I also think this is wrong , because the carboxylic acid would get deprotonated by the amine to form a carboxylate salt. The salt can undergo dehydration to form your desired amide under high temperatures (140 - 210C suggested in calyden Chapter 11) I would suggest the use an ester or a more reactive acid chloride with an amide so that you get a successful substitution. Forgot to mention that there is no need for C=O activation as amides are already very good nuclephiles and carboxilic acids decent Electrophiles.
And even if protonation of the carbonyl oxygen occurred, this would be an extremely acidic proton and this be deprotonated by the amine which again would render it non-nucleophilic
also carboxylic acids react with amines to form a carboxylate ion and an ammonium ion, which would then make the carboxylate unable to undergo nucleophilic attack
Thanks, that was helpful, I think your videos would be better if you removed your hands more often so people could see the overall reaction or take a screen shot.
This is not the correct mechanism for amide formation LOL since primary amine is relatively basic and carboxylic acid is acid 1* amine will just grab the H from carboxylic acid and the reaction will stop right there. Garbage video
I also think this is wrong , because the carboxylic acid would get deprotonated by the amine to form a carboxylate salt. The salt can undergo dehydration to form your desired amide under high temperatures (140 - 210C suggested in calyden Chapter 11) I would suggest the use an ester or a more reactive acid chloride with an amide so that you get a successful substitution. Forgot to mention that there is no need for C=O activation as amides are already very good nuclephiles and carboxilic acids decent Electrophiles.
This mechanism is not in my book and is SO hard to find on google, thank you so much for making this.
Yes I do love amides, particularly lysergic ones
Marc Jou
Fuck off then
@@gretawilliams8799 I do not think you got the joke mate :)
haha this is funny.
love the ending. and thanks for uploading
Thie Curtis
Fuck off then
Shouldn't we use an Acyle Halide RC=O(Cl), instead of a carbossilic acid to prevent a neutralisation reaction?
AMINE CANT REACT WITH CARBOXYLIC ACID
@@tktkho4415 i think it can and make amides
Is there oxynium ??
What if there are 2 moles of the amine?
Any proton source would render the amine non-nucleophilic.....
And even if protonation of the carbonyl oxygen occurred, this would be an extremely acidic proton and this be deprotonated by the amine which again would render it non-nucleophilic
also carboxylic acids react with amines to form a carboxylate ion and an ammonium ion, which would then make the carboxylate unable to undergo nucleophilic attack
this guy is right lol the amine would be way more basic than the carboxylic acid
Why does the proton transfer happen?
Thanks, that was helpful, I think your videos would be better if you removed your hands more often so people could see the overall reaction or take a screen shot.
Coooool!!!
This is not the correct mechanism for amide formation LOL since primary amine is relatively basic and carboxylic acid is acid 1* amine will just grab the H from carboxylic acid and the reaction will stop right there. Garbage video
yes you are right, in actual this reaction take place in the presence of DCC, DCC induced coupling to form an amide linkage.
@@surajmahaguru309 DCC is not water soluble, EDC will work probably.
I don’t get it
@shrutivenkatesh3416 did you get it ?