20. Human Genetics, SNPs, and Genome Wide Associate Studies
ฝัง
- เผยแพร่เมื่อ 4 มิ.ย. 2024
- MIT 7.91J Foundations of Computational and Systems Biology, Spring 2014
View the complete course: ocw.mit.edu/7-91JS14
Instructor: David Gifford
This lecture by Prof. David Gifford is on human genetics. He covers how scientists discover variation in the human genome. He discusses how to prioritize variants based on their importance. And then covers how to prove causation, not just correlation.
License: Creative Commons BY-NC-SA
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hands down one of the best lectures I've ever seen about this. Absolutely incredible, and surprisingly accessible.
I agree. absolutely amazing, fine explanation for the non-professional in computational bio either
A truly well-delivered lecture is a beautiful thing to behold.
Been looking for a good video that can give me an overview of GWAS. This is great. Thank you.
me too,
A beautiful lecture that helps me learn a lot, thank you very much professor!
A beautiful lecture, this helped me a lot in GWAS background study.
Great teacher
Thank you.
I have a question which I am unable to find in published papers. Does a small term or long term stress (any kind of) could introduce SNPs in an individual (or any species)?
Whoever spoke up at ~54:18 --- plz be my friend
1:14:03 Association Variant Pedigrees (enhancers & mutating NSP position tests to elucidate promoter of gene proper) [causality claims of fctn]
Does anyone know where the plot at 30:00 is from? I can't seem to find it anywhere.
RMF 'bug cln .
19:15 Polygenetics (maybe, nearly, w/no follow up replication or Tx/Rx) comes up w/the win for 50& genetic loading for associated risk, maybe probably.
You sound very confident
Take love from Bangladesh😍
57:25 assuming independant reads, eq from ma/da (Haplo lily pi fcnt)[Bayes Inf]
I feel bad because the class is very unresponsive to the point where the teacher starts to disengage about 20 minutes in. At which point the lecturer and the students lose a connection (my hypothesis), and he starts to doubt how interested everyone is. We appreciate you Mr David Gifford, don't ever forget that! Always believe in yourself and don't let the dulled minds of the mob get you down!
1:48 fewer assumption analysis
42:16 steps for gene check
I have a theory that onc u start losing sleep.....it's a slippery slope...brain areas deactivat...less sleep needed....less of several functioning
1:16:30 Ident twins studies show no great personal genome med promise in path, nor risk reduction in neg findings.
1:07:15 Local assembly of reads
32:44 In recessive illness, taking out primary in x+y line = bad news [phasing of varience]
1:15:38 monozygo twins brawl starter in genetics bars
4:13 A lot of correlational gobbledegook, given the claims that some corners of this field keep making - that lead no where
The person who opened a can at the beginning is kinda rude.
41:38 reads irl
12:20 this is why genetic research never leads anywhere.