Exploring fat loss supplements and drugs: L-carnitine, yohimbine, & more | Peter Attia & Derek MPMD
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- เผยแพร่เมื่อ 24 ม.ค. 2025
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This clip is from episode 291 ‒ The role of testosterone in males and females, performance-enhancing drugs, sustainable fat loss, supplements, and more with Derek, More Plates More Dates. Derek is a fitness educator, the entrepreneur behind More Plates More Dates, and an expert in exogenous molecules commonly used and misused by bodybuilders and athletes.
In this clip, Derek and Peter discuss:
Why do people inject L-carnitine?
How effective is caffeine both in terms of its effect on appetite and potentially its effect on fat oxidation?
How does caffeine compare to ephedrine?
And more
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About:
The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
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Yohimbe discussion is at 8:01
Your welcome
Thnks
ty
Thank you
Not all heroes wear capes
Thank you
Started injectable carnatine a month ago with the hopes of having bettter climbs and knocking up my wife. I noticed better climbs for sure but i didnt expect it to smack my depression in the face. I havent felt this calm as an adult and just not as anxious in 20 years. I wish i hopped on years ago. Turns out there is literature confirming its impact on depression.
Really?! Damn this is what I need. Been having a rough time last few months. Definitely gonna check it out. Thanks
how much do you take and how often? where do you get it from? Willing to try anything at this point for the depression
where else can I find carnitine (avoiding the inyectable form)?, amazing that help you a lot
@@ozzie4306please check with your doctor first.
@@EyscSome supplement stores, both online and physical, will sell liquid l carnitine that you just drink, it has like 3g per serving, but you need like 5-6g to get the same bio-equivalency as 500mg injected. There are of course also capsules and pure powder, both very cost effective
I know Peter Attia is a MD but hearing someone in this space mention GMP, sterile water, etc it’s refreshing to hear for me considering I’ve worked in pharmaceutical manufacturing
hearing him say HOW WOULD A NORMIE ''serialize water!!!?!?!'' I just dispair that he actually passed his MCAT at this point.
I've used L-carnatine for several years. Definitely improved my half marathon times and speeds up weight loss for sure. 2,000 mg works great for me. Doesn't work if you dont exercise, being fasted speeds up fat loss with it.
Don’t take it in pill form or injectable?
@@matty4nattyinjectable is gold standard , works immediately.. oral sucks
I've read you have to take like, 4 grams orally to get an "efficacious" dose, and it can affect TMAO in the gut.
@@NavaDownSouth can you recommend an injectable L carnitine?
Thanks
@MrMJG12 I can't hook you up with a good supplier if your in the US. Usually takes about 2 weeks for shipments to arrive.
The way I understand yohimbine is that it works if you work. If you take it and just sit on the couch, it's not gonna do anything. I also read somewhere that it needs to be taken on an empty stomach because insulin affects it somehow. So, there are no carbs with it usually.
You are correct. In my experience it also works well if you take it like 4 plus hours after a meal on a relatively empty stomach. It's useful for fasted training and pushing a meal off to a later time
@rjburger1234 I haven't tried it but a bodybuilder I know recommends it for fasted cardio.
@@nboss968 It's gonna hit you like a truck in a fasted state which is a good thing in a dieting context
Disagree. I took it once some years ago… 5 or 10mg from memory, and I was just at home chilling. Within an hour I was shaking, sweating, feverish, and feeling incredibly unwell. It’s seriously strong stuff and I didn’t have to do anything to get a volatile reaction
@@mjrowdenin that case it was definitely just too much. Some side effects may be unavoidable but it shouldn’t be crippling. Maybe try alpha yohimbine as it can have less side effects.
My experience with Yohimbe: I’ve been taking a Yohimbe supplement for quite a while (on/off cycles. Maybe since 2012 or so. I will not name the brand.) After that brand stopped making the yohimbe supplement. I moved to Yohimbe (raw/powder form). I have had no issues with it. As an Amateur Bodybuilder I do train hardcore so I make sure to reap the benefits when I take it.
Yohimbe jacks me up to the extreme. It feels like my body temperature is at 105. It's crazy how different everyone is when it comes to taking things.
“I will not name the brand”.
Nobody asked.
I bought Yohimbine years ago. 5 or 10mg but I struggle to remember. Took it only once. It may be incredibly unwell. Violent shakes, sweating, burning up. Seriously strong stuff and I couldn’t cope
@@dylaneckhoff2784you clearly care a lot, lil boy, given that you're crying in the comments
@@vakari8507"lil boy" -🤓
I really wanted to know why they were injecting it and he cuts him off to ask an obligatory question.... 🤦♂️
me tooooooo
@@schoolofhotHe said in another video is because its bioavailability is low meaning its absorption in the stomach is low (around 10% or less depending on gut health) so injecting it is usually better cost wise and dose wise
taking L-Carnitine from Swisschems and really helps a lot for fatloss.
Oral or inject
anally
@@Origin22Inject is the only way to go
Facts just started using it and the shit works, injectable works best as it’s more bio available and better for other health metrics
Took yohimbe years ago, horrible; made heart skip beats, tingling in fingertips, no cardiac problems, don't recommend, anxiously laid in bed waiting for it to pass
😂😂 definitely using it wrong or you have a condition and should get checked.
@@Antonio-xu3vv neither; different drugs affect people differently
Sounds like maybe you were just falling in love
Everyone I know who has tried yohimbine says the same thing, it's a panic attack in a bottle. Ephedrine lite.
Dosing is an issue, that could be factor in a large portion of these comments.
The delt lord has arrived to bestow supraphysiological levels of information on how to get diced to the socks and absolutely peeled out of your gourd
It's super efficacious
Laughing crying face emoji and a fucking fire emoji
WHAT THE FUCK MAN...😅😅😅
I got fucking shredded in 2020 on yohimbine and running. Fantastic for a cut but you will feel it
How do you use it like at what time ,empty stomach, before cardio or weight training?
@@himanshu7851before am fasted cardio. For cut. Recomended dose is based off weight.
Don't use the highest amount right away because you don't know how your body will feel. It could fuck you up if your not ready or your body won't tolerate it. 😂
Note you still have to put in the work and have proper macros. I was just seeing how shredded I could get in 4months. Diet macros on point, stupid cardio 5miles a day, weight training 5 days a week.
Did u face any side effects?
What I have seen over the years is everyone is a bit different in their ability to utilize supplements. Injectables like Glutathione, L carnitine, hormone D3 may be needed as a injection. I've seen people use high amounts of d3 and still be low and others nothing or low amounts and do incredible. Same with creatine.
They're fat and dosage of D3 is too small. It's stored in fat. Carnitine doesn't absorb in the stomach...
@@MarkRodriguez-l4m No, some of these people are not any way fat, still low D levels! And if you reread I said creatine. Not carnitine .
@@quantumfx2677 I've read that if the body has various toxic heavy metals buildup, it will naturally suppress vitamin D levels to prevent further absorption, thereby keeping D levels low despite supplementation. Run some heavy metals tests. Doctors data on amazon is ~$120. 😎
I used to love the euphoric effect of ephedrine
You still can. Over the counter, the product is called BRONKAID 25mgs of PURE ephedrine and 200mgs bronchial dilator, which will help further performance opening your airway. Take caffeine at 200mgs and stack the 25mgs of ephedrine (2:1) and watch the fat melt away.
@@sg255010 we can't get it here in the UK unfortunately, we used to have chesteze which was very similar, but it got withdrawn.
@@sg255010 i take BRONKAID with caffine but i don't notice any euphoric effects
Were you ripped out your tree?
Boiling works well to sterize water. If you want a higher temperature, use a pressure cooker. Even pharmaceutical companies use this method. It's been around thousands of years. It's why people drank beer in the middle ages not to get sick from water straight from wells or streams. Is there a better way?
Just get 30 ml bacteriostatic water for $7
Buy distilled water, mix in benzyl alcohol at a 1/100 ratio to the water, bam you've made bacteriostatic water, liters of it for barely any money.
They do use bacteriostater water lol not sure how they didn't know this
@IISocratesII homebrewing is effective and easy, Derek has a conflict of interest for prescription TRT. You can buy the powders for test or anything for pennies in comparison to the actual meds
@@xCestLaVie1 I am aware, Chinese raws cost very little.
Duuuude. Derek is a smart MF!!! Every time I see him, he seems to know more and more. 👏 👏 👏
L Carnitine orally has helped regarding gut and heart health. It’s good stuff
When did you take it ? Thanks!
Let Derek talk man, stop interrupting.
True story: A few years back I had to move, I'm a Leo so I didn't as anyone for help. Me and my wife were moving from a 3 BD house to another 3 BD house. I took a 9mg does of Yohimbe and completed the entire move by myself in 8 hours.... non stop! the stuff works too well!
what's a leo ??
@@nach-fr an excuse adults use to justify their weird behaviours
I used to take yohimbe before tennis or cycling, and it was night and day difference from caffeine. I can only imagine that it would be interesting for weight training. The vaso dialator effect could potentially lead to some weird interactions at the gym though.
Stuff made me feel terrible. I’ve tried it twice but never again
where can I get that Senna t-shirt?
Senna shop
One question, if my goal for using carnitine is not for anabolic gain but only mainly for fat loss are oral 500mg tabs enough for that purpose?
I would add at list 10 more seconds of the final tune... it's more energizing than all those supplements... "it keeps you alive ... fast and furious!"
I never know where the answer is with these two.
They speak more in puzzles, so you need to do a bit of leg work. Mainly because their TH-cam content is a funnel for their businesses.
In order to achieve the benefits of L-Carnitine you need a very long loading phase, up to 24 weeks, and it needs to be taken with 40-80 grams of carbs to increase bioavailability and transport into the muscles. In general it helps by enabling your cells to use more energy from fat, so it benefits Low Intensity Steady State exercise. It helps you to burn more fat as you do your zone 2, improves zone 2 total work output, and improves blood lipid profile.
TMAO production can be attenuated by taking Berberine.
works immediately, and you can use it fasted , your bro science needs correcting 😂
@@NavaDownSouth cite your sources bro
I’m referencing actual studies on people. If I could include links in TH-cam comments I would
@5kribbles not replying to be shitty or disagree just interested in the study. Can you post pubmed ID?
Are you referring to injectable or oral l-carnitine? Injectable has no loading phase and its ideal to keep insulin response low in order for the l-carnitine to have its largest fat burning potential. I see it regularly with my clients, when they incorporate l-carnitine by the next week their circumference decreases rather dramatically. Would love to see the pubmed articles you're referencing in case I'm wrong 🙌🏻
At 6:21 grow what? Leaner, or wean...?
Grow leaner 🥲like lean gains
I had the same question XD
On Derek's channel he's very pro L-carnitine and Yohimbine and here he's like it's not that great. I don't get it
This is a more recent video. I guess he experimented and did more research.
Yeah that was 4 years ago wernt it 😅
@@pabskingofswing7540idk what changed, he said that he had been taking yohimbine for years and it worked great for him
What is Derek's shoulder routine? That boy is jacked!
What about liposomal delivery?
Yohimbine is amazing got noticeable results in 4-5 days
I was going to subscribe but the way he kept interrupting pissed me off
Wait, so why do so many energy drinks contain a fat loss drug?
L carnitine is a amino acid from red meat and some other sources.
It’s not a drug. Also, 2g/day taken orally is a minimum effective dose for most and most energy drinks have a gram of l carnitine at most
L-Carnitine has been a wonder drug for me. The bodyfat has actually melted off; I can vouch for that.
Brand?
@@Redwood14, jarrow formulas, fitness support. It has worked for me.
@@Redwood14 Get some Carnipure, brand doesnt matter
@@hamdi9022thank you!!!
Are you injecting or taking orally? How much?
IM L-Carnitine has been a positive experience. Would suggest.
I am considering to add yohimbine to my regimen; only thing want to understand if it has any material side effects and whether one should take it ongoing similar to creatine or on and off basis; and lastly would the fat build back up after dropping it or not necessarily
Don't , Yohimbine is life threatening.
Yohimbine is no joke. In my experience it is without a doubt an extremely strong stimulant, but unlike amphetamine type stimulants, it is very uncomfortable at stimulating doses. It is accompanied by a strong increase in blood pressure at stimulating doses. I would not recommend anyone take it as a pre workout.
In fact, I’d go as far as to call it a “torture stimulant”, due to how uncomfortable of an experience it was for me, and is certainly not an experience I would ever care to repeat.
Derek's clinic "Marek Health" recommends taking L-Carnitine so what's up with this bro?
Yohimbine made my heart race. I don't recommend for people with sensitive hearts.
Hi can anyone recommend an injectable L carnitine? Thanks
Would veterinary L Carnitine work for fat loss? .....asking for a equine friend..ahem
Carnitine is amazing.. Total game changer pre workout injectable
What about the methylation of carnitine? I take Trimethylglycine, and it helps methyl lots of things, aminos. And L Carnitine?
Brother you can't methylate shit in your stomach
does l carnitine impact thyroid?
Yohimbe is what I imagine a bad trip feels like. Absolutely hate the stuff.
L-carnitine as a pill works too?
90% gets pooped out and you need at bare minimum 400 mg in the system. So 4 g works as ingestible. Youd also have to stack it, prefer you take it 4 hours later is trimethylglycine and black garlic
"One day where you need a bump".... I hear you big man
derick literally has a video where he advocates for using injectable L carnitine. he describes "burying the needle' in his ass. so now because he is in front of an MD he is shy.
Compounding pharmacies are dodgy?
What next, the deadly perils of water?
I'm out
Dude, let him answer a freaking question...
Brutal, he was just about to unpack the injections and cuts him off, so bad
Yohimbine will light you up. I’ll never take it ever again. Sent me to the er for tacicardia. MMV
Tachycardia
what a bs. you decided we need to know this but not the dose.
Isint L Caratine in monster ?
The doctor interviews the bro scientist? Oh how the turntables
This man cuts Derek off at every question
Seriously! Dude needs to let him finish his sentence
Derek is irrelevant he sells turkesterone
Derek was fed up with it. So was I.
??? Lmao no he does not. Derek says like 100 words to his 1 this entire video
Dr. Attia is pretentious and inconsiderate
L carnitine capsules good for fat lose driving all day person
Derek’s face looks really full rn
Id trust MPMD over any MD when it comes to bodybuilding pharma tbh
The premise of injectable l-carnitine lacks specific experimental evidence (for pretty much every claim Derek makes) and when considering the putative IM or subQ pharmacokinetics and established endogenous basal regulation- there really isn’t much of a theoretical rationale either.
Once absorbed (orally or from the injection site) carnitine has a low volume of distribution (0.2L/kg), with no plasma binding, slow rate of tissue disposition (with lowest/slowest uptake in skeletal muscle)- where for the lions share of dose administered; will
essentially dictate a one compartment elimination model with predominant renal excretion, using the same transporter for resorption as that for skeletal muscle uptake- where the threshold for resorption seems to fall within endogenous ranges (40 micromolar) anyway. With such in mind- increasing the carnitine pool by such a meagre amount and in what would be an extremely slow manner (only for it to be rapidly regulated anyway), and attempting to exploit any pharmaceutical advantage seems almost not worth the hassle of uncomfortably injecting a hypertonic water solution daily and predisposing risks that come along with that (infection, bruising, etc).
I inject all my supplements 🥰
Attia why interrupt your own guest
Wait what?! They really inject l carnitine in America? 😂
You can buy sterilized water to mix it with for injection
senna shirt....
Damn Peter be cutting off Derek every chance he get's in this clip haha
the delt master has arrived at supraphysiological levels of adipose tissue it seems
Wow the comment section become a druggy forum.
If anything, the take away from this conversation was more something like: most of the stuff is not worth it.
Weird to see people trying to "improve their marathon time" by injecting stuff. I hope they are professionales, because if not, it just sounds ridiclious to me.
Just because you're terrified of injecting stuff doesn't mean it's a bad thing. Some things are perfectly safe to inject, even if they may not have any benefit.
Totally agree with you. I've stopped watching Peter attia videos as well.
It’s not heroin, it’s L carnitine. If you can take something in a way that makes it more bioavailable then why not? It’s not making anyone a “druggie”. That’s pretty judgmental.
Dude you’re scared of a naturally occurring amino acid? That’s completely legal? And has studies?
Doesn't Derek heavily push l-carnitine in his Gorilla mind products??
Just searched his site and didn’t find any
@@mjrich13It’s the “androgen receptor” supplement
L-Citrulline not Carnitine
Hate how he's constantly interrupting, Jesus.
Derek's lips are amazingly dry... is it the weird things he takes?
permanent damage from accutane, he mentioned it other times
Dreadful interview skills. Was about to hear a ton of key answers to questions you killed before they left Derek's mouth.
You can buy sterile water… it’s called “bacteriostatic”. I’d be more concerned about having a pure raw form of Carnitine than I would about the soluble.