Links for this episode 03:45 Hospital admissions during Omicron and Delta variant outbreaks (Lancet) 06:20 Viral load in unvaccinated and vaccinated individuals (Nat Med) 12:04 Predictive Capability of symptoms in children (Clin Inf Dis) 12:26 Comparison of antigen tests (medRxiv) 21:53 Incidence of Myocarditis after COVID19 and non COVID19 vaccination (Lancet) 26:05 Steroids during viral replication phase (Resp) 27:03 Paxlovid efficacy and safety (Pfizer) 27:05 Paxlovid for standard risk patients 32:55 Fluvoxamine and Outpatient Management (JAMA) 37:23 Sabizabutin efficacy and safety (Veru) 41:01 Colchicine and lack of benefit (Lancet) 42:16 SARS CoV 2 prevalence in Africa (medRxiv) 43:46 Reducing risk over the holidays 44:27 Contribute to ASTMH fundraiser at PWB Dr Griffin’s treatment guide 45:14 Letters 45:21 Eben 6 year old periocarditis is it long term 47:27 Charlie 75 year old covid with risks and antivirals 49:18 Jessie 85 year old covid and Paxlovid 51:21 Philip Dengue survivor and dengue vaccine Second illness can be more deadly
The objective of the Zoe project when mentioning altered symptom profile (or really a complete symptom profile) is not differentiating between the variants. It's about getting GB officials to modify their information when to suspect Covid and get a test.
For me, at this point, this is the quote that really matters: "We need all hands on deck. If the providers out there are not educating their patients, are not advocating for their patients, are not communicating the urgency of responding in that window, yeah, our hospitals are gonna start to get busier."
This breakdown on treatment of Covid is so vital and informative. I am sending this to my brother and his family. This episode should be mandatory viewing.
Listening to these two guys talk about COVID is always a highlight of my week. I do hope, though, and I say this with utmost and enormous respect, I hope it won't be a highlight of my week a year from now.
It is discussed in relation to Zika: TWiV 454 (Aug 14, 2017) TWiV 410 (Oct 9, 2016) Also see ref: Does prior dengue virus infection exacerbate Zika virus disease? virology ws
My 1 1/2 year old son has been sick it seems for months he has congestion and stuffed nose. We caught covid back in late December of 2021. 😢 the peditrician has not done any serious testing they keep assuming he is teething or ear infection and just give amoxcillin. He has all his teeth and no ear infection, this has been constant...it scares me to death.
@@gribbler1695 in the amount of people with upper respiratory tract infections, theses guys are dumb enough to say kids need to be vax so they could horrifically unusual when they're only just slightly elevated for narrative effect
hi I am trying to understand the wave pattern have been doing CAI on the way up and the way down per country...haven found anything yet ...only that CAI ranges 0.68 to 0.709 . then decided to optimize...an use optimized per orf and use that as a blast ro check on %similarities . but no luck yet as to find an insilico reason ...maybe need control on sequences by outcome and symptoms ...as raw data at NCBi just by date nothing yet
@@gferraro8353 yes just found out. In UK the BBC reported not any of the HV A to E....and reacently suspected Anedenovirus? If you find new info please share. Thanks
@@gferraro8353 yes they tested, article says some tested positive, how ever info is limited as kind of test (i.e.Antigen, Ab,PCR) CDC in Atlanta maybe looking hope more info is available soon
Most of the severe illness is the result of how your immune system responds to infection, i.e. cytokine storms. This is why monoclonals need to be given as early as possible to have benefit. If you observe disease progression, there is something informally termed the "dead cat bounce" which represents the time between the initial illness from the infection and the resulting illness from the cytokine storms which ultimately causes fatality. People often think they've recovered and then the results of the cytokine storms escalate. The earlier you get monoclonals, the lower the damage from that secondary mechanism.
74 cases of child hepatitis, in uk since Jan 2022. 6 liver transplants needed so far but no deaths. Is there any link to covid? That's the question. NONE of the children had been vaccinated against covid 19, and the WHO is saying parents should be watching out for symptoms of hepatitis and ensure their children employ good hand sanitation. Are you hearing anything similar in US??
@@gferraro8353 thank you, I am usually sleeping when they do Q&A, so have to watch on a catchup. I'll keep my fingers crossed that you get on the chat, and that they can respond. All the best to you, from London. Xx
About a week ago a 16 year old boy died of myocarditis 2- 3 weeks after 1st Pfizer dose, here in NZ. We will never know if the vax caused it but it is thought likely. It must be incredibly rare, and his parents surely understand this - they make a point of saying they do not want their child's death to put people off getting vaxxed, or to be used by anti-vaxxers.
Looking at what Russia is willing to do to civilians and the lies they tell , sure seems plausible they filled the net full of antivax and anti max rubbish.
According to Pfizer, it is about 1 in 10,000 in the general population but we know that it is much much higher in young males 12-35. I don't think it can be called rare in that population.
Does catching the FLU make you "weaker" vs. coronavirus...or perhaps other viruses as well during your illness? I mean, we never really checked before, but what if once your body is fighitng one virus, you're more succeptible to infection with other viruses of the same area effect. Like T-Cell or B-Cell depletion mechanism perhaps? I mean, if we start testing people for lots of things, would we find influenza hospitaliztions include mostly those with RSV, Rhino, etc. co-infections?
Yes, UK study on co-infections SARS-CoV-2 & other RID (7000), found 70% increased risk of ICU & ventilation, 50% increased risk of death with combination of SARS-CoV-2 and influenza infections. SARS-CoV-2 plus adenovirus, increased risk of death. From memory, think there might have been increased risk of hospitalisation with SARS-CoV-2 and RSV co-infections.
@@RiDankulous Yes, prompted me to book in for a flu shot (beginning of flu season in AU, southern hemisphere). Here's source of stats: (Australian podcast) Coronacast: Our first proper flu AND covid season looms Wed 6 Apr 2022 And I imagine they were quoting from the following study: SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses Lancet. 2022 16-22 April; 399(10334): 1463-1464.
Re: the patient co-infected with flu and COVID. How can you tell these two diseases are present as distinct clinical entities when there is so much symptom overlap?
Did the Lancet article separate out myocarditis seen in young men post vaccination? Sadly, I've lost confidence in The Lancet since their rather humiliating Surgisphere debacle.
No. 'Most of the studies included in our analysis did not report on myocarditis or pericarditis specifically, but grouped both complications under the umbrella term myopericarditis.' The article is covered here: Myocarditis low after COVID-19 vaccination, but odds elevated in male teens, young adults (Healio, January 25, 2022)
Well my Good Friday dinner was a Covid spreader. It is not a nice feeling. I tested positive this morning. Glad that we are all vaccinated. My young grandkids are not. I am very worried for them. I should have known better. My son had it and didn't have symptoms till the wee hours of Saturday morning.
Q - Why did India not allow mRNA vaccines to be used in their country? A - Moderna and Pfizer will not accept legal responsibility for the safety of their product. Q2 - Why isn't this question allowed by the moderator (this will be deleted soon). Cheers!
I suppose you are trying to introduce FUD( fear, uncertainty, and doubt) into vaccination. But India itself is a vaccination powerhouse. They are testing their own mRNA vaccines. 11.4 billion doses of SARS2 vaccine have been administered, many of them mRNA based. The vaccines have a superb risk-reward ratio.Your doctor can tell you which kind of vaccine is right for you or if you are in a subgroup that should have the doses spaced farther apart. timesofindia.indiatimes.com/india/phase-23-trial-data-of-indias-first-mrna-covid-vaccine-submitted-to-dcgi/articleshow/90312071.cms
And some other reasons - they cost a few times more than their local vaccine (AZ's Covidshield), and much of India lacks the ultra-cold storage necessary. They are trialling their own mRNA vaccine now, which overcomes these issues. Will it have a similar safety profile?
I would really like to know if anyone has looked at the incidence of myocarditis in vaccination changed when we stopped regularly checking to make sure the needle hadn’t hit a vein. There are enough people who were taught to check for that saying they rarely saw blood, but in their careers they did see it happen. At what rate? 33 in a million maybe? But I think we would have to keep track of method of injection on a large scale to test the theory now.
It is not. 'Throughout this period [Omicron wave January 6-March 21, 2022], the COVID-19 mortality rate in Hong Kong (37.7 per million population) was among the highest reported worldwide since the COVID-19 pandemic began' Ref: COVID-19 Mortality and Vaccine Coverage - Hong Kong Special Administrative Region, China, January 6, 2022-March 21, 2022
do you have a viable culture as evidentiary support for theoretical propositions? Or are you simply ignoring boolean algebra? One thing is certain, it is obvious how superstitions and religious dogma starts.
@@fslknsadglkdahawerykljwa3aw643 you think using aborted embryonic trachea tissue is evidence for HCoV-OC43 in the 1960's? Do you need any further translation? Or is your despotic fiscal ideology incapable of comprehending the scientific method?
Having a BA in microbiology and an MA in computer science, I feel qualified to say that boolean algebra has nothing to do with virology. There are no logic gates in tissue culture. Stop spamming us,
@@deborahfreedman333 so the pea experiment has nothing to do with evolution every four years... I think you should return your qualifications for proper qualifications! You do know polymer chains are measured in bytes? Now provide one culture as evidentiary support to validate your acumen! 30 years of speeding up generations of e-coli with two base pairs and it is only now thought a speciation event occurred.
Links for this episode
03:45 Hospital admissions during
Omicron and Delta variant outbreaks (Lancet)
06:20 Viral load in unvaccinated and vaccinated individuals (Nat Med)
12:04 Predictive Capability of symptoms in children (Clin Inf Dis)
12:26 Comparison of antigen tests (medRxiv)
21:53 Incidence of Myocarditis after COVID19 and
non COVID19 vaccination (Lancet)
26:05 Steroids during viral replication phase (Resp)
27:03 Paxlovid efficacy and safety (Pfizer)
27:05 Paxlovid for standard risk patients
32:55 Fluvoxamine and Outpatient Management (JAMA)
37:23 Sabizabutin efficacy and safety (Veru)
41:01 Colchicine and lack of benefit (Lancet)
42:16 SARS CoV 2 prevalence in Africa (medRxiv)
43:46 Reducing risk over the holidays
44:27 Contribute to ASTMH fundraiser at PWB
Dr Griffin’s treatment guide
45:14 Letters
45:21 Eben 6 year old periocarditis is it long term
47:27 Charlie 75 year old covid with risks and antivirals
49:18 Jessie 85 year old covid and Paxlovid
51:21 Philip Dengue survivor and dengue vaccine
Second illness can be more deadly
thank you Les!
Yes, thanks for this, I never thought I needed it until you did it. 🤘
Thanks Les
Thank you Professor Vincent and Dr. Daniel Griffin as always for the clinical updates.
Thanks Vincent and Daniel! I stay up every Friday night to get caught up.
Me too 🤣
Comes out Saturday afternoon here - no need to stay up, usually watch before dinner Saturday night.
@@strphenz Saturday breakfast time for me in Turkey.
The objective of the Zoe project when mentioning altered symptom profile (or really a complete symptom profile) is not differentiating between the variants. It's about getting GB officials to modify their information when to suspect Covid and get a test.
From ireland good to see ye,thanks for all ye do just love when I'm awake to be part of yer podcasts vincent look forward to all
Great quotation this week!
Yes!!
Asimov rock the world!!!!
Thanks Vincent and Daniel. From Queensland Australia 🙂
For me, at this point, this is the quote that really matters:
"We need all hands on deck. If the providers out there are not educating their patients, are not advocating for their patients, are not communicating the urgency of responding in that window, yeah, our hospitals are gonna start to get busier."
This breakdown on treatment of Covid is so vital and informative. I am sending this to my brother and his family. This episode should be mandatory viewing.
Listening to these two guys talk about COVID is always a highlight of my week.
I do hope, though, and I say this with utmost and enormous respect, I hope it won't be a highlight of my week a year from now.
Glad you mention Zoe and emerging treatment possibilities. Also intrigued on the dengue topic. Prayers for peace and health in this holiday season.
This talk is so incredibly informative, Dr. Griffin. Thank you on behalf of everybody listening to you. You are a hero.
Any Twiv regs know which episode discusses Dengue with ADE & FC receptors?
It is discussed in relation to Zika:
TWiV 454 (Aug 14, 2017)
TWiV 410 (Oct 9, 2016)
Also see ref: Does prior dengue virus infection exacerbate Zika virus disease? virology ws
@@gribbler1695 Thank you!
Thank you, happy Easter or Passover. Thanks for all you do.
Not sure Vincent will see this. But this update isn't yet up on Spotify. Not sure if that's an oversight.
Thank you! Very specific and informative.
My 1 1/2 year old son has been sick it seems for months he has congestion and stuffed nose. We caught covid back in late December of 2021. 😢 the peditrician has not done any serious testing they keep assuming he is teething or ear infection and just give amoxcillin. He has all his teeth and no ear infection, this has been constant...it scares me to death.
Go to a different doctor. You have a right to a second opinion.
Thanks for the excellent update. Happy Easter.
What are the numbers from 2018 to compare and see if theirs a difference?
A difference in what?
@@gribbler1695 in the amount of people with upper respiratory tract infections, theses guys are dumb enough to say kids need to be vax so they could horrifically unusual when they're only just slightly elevated for narrative effect
Great quote, and always look forward to this great informative,entertaining channel.
Thanks from🇿🇦
hi I am trying to understand the wave pattern have been doing CAI on the way up and the way down per country...haven found anything yet ...only that CAI ranges 0.68 to 0.709 . then decided to optimize...an use optimized per orf and use that as a blast ro check on %similarities . but no luck yet as to find an insilico reason ...maybe need control on sequences by outcome and symptoms ...as raw data at NCBi just by date nothing yet
codon pair deoptimization..still learning about
how optimized CAI are the mARN vaccine sequences? compared to circulating viral S sequences?
any news on the hepatitis observed in UK and elsewhere in the las 2 weeks?
@@gferraro8353 yes just found out. In UK the BBC reported not any of the HV A to E....and reacently suspected Anedenovirus? If you find new info please share. Thanks
@@gferraro8353 thanks maybe you are as me member on a MIS-C support group. Have a great wekend, its a small world after all
@@gferraro8353 yes they tested, article says some tested positive, how ever info is limited as kind of test (i.e.Antigen, Ab,PCR) CDC in Atlanta maybe looking hope more info is available soon
Can you give monoclonals a bit later a still get benefit ?
Most of the severe illness is the result of how your immune system responds to infection, i.e. cytokine storms. This is why monoclonals need to be given as early as possible to have benefit. If you observe disease progression, there is something informally termed the "dead cat bounce" which represents the time between the initial illness from the infection and the resulting illness from the cytokine storms which ultimately causes fatality. People often think they've recovered and then the results of the cytokine storms escalate. The earlier you get monoclonals, the lower the damage from that secondary mechanism.
Yes it is true without doubt but I’ve read newspaper reports of some feeling lousy with mild shortness of breath getting Paxlovid and getting better .
Ugh that bar chart. Edward Tufte would have a field day with that thing.
74 cases of child hepatitis, in uk since Jan 2022. 6 liver transplants needed so far but no deaths. Is there any link to covid? That's the question. NONE of the children had been vaccinated against covid 19, and the WHO is saying parents should be watching out for symptoms of hepatitis and ensure their children employ good hand sanitation. Are you hearing anything similar in US??
@@gferraro8353 oh dear. I hope they find the link to the cause and put out some good advice to parents.
@@gferraro8353 thank you, I am usually sleeping when they do Q&A, so have to watch on a catchup. I'll keep my fingers crossed that you get on the chat, and that they can respond. All the best to you, from London. Xx
About a week ago a 16 year old boy died of myocarditis 2- 3 weeks after 1st Pfizer dose, here in NZ. We will never know if the vax caused it but it is thought likely. It must be incredibly rare, and his parents surely understand this - they make a point of saying they do not want their child's death to put people off getting vaxxed, or to be used by anti-vaxxers.
Look up Ernest Ramirez
He is also 16 year old died in his yard after dose.
Looking at what Russia is willing to do to civilians and the lies they tell , sure seems plausible they filled the net full of antivax and anti max rubbish.
According to Pfizer, it is about 1 in 10,000 in the general population but we know that it is much much higher in young males 12-35. I don't think it can be called rare in that population.
His parents are good people, they aren't letting their grief prevent them from being compassionate
The antidote to coronavirus is ammonia.
Hungarian discovery November 2021
OGYI13376
Search for it!
I went to show notes, and the links didn't work. I'll try later. Is that normal?
Does catching the FLU make you "weaker" vs. coronavirus...or perhaps other viruses as well during your illness? I mean, we never really checked before, but what if once your body is fighitng one virus, you're more succeptible to infection with other viruses of the same area effect. Like T-Cell or B-Cell depletion mechanism perhaps? I mean, if we start testing people for lots of things, would we find influenza hospitaliztions include mostly those with RSV, Rhino, etc. co-infections?
You should come back and ask this on the Q&A with A&V.
Yes, UK study on co-infections SARS-CoV-2 & other RID (7000), found 70% increased risk of ICU & ventilation, 50% increased risk of death with combination of SARS-CoV-2 and influenza infections. SARS-CoV-2 plus adenovirus, increased risk of death. From memory, think there might have been increased risk of hospitalisation with SARS-CoV-2 and RSV co-infections.
@@RiDankulous Yes, prompted me to book in for a flu shot (beginning of flu season in AU, southern hemisphere).
Here's source of stats: (Australian podcast)
Coronacast: Our first proper flu AND covid season looms
Wed 6 Apr 2022
And I imagine they were quoting from the following study:
SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses
Lancet. 2022 16-22 April; 399(10334): 1463-1464.
Re: the patient co-infected with flu and COVID. How can you tell these two diseases are present as distinct clinical entities when there is so much symptom overlap?
Testing?
It’s covered in the video.
@@Gieza-Brake-Pahl So you can't just tell me? I already watched the video. Not helpful.
@@agentsmithisalive it was the molecular testing...
@@jac9366 Thank you!
5:45 ủa chỗ này là sao ta?
Did the Lancet article separate out myocarditis seen in young men post vaccination? Sadly, I've lost confidence in The Lancet since their rather humiliating Surgisphere debacle.
I would think each study needs to be judged on it's own merit rather than where it's published?
No. 'Most of the studies included in our analysis did not report on myocarditis or pericarditis specifically, but grouped both complications under the umbrella term myopericarditis.'
The article is covered here: Myocarditis low after COVID-19 vaccination, but odds elevated in male teens, young adults (Healio, January 25, 2022)
case in 46:00 check for MIS-C
Do severe initial symptoms - high fever very sore throat prostration portend severe deterioration?
These are great questions to ask on Vincent's livestream Q&A show on Wednesday evenings 8.30 pm
My neighbor's just said they were all diagnosed with the flu.. it must be lagging this year in AZ. It's been over 90• and it's past 3/31.
Well my Good Friday dinner was a Covid spreader. It is not a nice feeling. I tested positive this morning. Glad that we are all vaccinated. My young grandkids are not. I am very worried for them. I should have known better. My son had it and didn't have symptoms till the wee hours of Saturday morning.
Q - Why did India not allow mRNA vaccines to be used in their country?
A - Moderna and Pfizer will not accept legal responsibility for the safety of their product.
Q2 - Why isn't this question allowed by the moderator (this will be deleted soon).
Cheers!
I suppose you are trying to introduce FUD( fear, uncertainty, and doubt) into vaccination. But India itself is a vaccination powerhouse. They are testing their own mRNA vaccines.
11.4 billion doses of SARS2 vaccine have been administered, many of them mRNA based. The vaccines have a superb risk-reward ratio.Your doctor can tell you which kind of vaccine is right for you or if you are in a subgroup that should have the doses spaced farther apart.
timesofindia.indiatimes.com/india/phase-23-trial-data-of-indias-first-mrna-covid-vaccine-submitted-to-dcgi/articleshow/90312071.cms
And some other reasons - they cost a few times more than their local vaccine (AZ's Covidshield), and much of India lacks the ultra-cold storage necessary.
They are trialling their own mRNA vaccine now, which overcomes these issues. Will it have a similar safety profile?
I would really like to know if anyone has looked at the incidence of myocarditis in vaccination changed when we stopped regularly checking to make sure the needle hadn’t hit a vein. There are enough people who were taught to check for that saying they rarely saw blood, but in their careers they did see it happen. At what rate? 33 in a million maybe? But I think we would have to keep track of method of injection on a large scale to test the theory now.
What specifically is wrong with taking aspirin if you have covid? Dont they recommend ibuprofen? Why would that be a good idea and aspirin bad?
Two completely different drugs. Listen to his explanation.
Does no one dare say this omìcron is less virulent
It is not.
'Throughout this period [Omicron wave January 6-March 21, 2022], the COVID-19 mortality rate in Hong Kong (37.7 per million population) was among the highest reported worldwide since the COVID-19 pandemic began'
Ref: COVID-19 Mortality and Vaccine Coverage - Hong Kong Special Administrative Region, China, January 6, 2022-March 21, 2022
It’s sabizibuLin
Chúc cho Đức Thật nhiều sức khỏe.
25
do you have a viable culture as evidentiary support for theoretical propositions? Or are you simply ignoring boolean algebra? One thing is certain, it is obvious how superstitions and religious dogma starts.
This is an amazing shitpost, please keep it up!
That's a big word salad for saying you didn't comprehend anything the doctor said.
@@fslknsadglkdahawerykljwa3aw643 you think using aborted embryonic trachea tissue is evidence for HCoV-OC43 in the 1960's?
Do you need any further translation? Or is your despotic fiscal ideology incapable of comprehending the scientific method?
Having a BA in microbiology and an MA in computer science, I feel qualified to say that boolean algebra has nothing to do with virology. There are no logic gates in tissue culture. Stop spamming us,
@@deborahfreedman333 so the pea experiment has nothing to do with evolution every four years... I think you should return your qualifications for proper qualifications! You do know polymer chains are measured in bytes? Now provide one culture as evidentiary support to validate your acumen! 30 years of speeding up generations of e-coli with two base pairs and it is only now thought a speciation event occurred.