HIV and AIDS : Pathology
ฝัง
- เผยแพร่เมื่อ 3 ธ.ค. 2024
- Pathology lecture and lessons of life for living a beautiful life.....
HUMAN IMMUNODEFICIENCY VIRUS (HIV)
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●LENTIVIRUS (slowly replicating RETROVIRUS) that causes the acquired immunodeficiency syndrome(AIDS)
●a/k/a---“ Slim’s disease “ ( d/t weight loss)
● Commonest secondary immunodeficiency disorder
● Most patients with HIV infection progress to AIDS after a chronic phase lasting from 7 to 10 years.
●Most common mode of spread --- (75% of all cases)Sexual contact ( most commonly from Male to female ).
● Risk of transmission with needle stick injury--- 0.3%.
● Commonest cause of AIDS in children --- Vertical transmission
● BLOOD BANK and HIV ( Harrison18/e page no - 1513 ):-
●Blood collected for transfusion is routinely screened for both HIV-1 and HIV-2
A) HIV transmission is by-------
1) whole blood
2) packed rbc
3) platelets
4) leucocytes
5) plasma
B) No-HIV -Transmission is seen with
( processing procedure will inactivate virus in all given products) ---
1) hyperimmune gammaglobulin
2) hepatitis B immune globulin
3) plasma derived hepatitis B vaccine
4) Rh0 immune globulin
■ HIV Epidemiology:-
● HIV-1 ---- most common type a/w AIDS in the United States, Europe, and Central Africa and India.
● HIV-2----- in West Africa and India.
● HIV-1 three subgroups
1) M(major)
2) O (outlier)
3) N (neither M nor O)
● Group M ( subtypes or clades ;A to K ) ----most common form worldwide
1) Subtype B --- most common in western Europe and United States
2) Subtype E --- most common in Thailand.
3) Subtype C (fastest-spreading type worldwide) --- most common in India, Ethiopia, and Southern Africa.
● Most common cause of AIDS in India--- HIV-1 group-M , Subtype-C.
■ life cycle of HIV:-
● HIV infects cells by using ---- CD4 molecule as receptor and various chemokine receptors as coreceptors.
● CD4 receptors are required for entry of HIV in Brain
a) macrophages /monocytes
b) dendritic cell
c) CD4T cells (worse affected cells)
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Are u have a any scientific paper there is proven hiv is a cuase of aids
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Topics (High yield topics for NEET PGMEE also)
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Best wishes to everyone.....
These type of teacher is all we want.... Respect from heart thanku so much sir❤
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You are awesome sir,please cover all the chapters of pathology. It would be really beneficial to us.
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Sir.. U are a magician..😊🙏
Dear Dr. Your teaching is very impressive with appreciation and thanks
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More about HIV AIDS
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Wow super lecture thanks Sir,now clear my concept keep it up sir
Sir your Lecture is Very crucial for me. I hope you will upload more videos on The Cholera, TB, syphilis Malaria etc
Thank you
Point to point clarity thank u sir
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Very nicely explained!
Thank you Sir..
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Sir pls upload more videos your lecture very helpful
Thank you sir , crystal clear explanation ❤
Kindly arrange lectures for PG Pathology students..
Thank you sir ❤well teaching sir ❤
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Amazing, Sir.
Thank you so much.
2/FEB/2022, 12.00 PM IST
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Respected sir thanks a lot for this amazing explanation 😇
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Sir please make video on Pathophysiology of fever🙏🙏
Thank you so much sir for this and every other lecture you upload 🙏☺
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simply awesome!! thank you!!!
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Thanks sir ❤️ it is very helpful
Thanq sir..much much needed video
I love your videos Sir, I've no words to thank u.
Sir please make videos of systemic pathology. At least please cover MCI Competencies.
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Very good explanation😊
Wow sir you teach like of extraordinary or high level🧐🧐
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@@DrDeveshMishra please sir upload more videos for b.pharma students 2nd sem.
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Love from Kashmir.. Very beneficial sir
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Absolute legend.
Great lecture sir🙌
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Ur the best 🎉sir
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Thanks a lot sir
الشرح كلش حلو عاشت ايدك😅💛
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Really Excellent
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Excellent explanation ❤
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Very understandable! God bless you sir😊
Hello sir I have one dout in hiv 1 &2 and they have lot of strains and subtypes so the antibody test and fourth generation test and rna pcr test can detect all types of hiv strains and subtypes ??? Please give me reply sir
gud work keep it up sir plz upload more videos
Thankyou so much sir ji 🙏
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Please upload sir how to study glomerular (em/LM/ structure
Surely
Hi sir please answer....hiv test ka window period kitna hota ha
Amazing lecture covering everything we need to know about HIV.
1 doubt sir...
Which helps in penetrating host cell?... Gp120 or CCR5/CXCR4
Both
@@DrDeveshMishra Sir there was a ini pyq where we have to select 1 from, Which helps in penetrating into host cell ?
A) gp41, B) gp120 C) CCR5 D) CXCR4
Thanks dr😊
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Sir plz upload videos on renal pathology
Excellent teaching sir
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Thank you so much sir!! U made all the points very clear!!
Thank u so much. Wishing you great success ahead👍
Sir please add A video on Coombs Test
Respected sir thank you lot please make more videos on pathology sir due to pandemic again we are at home ❤️🙏🏼
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Sir plz upload videos on non Hodgkin's lymphoma
Thank u sir 😇
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H.i.v patient ko नींद की दवाई दी जा सकती है?
CCR5 are not present on t-cells
Plz upload same more videos sir
Thanks sir
Sir,where is the HIV DNA formed!In cytoplasm or host nucleus?
Thanks sir 🙏
sir HIV 2 is most commonly present in West africa and india as per as Robins and Harsh mohan.
Yes
But it means HIV 2 most ofyern founded in africa and asia ...But Not more than HIV 1 .
I hope u got this point
Plz explain spegra tablet
17:25 sir they not Africans they Northern Europian people who having mutations against gp120 ‘s coreceptor.
In southern african also it is seen👍
Awesome sir❤
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Isn’t most common route male to male?
🕉 No
Dear Sir
Most sexual transmission has occurred among homosexual man.
From Robbins
But in lecture u r saying that M to F transmission is most common.
Plz solve this controversy
Thats the US data, even u can see in next paragraph its written , Globally Heterosexual transmission is most common
@@DrDeveshMishra exactly sir.. It's written there
Sir you didn't say about HIV-2
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Hello sir I had unprotected sex at the age 19 now my age is 25 .is their any risk bcoz till now I don't see any symptoms and now I become more healthy and fit as compare to past .i don't have any problem. Now that boy got married and have 1 child whom I was in relationship.can I safe now?
Get RTPCR done for yourself
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NHL is not most common HIV malignancy . in robbins page no. 253 kaposi sarcoma is most common
Follow this data which i have said these are WHO annd Harrison updates👍