If they could make a product that would extend a dog's life, that would generate enough income to fund aging research for decades. People love their pets! Who wouldn't want their dog to live longer?
@@0202-n7wIf I could make a momma beef cow live 2 years longer, that would be almost $3000 I could make. Times 100 cows is $300,000. Sign me up. Right now, to cull out a cow you have to sell her at a low price times scale weight. And you either have to buy a new younger cow or allow one of your heifers to join the herd. You lose money by keeping a cow you couldve sold. Then you gotta wait for her to get pregnant, hope she has an easy birth, then wait for that calf to get big enough to sell. And a cow you buy may already be a few years old, she may or may not have a calf already. It can be a multi year process before you make profit again. Even a 2 year extension would be a drastic improvement.
Have you seen Vladimir Putin lately? He literally looks younger than he did 5 years ago. He's 71 I recently saw him do a backflip. And guess who in reality is the world's richest man? Yeah he's pretty much The real world version of Doctor Doom!
The IL-11 gene knockout seems the most valid and researched. The Telomere repair drug would be the easiest to use. I hope that both continue to pursue and publish research.
Hi Lifespan News, I was wondering if you've been following the work of American biologist Michael Levin. His research in areas like aging, cancer, and regenerative medicine seems groundbreaking. From what I’ve seen, he’s onto something potentially transformative in how we approach these challenges. I highly recommend keeping an eye on his work.
Telomere length matters more, the more times that the cell has already replicated. Daughter cells are more sensitive to the reduction. This doesn't matter until well into geriatric years. Telomeres may be important for reducing cancer rates during targeted demythylization.
3:00 The first time I heard about the new telomere drug was about a dog that got their cancer cured, which immediately did not make sense to me, as previous telomere lengthening drugs would actually cause cancer, which is why no telomere treatments are available yet, despite telomerase being known for over 2 decades. So I don't have high hopes. I have not heard of IL-11 before, so I have no idea what to make of it. But it is weird that the gene stuck around for so long, so maybe it is good for something in early life? 10:15 Yeah, the telomere drug sounds too good to be true. I'd love to be wrong though.
It was feared that extending telomeres would cause cancer (or something indistinguishable from it, actually), but when scientists successfully modified mice with very long telomeres they lived healthier lives and were less likely to die of cancer, or die of it later (mice usually die of cancer rather than heart disease). We don't know if that will hold for humans...probably. There are less senescent cells, so less inflammation from the "Senescence-associated secretory phenotype (SASP)" effects. Which seems like it has more to do with the origins of most cancers. There are humans who were born with longer telomeres. In one population (Nicoya) it seems to help them live longer, but we don't know if people with longer telomeres in general live longer in other places.
My dude, I'm as skeptical as the next guy, but implying that the CEO passing away is somehow reason to be skeptical of their research is pretty simple minded. It's not as if they're claiming to have discovered the literal fountain of youth.
Thank you so much for this video. I saw the ABC news video, and because I so loved my dogs which had passed away, I really wanted to support the research. I thought how nice it would have been if my dogs had access to those pills during her final days. So, I bought some shares immediately. And I was going to ask my friends who love dogs to buy some also. But after watching your video, I started to think. Even if the medication can lessen the demage of the telomere, and cells can duplicate to generate new cells, the effect of reversing aging could not have happened in a few days. Also, how could the medication selectively targeted what cells. If it was not selective, then actually, the cancer cells could grow aa much as the healthy cells. Not to mention that arthritis is the inflammation of the joints which cannot be resolved even if cells duplicate. One needs to modulate the immune system instead of just making cells divide non selectively. Basically, my senses came back. The ABC news video plays to our emotions as we love our dogs sooo much that we are thinking with our heart, not our brain. I just sold all my TELO stock at a very small loss. Thank you.
The herb Astragalus is one of the few natural sources of telomerase, while Lutein blocks the iL-11 pathway. Been using Astragalus for years and it does seem to slow down aging. Just started the Lutein so it's too soon to say yet. Astragalus has been known as a 'longevity' herd in Chinese medicine for centuries.
One does not preclude the other. You need, on top of the basics, is the trifecta of longer telemeres, mitochondrial health (NAD+ and sirtuin), and clearing old cells (senescent).
It's interesting that both stories involve interleukins (11 and 17) the one thing I do understand, is the reduction of inflammation may improve health.
The molecule is Cycloastragenol. There is more than one species of Astragalus, so there is no guarantee that the Astragalus extract you buy has that. Swanson has a Telomere Formula. I trust Swanson, they are pretty decent. Lots of supplement scammers out there. I just get heart palpitations when I take the stuff, though. Don't expect it to lengthen anything but telomeres for white blood cells. Those naturally extend. Cycloastragenol just turns on that natural mechanism. The body needs some cheats to get around the Hayflick cellular division limit. For red blood cells, that cheat is that the circulating red blood cells don't have nuclei. That is why they have that crazy dimple shape. The thing that normally would be in the center...DNA is missing because it never divided. Cells are limited to about 50 divisions after birth. As the life of a red blood cell is only 120 days, you would be limited to 6,000 days or 16.4 years, if the DNA divided and there were no tricks. Other cells that have fast turnover may rely on stem cells to refresh their populations. White blood cells have taken the more dangerous path of extending their own telomeres. Dangerous because this is what cancer does, enabling it to divide without limit. They still study cancer using cell lines they gathered in the 1960s. It was feared that extending telomeres would cause people to die of cancer more often. That appears to not be true. When they modified mice to have longer telomeres, they got cancer less rather than more. That was a bit of a shock. The only way we would know if that holds up in humans is to genetically modify human embryos like the mouse embryos were modified. That would be illegal in the US. So any test of the idea would have to take place in some country that would allow it. My guess is that you would get similar results to the mice. People that lived 15--20% longer, who had good glucose, trim, and healthy. Actually, it might not actually be illegal, now that I think about it. I think the modifications were a little different, and would not likely modify the germ line. I could be wrong.
@@Sleepdriver1984 It has very low concentration of active ingredients though. I doubt that even TA-65 shows measurable effect, let alone trace amounts of this stuff found in a plant.
Knowing what I know about biochemistry, it’s never going to be that simple wether it’s through the use of drug chemistry or genome editing, the body has literally millions of chemical switches, when you’re born, they’re tuned like a clock, over time individual homeostatic processes break down in the pipe line, the problem with drugs or using gene editing is that yes they turn on good switches, however, they don’t target the overall big picture of what pattern all of the switches are supposed to activate in, only individual sites. It’s like water locks, at a port, they have to open in a certain orders for a ships to pass through, if the wrong lock opens up at the wrong time, the wrong compartment gets flooded & the ship cannot pass. In other words, drugs often times target one process in a whole line of steps, which eventually causes the body to operate out of synch, hence side effects & in this case, you’ll probably enjoy a couple years of stellar health then systemic burn out will occur.
David Sinclair looks very young for his age also ..... Its the "driving back of Yamanaka Factors" that they are achieving these results that and the Horvath Clocks.....
Yes, well I heard😏 there's been experiments that extended the telomeres but they still lost some cells. But yes it will to some point extend life/life style. I know I am still enthused. 👌🧐😜😎🤙
Clean-up, IL-11! My first response is to wonder why the human genome would hang on to something so destructive. Is it because thinning is good for the herd? But that would necessitate a positive aspect as well that would perhaps allow the animal to reproduce at a preferential rate before nose-diving. Perhaps IL-11 as stated does have some protective qualities in youth that drop out quickly after a certain trigger. I would be reticent to eliminate it without much deeper investigation as turning off a switch that may be unknowingly wired to the mainframe may cause more unforeseen problems in the long run' Likewise throwing enzymes to redress telomeres may lead to hormone changes which the rest of the body is unable to process, e.g. if HGH tries to make bones grow when the formations are already set might this lead to new strains of leukemia? Too bad we spend so much money on erection pill research and vanity drugs for weight loss rather than fix our food system. Fast food - if it doesn't kill you one way, it'll kill you another.
2 dogs tells you absolutely zero. And there is hooey as well. No. Telomeres are not the only thing driving aging. They are not even the biggest. Scientists genetically engineered mice with absurdly long telomeres. They were healthier, but they only lived 12.75% longer. These telomeres were long enough to not contribute to aging. This is the best case, scenario. You are never going to get this good of a result from a drug. And with a drug you have a big obstacle. There is no way to lengthen all the telomeres of all the cells to ideal lengths. If they are phenomenally long, then cell division will take a lot of time. And DNA is most vulnerable in this division phase. The DNA is much more easily damaged by radiation, or chemicals when it is dividing. Being tightly packed in a ball is much safer. At some length, it probably is not even possible to successfully divide. There is no natural stop point where the chromosome's telomeres says "Okay that is a good level, I am full." Also, all the telomere extension I have seen drugs do, has only affected white blood cells. Those telomeres naturally extend. Provoking them to extend is more of a parlor trick, as we are made of a lot more kinds of cells than just white blood cells. If you actually want the other cells' telomeres extended, the only possibility I know of is the genetic modification Elizabeth Parrish had done. Even then, you probably need a massive dose so it runs out of white blood cells, platelets and endothelial cells, and starts affecting other tissues. Anything close to uniform coverage is a pipe dream at this point. No, most of the aging reversal field is no longer focused on telomeres, like they were 25 years ago. We know that we age in many ways, so scientists have been looking at all these other ways and also identifying other ways we age, because the sooner we find them, the sooner we can do something about them. The hottest area at present for reversal is reversing DNA methylation pattern changes. Senescent cell clearance is also interesting and has had some interesting results. Tweaking mitochondria is also big, but you can probably get better results there by just doing 8 minutes of HIIT exercise every day. There are already pills to extend telomeres. But as I was saying, they only extend telomeres for white blood cells. Perhaps still useful. I would not expect anything dramatic. Scamming loving pet owners sounds like a profitable racket. Not saying that is what they are doing... And obviously people are going to say they are ordering it for their dog, but take it themselves. Honestly, who did not think of that? And these guys would be covered. They only sold it to you for your dog. You can't even tell anyone it did not work for you, or it made you sick. I guarantee you, no dog-bone flavor is going to be added.
In addition, (and this may expose my limited understanding of telomeres), the explanation of telomeres protecting the DNA ends, should only be an issue when the telomeres run out. Yet ageing starts in out twenties. I'd think most cells still have plenty of telomere at this age. This seems like a binary effect to me. Also, I'm pretty sure I've heard most people don't run out of telomeres before they die. Anyone please correct my mistakes here, I hate being wrong :)
@@mrleenudler Actually, you start aging when you are just a few divisions in, after fertilization, as per experts in DNA methylation. And some cells at random just divide more often. Unlike what he said here, when cells hit the division limit, many do not just die. They become senescent cells. When the DNA frays, it makes proteins that are coded for in that area. And it makes them like crazy. These pollute the areas around the cells, causing inflammation. This is termed: Senescence-associated secretory phenotype (SASP) and is another driver of aging. But as we are composed of a huge number of cells, we still get senescent cells when we are very young, far less, but even 5-year-olds have them. I don't know when the first ones are formed, but I would not be surprised if we had a few when we were born. It is a complex topic, because some senescent cells may be beneficial helping with healing, when we need a little inflammation. It is assumed there are different types. We are now trying to figure out the different types and trying to develop senolytics (senescent cell killing molecules), that target the bad ones. Some are really crazy. They can be huge and literally eat other cells to get more building blocks to pump out more of those random proteins coded for at the end of the chromosomes. Your cells have different length telomeres. Cells from tissues, that divide more frequently, get shorter quicker...but it is not uniform in each tissue. We also have stem cells which just sit around not dividing until they are called upon. These can refresh the tissues that are wearing down. We have quite a few in the sinuses, as that tissue is frequently damaged by pollution in the air...even from ozone from waterfalls. A tissue can run out of stem cells. One of the first, commonly, is immune system cells, particularly the ones that really target a novel infection. I said before that white blood cells can extend their telomeres. Well, that can be insufficient, as DNA damage accumulates, generation after generation of cells (likely the real reason we have the telomere length we have). Stem cells can rejuvenate and do, but there are less for this system because it needs them less, at least in youth, because they extend their own telomeres, rather than relying on stem cells, generally. This is why there are so many deaths due to flu and other upper respiratory infections in the elderly...they did run low on viable cells to replicate. These are not the first to run out, but when they do, you may not have long to live. The first to run out or run low are cells that make secretions in the skin. Those silly cells make what they are supposed to make and divide to have one of the daughter cells rupture and release the natural moisturizer. They can't divide any more times than other telomere limited cells, so your skin loses the natural moisturizer. But that does not kill. You can buy other moisturizers, and apply them to the skin, of course. There was an experiment (the TRIIM (Thymus Regeneration, Immunorestoration, and Insulin Mitigation) trial) where they did greatly restore the thymus which shrinks in aging because those stem cells run out that help replace DNA damaged immune cells because of the large number of divisions. I suspect it just recruits most of the stem cells that are left. Hard to say if this is good or not. It might just be burning the fuel faster, as it were. If it recruits stem cells that were never likely to be used in the thymus, then it is probably beneficial. The woman that lived the third longest of anyone verified, appears to have died due to too few and poorly diversified immune cells. But you don't have to be that old for this to be a problem. It is #12 in causes of death in the US. #6 in people 90-99. And in 100 and older, it is #4.
Mabye he didnt die... it turned into a 16 year old and now has a new ID... maybe he building up a new team called the Avangers... and he says: "No we need a green guy!" XD
Not sure how wise it is to give someone a drug that turns off the IL-11 gene. Our bodies are a rather complex chemical machine that works to establish balance, so if we just turn off IL-11 what is the other side of the coin we will be giving full function to without anything to inhibit it... This could be good for aging slowly or non-agni, but what if there is another branch to the chemical chain we do not yet understand?????
OK, yeah they need to release the results of these studies. If they really show it works in mice and dogs, that seems like enough to move to human trials to me.
Tbf, they're still testing it. Not even the ceo who died was ready to test it. Since its still pretty new. Since even if it works in dogs it has to be tweaked more for humans.
Dogs are very similar to us in their biology. If a drug works on them, it is much more likely to work on us. Mouse studies rarely translate over to humans.
The proof is in the pudding, the treatments will either work or not. The daylight between medical research and big business is pretty slim these days, so skepticm is always warranted (with David Sinclair as a cautionary tale).
If the good doctor truly believed his drug reversed aging, he should be expected to try ot on himself. After all, who wouldn't, if he really believed it. When I see the good doctor looking 20 years younger, then I will believe him.
reminds me when Malcolm in the original Jurassic Park said: "I'll tell you the problem with the scientific power that you're using here: it didn't require any discipline to attain it. You know, you read what others had done and you took the next step. You didn't earn the knowledge for yourselves so you don't take any responsibility for it. You stood on the shoulders of geniuses to accomplish something as fast as you could and before you even knew what you had, you patented it, packaged it and slapped it on a plastic lunchbox and now you're selling it! Your scientists were so preoccupied with whether or not they could, they didn't start to think if they should." Regarding aging... you can get hit by a bus, game over. LESS THAN 3% mortality annually from old age. Do you want to guess how many pass away from HUNGER annually? but no this is more important? People don't think critically, because this show where funds are allocated, to "resolve a problem which it is not". Comments shows how selfish we became, because there are FAR MORE URGENT problems... however, if anything, given the perspective as I did, it shows ignorance
All you're saying here is that we shouldn't be chewing gum while riding our bike. Traffic safety (getting hit by bus as you mentioned) is constantly being worked on by people in that sector. And now a different sector is working on another cause of death (the medical sector, aging) so why not do both?
@@Torian1o1 All I am saying is that there are more pertinent issues, if we consider the medical industry say Dementia, Cancer, etc... I don't care much whether they do research on increasing our lifespan. I meant no ill intent.
@@xXstevilleXx No ill intent was inferred :) One side note to this though: I don't know how old you are, but I am 35 and though I still have many decades ahead of me, I would certainly like aging to have been solved before I die of age-related causes :P I suspect anyone who likes living would agree, even if most might say 'well yes but maybe when I'm X age I will want to die!'. In my experience, even the very old don't suddenly start thinking 'this is enough, I don't like living anymore' unless they are in constant pain or other suffering.
@@Torian1o1 I completely agree, I am 42 so a bit older, but nonetheless, I mean, I people want to allocate money and resources to prolonging how long we can live, sure, but see here is my concern: it still does not do away with medical conditions as per the two examples mentioned. Personally, I am not concerned about death :) never have been... maybe I am just biased in thinking a good live without all the medical issues opposed an extended live but with the aforementioned unresolved. So, I have nothing against life extension per se, maybe those doing so research do take this into consideration. I do not know, but it is a fascinating video and I do appreciate the kind reply.
@@xXstevilleXx "it still does not do away with medical conditions as per the two examples mentioned." I hear you. Fortunately, research into one thing tends to yield results in other areas too. For example, nuclear bombs + space travel eventually led to MRI and CAT scanners as well as radiotherapy. I'm pretty sure that once we get anti-aging down, that also yields a robust cure for cancer and who knows what else. I'd argue it's better that we do research it than not :) I'm very glad we can have such a calm discussion about this too. That's a rarity sometimes on the internet.
The idea of wanting to look 25 forever is wild. I'd much prefer (and think it's more realistic) to look 35-45ish if age-slowing/reversing medications become available in the near future. And frankly this would be much better. Why the hell would you wanna look like a kid forever? lol
The telomir people don't trust their product enough. They all look ... not young. And I certainly would not expect the age related conditions to go away with in a week. That would imply that there is such an inhibitory effect on the cells and tissue due to telomere length, that the moment the cells get longer telomeres they go nuts repairing the tissue... But I mean also your videos abit ... deceptive and not really as factual as it is suspenseful or sticky, what ever term you want to use to increase your view time. Evidence, you wait for most of the video to be over before you go into the scientific methods used in the studies for il-11... As a youtuber with a differnt channel I can't really blame you, but I see it and don't like it as just a viewer with a science degree.
Doesn't sound so great. The hard work is where you get most of the results, diet, caloric restriction, fasting, exercise, sleep, toxin avoidance. Some synthetic shortcut sounds good, but sketchy on the outcome. This sounds like a money grab. BTW I'm 59 and i just got my True Diagnostic epigenetic test results, my rate of aging is .72 My telomeres are longer than my chronological age but I want to improve them even longer as much as possible.
I am slim, do intermittent fasting, lots of cardio, I take my sleep pattern seriously, mostly plant based diet, low alcohol intake. Yet my Grim Age test has me at +8 from my chronological age. I want my Pill.
@mrleenudler Did you draw blood during an extended fast? That can throw off your hormones and could impact result. Also if you had some temporary condition. The True Diagnostic test with Pace and Symphony Age will give you a lot of info and show what you can do to improve your results while periodically retesting. Sounds like you're doing the right protocol, but possibly there is something else that can be addressed.
You really need to consider WHAT it is you are extending. You are *NOT* extending your young self. No, you are extending the deep deep old age, fraught with pain, disability, and overall misery. For many of you, you will be wishing for the sweet sweet release of death, due to daily and hourly pain, drug side effects, and other comorbidities. Take it from someone in chromic daily pain. It is shite. And all of you will have some or more of this shite on the extending end of your life. Now that you are aware as to *WHAT* you are extending, continue with your regularly scheduled programming.
If they could make a product that would extend a dog's life, that would generate enough income to fund aging research for decades. People love their pets! Who wouldn't want their dog to live longer?
This is a great point, we also have things like dairy cows or egg producers, the impact of something like this would have immense economic impact
@@0202-n7wIf I could make a momma beef cow live 2 years longer, that would be almost $3000 I could make. Times 100 cows is $300,000. Sign me up.
Right now, to cull out a cow you have to sell her at a low price times scale weight. And you either have to buy a new younger cow or allow one of your heifers to join the herd. You lose money by keeping a cow you couldve sold. Then you gotta wait for her to get pregnant, hope she has an easy birth, then wait for that calf to get big enough to sell. And a cow you buy may already be a few years old, she may or may not have a calf already. It can be a multi year process before you make profit again. Even a 2 year extension would be a drastic improvement.
Two red heelers living for 40 years They would be doing math within 20
You can find it mentioned. But it was tested with human embryos and extended them by 200 percent.
Or our cats
We will know age reversal is very near when we see our billionaires
like Bill Gates or Elon Musk suspiciously looking like teenagers. 🤔
Have you seen Vladimir Putin lately? He literally looks younger than he did 5 years ago. He's 71 I recently saw him do a backflip. And guess who in reality is the world's richest man? Yeah he's pretty much The real world version of Doctor Doom!
You might have caught a Larry Ellison who is the Oracle guy. He is 80 years old but I would not guess him older than 60.
Yeah, teenage demons 😈😈
@@rev.jonathanwint6038 LOL!
Maybe not all of them, I mean Steve Jobs let himself rot with a curable form of cancer out of arrogant hubris
"This should work as well as humans as it does for mice"
Every phone study ever
It doubled human embryo length... the telomir one.
The IL-11 gene knockout seems the most valid and researched. The Telomere repair drug would be the easiest to use. I hope that both continue to pursue and publish research.
Hmm....maybe that CEO gave himself a new identity and will show up again as a newly hired 30 year old CEO. 😊
I don't need to live forever, just a long healthy and active life.
why not forever? there's plenty of stuff to do and to learn for several hundreds of years.
@@RandomGuy-lu1enI want to live forever I don’t see the reason to die. There’s so much to do
Hi Lifespan News,
I was wondering if you've been following the work of American biologist Michael Levin. His research in areas like aging, cancer, and regenerative medicine seems groundbreaking. From what I’ve seen, he’s onto something potentially transformative in how we approach these challenges. I highly recommend keeping an eye on his work.
very interesting times and sooner or later the cures will come
I think on may David Sinclair will test his medication to human yay🎉🎉🎉🎉
@@thuptendlama6091 alas because of regulation it will take up to a decade for trials to be over.
Perhaps they will but not for you, not for me.
@@bulkypug3811 sooner or later for you and me
@@thuptendlama6091 He's so shady, he should test it on himself first.
Loved the humorous take on longevity breakthroughs!
"I am not sure if that makes it worse or better. "
Yes.
Telomere length matters more, the more times that the cell has already replicated. Daughter cells are more sensitive to the reduction. This doesn't matter until well into geriatric years.
Telomeres may be important for reducing cancer rates during targeted demythylization.
Babe wake up another Lifespan News banger just dropped
I think Prof. Greg Fahy is also another good example with his reversal of the Thymus Gland .... this man looks younger ever time i see him ...
You’re a very entertaining fun presenter, keep up the great work
3:00 The first time I heard about the new telomere drug was about a dog that got their cancer cured, which immediately did not make sense to me, as previous telomere lengthening drugs would actually cause cancer, which is why no telomere treatments are available yet, despite telomerase being known for over 2 decades. So I don't have high hopes. I have not heard of IL-11 before, so I have no idea what to make of it. But it is weird that the gene stuck around for so long, so maybe it is good for something in early life?
10:15 Yeah, the telomere drug sounds too good to be true. I'd love to be wrong though.
It was feared that extending telomeres would cause cancer (or something indistinguishable from it, actually), but when scientists successfully modified mice with very long telomeres they lived healthier lives and were less likely to die of cancer, or die of it later (mice usually die of cancer rather than heart disease). We don't know if that will hold for humans...probably. There are less senescent cells, so less inflammation from the "Senescence-associated secretory phenotype (SASP)" effects. Which seems like it has more to do with the origins of most cancers.
There are humans who were born with longer telomeres. In one population (Nicoya) it seems to help them live longer, but we don't know if people with longer telomeres in general live longer in other places.
20 decades, hmmm 200 years. 1820. Not likely. 😅
Based content & thumbnail art. Longevity for all.
My dude, I'm as skeptical as the next guy, but implying that the CEO passing away is somehow reason to be skeptical of their research is pretty simple minded. It's not as if they're claiming to have discovered the literal fountain of youth.
Dang lotta views, good job!
Thank you so much for this video. I saw the ABC news video, and because I so loved my dogs which had passed away, I really wanted to support the research. I thought how nice it would have been if my dogs had access to those pills during her final days. So, I bought some shares immediately. And I was going to ask my friends who love dogs to buy some also.
But after watching your video, I started to think. Even if the medication can lessen the demage of the telomere, and cells can duplicate to generate new cells, the effect of reversing aging could not have happened in a few days. Also, how could the medication selectively targeted what cells. If it was not selective, then actually, the cancer cells could grow aa much as the healthy cells. Not to mention that arthritis is the inflammation of the joints which cannot be resolved even if cells duplicate. One needs to modulate the immune system instead of just making cells divide non selectively.
Basically, my senses came back. The ABC news video plays to our emotions as we love our dogs sooo much that we are thinking with our heart, not our brain.
I just sold all my TELO stock at a very small loss.
Thank you.
The herb Astragalus is one of the few natural sources of telomerase, while Lutein blocks the iL-11 pathway. Been using Astragalus for years and it does seem to slow down aging. Just started the Lutein so it's too soon to say yet. Astragalus has been known as a 'longevity' herd in Chinese medicine for centuries.
One does not preclude the other. You need, on top of the basics, is the trifecta of longer telemeres, mitochondrial health (NAD+ and sirtuin), and clearing old cells (senescent).
Also check out peptide Epithalon...it is being found to lengthen telemeres.
It's interesting that both stories involve interleukins (11 and 17) the one thing I do understand, is the reduction of inflammation may improve health.
There was TA-65 that everyone forgot about
Astragalus is more affordable
The molecule is Cycloastragenol. There is more than one species of Astragalus, so there is no guarantee that the Astragalus extract you buy has that. Swanson has a Telomere Formula. I trust Swanson, they are pretty decent. Lots of supplement scammers out there. I just get heart palpitations when I take the stuff, though.
Don't expect it to lengthen anything but telomeres for white blood cells. Those naturally extend. Cycloastragenol just turns on that natural mechanism.
The body needs some cheats to get around the Hayflick cellular division limit. For red blood cells, that cheat is that the circulating red blood cells don't have nuclei. That is why they have that crazy dimple shape. The thing that normally would be in the center...DNA is missing because it never divided. Cells are limited to about 50 divisions after birth. As the life of a red blood cell is only 120 days, you would be limited to 6,000 days or 16.4 years, if the DNA divided and there were no tricks. Other cells that have fast turnover may rely on stem cells to refresh their populations. White blood cells have taken the more dangerous path of extending their own telomeres. Dangerous because this is what cancer does, enabling it to divide without limit. They still study cancer using cell lines they gathered in the 1960s. It was feared that extending telomeres would cause people to die of cancer more often. That appears to not be true. When they modified mice to have longer telomeres, they got cancer less rather than more. That was a bit of a shock.
The only way we would know if that holds up in humans is to genetically modify human embryos like the mouse embryos were modified. That would be illegal in the US. So any test of the idea would have to take place in some country that would allow it. My guess is that you would get similar results to the mice. People that lived 15--20% longer, who had good glucose, trim, and healthy. Actually, it might not actually be illegal, now that I think about it. I think the modifications were a little different, and would not likely modify the germ line. I could be wrong.
@@Sleepdriver1984 It has very low concentration of active ingredients though. I doubt that even TA-65 shows measurable effect, let alone trace amounts of this stuff found in a plant.
Well done
Should be a big battle between tobacco companies and big pharma 😮
Knowing what I know about biochemistry, it’s never going to be that simple wether it’s through the use of drug chemistry or genome editing, the body has literally millions of chemical switches, when you’re born, they’re tuned like a clock, over time individual homeostatic processes break down in the pipe line, the problem with drugs or using gene editing is that yes they turn on good switches, however, they don’t target the overall big picture of what pattern all of the switches are supposed to activate in, only individual sites. It’s like water locks, at a port, they have to open in a certain orders for a ships to pass through, if the wrong lock opens up at the wrong time, the wrong compartment gets flooded & the ship cannot pass. In other words, drugs often times target one process in a whole line of steps, which eventually causes the body to operate out of synch, hence side effects & in this case, you’ll probably enjoy a couple years of stellar health then systemic burn out will occur.
David Sinclair looks very young for his age also ..... Its the "driving back of Yamanaka Factors" that they are achieving these results that and the Horvath Clocks.....
Yes, well I heard😏 there's been experiments that extended the telomeres but they still lost some cells. But yes it will to some point extend life/life style. I know I am still enthused. 👌🧐😜😎🤙
Clean-up, IL-11! My first response is to wonder why the human genome would hang on to something so destructive. Is it because thinning is good for the herd? But that would necessitate a positive aspect as well that would perhaps allow the animal to reproduce at a preferential rate before nose-diving. Perhaps IL-11 as stated does have some protective qualities in youth that drop out quickly after a certain trigger. I would be reticent to eliminate it without much deeper investigation as turning off a switch that may be unknowingly wired to the mainframe may cause more unforeseen problems in the long run'
Likewise throwing enzymes to redress telomeres may lead to hormone changes which the rest of the body is unable to process, e.g. if HGH tries to make bones grow when the formations are already set might this lead to new strains of leukemia?
Too bad we spend so much money on erection pill research and vanity drugs for weight loss rather than fix our food system. Fast food - if it doesn't kill you one way, it'll kill you another.
Telomir Pharmaceuticals have the videos and pictures of the reverse aged mice in their interview with Adam Sarhan.
thanks man'
2 dogs tells you absolutely zero. And there is hooey as well. No. Telomeres are not the only thing driving aging. They are not even the biggest. Scientists genetically engineered mice with absurdly long telomeres. They were healthier, but they only lived 12.75% longer. These telomeres were long enough to not contribute to aging. This is the best case, scenario. You are never going to get this good of a result from a drug. And with a drug you have a big obstacle. There is no way to lengthen all the telomeres of all the cells to ideal lengths. If they are phenomenally long, then cell division will take a lot of time. And DNA is most vulnerable in this division phase. The DNA is much more easily damaged by radiation, or chemicals when it is dividing. Being tightly packed in a ball is much safer. At some length, it probably is not even possible to successfully divide. There is no natural stop point where the chromosome's telomeres says "Okay that is a good level, I am full."
Also, all the telomere extension I have seen drugs do, has only affected white blood cells. Those telomeres naturally extend. Provoking them to extend is more of a parlor trick, as we are made of a lot more kinds of cells than just white blood cells. If you actually want the other cells' telomeres extended, the only possibility I know of is the genetic modification Elizabeth Parrish had done. Even then, you probably need a massive dose so it runs out of white blood cells, platelets and endothelial cells, and starts affecting other tissues. Anything close to uniform coverage is a pipe dream at this point.
No, most of the aging reversal field is no longer focused on telomeres, like they were 25 years ago. We know that we age in many ways, so scientists have been looking at all these other ways and also identifying other ways we age, because the sooner we find them, the sooner we can do something about them. The hottest area at present for reversal is reversing DNA methylation pattern changes. Senescent cell clearance is also interesting and has had some interesting results. Tweaking mitochondria is also big, but you can probably get better results there by just doing 8 minutes of HIIT exercise every day.
There are already pills to extend telomeres. But as I was saying, they only extend telomeres for white blood cells. Perhaps still useful. I would not expect anything dramatic.
Scamming loving pet owners sounds like a profitable racket. Not saying that is what they are doing... And obviously people are going to say they are ordering it for their dog, but take it themselves. Honestly, who did not think of that? And these guys would be covered. They only sold it to you for your dog. You can't even tell anyone it did not work for you, or it made you sick. I guarantee you, no dog-bone flavor is going to be added.
In addition, (and this may expose my limited understanding of telomeres), the explanation of telomeres protecting the DNA ends, should only be an issue when the telomeres run out. Yet ageing starts in out twenties. I'd think most cells still have plenty of telomere at this age. This seems like a binary effect to me. Also, I'm pretty sure I've heard most people don't run out of telomeres before they die.
Anyone please correct my mistakes here, I hate being wrong :)
@@mrleenudler Actually, you start aging when you are just a few divisions in, after fertilization, as per experts in DNA methylation. And some cells at random just divide more often. Unlike what he said here, when cells hit the division limit, many do not just die. They become senescent cells. When the DNA frays, it makes proteins that are coded for in that area. And it makes them like crazy. These pollute the areas around the cells, causing inflammation. This is termed: Senescence-associated secretory phenotype (SASP) and is another driver of aging. But as we are composed of a huge number of cells, we still get senescent cells when we are very young, far less, but even 5-year-olds have them. I don't know when the first ones are formed, but I would not be surprised if we had a few when we were born. It is a complex topic, because some senescent cells may be beneficial helping with healing, when we need a little inflammation. It is assumed there are different types. We are now trying to figure out the different types and trying to develop senolytics (senescent cell killing molecules), that target the bad ones. Some are really crazy. They can be huge and literally eat other cells to get more building blocks to pump out more of those random proteins coded for at the end of the chromosomes. Your cells have different length telomeres. Cells from tissues, that divide more frequently, get shorter quicker...but it is not uniform in each tissue. We also have stem cells which just sit around not dividing until they are called upon. These can refresh the tissues that are wearing down. We have quite a few in the sinuses, as that tissue is frequently damaged by pollution in the air...even from ozone from waterfalls. A tissue can run out of stem cells. One of the first, commonly, is immune system cells, particularly the ones that really target a novel infection. I said before that white blood cells can extend their telomeres. Well, that can be insufficient, as DNA damage accumulates, generation after generation of cells (likely the real reason we have the telomere length we have). Stem cells can rejuvenate and do, but there are less for this system because it needs them less, at least in youth, because they extend their own telomeres, rather than relying on stem cells, generally. This is why there are so many deaths due to flu and other upper respiratory infections in the elderly...they did run low on viable cells to replicate. These are not the first to run out, but when they do, you may not have long to live. The first to run out or run low are cells that make secretions in the skin. Those silly cells make what they are supposed to make and divide to have one of the daughter cells rupture and release the natural moisturizer. They can't divide any more times than other telomere limited cells, so your skin loses the natural moisturizer. But that does not kill. You can buy other moisturizers, and apply them to the skin, of course.
There was an experiment (the TRIIM (Thymus Regeneration, Immunorestoration, and Insulin Mitigation) trial) where they did greatly restore the thymus which shrinks in aging because those stem cells run out that help replace DNA damaged immune cells because of the large number of divisions. I suspect it just recruits most of the stem cells that are left. Hard to say if this is good or not. It might just be burning the fuel faster, as it were. If it recruits stem cells that were never likely to be used in the thymus, then it is probably beneficial.
The woman that lived the third longest of anyone verified, appears to have died due to too few and poorly diversified immune cells. But you don't have to be that old for this to be a problem. It is #12 in causes of death in the US. #6 in people 90-99. And in 100 and older, it is #4.
@@ChessMasterNate Thanks for the comprehensive answer, I learned a lot! Including waterfalls creating ozone!
The only cells in humans that do not get shorter telomeres as they divide are cancers.
So there is no conclusion
Mabye he didnt die... it turned into a 16 year old and now has a new ID... maybe he building up a new team called the Avangers... and he says: "No we need a green guy!" XD
For example, Dr. David Sinclair, is exatly were he must stay, into the Harvard Medical School of Medicine.
You should have checked the synthetic alkaloid patent.
If it's backed by a celebrity scientist, it's at best hype, but more likely a scam.
Have you seen Harold Katcher's Hand ? He has reversed his age of his skin clearly with one topical application of his and Akshay's (Yuvan) E5.
Well I hope they come up with antiaging drugs but I'm very cautious
Not sure how wise it is to give someone a drug that turns off the IL-11 gene. Our bodies are a rather complex chemical machine that works to establish balance, so if we just turn off IL-11 what is the other side of the coin we will be giving full function to without anything to inhibit it... This could be good for aging slowly or non-agni, but what if there is another branch to the chemical chain we do not yet understand?????
That's why we do animal trials :)
Why "vs." instead of "plus"?
OK, yeah they need to release the results of these studies. If they really show it works in mice and dogs, that seems like enough to move to human trials to me.
Tbf, they're still testing it. Not even the ceo who died was ready to test it. Since its still pretty new. Since even if it works in dogs it has to be tweaked more for humans.
We need a cure for sepsis
Just when you though technology couldn't mess us up worse, it denies us the sweet release of death...
Great video! So disappointed regarding the use of dogs to make their dollars.
But not mice?
@@jhunt5578 excellent point! 🙌
Dogs are very similar to us in their biology. If a drug works on them, it is much more likely to work on us. Mouse studies rarely translate over to humans.
The proof is in the pudding, the treatments will either work or not.
The daylight between medical research and big business is pretty slim these days, so skepticm is always warranted (with David Sinclair as a cautionary tale).
Sinclair is all hype for the $$$. We haven't actually seen results from his lab yet. We have seem bizarre plastic surgery on his face, however.
The telomeres ones seems fishy, IIL11 is way more promising @3:05
Eat low cal, high nutrition with all the fats we are told to avoid. You line 10 years longer.
If the good doctor truly believed his drug reversed aging, he should be expected to try ot on himself. After all, who wouldn't, if he really believed it. When I see the good doctor looking 20 years younger, then I will believe him.
reminds me when Malcolm in the original Jurassic Park said:
"I'll tell you the problem with the scientific power that you're using here: it didn't require any discipline to attain it. You know, you read what others had done and you took the next step. You didn't earn the knowledge for yourselves so you don't take any responsibility for it. You stood on the shoulders of geniuses to accomplish something as fast as you could and before you even knew what you had, you patented it, packaged it and slapped it on a plastic lunchbox and now you're selling it! Your scientists were so preoccupied with whether or not they could, they didn't start to think if they should."
Regarding aging... you can get hit by a bus, game over. LESS THAN 3% mortality annually from old age. Do you want to guess how many pass away from HUNGER annually? but no this is more important? People don't think critically, because this show where funds are allocated, to "resolve a problem which it is not". Comments shows how selfish we became, because there are FAR MORE URGENT problems... however, if anything, given the perspective as I did, it shows ignorance
All you're saying here is that we shouldn't be chewing gum while riding our bike. Traffic safety (getting hit by bus as you mentioned) is constantly being worked on by people in that sector. And now a different sector is working on another cause of death (the medical sector, aging) so why not do both?
@@Torian1o1 All I am saying is that there are more pertinent issues, if we consider the medical industry say Dementia, Cancer, etc... I don't care much whether they do research on increasing our lifespan. I meant no ill intent.
@@xXstevilleXx No ill intent was inferred :)
One side note to this though: I don't know how old you are, but I am 35 and though I still have many decades ahead of me, I would certainly like aging to have been solved before I die of age-related causes :P
I suspect anyone who likes living would agree, even if most might say 'well yes but maybe when I'm X age I will want to die!'.
In my experience, even the very old don't suddenly start thinking 'this is enough, I don't like living anymore' unless they are in constant pain or other suffering.
@@Torian1o1 I completely agree, I am 42 so a bit older, but nonetheless, I mean, I people want to allocate money and resources to prolonging how long we can live, sure, but see here is my concern: it still does not do away with medical conditions as per the two examples mentioned. Personally, I am not concerned about death :) never have been... maybe I am just biased in thinking a good live without all the medical issues opposed an extended live but with the aforementioned unresolved. So, I have nothing against life extension per se, maybe those doing so research do take this into consideration. I do not know, but it is a fascinating video and I do appreciate the kind reply.
@@xXstevilleXx "it still does not do away with medical conditions as per the two examples mentioned."
I hear you. Fortunately, research into one thing tends to yield results in other areas too. For example, nuclear bombs + space travel eventually led to MRI and CAT scanners as well as radiotherapy. I'm pretty sure that once we get anti-aging down, that also yields a robust cure for cancer and who knows what else. I'd argue it's better that we do research it than not :)
I'm very glad we can have such a calm discussion about this too. That's a rarity sometimes on the internet.
The idea of wanting to look 25 forever is wild. I'd much prefer (and think it's more realistic) to look 35-45ish if age-slowing/reversing medications become available in the near future. And frankly this would be much better. Why the hell would you wanna look like a kid forever? lol
Timestamps would help your nice future videos ❤
Hmmm wonder why they gave Jack Szostak the Nobel Prize for the discovery of telomeres! Guess that is a scam also!😮
Fasting increases your life span by a lot
I don't care about living longer but if my dog could live longer I would be game
One magic pill that is supposed to improve everything, wow almost sounds like NMN 😆
Don’t forget that CEO could have died by actually taking the drug.
Telomir smells scammy as hell. (3:07) Edit: At end of video, it sucks even more. We've known for ages that telomeres are not magic.
Hey, Yanks! The word is aglet. 8:00 telomeress are not the answer
Tam-818
New telo water enhancer, ok.
The telomir people don't trust their product enough. They all look ... not young.
And I certainly would not expect the age related conditions to go away with in a week. That would imply that there is such an inhibitory effect on the cells and tissue due to telomere length, that the moment the cells get longer telomeres they go nuts repairing the tissue...
But I mean also your videos abit ... deceptive and not really as factual as it is suspenseful or sticky, what ever term you want to use to increase your view time. Evidence, you wait for most of the video to be over before you go into the scientific methods used in the studies for il-11...
As a youtuber with a differnt channel I can't really blame you, but I see it and don't like it as just a viewer with a science degree.
So, you can mRNA-нокаут, либо и правда with antibodies. But you should not wait for 2030, with AlphaProteo, or mRNA-printers
Doesn't sound so great. The hard work is where you get most of the results, diet, caloric restriction, fasting, exercise, sleep, toxin avoidance. Some synthetic shortcut sounds good, but sketchy on the outcome. This sounds like a money grab.
BTW I'm 59 and i just got my True Diagnostic epigenetic test results, my rate of aging is .72
My telomeres are longer than my chronological age but I want to improve them even longer as much as possible.
Use Astragalus
I am slim, do intermittent fasting, lots of cardio, I take my sleep pattern seriously, mostly plant based diet, low alcohol intake. Yet my Grim Age test has me at +8 from my chronological age. I want my Pill.
@mrleenudler Did you draw blood during an extended fast? That can throw off your hormones and could impact result. Also if you had some temporary condition. The True Diagnostic test with Pace and Symphony Age will give you a lot of info and show what you can do to improve your results while periodically retesting.
Sounds like you're doing the right protocol, but possibly there is something else that can be addressed.
@@invertage Just the regular morning fast. Crossing my fingers for temporary condition
@mrleenudler Data on biomarkers/bloodwork will help you understand what's impacting your results. Good luck.
This has the stench of con job all over it!
Wow, actual news for once. Are you feeling ok?
The reason why they want to increase lifespanish, to make their slaves live longer ... No retirement benefits till 90 😂
well is this guy even a scientist?? XD
I do not believe the telomere stuff.
You do know you can go to jail for scamming investors just saying!!😮
I think telomir1 is trustworthy
I also am giving a down 👎 vote because I think the content creator has been paid off.
You really need to consider WHAT it is you are extending. You are *NOT* extending your young self. No, you are extending the deep deep old age, fraught with pain, disability, and overall misery. For many of you, you will be wishing for the sweet sweet release of death, due to daily and hourly pain, drug side effects, and other comorbidities.
Take it from someone in chromic daily pain. It is shite. And all of you will have some or more of this shite on the extending end of your life.
Now that you are aware as to *WHAT* you are extending, continue with your regularly scheduled programming.
Hype dogging BS!
Cyclo astrogenol does the same thing
Il-11 is legit