. Would it make sense to get the PSMA-PET just to make sure that the cancer is not growing?
As a stage4 9gleeson score my understanding from everything I have looked at is if your PSA is below 4 then the cancer is relative stable. Mine has dropped well below zero as of last month. Oncologist agreed with me that a PET scan was not going to show any changes. She also agreed that if my PSA started to rise then we would do PSA-PET scan.
Really it is on a personal level as here they say it is worthwhile in case there are spot cancers. I research constantly to keep up with treatments and abreast of my own treatment. My life my decisions.
Is some hearing loss still a potential side effect of chemotherapy ? Can an Ice Cap assist with that region as well ??
I am fighting now..
I had six cycles of Taxotere, and it was not as bad as I feared beforehand, but I was still very glad not to have a seventh. I got very good results.
The following year, I had six cycles of Jevtana. Again, I was very glad not to have a seventh cycle. But I got even better results, and two-and-a-half years later my PSA is still down at ~0.01.
I am an outlier, though, in that for me the side effects of Jevtana were harsher, particularly the taste perception and GI-related ones, and lasted longer. Still, it all turned out to be very worthwhile.
Can you get a PSMA-PET scan with your PSA being that low?
@@user-ig6hj5mr8g Can? Yes. Will? No. If (well, when) my PSA climbs up above 0.5, that is when I will pursue a PSMA-PET scan. I hold out hope that is a long time off yet.
Question. If you used radiation alone wouldn't that kill the cancer. And wouldn't it thus lower your p s a naturally with no medications. It seems to me that it would. The medications are only there to get money to the pharmaceutical companies. Boy, I am sure confused. I have prostate cancer and I just don't know what to do anymore. Please, Someone please reply to my dilemma. I don't know why doctor schultz is so against surgery. After listening to all the horror stories with the side effects with radiation and medication I am thinking about surgery. I am gleason seven and only in the prostate. Hoping surgery would just get it all out end of story. I think I would rather have diapers for a long time rather than going through the side effects of a d t.
Turkey tail, ivermectin, fenbendazole ...
😄😎