A new therapy to prevent pneumonia associated with patients being treated on a ventilator

Overall winner of The Medical Futures Innovation Awards Respiratory Innovation Awards 2011
NOX: Prevention of Ventilator Associated Pneumonia
Dr Joanne Stewart, Dr Arthur Tucker, Professor Charles Hinds and Team
Queen Mary University of London & Barts and the London NHS Trust
What is it?
This is a new therapy to prevent the development of pneumonia associated with patients being treated on a ventilator. This innovation consists of a liquid that produces nitric oxide, a chemical that plays a key role in the body’s defenses against infection, but whose levels are significantly reduced during severe illness.
What’s new?
The team are the first to consider the possibility of restoring normal physiological levels of these natural defenses by delivering a liquid solution into the mouth and stomach of patients whose lungs are being mechanically ventilated. Unlike antibiotics the oxides of nitrogen (NOx) produced by the solution will kill resistant bacteria (such as MRSA) and fungi. Moreover, the routine use of the NOx solution for prevention will not encourage the emergence of resistant organisms.
Who will use it?
More than 60,000 patients are mechanically ventilated in UK intensive care units annually, with an average stay of five days and a cost of more than £500m. Up to a third of these patients develop pneumonia. The team envisage that their treatment will be administered to all patients worldwide, being placed on a ventilator, to prevent them developing pneumonia.
@qmul @bartshospital @medicalfutures
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