Villains Defeats 158

Liam McPoyle and Ryan McPoyle from It's Always Sunny in Philadelphia
Joseph Martello/Hammerhead from Spider-Man: The City That Never Sleeps
The Director from Nimona
Scott Tenorman from South Park: Tenorman's Revenge
Queen Nerissa/Chelsea Van Der Zee from Ruby Gillman: Teenage Kraken
Japanese Announcer from South Park Let's Go Tower Defense Play!
The Beldam/Other Mother from Coraline
The Inferi from LEGO Harry Potter and The Poorly Written Sextet
Max Dillon/Electro, Adrian Toomes/Vulture, Aleksei Sytsevich/Rhino and Mac Gargan/Scorpion from Marvel's Spider-Man
Brian Durlin/Savant from The Suicide Squad

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I like all.

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Dr. Pestus from Disney's Lilo and Stitch (GBA)

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Malt from Larva Pendant
Drakken Joe from Edens Zero
Big Mom/Linlin Charlotte from One Piece
The Curious Cat and Neopolitan from RWBY

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Khyber from Ben 10:Omniverse