Thanks, Mahelet! Physiology is pretty awesome, and I love including those examples to show how it applies to real life. For more info on action potentials, you can check out the video below: th-cam.com/video/ol8Z2NfFYpg/w-d-xo.html Happy studying!! :D
Yeaaaa that last bit was probably the best way anything could ever be taught. You learn and understand it without even trying to remember it. The power of practicality!
I have been reading my physiology book to understand all of this but reading was confusing me, your video and the way you explained everything was really good ! You helped me a lot and now I understand way better. Thank you so much!
You're welcome! Videos and visuals help me understand things too! :D That's why I made these videos for my students. Feel free to share this video and subscribe for more videos coming soon!
I'm hanging out with my Bride who is a Nursing Professor and got interested in her course on reading ecg/ekg. I have become fascinated. Your video is blowing my mind on helping me to understand what's happening in this process. Very helpful! Thank you!
Wow brother....WHAT A CREATIVE APPROACH....to explain these concepts.... REALLY STUNNING EXPLAN ATIONwith lively examples...I can write an essay here about good things in this video.... LOTS OF LOVE FROM INDIA
Wow i was total confused about the Refractory period but after watching this video it was all crystal clear looking foward on your following Physiology/anatomy videos. I wish you could be my lecturer❤🇿🇦
Hi, thanks for your video. It helped me a lot, because my professor said that the relative refractory can be located between -55 and -70 about. But his statement does not justify the need of an higher stimulus and it was driving me crazy XD. But when you said we can talk about relative refractory between -70 and -90 (hyperpolarization), it made sense. Indeed when we are below -70, we need a "stronger" stimulus in order to reach the threshold. Indeed if we are between -55 and -70 why should I need a stronger stimulus? The normal one would be sufficient. I hope I wrote everything right, because I'm italian and my English is not perfect. Thanks again =)
Grazie, Luca! :) So glad it helped! Feel free to share with others in your class! (oh and your English is great! Especially given that you're talking about physiology, a highly technical subject. Amazing job!). Good luck studying!
Easy to understand the concept with the help of animations now it will store in my long-term memory 👍 I will recommend your channel to all my medicos friends From India
I've been binge watching all your videos and with just a few minutes, I understood all the lessons taught last semester just by watching your videos! I tried reading physiology books and even I haven't learned anything well by my professor but you did it! Just by giving straight to the point explanation and examples made the confusing lessons easy. Thank you so much! I subscribed and turned the bell for you! Please upload more videos! Can I suggest for videos on chemical synapses, smooth muscle and cardiac muscle contraction? Thank youuu so much!
@@physioflip Wow that's great. You work hard when you love something. I also have a channel. This one. But I've only uploaded 2 to 3 Anatomy videos and more will be coming soon. I have other videos as well. I just unfortunately broke my tripod recently so.... 😅
thank you!! i was so confused as to why there was an activation gate and inactivation gate... like why couldn't there just be a singular gate that opened and closed haha (but after your video, i know the importance of both gates). thanks so much again!
This is Surreal honestly. I am totally spell bounded with your explanation and animation skills. Give yourself a pat on the back, cause you just did something great!
Pat myself on the back? Don’t mind if I do :D Seriously tho-thank you! I’m a physio professor who’s learning how to animate and share these videos not only with my students but anyone who’s interested. Really glad you liked it!
hi professor i have a question how can na+ voltage gated channels restore the initial position and why k+ gated channels are slow to open and slow to close congrats your channel has just got into my favorite youtube channels list keep going
Hi Maria! The voltage gated Na+ channels are opened by depolarization (cell getting more +). This means that repolarization (cell getting more negative) will restore the initial position of the voltage-gated channel. + charge opens, negative charge resets. Hope that helps!
Trank you very much for the video , I still have a question , The Action Potentials in the refractory period are smaller than the normal ones, but I don‘t see that in the Books . They often draw action potentials with the same height?? Why is that , does that mean they are not always smaller ?
Hi Ba! The effect you are mentioning is definitely real. Not too sure why it’s not in particular books :|. Here’s a guess as to why though: Action potentials, even if they are smaller in magnitude during the relative refractory period, are still “all or none”. That is, if you do reach threshold, an action potential will start and finish (even if it doesn’t get all the way up to +30). So, the smaller amplitude doesn’t affect neuronal signaling. Maybe that’s why some texts might not mention it? ¯\_(ツ)_/¯
@@physioflip thanks bro!! No one was explaining that simple....everyone just say ups and downs and not simple.....i always love clear and simple discussions.just like u explained🙂👍
Exactly! The inactivation gate CLOSES when the cell becomes more POSITIVE. This is necessary to shut off the voltage gated sodium channel. What this also means though is that if another stimulus tries to activate these channels by making the membrane positive, the inactivation gate will just remain closed (since it closes due to positive charge). So its kind of like this: 1.) Original stimulus makes membrane + enough to -55mV. 2.) Activation gate on voltage gated Na+ channel opens. 3.) Membrane depolarizes strongly to ~+30mV. 4.) Inactivation gate closes (after a certain amount of time because cell has become more +) Now, let's say ANOTHER stimulus comes in, trying to make the cell + enough to activate the voltage gated Na+ channels.... 5.) New stimulus tries to make cell more + to begin a new action potential. 6.) Inactivation gate will remain closed because this inactivation gate CLOSES with increased +. If the membrane is already very + due to the depolarization or the inactivation gate is already closed, trying to make the cell more + won't and can't open the inactivation gate. 7.) So, we are in the absolute refractory period. Happy learning!
@@hassanmarwat5723 Working on some new videos in the coming weeks! Stay tuned! Don't forget to subscribe so you get notified of the new content. Hope to get to some endocrine topics soon. Have fun learning physio! :D
![[Sub Thai] APT. - ROSÉ & Bruno Mars](http://i.ytimg.com/vi/bYjhzP8x_uc/mqdefault.jpg)
this was super helpful! I really liked the application you included at the end!
Thanks, Mahelet! Physiology is pretty awesome, and I love including those examples to show how it applies to real life. For more info on action potentials, you can check out the video below:
th-cam.com/video/ol8Z2NfFYpg/w-d-xo.html
Happy studying!! :D
.
Mk@@physioflip ...xm.
Yeaaaa that last bit was probably the best way anything could ever be taught. You learn and understand it without even trying to remember it. The power of practicality!
massively underrated channel
If I could like this comment twice, I would :D
Trueee.
Very underrated
So truuuuueeeeeeee
I have been reading my physiology book to understand all of this but reading was confusing me, your video and the way you explained everything was really good ! You helped me a lot and now I understand way better. Thank you so much!
You're welcome! Videos and visuals help me understand things too! :D That's why I made these videos for my students. Feel free to share this video and subscribe for more videos coming soon!
I'm hanging out with my Bride who is a Nursing Professor and got interested in her course on reading ecg/ekg. I have become fascinated. Your video is blowing my mind on helping me to understand what's happening in this process. Very helpful! Thank you!
Wow brother....WHAT A CREATIVE APPROACH....to explain these concepts.... REALLY STUNNING EXPLAN ATIONwith lively examples...I can write an essay here about good things in this video....
LOTS OF LOVE FROM INDIA
What kind words! Thank you, Rashmi! So glad it helped!
I am shocked
This is the best explanation in TH-cam,yet it doesn't have million subscribers!
If can I only like it million times
Wow i was total confused about the Refractory period but after watching this video it was all crystal clear looking foward on your following Physiology/anatomy videos. I wish you could be my lecturer❤🇿🇦
Hi to you, Mokamoli and South Africa! :D Glad I could help!
So far the best video on TH-cam for Action Potential.
Wow-I'm going to frame this comment on my wall somewhere! :) Thank you!
This is very well done! I finally understand it. Keep up!
So glad to hear it, Hagi! Be on the lookout for new videos soon :D
I love your videos . Your videos make myself understand the concept more clearer and I started loving physiology ☺️
Thank you sir. Finally I understood.Lots of love from Nepal💗
From Nepal? So cool! Thanks, Sagar!
It took me a while to find this video but now I understand what is going on. Thank you!
That makes me so happy, Diana! Feel free to share with others who you think might benefit too! 👍 Have fun learning physio!
@@physioflip I will for sure!
Hi, thanks for your video. It helped me a lot, because my professor said that the relative refractory can be located between -55 and -70 about. But his statement does not justify the need of an higher stimulus and it was driving me crazy XD. But when you said we can talk about relative refractory between -70 and -90 (hyperpolarization), it made sense. Indeed when we are below -70, we need a "stronger" stimulus in order to reach the threshold. Indeed if we are between -55 and -70 why should I need a stronger stimulus? The normal one would be sufficient. I hope I wrote everything right, because I'm italian and my English is not perfect. Thanks again =)
Grazie, Luca! :) So glad it helped! Feel free to share with others in your class! (oh and your English is great! Especially given that you're talking about physiology, a highly technical subject. Amazing job!). Good luck studying!
Easy to understand the concept with the help of animations now it will store in my long-term memory 👍
I will recommend your channel to all my medicos friends
From India
Please do! Thank you, Abhisek!!
This is it. Thank you so much.. this video helped me understand. Most def recommending theist my class mates!!!
🙏🙏Sooo glad it helped! Thank you for recommending it. That’d be amazing! Stay tuned for more videos too.
I've been binge watching all your videos and with just a few minutes, I understood all the lessons taught last semester just by watching your videos! I tried reading physiology books and even I haven't learned anything well by my professor but you did it! Just by giving straight to the point explanation and examples made the confusing lessons easy. Thank you so much! I subscribed and turned the bell for you! Please upload more videos! Can I suggest for videos on chemical synapses, smooth muscle and cardiac muscle contraction? Thank youuu so much!
That was super cool n everyone can relate too..especially those who dont study bio...n the explanation was on point
Woohoo! Glad to hear it. Thanks, Shuaige!
At 4.25 the question is why the inactivation gate cannot be opened, but i cannot find the response in the comments. Why not add it in the description?
I dont know how to say thanks to you 😍😍 ......... best video on action potential !!!!!
Saying it’s the “best” video is the BEST way to say thanks 🤩. Glad it helped!
GOATed vid. Best one I came across.
Thanks a lot. You made the concept super easy.
Yay! Glad you liked it!
Superb, well illustrated, and concise!!!God bless you❤️
Excellent explanation🔥🔥... Love from India🇮🇳❤
From India?! Awesome! 🇮🇳 Thank you, Subham!! Glad it helped!
@@physioflip ❤😊
Wow it’s interesting and I’m enjoying in every second
Thanks, Abdullah!
Excellent explanation sir. Thanks a million
Hayee,this was so good and clear 😌💙
Wow. You made this so easy! Thanks and keep making more. 👍🏻
Thanks! :) I love physio and love explaining it. Glad it could help!!
@@physioflip Wow that's great. You work hard when you love something.
I also have a channel. This one. But I've only uploaded 2 to 3 Anatomy videos and more will be coming soon. I have other videos as well. I just unfortunately broke my tripod recently so.... 😅
Cool! Have fun making videos!
@@physioflip Thanks! You too! 😊👍🏻
i cant believe you made the topic so easy.
Thanks, Abdur! Physio’s definitely a tough subject so I’m glad to hear this was easy to understand!
thank you!! i was so confused as to why there was an activation gate and inactivation gate... like why couldn't there just be a singular gate that opened and closed haha (but after your video, i know the importance of both gates). thanks so much again!
Yay!
Thank you so much for this amazing video!!
Thank you so much for this amazing comment!! 🤗
Super helpful, thank you from the deepest part of my heart. ♥️♥️🥺
Thank you. You explained very clearly.
Glad it was helpful!
Thank you so much. It is a perfect video. I have understood very well now :D
Perfect video?! Woohoo! Thank you, Aysu!! So glad it helped.
Wow so amazing so conceptual.
Coming across your video was a big W.💪🖤
Absolutely brillliant
i loved your approach keep it
I can’t thank you enough for this explanation! ❤
This is Surreal honestly.
I am totally spell bounded with your explanation and animation skills.
Give yourself a pat on the back, cause you just did something great!
Pat myself on the back? Don’t mind if I do :D Seriously tho-thank you! I’m a physio professor who’s learning how to animate and share these videos not only with my students but anyone who’s interested. Really glad you liked it!
Thank you so much sir
You did an amazing job
Thank you, Hira!!
very nice explanation 🙏
Wow ur amazing teaching
Super helpful video sir keep.doimg like this🙏🏻💙🤗
Thank you for the kind words! If you'd be interested in supporting the channel to get more videos, you can visit: www.patreon.com/physioflip
Omg 😭😭😭 I love u ❤😭😭😭😭 you are an artist
Thank ypu so much, this was (and is) a REALLY GOOD explanation!!!
Thank you! This is so helpful.
BEST CHANNEL
Just brilliant.thank you🙏
Nice vdeo sir🌟gud vdeo about refractory period in utube🔥
Thank you!!
Great video, thanks!
hi professor i have a question how can na+ voltage gated channels restore the initial position and why k+ gated channels are slow to open and slow to close
congrats
your channel has just got into my favorite youtube channels list
keep going
Hi Maria!
The voltage gated Na+ channels are opened by depolarization (cell getting more +). This means that repolarization (cell getting more negative) will restore the initial position of the voltage-gated channel. + charge opens, negative charge resets.
Hope that helps!
Great great great great great !!!!!
perfectly explained
isn’t refractory period only shows in cardiac muscle?.
Or all muscle & nerve action potential has refractory Period?
fantastic video
fantastic comment
Thanks, Majid! :D
Thank you so much ✨
Trank you very much for the video ,
I still have a question ,
The Action Potentials in the refractory period are smaller than the normal ones, but I don‘t see that in the Books .
They often draw action potentials with the same height??
Why is that , does that mean they are not always smaller ?
Hi Ba! The effect you are mentioning is definitely real. Not too sure why it’s not in particular books :|. Here’s a guess as to why though:
Action potentials, even if they are smaller in magnitude during the relative refractory period, are still “all or none”. That is, if you do reach threshold, an action potential will start and finish (even if it doesn’t get all the way up to +30). So, the smaller amplitude doesn’t affect neuronal signaling. Maybe that’s why some texts might not mention it? ¯\_(ツ)_/¯
@@physioflip yes, thank you :)
Best vedio ever🥰🥰
Perfection 🙂❤
Thank you
U helped me a lot
You got it! Good luck studying 👍👍
@@physioflip thanks bro!! No one was explaining that simple....everyone just say ups and downs and not simple.....i always love clear and simple discussions.just like u explained🙂👍
@@hassanmarwat5723 Physio is too interesting to just talk about ups and downs Am I right? :D
clearly got it
That was great
Thx
good stuff bro
amazing! thankyou so much
Thanks, Sofia! Happy learning!
Thx man!
You got it, Zainab! 🤜🏽🤛🏽
Thanks😊
Thanks
Great job thanks ❤️
Of course! ;) glad to helped! Don’t forget to subscribe and stay tuned for more :)
Veryyyyy helpful
Awesome! Good luck studying. You can do it! :D
why can't the inactivation gates be opened?
is it because the inside of the cell has become much too positive?
Exactly! The inactivation gate CLOSES when the cell becomes more POSITIVE. This is necessary to shut off the voltage gated sodium channel. What this also means though is that if another stimulus tries to activate these channels by making the membrane positive, the inactivation gate will just remain closed (since it closes due to positive charge). So its kind of like this:
1.) Original stimulus makes membrane + enough to -55mV.
2.) Activation gate on voltage gated Na+ channel opens.
3.) Membrane depolarizes strongly to ~+30mV.
4.) Inactivation gate closes (after a certain amount of time because cell has become more +)
Now, let's say ANOTHER stimulus comes in, trying to make the cell + enough to activate the voltage gated Na+ channels....
5.) New stimulus tries to make cell more + to begin a new action potential.
6.) Inactivation gate will remain closed because this inactivation gate CLOSES with increased +. If the membrane is already very + due to the depolarization or the inactivation gate is already closed, trying to make the cell more + won't and can't open the inactivation gate.
7.) So, we are in the absolute refractory period.
Happy learning!
Finally !!! That's what i needed .. thanks alot 💜
Yay!! Awesome! Glad I could help. Good luck studying!
Wwoooow bro so simple
Thanks, Hassan! Glad you like it! Feel free to share with anyone else you think could use it. 👍
@@physioflip Sir! Can u upload videos on endocrine system like this ..i would really appreciate it 🙂
@@hassanmarwat5723 Working on some new videos in the coming weeks! Stay tuned! Don't forget to subscribe so you get notified of the new content. Hope to get to some endocrine topics soon. Have fun learning physio! :D
@@physioflip Thanks sir!you are really a blessing 🙂
@@physioflip sir ...when is endocrine ariving😁
Thnxxxxxxxx🦋💗
I lovvvvvvvve youuuuu
👏👏👌
🙏 🙏 🙏