We Just “Cured” Type 1 Diabetes!
ฝัง
- เผยแพร่เมื่อ 31 ธ.ค. 2024
- A 25-year-old woman with type 1 diabetes started producing her own insulin less than three months after receiving a transplant of reprogrammed stem cells. She is the first person with the disease to be treated using cells that were extracted from her own body. Read the paper here! www.nature.com...
💪 JOIN [THE FACILITY] for members-only live streams, behind-the-scenes posts, and the official Discord: / kylehill
👕 NUCLEAR WASTE WARNING MERCH OUT NOW! shop.kylehill.net
🎥 SUB TO THE GAMING CHANNEL: / @kylehillgaming
✅ MANDATORY LIKE, SUBSCRIBE, AND TURN ON NOTIFICATIONS
📲 FOLLOW ME ON SOCIETY-RUINING SOCIAL MEDIA:
📷 / sci_phile
😎: Kyle
🎬: Charles Shattuck
🎞: Kevin Onofreo
✂: Nate Berger
🤖: @clairemax
🎨: Thorsten Denk www.z1mt.com/
🎼: @mey
🎹: bensound.com
🎨: Mr. Mass / mysterygiftmovie
🎵: freesound.org
This is one HELL of a Step 1 if it works consistently.
Absolutely.I hope she continues to do well!!
@@aazhie On that, we are of one mind.
The way we should move forward is by making this cheaper and more reliable
@@Gamerphoenix135 This is also true.
Lol… this is not a step 1. Treatments for type 1 already exist
inb4 insulin manufacturers lobby Congress for increased regulation on non-pharmaceutical treatments
Either that or the scientists who worked on this all get on a flight that just so happens to crash, while their lab 'accidently' catches fire
@@wpsp2010Don't fly Boeing.
Because alternative medicine doesn't kill enough people every year....
Just make it public info.
Can't I just live in my own little fantasy world where people are good natured.. lol :(
My dad just passed away from type 1 diabetes this summer. He was only 49. Cannot overstate how important this is. Thank you to the researchers out there potentially saving lives
I'm sorry for your loss 🙏
I’m sorry for your loss. My husband has type 1… may I ask when was your dad diagnosed? How man years did he live with it?
@@Sunny-Smiles1234😢😢😢 may God bless you. You and your husband are in my prayers.
Sorry for your loss
I'm very sorry for your loss. Sincere condolences. 🫂❤️🩹
A once every 5 year treatment is still incredible. This is amazing!
I would argue even once a year treatments over almost everyday treatments
Yes, you can live your life normally without worrying about anything. Just go for the treatment once every 5 years - it will be cheaper and life will be much better! If they can make this available for Type 2 Diabetes as well, that person will have their praises sung for generations to come!! How much money they want, we will all give! Just help us get cured.
I take this with a grain of salt because decades ago Japan claimed they had a pill that effectively cured type 1 diabetes. I want to be hopeful, but a type 1 cure has been in the headlines many times over the years. Hell, at one point I remember reading about some miracle cure for all diabetes. Thus far it's all hit some wall and despite possible short term gains they all lose funding due to the setback.
Considering some of the awful stuff people with Tyoe 1 go through...if you had to do this once a month it would be incredible!
Being able to essentially "reset" a cells differentiated state will go far beyond just type 1 diabeties and it this pans out sets researchers up for rapid cellular therapy for MANY of our current chronic diseases
A lot of near term promise for exocrine/endocrine or bleeding disorders. If the body doesn't make the thing, tell cell to make the thing and stick them in (assuming an autoimmune reaction doesn't redevelop in cases like Type ai diabetes). I'm actually working on a project reprogramming stem cells into alveolar lung cells (for drug/genetic testing purposes mostly). If we were to use them clinically for lung diseases, we'd have to find a way to make the new cells replace the damaged/fibrotic regions. A lot more difficult
I just also think that we opened up something that we could use to heal all kinds of illnesses …re-programming is one of the keys.
This is old tech. I initially started into stem cell research with this in mind - then I realized that they just really liked using fetal cells, so I got out. Cost effectiveness is the bottom line.
Rest assured, the masses are likely a decade away from seeing this. It will be reserved for the elite.
@@piterpraker3399I completely agree. These are well known methods. Not to mention type 1 diabetes is an autoimmune disease. So the patients immune system will keep killing of the transplanted cells. This is hardly new or a cure.
@@piterpraker3399 Yeah. The whole "we have to use fetal stem cells" line always sounded like an excuse to me. Adults have stem cells, too. From what I've heard, they're also a lot more stable than fetal stem cells.
Great! Until pharmaceutical companies lobby to kill competition for this treatment and jack the price up to $500K per dose
Type 1 is only like 6% of the diabetic population. True, they are forced to spend a bunch, but the real money for those companies is in the GPL-1 meds that non-diabetics are scrambling to take for weight loss.
They might try to bury it, but insurance companies will also have reason to lobby to get it approved since they end up paying for those meds usually.
Only 500k? That's cheaper then 80 years of insulin pumps glucose readers insulin needles alcohol wipes and other supplies Like emergency supplies
Wow, imagine free and universal health care
Must be amerucan companies .. in Europe the insulin meds are cheap as pasta
Please don't jinx it, this could be so wonderful if it works ☹️
Thank you for reporting on this, Kyle!
Signed, a very tired type 1 diabetic
My friend died in July 2024 from over 40 years of Type 1 diabetes complications.
I am a surgically induced diabetic, wishing islet cell transplantation was way past experimental trials when most of my pancreas was removed. So much of it was removed that it is now the size of a golf ball.
A step for type one is a step for all diabetes. My brother died from type one several years ago, and I died from type 2 about 6 years ago. (Heart attack, died, came back. 45 min CPR, 3 weeks coma.)
same here brother, hopefully some day we can get rid of this god damn condition, if the capitalists who are profiting off of our suffering allow it, of course.
i just wanna eat some ice cream after lunch and take a nap not having to worry about this shit >:/
Also signed, another very tired T1
717
Tysm for addressing type 1. I feel everything is always about type 2. ❤
Can this work for type 2 ?
@ Get out. Look up the difference between type 1 and 2.
@@jeffreychristopher5953
Type One is auto immune type two is Lifestyle choice usually…too much of the wrong foods and maybe lack of movement
As a type 1 for over 35 years, this is refreshing.
@@Esterfortofay357Some ethnicities are more prone to get type 2 diabetes even with a decent lifestyle, meaning for some genetic makeup might influence more than lifestyle.
Not only is this an amazing medical discovery, that will open major doors for millions of people ; but this will be a gigantic step forward in the survivability of disasters. The logistics around keeping insulin active are a nightmare in a chaos scenario.
You should see the calls for Epi pens from the people evacuated after the hurricane. They all went straight into Southern Yellow Jacket territory.
If this goes well, it would be really cool to see organizations that go into areas with upcoming disasters to help give this treatment so people are more prepared.
There was at least one reported case of a young Palestinian man with diabetes type 1 dying due to lack of access to insulin. It broke my heart as my brother has diabetes type 1, I can't imagine how scary and painful his last moments must've been💔
every year there's a new article claiming that they cure diabetes, this isn't new, nothing ever changes
@@bruhyou4305And nothing ever will, too much $ to be made!☠️
Even if she does only produce enough for 5 or so years, imagine just having to get a treatment like that every 5 years, instead of having to worry about how much insulin you have *all the time*.
Even if it doesn't end up a permanent "cure", this is GROUNDBREAKING.
I imagine the procedure will be extremely expensive in the US. Probably more than taking insulin. At least at first.
It's not, the patient had to be on immunosuppressants, which have worse side effects than the type 1 diabetes. Making beta cells from stem cells is the easy part.
On the other hand you're now running into a potential issue where you'll end up with an insulin-deficiency because you didnt get your ( hopefully mandatory at that point ) check-up to catch when those cells stop producing enough insulin
there's this concept called a "functional cure" which usually pertains to controlling a viral infection after treatment, but I imagine that it might apply here, where there is still some underlying risk of relapse, but otherwise, it is controlled without continued treatment.
@@_ch1pset Yes functional cure is used in T1D to refer to a future more advanced version of the current hybrid-closed loop systems where an algorithm automatically adjusts insulin infusion rates based on readings from a continuous glucose monitor. Currently they require a lot of user input still, but with faster insulins the gap is closing.
Now remember kids, none of the researchers have self deleting thoughts.
Right, next day in the news : “The researchers all sadly passed away at the same time, they all coincidentally slipped and fell down the same flight of stairs at the same time.. completely accidental and un related to their research.. details at 11 stay tuned.”
are you their therapist or how do you know?
@@Modioman69 And they accidentally destroyed/hid their research materials while dying.
I know; the government needs to stop suiciding smart people, who realistically, are the people who’ll ferry us into the future.
I mean what's far more likely to happen here is that this gets bought out and then we never hear about it again, stuff like that happens all the time, companies buying their competitors out and then shut them down.
Keep moving forward... Thank you for doing the work...
I am listening...
Again thank you
Type 1 diabetic here. This is awesome but I can't wait another 15 yrs.
type one here too, still waiting for "artificial pancreases"
@@raynjpg yeah. I'm sure the technology is out there.
Hello, brothers. I would be shocked if this kind of thing was widely available before I'm an old(er) man, but we can hope.
@@nathanforrest3483the elites have all the cures to everything
@@raynjpg be the change you wanna be, become a doctor lol
Why isnt this all over the news? This girl should be on every talk show. These scientists should be on magazine covers!
a few reasons:
-It has worked on one subject so far
-there is no know timeframe for the treatment: will it last? or will she revert back to hacving T1D? (this is the reason for the 5 years)
-the treatment need to be reproducable multiple time in multiple enviroment
It's in-vitro
Because 1 patient cured isn't a cure, esp when it's temporary. It's at best a treatment. It also won't be helpful for 95% of diabetes patients because they don't have type 1
@@Zankyo137 All those arguments goes out the window when the science is favorable to the news agenda, even if this isn't against their agenda, it's not positive enough to show up there.
Yes this should be in the news, in the same exact way it is here, a tale of a promising future for everyone.
Remember, nowadays news treat science the same way the USSR treated it, if it's positive to their world view, share, if it's neutral or negative, it never happened.
@@MihzvolWuriar i'm not american, elsewere science is treated better than that in the news.
so you argument is not valid
PLEASE spread awareness that this technique is not being used yet. Please tell people who need this to not go to hospital for this. It is really starting become a problem for the nurses and the doctors across the world. People are demanding that they want the same thing even if it is experimental. Doctors are needed to be trained to do this properly. There is a reason why this is experimental.
The full story (as far as I know):
The woman had kidney transplant and was using immunosuppressants. And the doctors went "since she's already using immunosuppressants why don't we transplant a pancreas her too" since she's type 1 diabetic and her pancreas is not working properly. But even while she's using immunosuppressants her body rejected it so they had to remove it. Now without a pancreas, they resorted to this. I dont know where they got the cells exactly but they made the root cells and injected into her abdomen. After a while, they saw a lump of flesh acting as a pancreas producing the insulin she needed.
Edit: the lump of flesh part is my speculation because it was not mentioned how she was producing insulin in the article.
Do you know the name of the paper of this research I would love to read it.
Thank you.
They should be demanding it. The pace of development is far to slow. Why should we wait 5 year for a single case study before starting a wider trial?
I though the replanted cells were put into her liver and they started produce Insulin
@@mason6883 because if there is a problem with the root cells they plant, many people will die regardless of their genetic variety. 1 and 1000 people is not so different right now. The only difference is how many lifes are at stake if something goes wrong.
This is why I LOVE studying genetics! You might just change the word
One MASSIVE detail you didn't mention is the patient that was "cured" was on immunosuppressant drugs from a previous liver transplant. The main issue with type 1 is the immune system kills the cells that produce insulin.
It's cool that they were able to program cells in this way, but until they can prove an active immune system won't just kill the new ones we should remain skeptical.
Is that what causes it? An autoimmune response? All i remember hearing when i was diagnosed was that they didn't know the cause.
That's probably why they want her to continue under observation for five years. That'll probably be enough time to get off the immunosuppressants (depending on the reason she was on them in the first place) and have any lingering stuff from that cycle out. And then, of course, keep producing insulin afterwards.
If immunosuppressants are required for the treatment to work I think that'll just be another step in the process, and not so big a deal.
@@Whitewing89They don’t know what _triggers_ the autoimmune reaction, but after that, they know _exactly_ what happens.
If they could discover the trigger, they would also be able to block it. Perhaps even make a DMT1 vaccine. But alas.
@@Whitewing89you are thinking of type 2. The cause of type 1 is well understood, though what triggers the autoimmune reaction is not.
@@decayingsun5798why would she be able to go off immunosuppressants after five years? The body would still attack any insulin producing cells, the immunosuppressants aren’t needed because they are transplants but because it’s an autoimmune disease.
Big pharma around the corner making it's price at 5k each treatment with shitty insurance covering it
First: this is Chinese study. Second: (assuming you are in the U.S) Then get rid of your shitty nonfunctional "healthcare" system and take a page from Europe (not Canada, our healthcare system *is* better than yours, but *the* laughing stock of Universal Healthcare). Just surgeries alone would be between 40-90% cheaper, never mind stuff like Insulin (iirc, it's currently $20 CA, that's closer to $15 US). You could cut the money expenditure in healthcare in *half* , and still have more free money to put where it's needed!
@@hanzzel6086 ooh yeah good one there, that guy should just remove the healthcare system in his country, im sure thats helpful!!!
@@hanzzel6086yeah because the UK’s “free” healthcare isn’t crumbling. Mark Cuban proved private healthcare works when he made his own pharmaceutical company and didn’t take insurance. He sells affordable pharmaceutical. Wow imagine that. A world where government isn’t necessary.
@@jasonbfhfj8132tell that anyone in Europe I dare you
@@hanzzel6086 Nahhhh the US is cooked bro it's going to be a sh*thole forever
It's going to continue to be the worst county in the Americas to live in (after Venezuela) til the end of time
My 17yr old son got diagnosed with Type 1 diabetes at 6 yrs old and is both on the Dexcom G6 and omnipod,so I’ll definitely be keeping my eye on this🤗
I lost my little cousin to diabetes. Im sure she wouldve been proud to hear all this progress coming in. I miss her every day man this makes me really fucking happy
From which country are you
@@ManiyaVinas usa
@@ManiyaVinasThe healthcare system is so incredibly fucked here, in fact every single system in the US is broken beyond repair
@@blazesalamancer8767
the systems were never designed to work, only to operate at thinly veiled minimum viability in order to placate the population into believing we have "systems" that actually do anything besides funnel billions of dollars to a few hundred people.
What's crazy is how they seem to keep "rediscovering" this same possible cure (Convert patient's own cells into pluripotent stem cells, then "tease or coax" those pluripotent cells to become insulin producing cells, ready to transplant to then cure the patient of diabetes) Then... they pull the rug under our feet by saying that they're still in the early stages (they've been in the "early stages" for this kind of stuff for the past 20 years, or more) and much more research needs to be done before someday they can begin long term testing so that they can determine if it safe for Humans before the preliminary trials can begin. I've already memorized this from so many times over the years I keep reading about this astonishing breakthrough that they keep making again and again ad nauseum!
The longer you live with T1D the less excited you get over news like this. I’m immediately asking if they’ve got a way to suppress the autoimmune response that could attack the cells, etc. But maybe this time is the charm.
This ^... Honestly whatever Kyle is talking about sounds like it's only addressing the symptoms that is called diabetes, not the disease itself, the auto-immune deficiency.
That was exactly what I was thinking. I guess immunosuppressants could possibly work, but I'm not sure.
Why would her body reject her own cells? Im sorry, I'm just genuinely curious, and don't understand
You got it, she got this treatment because she's already taking immunosuppressants for a liver transplant.
how many t1 diabetics would want to charge from using insulin (and many people have pumps now) to having to take immunosuppressant drugs
My Grandfather was type one diabetic, he died just last year. I wish he could have been around to see this.
How old was he?
You know same thing wit my father, only thing was he had type 2, wish he could have seen this aswell
Don't you get type 1 through genetics? Watch out
Why? This method isn't new and it isn't a cure or even a good therapy. Type 1 is an autoimmune disease and all the grafted cells are killed off by the host immune system.
@@rogeliomolinero2498 This treatment would not help a person with type 2 diabetes - they make enough insulin, the other cells int he body are just resistant to the effects of it.
We would be 50 years ahead in medical science and would have saved millions if we weren't so absurdly obsessed with absolutely perfect safety.
Man, R.I.P to the researchers and condolences to their families.
And everyone in this comment section.
the researchers are from china and are sponsored by their government, which means i doubt the cia is gonna snipe them
What??
@@mspaperlapap7706 Big Pharma is going to either A) off the researchers, or B) lobby against this, causing the researchers to off themselves.
There are prolly 5 hitmen at their location claiming they commited suicide by sniper at the back of the head. 😢
Wait till big pharma hears about this
Yeah the American insulin cartel is gonna be working to stomp this down
Who do you think is paying for this research?
@@watcherofwatchers Our taxes probably.
@@trevor_kelleyif it's at an university, students maybe
@@trevor_kelley Actually, no. The Chinese government, as this is the result of a Chinese university study.
Had this been a US-based study, it likely would have been funded by "big pharma," because that's who funds most treatment research like this.
The pharmaceutical industry gets bad press, sometimes deserved and sometimes not, but they are responsible for drugs and treatments that save lives every day.
There would be substantially less treatment options without the profit motive.
I pray to God this is pushed further. My sister is type-1, and has survived some absolutely scary hospital stays.
I had a friend who lost most of his eyesight, then developed skin nodules, then lost a leg and eventually his life to type1 diabetes.
When he was first diagnosed at pre-school age, the first doctor to talk to him when he woke out of his (first) diabetic coma told him, "You shouldn't be alive!"
-
He made that doctor a liar for almost four decades.
Have had T1 for several years, never had anything close to this happen. This only happens if you literally never take your insulin. Darwin Awards for T1Ds who end up dying because of it.
My brother has had a lot painful injuries due to hypos, including a broken nose, broken teeth, a dislocated shoulder and more. It's hard to regulate your own blood sugar every single day, it can go right for months but it only takes one mistake for a bad outcome to happen. Thank God he hasn't been in a fatal accident or has any health complications. He lives very healthy and goes to the gym every day. I pray your sister stays safe and happy❤️
@@MonkeyJedi99mate your friend isn't taking care of himself. I've had type 1 for over 30 years and no issues at all. You just can't be lazy about taking insulin
@@FB94121 You might have missed the past-tense in my tale.
As for him not caring for himself, he had periods where insurance kept refusing him coverage, some bouts of severe depression when he let his self-care drop, and such.
A decade ago someone was badly burned and his medschool friend used a sprayer to spray skin cells onto the badly burned face and neck. The man healed perfectly with an absence of melanyn ; no scars. We still don't have FDA approval of something that was so effective. Why?
Because someone with money has to spend all the money it takes to get it approved (in the hopes of making more money than they spent).
@asktheetruscans9857 yeah thanks for the pessimist bs answer.
Because a sample size of one isn't a study and taken out to a patient pool of thousands who knows what complications might arise.
Hey Kyle, type one diabetic here. This is truly insane, thank you for covering this so that it’s more widely known. I’m struggling with diabetes, and to hear that there might be an end in sight? It’s amazing. Thank you big man
As we longe dont know why the body attacks it self its unlikely to cure typ 1 sadly
@@ekarus4360it’s most likely due to the antigens or lack thereof. It’s an autoimmune disease and all of them act in the same way relatively.
As someone whose grandmother died of Diabetes, I can't help but shed a tear at this info.
Diabetes, like Cancer, was always considered like one of those "uncureable" diseases and I'm glad the World got proven wrong.
I really hope this method works, both for this woman, and for the World.
Yes. Nothing is truly “uncurable.” It’s just that these people in control of pharmaceutical companies know that they will lose money if a cure is found.
Hopefully methods like this can be used to treat things like hypothyroidism, it's nothing life threatening like diabetes or cancer but it's still not great
Considering how easy and effective it is nowadays to treat Diabetes or AIDS, both being diseases that where a death sentence only 30 years ago, its crazy how fast medicine has evolved. Don’t get me even started about the groundbreaking use of Penicillin since the 40s or the fact that ICUs only exist since the 70s and people who nowadays lie on an ICU and might be saved were usually doomed to die before the 70s.
The hardest diseases to cure are those that our bodies consider as normal. Cancer? That's just your own cells going a little bit freaky. Diabetes? Cells that's perfectly normal except they actually lacked an arm and a leg if you look closely. It's like our brains can't do shit to a body it literally controls so it decided to do use external force instead 😂
@@kaynor1260 would it work for pseudopseudohypoparathyrodism as well
From what I've read, this was a big step for the more prevalent type 2 as well. The other person, a 59 year old male, that was essentially cured in a similar study was type 2. There is a question of whether the body rejects these long term, and it's a chinese study, so it's yet unknown if we'll see progress in the US on this.
I wonder if in the future we’ll be able check for pancreas cell transfer compatibility the same way we do for transplant surgery compatibility.
Type 2 has been curable for decades.
Type 2 is virtually curable, but they don't like that term because it implies an easy mostly mediated cure through medicated recovery. But most of the time it's reversible, just requires changes to lifestyle. People suffer through due to the inability to make those necessary changes, whether that be diet or inactivity. Honestly, like genuinely, it's a shame that's how most people see diabetes. It's self induced diabetes that could've been avoided most of the time for type 2, type 1 is purely genetic. It's not because you ate too much cake and your pancreas went oh no, that's alot of sugar. Problem is the average person doesn't know anywhere near enough about the human body to understand even the most basic disorders and diseases. The amount of people who don't understand the difference is astonishing, they just think "if you control your diet you'll get better", or the obligatory "you should stop eating so much sugar" or "aren't you a diabetic" when they see you eating something mildly sweet while your bloodsugar isn't even reading anymore it's so low. People are fucking stupid, surprisingly stupid and incredibly ignorant of these things, and now they only associate diabetes with morbidly obese people because people are eating absolute shit day in day out. One is an autoimmune disease, the other, or second is eating far more than your functioning pancreas can keep up with. Two is reversible, with work of course, one is forever, depending on where this research goes. I'd rather have the opportunity to not be a diabetic then really most other things in life, countless type 1 diabetics agree with that sentiment and some are even envious that all it takes the type 2 are diet control and exercise. Thinking, if only it were that easy. Most of us do that already just to survive and afford insulin. Alot more costly when your having to take a metric f-ton to overcome insulin resistance from overuse. We need to make new terms to differentiate. Sure, we're both sugar bloods, but mine wasn't by choice.
@@theballindinosaurshould be noted that type 2 is not curable, only reversible to a degree. You can mitigate the damages and potentially no longer require insulin through lifestyle changes but it will always be there and any change in lifestyle could easily make it reappear
@@theballindinosaurTRUE THO
My mom is almost 70 now and has been a Type 1 Diabetic for 66 of those years. I'm 100% showing her this and I'm going to see if her doctor can find out information on this. 66 years of diabetic shock, hospital scares and kidney failure that comes with the dietary restrictions among other things.
As a type 2 diabetic this makes me happy! Glad those with type 1 have this bright light going for them. Hopefully this works out and can be a huge benefit to millions!
To my knowledge, both have the same issue, little to no insulin production. Why can't type 2 be treated with this
@TheBluePhoenix008 they are a little bit different. Type 1 your body basically stops making it and type 2 your pancreas makes less which causes your body to be less efficient in using insulin.
I could see it maybe working for type 2 but I would think type 1 is the "worse" of the two. I use that word loosely because they are both not good. So if they are getting treated that's awesome.
@@kwith my understanding of type 2 was that your body still produces it, but has started to develop immunity to your own insulin, so you need more and more of it?
@TheSeranath yea your pancreas doesn't produce as much and that reduced amount causes your body to become resistant to it and not use it as efficiently.
Yall tripping on edge cases of Type-2.
Leading cause of type-2 diabetes is too much sugar consumption for decades, making the pancreas produce more and more insulin regularly, thereby making all your cells USE more and more insulin, AND slowly adapting your entire body to higher and higher levels of regular blood sugar.
The very first and important bad thing is this higher sugar level. It ruins your blood vessels, the capillaries first. This increases your risk for all kinds of cardiovascular diseases. In later progress, it also kills the nerves in your extremities cuz they don't get enough blood flow, thereby reducing your ability to feel all sensations in your feet and hands for example and slowly ruining your eye-sight.
Now some of you talked about reduced insulin efficiency and yes this is the Type-2 Endgame. At some point, if the patient doesn't change their life drastically, it can't be treated with pills anymore and you will need Insulin top-ups.
The drastic change in life-style and avoidance of sugar in food and drink is the ultimate prevention for type-2 diabetes. Type-1 is unfortunate, type2 is in 90% of cases, just your own fault for eating like shit for years and years.😢
So sorry to hear about the deletion of everyone working on the project
😂
Gets worse for big pharma. Chinese scientist also used the same process to cure type 2 about half a year ago, also still under testing. The authors originally thought type 1 diabetes possibly wouldn't be cured using this, because the immune system might reject the implanted cells, but were thankfully wrong.
Just a coincidence. Nothing to see here.
@@benmidnightflameit's not gonna get worse for big pharma,it's gonna get worse for them researchers, they dead
It's pretty f sad that big pharma doesn't want cures. They want money!
Will be following this story. My nephew is type 1 and will love to see this research bear fruit
Thank you for covering this
If this works, type 1 will become more survivable than type 2.
I won't be surprised if the big pharma cartel ends her before we get the 5 year results. They need money
@@aaronmicalowediabetes is plenty “survivable” it just takes management
My mother as well
My 17 yr old is too
Everyone should thank this woman for allowing to be studied like this. What a huge step in science. She must be something excited and hopeful for her own future as well. Just amazing work.
As a T1D this is huge!
I just really hope the news gets shared more
If you're an american? $600,000
This is barely at the discovery stage. The combination of "much more research", testing, evaluating for safety, and finally Human trials means this won't be available, if ever, to treat Diabetes for another 15 to 20 years.
Hello type 1 diabetic and engineer working on automating the manufacturing of personalized stem cell therapies here, I can't wait for this to be available!
when? I've seen articles claiming that they found a cure for like the last 10 years of my life. I don't know man but I just don't believe it anymore
the introduction was longer than the statement 😭
@@bruhyou4305 well seems like they are doing human trials so that's a good sign
@@Cheaplinx cause it's relevant
@@travishunter8573 yeah I guess, I just think we shouldn't get our hope up to much
Thats amazing. I wish my uncle was still around to get the treatment, but im glad it can (hopefully) help others in the future.
I’m so sorry for your loss love ❤
Been type 1 for 20 years. This stuff never makes it out of whatever phase that makes it disappear.
Totally agree and I've had type1 for 53 years so I've heard of many supposed cures that come to nothing.
True because there’s money in medicines. They don’t want a cure .
I have been suffering from type 1 diabetes for over 40 years. I can't wait another 5 years or more..
The Republican's will do as George Bush jr did and make it illegal.
More money in forever meds.
One of my oldest friends just died from type 1 not long ago. He was one of the sweetest humans on this planet and deserved a much longer life then 35 years. I wish they had discovered this sooner.
Wife wife passed away 12 years ago from complications of her type 1.
So many game changing advances have come about in the decade since she passed. It's bittersweet.
My late condolences man, some things don't get easier ❤️
I’m sorry man, hopefully nobody will have to die like that ever again.
Sorry for your loss. Was it uncontrolled? I did not know there could be complications wow
This needs more attention. Thank you for reporting on it.
Curing Diabetes will help so many people around the world.
It's fairly impressive they've already been making the insulin shots out of a modified e-coli virus.
I have type 2, I'd love to see something like this for the older set, I'm 64, been T2 for more than ten years. After chemo, it got MUCH harder to keep my glucose levels where they need to be. I guess the cell damage made it worse?
I’m T1 and any progress towards a cure/treatment is great news!
I hope you can get help soon!!
Praying protection & a full lengthy & healthy life over all in this operation. Thank you!
👑❤🙏🏽❤👑
My brother died from diabetic-related complications in his mid-30s, so it's good to hear that we are moving much closer to remove another disability from harming more people.
It's insane how a hundred years ago diabetes was basically a death sentence, and now we're this close to curing it for good. Science, babyyyy
No. It's a death sentence for people that eat exogenous glucose. That wasn't very available a hundred years ago, definitely moreso unavailable 200yrs ago
How did the genetics survive for so long of it were a death sentence?!? Lol
@@Baptized_in_Fire. How did Cancer survive, if it is a death sentence?
@@JohnnyNumber11 that is an illogical question that shows your lack of understanding of cancer.
@@JohnnyNumber11 the answer is that people still put toxic substances in their bodies, and there's way more toxins now than ever before in the world. Thank big ag, big "food", and big pharma, among others.
Once the news dies down after 1-2 years, either the researchers or the subject will mysteriously dissappear or self-delete themselves. They basically just told the entire industry they have 5 years to "take care of the problem."
R.I.P. in advance.
yeah because diabetes type 2 isn't going to be number one of mondern illnesses and insulin isn't already rare and not always in stock. not to forget that most countries don't have prices like the US does. I need to buy the insulin for my cat from my own money (no incurance no money from government or something) and I pay 40 Euro for what my human friend needs for half a year (as a human she doesn't have to pay for the insulin)...
@@lisah.7640 Insulin ISNT rare. Its made from yeast and bacteria's that are extremely common, and there are methods to make literal hundreds of gallons of the stuff in a week. But why would the pharma companies do that if they can just sell it to you for hundreds of dollars a litre lol.
@@lisah.7640Yea my human friend sometimes goes Ape shit & I gotta ‘rehumanize’ her. Government said something about pet fees ain’t applicable for human friends but ion know😂.(im jokin btw)
@lisah.7640 I think I speak for all Americans that is rather have to pay 40 euro for 6 months of medication than a single payment in the US
I mean, theoretically, that might be true.
However, there isa reason why it is only viable for Type I.
Type I is a genetic disorder and only 10 % of all diabetes patients are Type I. The overhwelming majority are Type II. And Type 2 works completely differently. Meaning that this form of therapy would not work at all.
+ this is probably not something that will work for everyone. The only question is if the pharma industry is willing to take a potential hit of a few millions tops. But I would not be surprised.
Hey Kyle, you have no idea just how much this means to me.
I've been a type 1 diabetic for about a decade, and just hearing that we're one step closer to this cure is just absolutely amazing.
I hope that she will be able to produce insulin within those five years.
We NEED to fund and support this research.
Go ahead then
Probably already is
Pharma will and then continue to force people into buying insulin.
the US will very likely try to halt this from even going much further, this was a discovery from China.
How do you think they made it this far? Shitloads of money.
What great news. I was briefly confused with all the comments, but then I remembered that in the USA you were really ripped off with the insulin price.
My partner was offered a job in Nashville a few years ago but we stayed in the UK when we discovered they won't give Med insurance to type1 diabetics in that state.
So sad to hear that the research facility was mysteriously burned down, the woman dead by suicide from 3 separate gunshot wounds to the back of the head, and that the people who discovered the medicine were imprisoned for life following a routine traffic stop.
where did you HEAR that? i wanna read the source.
@@Rosa_Neco it's a joke about the government killing off people who do research that would stop major profits- insulin, in this case
@@Rosa_Neco its a joke
@@randoavis2 shows how f*cked the world is when people believe it lol.
@@liammorris1018 people believe someone is a crackpot and believes it happened when it didnt
My boy was diagnosed at the age 5 with Type I. It’s been 6 years, this treatment can’t come soon enough, I’ll pray.
My mother has been type 1 since she was 11. Due to this any time any of us children were sick or wet the bed as young children she would check our blood sugar just to make sure it wasn’t pre-diabetes. Due to this she caught pre-diabetes in its earliest stage with my brother who was 8 at the time. She took him to the pediatrician, insisted it was pre-diabetes, and it was verified by some tests. The pediatrician wrote a prescription for some long acting insulin and that was that. Since my mother caught it so early and monitored it so vigilantly, over the course of the next 3 months his pancreas made a full recovery. He has never had complications with his pancreas since. This was in 2010 as well which makes it all the more impressive. He is 22 now :)
That's awesome!! Your mom is an amazing woman 😊
@@RSClassicAngel I agree!
A week later: "Scientists who were researching cure for Diabetes all found dead from heart attacks!"
Kira if he worked for a USian pharmaceutical company kek
Not all of them. Some of them flew on Boeing 737 Maxes that suffered 'unfortunate accidents' in which they were the only victim
Or buy the rights and sit on it.
"They suddenly died from 'bullet-in-brain' disease."
You're damn right!
This is awesome!! My oldest son, not even 9 yet just got diagnosed with type one diabetes so to know that he may not have to live with this for the rest of his life is Huge!
Maybe I am wrong, i don't like to be breaker of a bad news but i got diagnosed like 25 years ago and I had to listen to all these bollock talks about possible cure from a start too. Believe it or not. It is pretty annoying and it won't help him long term I guarantee it. Its better to not hope and make it part of your life and deal with it like now its part of him. It can actually lead him to good "manners" in terms like food, sport activities, focus on
his health, etc. You see diabetes is a huge business and curing it...would lower their annual profits.
He is at least lucky he has much better options for controlling it.
Don't feed him carbohydrates. Feed him beef and he'll have a better go of it
@@Baptized_in_Fire. oh yeah, meats and cheese in general are like a godsend! Thankfully he likes that stuff, he's also level 3 autistic (you know, non verbal, flaps, makes unique noises) so it's a struggle finding a lot of food he will eat, but the boy loves his meats
@@RainbowDash1995 I also have autism. I don't agree with the different classifications (including levels), but that's neither here nor there, I suppose. They were created by midwits that weren't autistic, based upon neurotypical ideas of fitting in. My IQ falls in the genius range, a few standard deviations above the norm for the population at large. I can force myself to speak to fools that can't think in public, but it's painful. I can also force myself to mask so hard that no one knows I'm stimming. It's hell, be glad your son refuses to see the alleged benefits of that nonsense, to fit in with those not of clear minds. Properly guided, he can potentially do great things that others can't. Meat is a great fuel source for this. Ik our sensory issues differ between people, but I found that only eating beef greatly reduced mealtime stress, and made things easier and more enjoyable in novel ways. Plus I only get hungry about twice a day, which makes lots of other things easier too. Oh, and no more constipation, which is common in autism. I wish you both the best.
Edit: careful with going overboard on cheese, it is a drug. Pick your poisons, but do so in moderation like others do with sugar. (Casomorphones, in cheese).
@@RainbowDash1995im also autistic and in school to become an autism specialist, and those classifications are outdated and based in ableism. Early research on autism comes from nazi Germany, if you dig into it enough. you can be, as you say, “level 1” and flap your hands, make noises. Strange way to describe it. Please look into ASD and avoid ABA, your child will thank you in the long run.
The fact that this managed to get out and wasn’t suppressed by big pharma is astounding. This is really exciting
Wouldnt count on it. The pharmaceutical industry isnt known for letting money slip right off their arms. I bet this whole breakthrough will be buried and forgotten in the future.....
On the USA
Exactly. Beat me to it. Was going to say: Rockefeller "medicine" will never allow it. If T1D is cured, their profits go away. This should be obvious.
I mean yea they get away with charging hundreds of dollars a month for a medicine that honestly is not that difficult to produce. Pretty much anyone who has either some skill with science or just sheer determination could make their own. The equipment isnt cheap (relative to the average person, dirt cheap to pharma) but yea it’s actually so fucked up
Not if we get this out there as much as we possibly can because we should not let this get buried.
@@sirirond1990 who do you think makes all the medicine for the rest of the world? 85% of medical advancement and drug creation happens in the US.
Omg... Im START crying immediately...
I was waiting for this and dreaming for this for the last 25 years... Thanks...
Are you in China?
No?
then you will never see it.
big Pharma make too much money keeping you alive.
This is a very preliminary thing. If you're type 1 this is hope but a better thing would be to fix the immune system be adjusting the immune cells that remember this kind of stuff so it no longer creates an auto-immune condition first. If the auto immune conditions could be fixed that alone would be a God send, soooo many conditions are just auto-immune conditions.
Fix that issue first and then fix the Diabetes and other conditions after
Let’s hope this is very viable, safe and cheap to reproduce.
This is a case study of one patient. We are still a long way from a cure. Kyle really shouldn't communicate in this way, it borders on misinformation.
Unfortunately, it probably won’t hit open market for anything under half a million dollars because insulin makes a lot of money
millions of people around the world let out a yell of excitement, and a handful of people around the world let out a scream of absolute horror and despair.
It's amazing all the advancements. The medical field has made in such a short amount of time. . It gives me so much hope for the future generations.
999 missed calls from Insulin manufacturers
2 bullets dodged
I lost my best friend a couple of years ago. She had type one since 6 years old, and passed away at 29. I'm glad to see that progress is being made in this field.
I am so sorry. That is way too young and an absolute tragedy.
If the price for Insulin wasn't artificially inflated and third world countries would be allowed to produce their own, it wouldn't be much of a problem. But still impressive
It's only artificially inflated in some places. It's like $7 for a vial in aus.
@@kahlzun yeah mainly US.
Insulin is free in most of the world. Thats a US exclusive problem
What should it cost? I would get a bottle of the stuff for $20 (not covered by insurance as it was for a pet) when I was giving my cat insulin for the last two years of his life.
@@TheEveryoneGamesis free because the US subsidized it
That's great! We need to make sure these researchers are safe
Wait until the researchers mysteriously “disappear”.
Do you know how most medical research works? Once the discovery is made, the info is basically out there immediately. No quelling progress.
those cia jokes are old and borong asf, can they end for once?!
@@democracy_enjoyer The implication is the pharmaceutical industry, not government. Corporations run this country, after al
You kinda paranoid?
@@CokSoku
Yeah and as you already said the Information is out there, so it's still a dumb "joke"
20 years ago when I was in seventh grade I did a project on stem cells being used to cure or treat diseases like this. Amazing to see it finally coming to fruition.
I've seen this one before, here's the issue: this doesn't cure the root cause and it only works for her because she's already on strong immunosuppressants. If these cells could survive without compromising your immune system for at least a year I'd call it a huge win, but the truth is that getting brand new insulin producing cells into a person was never the issue, it is keeping them alive. When I was diagnosed I was told it's okay, they're on the brink of the solution to this issue, just three more years and we'll have a cure! Well that was eleven years ago and we are still "just three years away" from a cure so yeah, hate to be the bearer of bad news, but it is what it is.
There are ways to manipulate cells to allow them to evade the immune system. Some cancer cells do it, for example. Seems like there's at least some effort in that direction, so maybe it'll really happen in your lifetime. 🤞
Exactly my thoughts on the matter.
There won't be a cure for type 1 diabetes until we can cure most auto inmune diseases
Same but for me was in 94. Doctor said 2-3 years and insulin pumps will be readily available as a transition to a full cure in the next decade... That did age well...
@@miguelg1716my mother desperately needs an insulin pump. Her diabetes is incredibly hard to control, as it's a mix of type 1 and type 2. But she's retired, and can't afford the $6k. 'Merica
Well, the difference is that these are her own cells, they should just be ignored by the immune system because of that
This is truly amazing! I Pray that it's a step in the right direction for it's lasting cure.
While people are here talking about how the companies will react, I would like to inform people in the USA that Walmart sells Insulin for $25
My 31-month old daughter just got diagnosed with T1D and that these developments are underway really warms my heart. I’m sure, in her lifetime, a way will be found.
If it’s not profitable then no. Only under special circumstances will this (might) be available.
@ what do you mean “not profitable?”
Corporations Wouldn't like this. A cured patient is a lost customer
This common rhetoric is old and tired, there is zero proof corporations want people to remain sick and in fact, withholding cures actually hurts their bottom line. There are essentially an infinite number of diseases humans can succumb two and there will always be new ones that nature creates every single day. Withholding cures would be universally stupid on the part of corporations.
The Nobel Prize for this needs to go to whichever lawyer figured out how to patent the patient's own cells.
I can only imagine how expensive it’ll magically be to retrieve a cell sample and modify it.
stem cell therapy is never cheap, but big pharma largely has no control over it. The patient in question is on anti rejection drugs after a liver transplant, which is why she didnt reject the cells
Honestly so damn cool to hear! My brother in law has had it his whole life. Would be amazing to see him be free of it.
will not free from it per say, just regain the ability to produce insulin.
I'm amused it was fixed with the equivalent of turning them off and turning them back on again
And a lifelong regimen of immunosuppressive medication
As a Type 1 diabetic who hates how expensive the medical industry is, this is huge
Proof stem cell research is one of the most important types of research
Not really. Its promising, but with its own drawbacks and issues, that remain unsolved (so far). Think of it as fusion reactors, insane potential, but you wouldn't see results even in decade, or two, or three...
Remember none of these researchers have suicidal thoughts
The biggest challenge from diabetes for me has been mentally. It made me extremely depressed to the point I didn’t care if I lived or died. I just wanted to feel normal again. Type 1 runs in my family. I’m not as depressed as I use to be but I still haven’t found that normal feeling. I hope there is a cure
There will be a cure. Stay strong brother.
same dude, I just want to fking relax without needing to think about this. there's so many things that I can't do I feel like there's a leash around my neck all the time
I feel the exact same way, my friend. This is a big step in the right direction for us though, and we've persisted this long! Might aswell stick around for the cure. 😉
Well well well, sad life you have there, but the pharmaceutics industry ain't letting this cure slide so they can reap their sweet insulin profits. A sad world it is
@@karhonglooi7485real jerk move you saw people admitting they're hurting and just had to spit on the little flame of hope they have nice move
I hope it works. I have a young friend who was diagnosed in your teens. This would be great news for her and others.🙏🙏🙏💕
As someone with T1D, this excellent news
Still going to be at least 7 years before it makes it to hospitals in the U.S/West. But still amazing news.
@@hanzzel6086nah. It'd be fast tracked through FDA like Covid stuff was. FDA Fast track is literally built for this.
we'd have had flying cars by now if researchers didn't have so many unfortunate "accidents"
nah, the reason we dont have flying cars is to PREVENT accidents.
@@agustinfranco0 just have AI to drive the cars
@@rabbaniazzahra1784 we are not even there for normal cars,
We already have flying cars. They are called planes and helicopters.
Flying cars are a very bad idea, cars in general are archaic and backwards
Insulin companies: and I took that personally
I mean it's just for one type of Diabetes not all of them
@@angelmatiastorres That's still a HUGE loss.
Any loss to profit for that matter is a huge loss and they will fight against it.
@@thatpandaz6094 Yea, that's like 30% of their profit margin.
I think of all of the type 1 students that I've had over the years and feel a lot of hope. This is research that I'll be following.
don't forget kids, if it's not profitable, it won't happen
you can make money out of almost everything
........
this whole argument "a cure of cancer will never be released as it is more profitable to heal" is bs
.......
if a company discovers it
they can demand insane premiums as they will control 100% of the market with it and make butloads of money
Itll cost at least 100000 to do the treatment. The pharmaceutical companies are not going to let this happen unless they can still get their bottom dollar. Diabetes is a life long check for them and has been for a while now.
Why would they not charge a fortune for it? This will cost them billions to develop and maintain and it is a very complex procedure
The infusions I receive for an autoimmune disorder costs over $130,000/yr and it is not a cure. I enrolled in a gene therapy clinical trial. I may never see the results of it, but my son may.
I've been type 1 for 57 years. Throughout my life there have been these BIG BREAKTHROUGH moments, with "a cure in sight!" But then disappear. There is a lot of furor to get research money. but so far, the external insulin pump is the only thing that has come through for us.
Type1 for 35 years here. I really understand your way of seeing it. None of the BREAKTHROUGHS have been worth the hype so far 😉
I have had a chronic autoimmune illness for 12 years and the amount of times a doctor has told me that they are close to at least a medicine to suppress it for normal life and then i never hear about the medicine ever again has just made me give up. I never believe them anymore.
@@JM-dc5rn Don't give up! Someday one of these cures will work. But a fair amount of skepticism and patience is necessary.
A friend of mine did this a year or so ago (don’t remember the exact time). She is producing insulin. She has not needed insulin for over a year, and has an excellent A1C. It is so exciting!!
OMG I said the exact same WHAAAAT when you said the title. We basically jinxed! You're pretty damn clever in knowing your audience ❤️
I felt a great disturbance in the Market, as if millions of Insulin Manufacturers suddenly cried out in terror and were suddenly silenced. I fear something great has happened.
I too can feel the force and it's strong with this one
The Pharmaceutical Empire will strike back.
Only in US. Cause insulin isn't actually very expensive even in canada. And same companies are actually doing (and are interested) with similar researches, you innovate or die with the industry. And if you were the one to kill it by making every other treatment obsolete...
Shout out to John James Rickard Macleod for co discovering insulin, couldn’t have done it without him
During his life he really didn’t get the credit he deserved and was only acknowledged properly after his death (typical), so I’m always happy to find any chance to mention John James Rickard Macleod and his co discovering of insulin
He’s buried 5 minutes from my house and my city recently opened a memorial garden in his honour (Aberdeen, Scotland)
Thanks for the information! I like knowing things like this! And yes, I think he deserves a Memorial Garden, at the very least!! I hope someone keeps it up! Would you please, if the ubiquitous "they" don't? Thank you again! Have a Verý Merry Christmas, & a Blessed New Year!!!
Thank you Mr. McCloud for all your work & the finished product! RIP!
I really really really hope this ends up working better than they even hoped for
this shi gonna be practically impossible to afford💀💀💀
Not if you live outside the US lol
At the beginning would be...but it will be cheap in the future.
@@rickdelpino472 If its expensive its only going to be because someone wanted to make alot of money. Either by being bought out for millions by someone to then jack it up. Or just a change of heart by the makers to do good
The only thing is for insurance this may be cheaper than paying for all of the medical supplies for the rest of your life.
To be fair, people said that about basically every major medical advancement, even ones that seem simple and affordable now like penicillin or x-ray machines.
As the father of an 11 year old who was diagnosed at 8 this is wild
The problem with this treatment is that it may not suit some to most type 1 diabetes patients as there is an autoimmune destruction of these cells in the first place (probably why a 5 year follow up is required), maybe with immunodepressants it could work, but then there is the problem of immunosuppresion itself
That's a really good point.
Not to mention the tendency of these types of treatments to turn cancerous.
I was also curious about that angle. I have damage to my islet cells from chemotherapy, so the same symptoms, but I'm not type 1 and my body wouldn't attack the cells.
Unfortunately, because few people like me exist, most research on transplants and cloning these cells involves/assumes use of immunosuppressants, which are a big NO for me.
Transplanted islet cells have been in use in procedures in Canada for over 20 years, so the cloning must be the first. Given the 20 years I just mentioned, I wouldn't get your hopes up for mass market - last I checked, you still had to get into a research study to get the procedure as a Canadian.
@@stephenmadl5609these treatments do not turn cancerous, they do not have their normal cell growth regulators turned off like cancer
The woman this was done on was already on immunosuppressants so yes, good chance they’d be needed if this method is replicated on other patients and as you mentioned, those cone with their own host of problems.
T1 here. Been a lot of 'cures' over the years. Don't get me wrong, I appreciate any attention brought to the disease, and I think you had a good take on this news in general. But I remain skeptical, because any time a 'cure' involves just getting the body to produce insulin again (which has been achieved in several ways now), the autoimmune response invariably kills off all those cells again.
What would be interesting is if one of these treatments could last even a month, let alone 5 years. A shot every month beats an insulin pump, or 5+ shots per day, and needing to constantly get insulin. So I'll keep on hoping and believing in progress!
As a Type 1, this is huge and I cant wait to hear what comes of this.
Type 1 diabetic here, very enthused to see some progress here since even my pump hasn’t had many major changes in 8 years.
They discontinued my previous pump that I’ve had for 7 years. It was like saying goodbye to an old friend.
My sister's endocrinologist predicted this about 35 years ago.
I was the one who predicted your sister’s endocrinologist would say that 70 years ago
I predicted flatscreen tvs 20 years ago
as Deadpool said " come back to us if you find type 3"