How to Calculate the Percentage Drug Release ? | Dissolution Data Calculation | In Hindi
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- เผยแพร่เมื่อ 8 ก.ย. 2019
- This video describes, How to calculate the percentage drug release from tablet dissolution studies. In the pharmaceutical industry, drug dissolution testing is routinely used to provide critical in vitro drug release information for both quality control purposes, i.e., to assess batch-to-batch consistency of solid oral dosage forms such as tablets, and drug development, i.e., to predict in vivo drug release profiles. There are three typical situations where dissolution testing plays a vital role: (i) formulation and optimization decisions: during product development, for products where dissolution performance is a critical quality attribute, both the product formulation and the manufacturing process are optimized based on achieving specific dissolution targets. (ii) Equivalence decisions: during generic product development, and also when implementing post-approval process or formulation changes, similarity of in vitro dissolution profiles between the reference product and its generic or modified version are one of the key requirements for regulatory approval decisions. (iii) Product compliance and release decisions: during routine manufacturing, dissolution outcomes are very often one of the criteria used to make product release decisions.Via wiki
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Excellent sir .. 👌🔥 thanks for providing information
Hi Sir, In min 13:39 you are summing up concentration 5ml (ug/ml) with cumulative 5 mL (ug), is this correct? does not look like it
SIR kindly explain the concept of Dissolution Efficiency (D.E) and fit factors (F1 & F2)
Thank you sir, i have found this video very helpful.
sir is there any relation between cumulative release and entrapment efficiency?
Very well explained cleared all doubts
great job sir,
thanks ..
Sir kindly make a video in which explain how to calculate entrapment efficiency and encapsulation efficiency
sir, what we have to do in case of replacemrnt with the fresh volume after suck
Hello sir. Why we have to dilute? If I take 1ml in each time into cuvette to measure the OD value it will be wrong?
Sir....In dissolution study of tablet for calibration curve pure drug to be used or the equivalent weight of drug from tablet is to be used ????
thank you so so so much sir for this video
Sir if i take 5 ml from simulated gastric fluid and add further 5ml to to my dissolution medium during invitro study.Still it will be necesaary to calculate cummulative.
Thankyou soooo much sir 🙏🏻🙏🏻
Thanks ...Sir plz tell... If my tablet weight is 200mg and dose of my tablet is 25mg ( actual drug in my tablet is 25mg) so for calculation of % drug release by which value I should divide
Either by total weight of tablet(200mg) or dose of drug in tablet(25mg)??
Sir i have 1 big query help
Tablet ko crush karke uska Absorbance lena he ya dissolution appratus me jo 5 ml suck karte he uska Absorbance lena he?? Help me
Hi Thanks for the video. It is very helpful. Just want to ask at 1:17 is it concentration or absorbance?
Concentration!
Where is the dilution preparation video? You said that it was in description box. But it is not here! Please sir provide it
Excellent sir..........very nice explanation....thank u
You're most welcome
Cumulative column doesn't seem correct, please revisit
sir please make a tutorial on dd solver and how to calculate f1 and f2 factors and selection of model. Thank you!
Sure we will work in it
Hi
Jab ham 5 ml concentration nikalate h to ham usi time turant 5 ml fresh media bhi add krte h brother..
Sir agar 5 ml buffer add kar diya hota to phr cumulative kaise nikalte
can we use this same formula when we maintain sink condition and replace the withdrawn quantity with new solvent?
Y to do that, if u increase the media then the dissolution power of medium also get increased it will affect the dissolution profile. Think of saturation concept.
Sir grnulestion ki fbd ke uper video banay pls
sir this video was very good . i need excel sheet of fi and f2 factors(similarity factors and dissimilarity factors
Email us at pharma4u123@gmail.com
Very nice video, sir please send me the excel sheet for calculation
What happen if we have withdraw 3 ml and we have 3 ml cuvette?
We can replace the 5ml every time when we take out and also we can maintain sink condition.
Yes but it can cause error. As fresh medium may interfere with dissolving power or medium. Ex. saturated medium can dissolve less solid then fresh.
But we are mimicing the invivo condition so we have to maintain the sink condition ryt??
This test is in vitro dissolution study . No need to justify sink condition After performing this test we have to correlate this data with in vivo study wich is known as ivivc
@@anishkumarsharma9952 yes we will maintain the sink conditions, by replacing the volume with fresh solution but calculation will be different for that to calculate percentage drug release
@@sohilakhtarshaikh2035 IVIVC is only possible when you mimic invitro conditions
Sir plz tell me do we have to discard that 5ml volume or put it back in the same solution.plz it is urgent
bro kya kiya aage phir?its urgent
Please upload this type of important video
Sure !
What is S1 ,s2 & s3??
thanks
hii...ohh i m here again after a year...lol
Hme paracetamol ka dissolution ka pH 7.4 ka standard curve aur calculation bta dijiye sir please
calculation same hota h laghbhag , only stadard curve ki equation change hojati hai.
120 percent release kaise hoga sir ,. Jbki overall amount to 100 percent h
Please make more videos for m.pharm Ceutics
Sure we will work on it
Sir agr dilute ni kiya toh?
5 ml is replaced after taking sample to maintain sink condition please make the correction.
Both procedures can be done , either add medium or minus 5ml at every point.
Is this the sams for transdermal patches?
No,
Sir is there any video for transdermal patch ??????
Franzz diffusion cell is use
Where is sink conditions
Please give the link of dilution vedio
th-cam.com/video/RBmYj55dFyo/w-d-xo.html
Sir amoxy clav 625 ka dissolution chart bhejdijiye plz
you have t change it as per requirement , i have diclofenac tablet chart. For getting it email us on pharma4u123@gmail.com
How can the percentage pe greater than 100 is it correct?
At laboratory level, 01. preparing small quantity of dosage form 02. Poor mixing and other things are some causes which result in error
How to take dilutions of ,5 ml 10 times kindly elaborate
Withdraw the sample with Pipette at regular interval and analyse with UV Spectroscope.
@@Pharmacy4uu sir u said to make 10 dilutions of 5ml
@@bismahahmad9922 When you withdraw sample it is highly concentrated, which is not detectable by UV. SO first you need to dilute that sample (10X) or more times to get results. th-cam.com/video/RBmYj55dFyo/w-d-xo.html
Yes sir u r right but what I mean to say k if we dilute 5ml 10 times so what will be the procedure eg adding 5ml conc in 100ml distilled water or 10ml
Dissolution ki sabki dilution tho same hi hoti h ?
sabhi? ki nahi hoti, jab tak standard curve ki graph me plot hone itni reading nahi ati dilution hote rehte hain
Can you please share the Excel sheet sir?
Email me at pharma4u123@gmail.com
sorry wrong. You are not maintaining sink condition? NO need to calculate for 5 ml.
So what we have to add 5Ml media everytime ?
@@Pharmacy4uu yes , in franz diffusion cell aparatus for drug delivery , we do the same , as you are taking some amount of sample at every time interval , we need to add the same amount of solution so as to maintain the conditions, or else the behaviour or solution left will be totally different , the replacement coefficient is further added to maintain the calculations
Can I get xcel sheet?
Check you email
F1 f2 pe bnao sir
Sure!
Improve your voice quality. Background
U need this excel copy sir
Email me on pharma4u123@gmail.com
@@Pharmacy4uu thank you sir I send to ur mail id
@@krish_krish354 pharma4u123@gmail.com
@@Pharmacy4uu I sent mail to u sir
Hello sir
Hello
Sir plz give me ur email...
I want excel sheet
pharma4u123@gmail.com
Sir excel sheet vej dijiye email - Bhupendrasinghb80@gmail.com
Check ur email