Celiac Disease Pathogenesis (Described Concisely and in Detail)

แชร์
ฝัง
  • เผยแพร่เมื่อ 16 พ.ย. 2024

ความคิดเห็น • 74

  • @evanmilby6995
    @evanmilby6995 7 หลายเดือนก่อน +5

    Probably the best animatic about Celiac disease

  • @simonmandel2621
    @simonmandel2621 2 ปีที่แล้ว +6

    Thank you for this video! I work in an Immunology Lab and am giving a presentation about coeliac disease to my team. This has given me a lot of help articulating it, so thank you 😊

  • @joc4709
    @joc4709 2 ปีที่แล้ว +3

    Amazing. I'm a student dietitian and this was presented more clearly than a recent lecture.

  • @DamjanManevski
    @DamjanManevski 2 ปีที่แล้ว +4

    I'm a Nutrition and Biomedicine Master and wow, what an explanation! Really good job mate

  • @dr.noir27
    @dr.noir27 2 ปีที่แล้ว +2

    i appreciate the time you spent on making these animations

  • @BenDabber
    @BenDabber 5 ปีที่แล้ว +33

    Playback speed at 1.5 is about right.

  • @aliceeleonor2911
    @aliceeleonor2911 2 ปีที่แล้ว +5

    Awesome video! The pathophysiology is explained on point. Thanks!

  • @mariaveresova8169
    @mariaveresova8169 หลายเดือนก่อน +1

    fantastic video, thank you very much

  • @howtomedicate
    @howtomedicate 5 ปีที่แล้ว +2

    Seriously, amazing videos. I am a 6th year Medical Student and this videos still help me!
    You even inspired me to make a channel on my own! I make YT videos on medical topics.
    And today I posted a video about celiac disease as well.
    Thanks for all the knowledge bombs, and thanks for the inspiration.
    Keep it up,
    So will I!

  • @AngryAmygdala
    @AngryAmygdala 6 ปีที่แล้ว +3

    You guys are the best, up there with Osmosis. Please, keep up the great work. I am fully supporting you.

    • @physiopathopharmaco4190
      @physiopathopharmaco4190  6 ปีที่แล้ว

      Thats so kind of you - thanks for all your support and all the best!

  • @Edward-ko9pn
    @Edward-ko9pn 6 ปีที่แล้ว +7

    It's amazing what us humans know about how the body works

    • @physiopathopharmaco4190
      @physiopathopharmaco4190  6 ปีที่แล้ว

      It truly is amazing

    • @brightdz2403
      @brightdz2403 4 ปีที่แล้ว

      Nope we know less than 1 percent and every now and then we know more new things about that 1 percent.

    • @petersosa268
      @petersosa268 4 ปีที่แล้ว

      @@brightdz2403 That “1%” is a whole lot though lol

    • @brightdz2403
      @brightdz2403 4 ปีที่แล้ว

      @@petersosa268 I said less than 1 😂😂😂😂

    • @Enthalpy--
      @Enthalpy-- 3 ปีที่แล้ว

      Laugh at neuroscience and genomics

  • @petertriantafillou8058
    @petertriantafillou8058 3 ปีที่แล้ว +1

    Great explanations Thanks so much!

  • @beautybeautyqueen6522
    @beautybeautyqueen6522 4 ปีที่แล้ว +2

    Thank you for such an amazing explanation♥️♥️

  • @angusmack.2202
    @angusmack.2202 2 ปีที่แล้ว +1

    Thank You too much 4 this! You really saved my project!! Very Clear Explanation :D

  • @asmajama7947
    @asmajama7947 4 ปีที่แล้ว +1

    Thank you so much for this amazing explanation🙏🏽

  • @زهراءحسينجباررفيش
    @زهراءحسينجباررفيش ปีที่แล้ว

    رحم الله والديك

  • @xbieberlicious
    @xbieberlicious 3 ปีที่แล้ว +1

    really nice

  • @asmaarady2829
    @asmaarady2829 4 ปีที่แล้ว +2

    thank you ,it was awesome

  • @xleo4096
    @xleo4096 ปีที่แล้ว +1

    Helps a lot!

  • @Elbuho17
    @Elbuho17 2 ปีที่แล้ว +1

    BEAUTIFUL !

  • @thatsverycool8264
    @thatsverycool8264 4 ปีที่แล้ว +1

    Just a quick question about AntiTTG, where do these come from? Are they due to mutations in B cell genes? Do people without celiac also have them?

  • @lazymedic5988
    @lazymedic5988 6 ปีที่แล้ว +1

    Brilliant..plzz upload videos on bone pathology..ua awsome

    • @physiopathopharmaco4190
      @physiopathopharmaco4190  6 ปีที่แล้ว +1

      Do you have a particular pathology of the bones in mind and Ill get started

    • @lazymedic5988
      @lazymedic5988 6 ปีที่แล้ว

      PhysioPathoPharmaco it would b great if u upload video on detailed pathology of osteoarthritis n osteoporosis with complications..plzzz

  • @leavesofchange
    @leavesofchange ปีที่แล้ว

    Does secalin get deamidated by tissue transglutaminase?

  • @giorgiobozzoni8681
    @giorgiobozzoni8681 6 ปีที่แล้ว +1

    thank you very much for your videos from Italy. i have a question for you and i hope you have time to answer me becuase this doubt stopped me to keep going studying.
    what happen to those who dont suffer coeliac disease, once the gliadin is inside the lamina propria of the gut? how do they break down gliadin to get its amminoacids? i mean gliadin goes intact into the lamina propria also for those who dont suffer coeliac disease, so they should have a way to digest it and get the AA.
    many foods have many allergen inside that cause immune response to those who actually havve food allergy for that specific allergen.
    but if i dont have allergy and i eat the food with allergen, and the allergen goes intact in the lamina propria without being digested by gut enzyme, how do i get its amminoacid anyway? my body wont waste them? thank you again

    • @physiopathopharmaco4190
      @physiopathopharmaco4190  6 ปีที่แล้ว +1

      There is decreased absorption for those with celiac disease due to morphological changes including Villous blunting and decreased surface area. Some don’t have these morphological changes despite having positive antibodies on a blood test. These may not have issues with absorption.

  • @tanmaymurur2377
    @tanmaymurur2377 5 ปีที่แล้ว +1

    Great video 👌 Isn't dermatitis herpetiformis also a manifestation of celiac disease owing to cross reaction of antibodies?

    • @jamyd7849
      @jamyd7849 5 ปีที่แล้ว +1

      Yes it is

  • @alysa4968
    @alysa4968 6 ปีที่แล้ว +3

    how was all of this going on inside me for 19 years and I didn't even know it

    • @alysa4968
      @alysa4968 6 ปีที่แล้ว +1

      also... really great video.

    • @physiopathopharmaco4190
      @physiopathopharmaco4190  6 ปีที่แล้ว +3

      Thanks for the comment, hope you're feeling better after going gluten free

    • @shamshahussein883
      @shamshahussein883 6 ปีที่แล้ว

      Alysa gluten free reverse able

  • @bio366geethasankar7
    @bio366geethasankar7 2 หลายเดือนก่อน +2

    🙏❤️

  • @meryamlazrak1329
    @meryamlazrak1329 ปีที่แล้ว +1

    thnk you sir

  • @sheilamacpherson4948
    @sheilamacpherson4948 3 ปีที่แล้ว +1

    Way above me.

  • @nj2147
    @nj2147 4 ปีที่แล้ว +1

    Thanks a lot..😊😊

  • @sondosalmadhlouh7872
    @sondosalmadhlouh7872 3 ปีที่แล้ว +1

    thank you!

  • @matthewhill6949
    @matthewhill6949 6 ปีที่แล้ว +1

    Great video. How did you illustrate this? What programs did you use?

  • @GauravSingh-tx4dt
    @GauravSingh-tx4dt 5 ปีที่แล้ว +1

    Sir can you please share the source of information..

    • @physiopathopharmaco4190
      @physiopathopharmaco4190  5 ปีที่แล้ว +2

      Much of that came from the Review article "The Role of Gluten in Celiac Disease and Type 1 Diabetes" published in the journal Nutrients.

  • @هدىعلي-ش1ز
    @هدىعلي-ش1ز 5 ปีที่แล้ว

    That was great thanks!

  • @Shilaan111
    @Shilaan111 5 ปีที่แล้ว +1

    great one thank youuu:))

  • @fuscaotunado1337
    @fuscaotunado1337 5 ปีที่แล้ว

    Can you give us the references you used? @PhysioPathoPharmaco

    • @physiopathopharmaco4190
      @physiopathopharmaco4190  5 ปีที่แล้ว +1

      Much of that came from the Review article "The Role of Gluten in Celiac Disease and Type 1 Diabetes" published in the journal Nutrients.

    • @fuscaotunado1337
      @fuscaotunado1337 5 ปีที่แล้ว

      @@physiopathopharmaco4190 tks

  • @khankaseparhnahagee9530
    @khankaseparhnahagee9530 4 ปีที่แล้ว +2

    Scientist should do something for this

    • @grizzy315
      @grizzy315 4 ปีที่แล้ว

      khan kase parhna ha gee yes, but there is not enough awareness for most scientists to research on the disease. its sucks but hopefully in the long run treatment is more effective.

  • @NadineBotterman
    @NadineBotterman 5 ปีที่แล้ว

    Is it true that your intestines FULLY heal after a glutenfree diet?

  • @tahiransari3917
    @tahiransari3917 5 ปีที่แล้ว

    Helpful

  • @khankaseparhnahagee9530
    @khankaseparhnahagee9530 4 ปีที่แล้ว +6

    Celiac is also spreading v quickly in the world like corona

  • @wem3121
    @wem3121 5 ปีที่แล้ว

    So the things that get the Disease started is a genetic predisposition of HLA II molecules AND an overexpression of CXC3 cytokines. Is that how it starts? And what about LT that escaped tolerance? Oh is that all those mechanisms at once?
    Thanks a bunch for the video. Im grateful 😍

    • @physiopathopharmaco4190
      @physiopathopharmaco4190  5 ปีที่แล้ว

      Yes several genetic factors can increase the risk - DQ2 and DQ8 and CXC3 cytokine expression

  • @MoustacheAlexander
    @MoustacheAlexander 2 ปีที่แล้ว

    Celiacs need to use hookworms. They put my celiac into full remission.

  • @Cr7goat.85
    @Cr7goat.85 4 หลายเดือนก่อน +1

    Could you speak a little bit slower next time?

  • @khawla-ez6cv
    @khawla-ez6cv 5 ปีที่แล้ว

    Thanks you

  • @UmeshKumar-xu2ng
    @UmeshKumar-xu2ng 2 ปีที่แล้ว

    Sir i have celiac disease and suffering from lack of sleep is this normal?pls reply🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🏻