I know one more distinction between RIPA & Ristocetin cofactor assay. RIPA uses patient's platelet rich plasma (tests at the same time vWF and native platelets function) while Ristocetin cofactor assay uses the patient's platelet poor plasma (with vWF but no native platelets) and adds ristocetin and exogenous formalin-fixed platelets which can passively agglutinate. Formalin does not allow the extrinsic platelets to secrete the vWF of their α-granules, and thus only the activity of the patient's intrinsic vWF is tested. In Bernard-Soulier: RIPA is hypoactive, while the ristocetin cofactor assay is normal (because the problem is in native thrombocytes, not in vWF). In Type 2B vWD: RIPA is hyperactive, because native thrombocytes are already fixed with vWF & small amount of ristocetin causes rapid reaction. While the Ristocetin cofactor assay is hypoactive, because when you take platelet poor plasma all the vWF is lost with thrombocytes.
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And my reading is now making Sense
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I know one more distinction between RIPA & Ristocetin cofactor assay.
RIPA uses patient's platelet rich plasma (tests at the same time vWF and native platelets function) while Ristocetin cofactor assay uses the patient's platelet poor plasma (with vWF but no native platelets) and adds ristocetin and exogenous formalin-fixed platelets which can passively agglutinate. Formalin does not allow the extrinsic platelets to secrete the vWF of their α-granules, and thus only the activity of the patient's intrinsic vWF is tested.
In Bernard-Soulier: RIPA is hypoactive, while the ristocetin cofactor assay is normal (because the problem is in native thrombocytes, not in vWF).
In Type 2B vWD: RIPA is hyperactive, because native thrombocytes are already fixed with vWF & small amount of ristocetin causes rapid reaction. While the Ristocetin cofactor assay is hypoactive, because when you take platelet poor plasma all the vWF is lost with thrombocytes.
Thanks for the explanation
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BT is also obsolete, and rarely used anymore. Thank you for the mention of Med Techs! :)
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You said " God bless lab scientists who has to deal with all these crab "
😀😀😀. Thank you
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Platelet aggregation test starts at 7:37
RIPA at 9:53
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What is RicoF test and Vwf:Ag test. If you know plz tell me
Im so grateful for your explanations, you are ultimately helping patients throughout the planet! God bless!
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Is this a type of cancer? Plz reply me
Is this a type of cancer? Plz reply me
Is this a type of cancer? Plz reply me
Is this a type of caccer? Plz reply me
How can we understand if it's von willebrand disease or bernard soulier using RIPA?
And I learned it while doing your gorgeous 50 hematology cases, they made me work hard)))
Юлия Шеина I am so happy to hear that...You're awesome 👏
I’m a new lab scientist trying to get my head around the tests. your comment at 6:35 made me laugh. Thank you for the detailed explanation
why ristocetin cof is decreased and ripa increased in same disease i.e type 2 b vwd.
Excellent thank you doctor
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Best teacher, thanks a lot
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Amazing!
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honest just wow
ur amazing
thank you
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Excellent explanation! Thanks a lot
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Thank you Sir 😊
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I have VW
Ohh 😮
I am sorry to hear that!
How is your health?