Even oral EDTA at 5% absorbtion over long term is manifesting as a very good action on biofilm & reduction of calcification of coronary blood vessels including capillary artheries & vans ....
How can CALCIUM disodium EDTA remove calcium from tissue when this specific EDTA form is already saturated with the element calcium. For sure disodium EDTA will remove calcium because it is not already saturated with that element. That is why disodium EDTA ("edetate disodium " ) was used earlier as calcium chelation agent, however edetate disodium, has a markedly improved ability to bind calcium; that is why this form is no longer used for chelation therapy due to the high risk for hypocalcemia. But does calcium disodium EDTA still do the job with calcium in the body?
Dear Sir I like your videos because they are crisp and you usually talk scientic and evidence based. Your this video was disappointing. 4 invitro studies, most by Indian authors, ?pharma sponsored and published in not so well known journals. No known hepatic renal hematological safety profile known in settings of sepsis. Afterall, it is a chelator (what about calcium magnesium levels in septic patients) and also an anticoagulant (Sepsis patients /mods patients already prone to bleed). And above all, the risks could be acceptable if the benefits are significant. Your talk on this molecule and favorable inputs will motivate use (misuse) of this molecule. This will send many ICU doctors on illogical spree of using this molecule in patients who are already critical. If pt die, they'll blame the disease, if pt survives then, voilà, EDTA is magic. Further more, your plan to use it in 30-40 patients, sponsored by pharma, for a drug that doesn't have gone phase 3 trial in setting of sepsis or safety studies in Sepsis patients, leaves a bad taste in mouth. Regards. Shiv
Even oral EDTA at 5% absorbtion over long term is manifesting as a very good action on biofilm & reduction of calcification of coronary blood vessels including capillary artheries & vans ....
I am from Zymes biosciences ,this video is useful for me also.
3 gm is the maximum dosage for EDTA which is 40 PFS of 75 mg and not 4 as mentioned by you. 1 gm is equivalent to 1000 mg. Please do look into it.
How can CALCIUM disodium EDTA remove calcium from tissue when this specific EDTA form is already saturated with the element calcium. For sure disodium EDTA will remove calcium because it is not already saturated with that element. That is why disodium EDTA ("edetate disodium " ) was used earlier as calcium chelation agent, however edetate disodium, has a markedly improved ability to bind calcium; that is why this form is no longer used for chelation therapy due to the high risk for hypocalcemia. But does calcium disodium EDTA still do the job with calcium in the body?
Also combination should be wisely choosen, CEFTRIAXONE SULBACTAM EDTA for eg
Max cumulative dotal dose 3000 mg: max daily dose 75 x 4 = 300 mg:
Most severe infections 75 mg q12 h
Sir, This is a very interesting molecule that seems promising. My doubt is, what is the timing of initiation of iv EDTA?
3 gm per day will lead to coagulation issues
Dear Sir
I like your videos because they are crisp and you usually talk scientic and evidence based. Your this video was disappointing.
4 invitro studies, most by Indian authors, ?pharma sponsored and published in not so well known journals.
No known hepatic renal hematological safety profile known in settings of sepsis. Afterall, it is a chelator (what about calcium magnesium levels in septic patients) and also an anticoagulant (Sepsis patients /mods patients already prone to bleed).
And above all, the risks could be acceptable if the benefits are significant.
Your talk on this molecule and favorable inputs will motivate use (misuse) of this molecule. This will send many ICU doctors on illogical spree of using this molecule in patients who are already critical. If pt die, they'll blame the disease, if pt survives then, voilà, EDTA is magic.
Further more, your plan to use it in 30-40 patients, sponsored by pharma, for a drug that doesn't have gone phase 3 trial in setting of sepsis or safety studies in Sepsis patients, leaves a bad taste in mouth.
Regards.
Shiv
Guess how much an edta+colistin drug course costs? Equivalent to a mbbs doctors monthly salary. Both being in india.