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You just did CPR on my study session!! Thank you!
proton transfers are my fav little game
love the explanation thanks !!!
If there was only HCl with no water would Cl- be deprotonating or would the amine reagent act as a base and deprotonate?
Wow, somehow I expected an indian dude to save me again
Just remember that all of the steps are reversible
Yes, and I definitely should have used reversible arrows (forgot).
Just remember if you are on fire , STOP, DROP and ROLL ... what am I doing 😞
Why does this mechanism even happen. Wouldn't the amine get consumed by the acid and lose its nucleophilicity
A weak acid is typically used for this reaction (pka 4-5) so the amine shouldn’t get protonated, only the O will get protonated to a water molecule to form a good leaving group
Thank you so much for this video, you are the first person on TH-cam that has actually made me understand the content (and made me pass my exam)🫶
You just did CPR on my study session!! Thank you!
proton transfers are my fav little game
love the explanation thanks !!!
If there was only HCl with no water would Cl- be deprotonating or would the amine reagent act as a base and deprotonate?
Wow, somehow I expected an indian dude to save me again
Just remember that all of the steps are reversible
Yes, and I definitely should have used reversible arrows (forgot).
Just remember if you are on fire , STOP, DROP and ROLL ... what am I doing 😞
Why does this mechanism even happen. Wouldn't the amine get consumed by the acid and lose its nucleophilicity
A weak acid is typically used for this reaction (pka 4-5) so the amine shouldn’t get protonated, only the O will get protonated to a water molecule to form a good leaving group
Thank you so much for this video, you are the first person on TH-cam that has actually made me understand the content (and made me pass my exam)🫶