Don't quote me because I may not be correct about this, but I believe that is due to the relatively high charge at the synapse diffusing to all of the rest of the cell body. For example, say you were to put a drop of food coloring into a small cup of water. There will be a high concentration of that food coloring at the site that it enters the water, but it will quickly distribute throughout the rest of the cup and become less concentrated. I assume this is a similar process to what happens to the charge from positive ions entering the neuron at the synapse as they progress toward the axon hillock.
Hey, opening of K+ channels will decrease the membrane potential by efflux of K+ ions, so it will lead to the membrane potential being more negative, i dont think that should be an example in EPSP? Anyone?
Glutamate typically acts at excitatory receptors such as NMDA and AMPA receptors. These are very complex and can promote the passage of Na+, Ca++, and K+ through the membrane depending on the local voltage. You are correct though that K+ flows out of the cell and decreases resting potential. That probably should have said Na+ and Ca++ for EPSPs instead.
Appreciate the way information is organized properly and explained :)
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Brilliant explanation of this concept & pretty good illustration for students of pharmacology & medicine.
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Very well explained thank you! just one question isn't the release of potassium ions a reason for inhibitory in the synapse?
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May i ask why there will be a lost in voltage across the neurone?
Don't quote me because I may not be correct about this, but I believe that is due to the relatively high charge at the synapse diffusing to all of the rest of the cell body. For example, say you were to put a drop of food coloring into a small cup of water. There will be a high concentration of that food coloring at the site that it enters the water, but it will quickly distribute throughout the rest of the cup and become less concentrated. I assume this is a similar process to what happens to the charge from positive ions entering the neuron at the synapse as they progress toward the axon hillock.
great explanation, thank you!
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Hey, opening of K+ channels will decrease the membrane potential by efflux of K+ ions, so it will lead to the membrane potential being more negative, i dont think that should be an example in EPSP? Anyone?
Glutamate typically acts at excitatory receptors such as NMDA and AMPA receptors. These are very complex and can promote the passage of Na+, Ca++, and K+ through the membrane depending on the local voltage. You are correct though that K+ flows out of the cell and decreases resting potential. That probably should have said Na+ and Ca++ for EPSPs instead.
While that's true to some extent, Na+ inflow is far greater than K+ outflow resulting in a net increase in membrane potential
You are right, it will be calcium instead of kalium
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Helpful, thanks!
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Effect of various potential has to gather
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Several presenaptic reach post at same time
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