Thank you for all involved in diagnosis and treatment of patients. Sometimes, cytosines in CAG triplets suffer a methylation followed by spontaneous deamination, resulting in the transformation of the CAG triplet into a STOP codon TAG. Glycosylases sometimes can't remove the error in time. Perhaps inhibitors of DNA methylation used to treat a form of leukemia, should be investigated as a potencial mean to retard the onset of diseases related to changes in the CAG triplet.
My otherwise healthy 50 yr old school teacher Aunt was diagnosed with familial ALS March 6, 2021. She died Sun Nov 28 just after midnight. She is my father's 3 rd sybling to die of it and by far the fastest. We are devastated. We live in constant fear of who next?
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Is a blood NFL test easy for one to get - or is this something available only at specialized medical institutions?
Thank you for all involved in diagnosis and treatment of patients.
Sometimes, cytosines in CAG triplets suffer a methylation followed by spontaneous deamination, resulting in the transformation of the CAG triplet into a STOP codon TAG. Glycosylases sometimes can't remove the error in time.
Perhaps inhibitors of DNA methylation used to treat a form of leukemia, should be investigated as a potencial mean to retard the onset of diseases related to changes in the CAG triplet.
My otherwise healthy 50 yr old school teacher Aunt was diagnosed with familial ALS March 6, 2021. She died Sun Nov 28 just after midnight. She is my father's 3 rd sybling to die of it and by far the fastest. We are devastated. We live in constant fear of who next?