The Endocrine Society should organize public discussion between Michael Holick and Marie Demay this month. The new guidelines and related articles are essentially back to square one.
This assessment is completely inadequate. Heartbreaking really to see Bikle and others on this panel and this monstrosity of this guideline. The very premise of 'what levels of vitamin D can we recommend to prevent disease in a healthy population' is an acrobatic act of contortions of physiology, political, or the very least profound ignorances, placed (burdened)on a micronutrient that is a cellular necessity that enables actions across all cells tissues and systems, which will neither cause, prevent or cure but rather enable cells to act out their instructions as they should in different wide array of cellular environmental stressors across endocrine, paracrine and autocrine, one can not separate. To apply xenobiotic study/research model is wholly inappropriate. To review garbage research you get garbage output. To tease out limited physiologic targets for the convenience of politics, and ignore the rest of its bodywide physiology is a bit like saying the brain is separate from the body,. Indeed it seems to be in this new generation of Endocrine Society leaders. Simply having enough of almost daily intake of the native vitamin D3 cholecalciferol is key to supplying the bodies needs in all compartments without compensations, that amount will be different, so it can't go by dose, but rather more appropriately by weight, to create and maintain the testing circulating metabolite calcidiol 25OHD3 a minimum 50ng/ml. Anything lower will cause compensations across a multitudes of cellular signaling, functions and abilities to properly modulate. How all these experts with lifetime in research and vast amounts of vitamin D physiology could allow the standing definitions all these many decades rife with inadequacies to continue is beyond me. And also to anyone who can read and understand the research and tease out the politics from sound science and mechanisms, and there are many, but ever so many more who can't. Credulity is the fodder for this beast of politics, tribal alliances, willful blindnesses, egos, and academic games. All it does is continue to obfuscate clarity and injure the health of our populations across the globe. One might even be tempted to claim malevolence and diverting the course of health care in a continuous harmful manner.
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The Endocrine Society should organize public discussion between Michael Holick and Marie Demay this month. The new guidelines and related articles are essentially back to square one.
This assessment is completely inadequate. Heartbreaking really to see Bikle and others on this panel and this monstrosity of this guideline. The very premise of 'what levels of vitamin D can we recommend to prevent disease in a healthy population' is an acrobatic act of contortions of physiology, political, or the very least profound ignorances, placed (burdened)on a micronutrient that is a cellular necessity that enables actions across all cells tissues and systems, which will neither cause, prevent or cure but rather enable cells to act out their instructions as they should in different wide array of cellular environmental stressors across endocrine, paracrine and autocrine, one can not separate. To apply xenobiotic study/research model is wholly inappropriate. To review garbage research you get garbage output. To tease out limited physiologic targets for the convenience of politics, and ignore the rest of its bodywide physiology is a bit like saying the brain is separate from the body,. Indeed it seems to be in this new generation of Endocrine Society leaders.
Simply having enough of almost daily intake of the native vitamin D3 cholecalciferol is key to supplying the bodies needs in all compartments without compensations, that amount will be different, so it can't go by dose, but rather more appropriately by weight, to create and maintain the testing circulating metabolite calcidiol 25OHD3 a minimum 50ng/ml. Anything lower will cause compensations across a multitudes of cellular signaling, functions and abilities to properly modulate.
How all these experts with lifetime in research and vast amounts of vitamin D physiology could allow the standing definitions all these many decades rife with inadequacies to continue is beyond me.
And also to anyone who can read and understand the research and tease out the politics from sound science and mechanisms, and there are many, but ever so many more who can't. Credulity is the fodder for this beast of politics, tribal alliances, willful blindnesses, egos, and academic games. All it does is continue to obfuscate clarity and injure the health of our populations across the globe. One might even be tempted to claim malevolence and diverting the course of health care in a continuous harmful manner.
Healthy people is not good for busine$$.