USMLE STEP 1 BIOSTATISTICS: DRUG ADS, ABSTRACT (PART 1)
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USMLE STEP 1 BIOSTATISTICS: DRUG ADS, ABSTRACTS. This is the first attempt to learn a strategy for Drug Ads. If you come across drug ads that we can share, please send to Randy.Neil8@gmail.com. If we can learn one point for the STEP exam, then it's a success.
This comment might be off-topic. But watching your videos made me realize that this world is a better place because of people like you. Thank you for everything.
We had no biostats course in our medical school. Your videos not only helped me ace my Step 1 and Step 2 Ck but also made me a whole lot more interested in Biostatistics. I will take Step 3 in a few days and prepping for Day 1 now.
Thank you for the kind comment. I appreciate your words!
hey there! first year resident in peds, i recently just passed step 3 with your lovely videos! i recommended your biostats vids to all my co-residents taking step 3 this year and they've found you IMMENSELY helpful
CONGRATULATIONS on Passing STEP 3!! Such a relief. "Enjoy" the rest of intern year. It's a lot easier when you get beyond INTERN year and go into your specific field... Thank you for taking time to leave a comment.
Hey! Is there a way we can get in touch? @ MD-co4lu
I can’t believe this for free. Thank you so much, you are the best!
You are most welcome.
If anyone has examples of DRUG ADs, please share. The hardest part was finding examples to work and put a strategy to. Please send any problems you'd like to see worked to randy.neil8@gmail.com
This is SO IMPORTANT. They are so intimidating and require so much time...and I never know how to tackle them..and waste time for naught. Thank you. Please continue to help ...need this for step 3
Morgan, Thank you for the comment. I need to make a PART II to cover the HAZARD RATIO etc and to discuss a few other areas... I am glad it was helpful...
Thank you so much doc.! you don't really know how much impact you have already created in my quivery biostats world. I had difficulty through out med school and even on step-1 but, when ever I had to review biostats I straight away watch your videos. They really helped me and reduce anxiety in solving biostats questions. I don't think there are any other better ways to explain these confusing concepts. Thank you keep doing these videos. Don' forget there are many students like me who are willing to watch your videos.
You finally made a video on drug ads!!! Thank you so much. It is really helpful. I love your videos. You make biostats so easy for everyone.
Ufaq, I am glad you find them helpful. Keep studying HARD!!
Oh my gosh, I am so so so relaxed after watching this. GOD bless you
Abdul, Glad it was helpful. Thank you fir taking time to comment.
This was amazing. I may owe you my career if I passed step. Thank you sensei. :)
Ahh... Tell you what. After you get into residency...you can get me drink... until then, KEEP STUDYING HARD!!!
Thank you so much!! this is really helpful. Please use drug ads from USMLE step 3 as these ad questions are hammered there. And please release part 2 of this video soon!
Saira, Thank you for the comment... As soon as I can find some Drug Ads or Abstracts to use, I will most definitely try and upload... Glad it was helpful.
Thank you Dr. Neil! I used your videos for step1&2 and now I'm studying for Step3 and I feel like I'm reading something totally different. This was very helpful. Looking forward to viewing more videos. #BiostatStep3Helpppppp
You are awesome!! Thank you for teaching all of us starving students! God bless
Chujinum, No worries... I was once in the same boat.
First time I've ever felt like I might be able to get some of these right. So thank you!!
CRUSH IT!!
Thank You Randy. These drug ads have been giving me so much problems. I will try your approach for my exam
Give it a try... If you come up with anything we can improve on... please share with us... We can all do this together.
@@RandyNeilMD hello Randy. It did my exam 2 weeks ago and I just got my results. Thank you. The only thing I may suggest is that you use more examples. The method clearly works. Do you guys have an email so that I may send possible drug add questions
As usual I’m really thankful for all the effort you’ve been putting in those videos ❤
Thank god i found this video. I was waiting for your video on drug ads for a long time!! You're awesome!
Dnutdemon, Glad it was helpful... Keep moving forward!!
Fun fact Dr. Neil, I was watching one of your bio videos and you posted this :), thank you for doing this
You must be having trouble getting to sleep...
@@RandyNeilMD haha...California time..still early :-)
This is a fantastic video bc you take a pragmatic, direct approach to quickly solving the questions at hand which not only saves time on the test which is critical but the math first approachable onlyliiking at the question is awesome . Thank you Dr McNeil, you give people like me a confidence boost! 👍 You are a God send 👌
Daniel, You are most welcome.
Thank you so much. You gave us a really simple way of tackling such problems instead of getting bogged down into the details.
Hamza, Thank you for the comment. I am glad the video was helpful. Let me know how else I can help...
@@RandyNeilMD your videos have covered biostats and most of behaviour science topics. I have watched all of them and they are very useful.. Would highly recommend to others. One thing that I think can be added is ethics section. Since IMGs are new to this subject and I personally face issues solving ethics questions. So it would be great if you add one ethics video addressing the common ethics question. Thanks again for such great videos..♥️
@@hamzayunus2548 Good point... let me see what I can find. Thanks Hamza
Thank you, I appreciate this as well as your dedication. I know this will make all the difference.
Brilliant. "If you could do it in your head you wouldn't be watching this video", ouch!
I am in that same boat.
Thank u very much. God bless u...love your technique how to handle this... ur explanation is good...
Thanks for comment... I hope it is helpful.
Received my ck score today.260+.Thank you so very much.Your videos have helped me crack both step1 and step2.
Dr. Neil... At 24:48 it says no CLINICALLY significant difference in BP REDUCTION b/w 3 doses. It doesn't require calculation. They seem to reduce BP, but they all bring it down by 8-12 mm Hg. The difference in reduction b/w them is 1-2 mm Hg. So, the difference of 1-2 mm Hg b/w them is not CLINICALLY significant.
Statistical significance and clinical significance are different concepts.
Please correct me if I'm wrong.
- Esha Vaish.
Your videos are amazing and very Cutely explained , please do make more
Glad it was helpful.
And i come here again close to CK to remind you that you are father of biostatistics 😅. Thank you sir.
CRUSH the EXAM!!! Just another step in the process...
Loving your videos!!!Thank you so much!!!
P K, Thank you for taking the time to comment.
Thanks Dr this is amazing video.u made it easy to understand.
Simret, You are most welcome. Thank you for the comment.
Where can I find the part 2 of this video? Thanks doc
Where is part 2 of this video?
Thank you Dr Neil for your great videos. Is there any part 2 for drug ADS? I could not find it !
Will be working on it...
@@RandyNeilMD 🙏🏻🙏🏻
Thank u very much. Very useful information.
Sumit, I am glad it was helpful. Thank you for the comment.
13:17 Roasted the whole audience xD
Got to keep it real...
aren't those supposed to be only for step 2 and 3? I took my step 1 two years ago and there was no question regarding the drug ads or the abstract.
Thank you so much. It was very helpful. Do you mind reviewing hazard ratio in drug ads? Seems to be in the tables alot in step 3 but not sure how to use it. Thanks !
Sanam, I will try and circle back and do a better job on some of the topics that are commonly asked..
@@RandyNeilMD Thank you so much for your time and help Dr. Neil! I also was looking for some coverage of the hazard ratio in your videos and from your comment, it sounds like you already covered this topic before, but I couldn't find anything when I searched "Randy Neil hazard ratios". I'm studying for step 3 so I'm very comfortable with a lot of the biostats basics and I was hoping I wouldn't have to watch every single biostats video. But it's hard to figure out which topics are covered in which videos to focus my time on the topics I need the most help in. It would be infinitely helpful if you would tag your videos with the biostats principles covered in each video so they'd show up in the TH-cam search better, or potentially list them in the titles/thumbnails like you already do for some. I know that's a lot of work and probably won't happen before I write step 3 but I figured I'd comment anyway in case it helps others. Thanks again!
Thank yo for your video Dr Neil.
I had one question of the Essepro question about the clinical significance. I’m unsure whether the Z value helps us with clinical significance. I believe that would help us understand the statistical significance. The clinical significance would require more data (to calculate the Cohen’s D or other routes), which isn’t meaningful since the difference of 2 in BP sound’s clinically insignificant. I believe it’s heuristic. I maybe wrong and would appreciate your insight here.
It's been so long since I've made the question and video I would have to re-acclimate myself to the question itself...
@@RandyNeilMD That's totally fine Dr. Neil. I appreciate your time in making the content for us all 🫡🙇♂
Thank you!! For making these fantastic videos.
Maleeha, You are most welcome. Glad it was helpful. Keep studying HARD!!
thank you sooo sooooo muchhh..i really needed this one..thank you so muchh..please make more videos
Thank you for the comment. Glad it was helpful.
You are the best
Humbled.
Thank you for this! Small q, though. Can we take the answer choices to be inherently true? I didn't know that EPCS is available at only specialty centers, so wasn't sure of it veracity per se. Would the test ever "lie" about facts?
Thank you! This says Drug ads part 1 , is there a part 2? I could not find when looking thru your channel
I had to give myself a goal to work towards... Working on it.
So helpful, thank you
You are most welcome Diana.
Thank you very much
Zahraa, You are most welcome...
@@RandyNeilMD
Could u help to find part2, please?
Thank you
You're welcome
@@RandyNeilMD how can you help me mastering the abstract question for step 2 ck please Dr Randy?
For the CI to be significant it cant include 0, the RR and OR cant include 1
Hello, thank you for your videos, we all appreciate your hard work. I sometimes get wrong values in my calculations because I dont convert the percentage nr to decimal points, could you please write down the formulas where we MUST use decimal nr? Thank you!
Thank you sir so much
. May I ask, where is pare 2 ?
why did u even think about allocation concealment. allocation concealment is good.
for question # 14, why not option D "patients were not blinded"?
Please guide
Thank you
thank u!
You are most welcome.
wait wait wait. they are not for step 1 are they? 😲 i haven't seen any question like this in UW or nbme. is this something i missed or the video is mislabeled?
Be prepared. EVERYTHING is fair game...
on 25:40 you just said : how i am gong to say if two things are statistically significant or not , BUT the question is asking ( choice D ) CLINCALLY different ......so i am confused is this famous formula the Z things telling about statically significant or clinically significant please clarify .
can someone explain confidence interval part tl me?
Thank you for amazing video Dr.Neil!I just had a question regarding the Drug Ad Question that in Q.60 at 24:19 option B if we double the dose ( making it 20 as effect of 5 mg is 10) so won't it cross 15mm of Hg mark?
hy ... do drug ads videos have more parts? this is part 1
I've just been busy and it's hard to make original stuff with drug ads... but I will try my best.
Thank you so much! Just in time for my exam.
I have one question. In the Essepro ad Q2, can we get to answer D "No clinically important difference.." directly because the p value is >0.05 instead of getting it through the formula?
I see what you are saying... When I see the large P-value I think they may be referring to the Drug vs. Placebo... Whereas the question is talking about between the medication doses themselves... I like your thinking though.
@@RandyNeilMD Got it. Thank you!! :)
Gold
Thanks Jose...!!
Thank you, Doc! 🙌🏾
Where i can find drug adds second part
Thank you for such an amazing explanation. I have a question regarding 2 problem part 3 (item#15).
For excluding option C you applied the whole formula to get z value of less than 1.96. What if we just compare the p values of median survival for class B and class C? p-value of class C is 0.05 which is obviously greater than class B (
Hadaya, You are going to make me work for this one... Give me a little time to review the question in the video...
Okay thanks 😅
Hey, someone can share part 2, please I did not find.
Thanks sir! Is there part 2 of this video?! Appreciated..
Xaaboo, I'm working on the second part... I want to make sure it has some quality ... It's coming.
Randy Neil, MD, wonderfully wonderful sir!
Done all
Is there anything extra or different on step2?
This should be enough to "hold your own"...
is this video for step 1 or step 2?
Hanan, There is a pretty strong overlap...both exams.
you are god
Appreciate the comment.
smoooth
Thank you
is this for step 2ck?
Mainly...
Please do more of these! You are so good at simplifying things and I finally understand it 😉👍
Thank you Jolie... I am working on some more material... Psych mainly. I just need more examples of Drug Ads... very hard to come by...
WOW! This was an amazing breakdown strategy! Who else wants Espresso after this :D
Drinks on me....after you get into residency.
Thank you! I struggled with these a lot and I haven't seen the Z value being used before and it really helps out. Great tip!
Glad it was helpful Mattie.
My interpretation of the last question:
(A) ↑sample size (N) correlates to ↑power and ↑statistical significance → comparing 4xx participants to 159 participants (placebo) exhibits relatively greater generalizability and validity
(B) Doubling 2.5mg to 5.0mg of ESSEPR) brought about a 1-2mmHg reduction in DBP and SBP. Doubling it to 10mg may or may not have the same effect (vague)
(C) Higher doses may or may not offer less/greater benefit (vague)
(D) Graph itself shows very poor clinical significance BETWEEN the 3 doses (1-2mmHg of improvement based on each dose)
(E) p value is high
Hope I was right.
Moral of this amazing video:
Scan for math
↓
Exclude bad choices (power>.05 of CI of 1.0)
↓
Use basic logic and analytical skills to pick what you can prove based on what is provided
thank you so much!!! I used your videos for step 1, and legit did so well on my biostats! Here's to hoping same for step 2 ck!
Saba, I'm glad you did well. Time to do the same for STEP 2 and 3... KEEP MOVING FORWARD!!
Randy Neil, MD iii jj
Hi Dr. Neil! Quick question about the problem at 25:00. I'm wondering if _"there is no clinically important difference..."_ gets at the concept of *clinically* significant versus *statistically* significant. In this case, the range in SBP between the 1mg and 5mg group is only about a BP change of 2 mmHg from baseline, which isn't clinically important. In this case you proved that there is no statistically significant difference between the groups. So in this problem the difference isn't clinically OR statistically significant. But in other problems, I'm unsure if we are supposed to equate statistical with clinical significance.
For example, in this problem, if the results were slightly different, you could theoretically get a Z score greater than 1.96 if a=7 and b=1. In this made up example, the BP change is still only 6 mmHg from baseline which, while statistically significant, still isn't really a meaningful reduction in BP. Just wondering if I am missing something or if you had additional thoughts. Thanks for your great videos! They are super helpful!
Spencer, Great feedback... I am hoping that they (USMLE) don't live in any 'grey area' of what is meant by "Clinical significance" other than if it was impactful treatment result, which can be somewhat subjective (ie. 1 less day of symptoms for a cold may be statistically significant, but not clinically per se)... The formula that we discussed for statistical significance is a "quick formula" that does come with some disclaimers (equal distribution). From my take away the clinical significance would have to show impact to the treatment, which leaves it a little subjective and not as concrete as 'statistical', therefore we can 'eyeball it' imo. I am hoping for everyones exam it's easy to determine and something obvious... I hope this helps.
@@RandyNeilMD how much difference is considered as clinically significant?
You have been helping me since step 1, I found you just by chance a week before my step 1 and have recommended you to everyone since then. May God bless you.
Thank you for such kind words. Glad videos have helped you.... KEEP MOVING FORWARD!!
Thank you so much! This came out just in time for my STEP 2 CK in 2 days.
Rodney, Crush the exam... one step closer!! Appreciate the comment.
Good luck!!
RETWEET!! My CK Exam is tomorrow and this (and your other review videos) were CLUTCH
In question 59, choice number 1 isn’t the best answer? Because they mentioned that on the last line of the question she can get 3 month supply of medication for free?
I would like to say thaaaank you very very much for your unique and smart explanation!
Thank you so much, I hope we'll be seeing more of these. Regarding the second example, question 60: Answer choice D refers to "clinically important difference", as opposed to "statistical significance", which you calculated for that option. I always considered these two to be different things. As in, we don't really care if it's statistically significant or not, we are only focusing on whether the amount of reduction in blood pressure is likely to have an effect on their health, clinically. Could you please comment on this?
Mehreen, I understand your question and you have a good point. If you can take a quick look at the response to "Spencer" below, I think it will answer... Difference between clinical versus statistical significance...
Just saw it, thanks! 😊
pls do more videos like this! This made so much sense, the more we can get exposed to different examples the better - thank you so much Dr. Neil
I will try. It's hard creating the question stem to fit into a video for these... that's the sticking point.
Where is part 2
Could not find it
Hi there,
For question #60, it seems that you may have done unnecessary calculation... Answer choice C is referring to the clinical significance, not the statistical significance, so couldn't we just have eyeballed the graph, determined that the BP reductions are more or less equivalent across groups, and arrived at the same answer without doing any calcs?
Thanks very much! I have found all your videos very helpful!
14:53 question no. 15 Option C is also correct, right?
P value of CHILD PUGH CLASS C (0.05) is statistically less significant than child pugh class B(
hello sir still waiting for part 2. thank you
Yeah, I need to work on that...
For the BP question, the answer choice you picked said no clinically significant difference. This means calculating the Z wouldn't be needed right? Because that's for statistical significance, no? Either way clinically, a numerical change in BP of 1-2 isn't clinically significant. Studying for step 3 right now and your vids are great!
Great video! One of the best Behavioral Science, BIOSTATISTICS and beyond Channels! Greatly appreciate.
Princess Z, You are way too KIND (as always). Thank you for commenting. Keep studying HARD!!
Great, short and succinct. Thank you, Mr. Randy!
Amazing Video for Step 2 CK!
Glad it was helpful.
This is such an amazing explanation. We need more of the ways to solve drug ads, please. It would be really helpful with more complex examples and ads. Thank you for always being there to help us out Dr. Neil.
Amna, Thank you for the feedback. The hardest part for me in the process of "drug ads" is finding examples... Hard to create from scratch and I don't have access to Qbanks anymore... Biostats should be our guaranteed points on the exam...
Exam in 30 days and I am struggling with the drug adsss!
You have been saving my life since step 1 Dr. Neil!
I request you to do more of these!!
Thank you very much for these videos! 💫💫💖💖
This is an awesome video. Really cleared my mind. Looking forward to more videos.
Apeksha, Thank you for commenting... Appreciate the feedback. Keep moving forward...
My Confidence now....growing.
Big big Thanks...
Hillol, I'm glad the videos have been helpful.
Beautiful videos.i have step 3 in one day hopefully i Will be able to ace it after watching your videos
Keep me posted on your progress!
What if I cannot select. Choose C?
Awesome !!! you made it so easy this drug Ads question . please do the uworld step 2 Ck drug Ads question as A example . Really appreciate if you do as example . Thank you
If anyone had access to the questions and can send... not a problem.
Is this for STEP 1 as well?
ur real intelligent person
thank u for ur effort
Syama, Thank you for the kind words. Trust me...I struggled all the way through..but found answers in TH-cam and others. Glad it was helpful.
Where can I find part 2 please?
When does part 2 come out?
Your videos are great! Thank you for sharing with everyone.
Anum, I am trying ... hardest part is finding examples to work... Questions that we can either use of alter so we don't get in trouble for using others material. I'd like to make it ASAP. Thank you for the comment.
@@RandyNeilMD Dr. Neil I sent you an email. Thank you.
Dr. Neil, is this for the purpose for step1 or is this the material of step2 and 3? I’d appreciate your input.
I'm getting more and more removed from STEP 1 ... but I think it's all fair game.
Thank you, Dr Randy for all that you do 👏👏
Much appreciated and grateful 🙏
You are most welcome
YOU’RE AMAZING!!!!!
Aanchal, Thank you for the kind words.
I wish I knew your channel before taking my exams.
I appreciate the kind words Kaddour.