NAD+ Boosters 2025 Update: Failure or Defence Against Aging? - Discussion with
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- เผยแพร่เมื่อ 9 ก.พ. 2025
- Nic from Physionic and Rimon are having deep dive into NAD+ Boosters, David Sinclair's work, and NMN controvercy. The full podcast is in Physionic's Don't forget to subscribe to his channel!
We dive into his theories on aging and critically examine whether they hold up under scrutiny.
One of the exciting aspects we discuss is how NAD+ boosters, like NMN, could potentially help you live longer and slow down the aging process.
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• A Deep Dive on NAD+ an...
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The Wellness Messiah podcast is available on Spotify, Apple Podcasts, and Overcast.
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Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities.
Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease.
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Some people here commented I'm trying to defend Sinclair.
Seeing a point of view of someone before you criticize their work, isn't "defending" them.
This approach demonstrates a commitment to fairness and objectivity in evaluating ideas and research. By attempting to understand someone's perspective before critiquing their work, you're engaging in a more thorough and balanced analysis, which is essential for meaningful discourse and scientific progress.
When you see the full podcast, you will see that Nic and I actually dismantle many of these theories, far from supporting them. But you must see things from a different perspective first, in order to come full circle in your understanding.
Everyone ages and loses their health as we speak unless you do something about it. Sinclair isn't relevant and won't change that. Aging and the loss of health are your real enemies. Check my comment here: 18:58
✅ Physionic's Podcast:
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Thanks for discussing with me. :)
You're the best
I stopped taking NMN under a year ago ( 73 yr. ). Slowly lost my energy and motivation.
Less and shorter walks and gym workouts for months. SCARY ! I started taking it again and
I'm getting my energy back. NAD levels must have bottomed out.
Niacin will do the same and much cheaper.......
I took NMN for more than a year. I saw no benefit.
@@Promqueen23 Try niacin. Proven to boost NAD level. Google the research. But if you are younger than 40, you are unlikely to notice any changes.
My two favorites! Ignore the haters.
Nice to see you two cooperating :)
my two favorite anti-aging guys in youtube together!
13:26 Very cool and helpful table!
I often wonder if I was a very aged person in a nursing home, horrible shape and about to die. Heart is ailing, lungs, kidneys, you name it. Suddenly all longevity and biohacking knowledge is downloaded into my brain. Dying is not an option. What do I use and do right now to keep myself alive and able to avail of better and better interventions? What is the true rescue formula? I won't give my opinion. I want everyone else's.
I take Niacinamide to help counter the effects of Photo aging (500 Milli grams) I also take 4 MG of astaxanthin and liposomal apigenin. since I have been taking these i have not needed any treatment (liquid nitrogen spraying) on pre skin cancer for the past two years!!!!!!!!! That is a massive improvement. I have never in the past 25 years of seeing a dermatologist for regular check ups gone TWO years without any treatments needed for pre skin cancer! for decades I would almost always need to get SPRAYED atleast once a year. NO NEEDS now since taking Niacinamide! I think this is a more economical way to BOOST NAD.
Whether or not there's a longevity benefit, I can tell you that as a person with decades long chronic fatigue and exhaustion, to the point where it can become very difficult to function, NAD boosters helped me to become relatively functional. In three days of beginning NMN, I could do things again. Mental benefit? Not much. Physical benefit? Quite noticeable. It probably isn't placebo effect, because I've tried everything under the sun for 25 years. Nothing had much of an effect no matter the fanfare or hype. Not one in 25 years? It shows I'm not prone to hype. Whether or not it extended my life, it surely improved my quality of life. That's worth a great deal to me. You do have to take measures against increased methylation. Let me warn others about that. Thanks for this video.
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Dr. Sinclair to you.
I've seen multiple research references which indicate lifestyle factors can normalize NAD+ or NAD+/NADH ,as well as other biochemical factors which are important to maintaining homeostasis and slow aging. Studies show, for example, that a reasonable amount of exercise elevates NAD+. (and immune function) as does mild CR or fasting which has many other benefits (DNA repair autophagy for example). Would really be good to pull these threads to together and hone in on levels effort at given ages to maintain these factors without relying on bottles of supplements. One additional thing about supplements, is that it seems much less efficient to throw in an exogenous bolus than have the body be stimulated to make what it needs at the right time given adequate substrates.
I Like Sinclair
He make fasting and b3 very popular
Soo interesting.
NMN should be taken sublingually.
what about nmnh?
long defended Sinclair with various theories about how NMN "still" helped despite clinical studies showing otherwise. Late shall the sinner awake. Nic you should stick to researchers and people with a relevant education at the bottom. Brad was one of the first to call Sinclair and got a lot of crap for it from all those he brainwashed. Messiah was more critical of Brad and was a Sinclair fan in the beginning
Brad Stanfield didn't cover NMN very well. He even ignored many studies that showed alot of benefits. Same applies to resveratrol
Not a "fan" of nobody... Seeing a point of view of someone before you criticize their work, isn't "defending" them.
When you see the full podcast, you will see that Nic and I actually dismantle many of these theories, far from supporting them. But you must see things from a different perspective first, in order to come full circle.
@@paulharrisonadventuregearm5457 absolutely. a terrible guy
@@paulharrisonadventuregearm5457Stanfield is far too negative for me. It's a global bias and maybe also a shock value marketing angle for his channel to $hi+ all over any supplement or therapy once any new study came out. I got fed up with all the negativity and quit his channel. Looking for a more mature and unbiased approach.
What about studies that shows heart issues and possible cancer if taking high amount Niacin/NR/NMN?
NMN does far more good for the heart. B3 is different to NMN with respect to the heart..totally different. B3 increases homocysteine if you don't take other supplements to counteract it... homocysteine is deleterious to the heart and blood vessels
It will be discussed in the next segment
Can you comment on sublingual absorption levels compared to normal oral intake
I still take nmn and res. Sure some speculation, but its part of my stack. Also remember Brad is not a expert either and has his own financial interests releasing even his own supplements.
❤️💖🙏❤️💖
i am exactly sharing your opinin about Sinclair. One part is his research, which is very good, and he other part is his business approach. If he found a greedy dumb company paying 700 million without doing proper due diligence. congratuations ! :)))
So, he is independent from the claws and dictate of big pharma, Nih etc forever.
Regarding the information theory of aging: that's the needed step, but he doesnot take it far enough. Information fist needs a poper energy metabolism, and NAD+ is certainly at a key and master regulation position within the metabolic network, coupling the immun system via CD38 with energy production, and the cell's vitality fight against entropy. Energy production and the informational integration of mitochondria with the nucleus is key for understanding the flow of negentropy , the appearance of cancer and senescence, which are very similar in their etiology.
Physionic lets gooooo
YESSSSSS!
Dr. Brad Stanfield did a video on this a while back. He points out that NMN must be converted back into niacinamide before converted into NAD (I think) or something like that and it’s a bit of a scam. He basically says take vitamin B3
I think Brad Stanfield is very wrong on that. Most studies show NMN directly converts to NAD+. There are many aspects wrong with Brad Stanfields critique of NMN and resveratrol
Baby born at ground zero?? I don’t think so. There’s 9 months of gestational epigenetic influences and exposures.
Hello! I think you two should go deeper and really find out if niacinamide is suddenly negative regarding NAD levels while all other forms of B3 are not? Don't think Matt Kaeberlain or others agree with you there. This shows how much influence Sinclair still has over you. Messisha wants to try to distance himself somewhat from Sinclair, but those of us who followed NMN closely know how it sounded when Stanfield stood alone against Sinclair and how Messiha and others more or less wanted to show that Standfield did not understand or misunderstand anything. Alternative explanations were put forward to support Sinclair's ideas… There's no going back on it now… Niacinamide included in so many supplements? That would be a scandal! although it has been shown to be good for skin health and is part of how NAD is recycled. When Messiah himself believes in the thesis and Nic nods in agreement... Your videos have dtor spread so I think you should clarify this and listen to more than Sinclair's theories
Rimon, you are so aggressive in this interview... What do you need to prove. You hardly allowed Wellness Messiah to speak. He was super pro, listened to your continued speech with your facts, with grace.
I am subscribed to both of your channels. I live tha information you both share. Thank you for doing the hard work for me 🎁💖
Rimon, I would listen and watch this interview again. Your passion is not serving you, in my observation. I feels like you are shouting your information, valid as it is.
Thanks for all that you both do for the validation I the world of living our best selves for a long as that might be.
Edit your comment please. Make sure u correct errors, typos, etc. Tap the three stacked dots to the right of your comment to edit it.
I'm not gonna share videos with stupid thumbnails. Followers might not care but when youre showing videos to people who arent on utube 24 7, they might not take it seriously
twins
You can tell physionic is a little skeptical of sinclair, the snake oil salesman.
Both of us, check my pinned comment.
Should talk of Younger You book by Fritzgerald...Sinclair nothing to do with epigenetics
Really awful Rimon with that mouth wide open look. What a cheap widely used stunt many podcasters now using. To me devalues host and content.
Sinclair’s primary reaction is the one where he sucks the money out of your pocket by selling you some snake oil that never works while telling you haw wonderful it was in his :trials."
Hello! I think you two should go deeper and really find out if niacinamide is suddenly negative regarding NAD levels while all other forms of B3 are not? Don't think Matt Kaeberlain or others agree with you there. This shows how much influence Sinclair still has over you. Messisha wants to try to distance himself somewhat from Sinclair, but those of us who followed NMN closely know how it sounded when Stanfield stood alone against Sinclair and how Messiha and others more or less wanted to show that Standfield did not understand or misunderstand anything. Alternative explanations were put forward to support Sinclair's ideas… There's no going back on it now… Niacinamide included in so many supplements? That would be a scandal! although it has been shown to be good for skin health and is part of how NAD is recycled. When Messiah himself believes in the thesis and Nic nods in agreement... Your videos have dtor spread so I think you should clarify this and listen to more than Sinclair's theories