Why the Membrane Becomes Un-Responsive || Absolute & Relative Refractory Period

📝 All topics from Membrane Potentials and Action Potential: www.nonstopneu...
🌐 Explore our entire animation video library: www.nonstopneu...
● Follow me at:
• Instagram: / nonstopneuron
• Facebook: / nonstopneuron
Refractory Period: Absolute & Relative Refractory Period
From initiation of action potential to just before repolarization is complete, no stimulus can generate a second action potential. This is called absolute refractory period. The reason for this is that the sodium channels are in inactive configuration, which cannot be opened. And they recover only after repolarization. During hyperpolarized state, a second action potential can be generated but it requires stimulus that is stronger than usual. The reason is, that the membrane is in hyperpolarized state due to continued potassium efflux, and, not all the sodium channels have recovered yet. So it requires stronger stimulus to recruit enough channels and generate action potential.
Chapters:
00:00 Intro
00:04 States of Sodium Channel During Action Potential
01:55 Refractory Period
02:13 Absolute Refractory Period
03:02 Relative Refractory Period
04:00 Summary
Dr Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.

[@karmicpopcorn6440]

I went through 5 other videos before this and remained confused. You finally explained it succinctly. Thank you.

[@chrisyu1024]

lol

[@mervey.7373]

That’s the video that i’m looking for for the last 20 minutes. Thank you so so muchhh🙏🏻🙏🏻🙏🏻

[@samionita2008]

Thank you

[@tyadams2063]

I was watching this 16 minute video for over hrs trying to figure it out lol. Thank you!!

[@alhaddi]

During the rising slope of the spike sodium channels are not inactivated .

[@honorialamin5404]

Thank you so much for this

[@Kpoll44-23]

Thank you ❤❤❤

[@usefmoha_med]

But in my text book relative refractory period is between the late part of the descending limb and -55 and the absolute refractory period is between -55 and the initial part of descending limb while the negative after potential is supernormal phase of excitability and tye hyperpolrization is the subnormal phase of excitability why U said that hyperpolrization is part of relative refractory period???

[@Abdo-vg1ni6mz2v]

What's this great videos 🎉🎉❤❤

[@Loveusmle]

We’ll explain

[@KarsazKaJinn]

But could you please explain how potential changes from hyperpolarised to resting potential? Won't the Potassium channels be closed and the sodium ones will be activated but closed also?

[@Muck-qy2oo]

That's a good question. From what I understand the pumps reverse and again pump potassium into the cell and sodium out of the cell.

[@TheRizard]

the NaK pumps reactivate to restore action potential and normal cell activities

[@subiyaumama5126]

Can you please upload the notes

[@sairachandio135]

Thumbs up 👍😎

[@tomcruise9317]

Osmole concept miliequalance tooo ppzzzz

[@user-rh5bf7gh1j]

the besssst

[@user-fb9ys8sb5z]

didnt understood even a single thing

[@NonstopNeuron]

It may be because of your poor English. It's not "didn't understood". It's "didn't understand". 😜.

[@TheRizard]

you did great explaining this dude but didn't have to obliterate my guy over here lol :) ​@@NonstopNeuron

[@chrisyu1024]

这个洋人配享太庙