I was wondering whether the researchers considered using Doppler ultrasound to measure cerebral blood flow. There is a Doppler ultrasound set-up at the Austin Hospital in Melbourne.
Hi Chris. How about measuring AMMONIA - particularly in the brain? Surely this metabolite would cause neuroinflammation? A malfunctioning urea cycle would cause this.
I started down the path of participating in a similar/recent study but what puzzled me was the subject selection process. Since there are no biomarkers that indicate these maladies, the study had to rely upon self reporting/identifying by potential participants or those whose doctors have "guessed" that their they have one of these maladies. I didn't understand this.
The researchers should have used the Canadian Consensus Criteria, International Consensus Criteria or National Academy of Medicine Criteria to select participants.
I have pots ..MSG gives me migraines . not sure if it's related . lol. also according to my DNA I have a faulty MAO a/b gene issue . My son has pots and a couple other people in my family have issues . I m near Chicago for study purposes if needed
Wouldn't the patient need to be on the extreme end of severe in order for a hand grip test to induce fatigue? I mean how do they know that this is enough to produce a signal to measure?
No, there's been one or two studies indicating that this is enough to make a difference in people who can get to clinics. Can't recall the details, think I found it/them just by googling hand grip test and me/cfs.
My husband when he was close to severe had muscle testing where he had to lift his foot an inch above the bed. It showed the amount of electrical signal in the muscle of his calf was what you would expect to see in someone running a marathon.
I was wondering whether the researchers considered using Doppler ultrasound to measure cerebral blood flow. There is a Doppler ultrasound set-up at the Austin Hospital in Melbourne.
Hi Chris.
How about measuring AMMONIA - particularly in the brain? Surely this metabolite would cause neuroinflammation? A malfunctioning urea cycle would cause this.
I too would love to be part of this study and am in Seattle WA USA
I have to be part of this study. Can we do this if in WA
I started down the path of participating in a similar/recent study but what puzzled me was the subject selection process.
Since there are no biomarkers that indicate these maladies, the study had to rely upon self reporting/identifying by potential participants or those whose doctors have "guessed" that their they have one of these maladies.
I didn't understand this.
Most of the serious me/cfs researchers use the ICC criteria to diagnose their participants.
@@rdklkje13I am not familiar with that. The study that I was invited into never asked me to substantiate my claim.
A MAJOR hospital/university.
The researchers should have used the Canadian Consensus Criteria, International Consensus Criteria or National Academy of Medicine Criteria to select participants.
I have pots ..MSG gives me migraines . not sure if it's related . lol. also according to my DNA I have a faulty MAO a/b gene issue .
My son has pots and a couple other people in my family have issues .
I m near Chicago for study purposes if needed
Wouldn't the patient need to be on the extreme end of severe in order for a hand grip test to induce fatigue? I mean how do they know that this is enough to produce a signal to measure?
No, there's been one or two studies indicating that this is enough to make a difference in people who can get to clinics. Can't recall the details, think I found it/them just by googling hand grip test and me/cfs.
My husband when he was close to severe had muscle testing where he had to lift his foot an inch above the bed. It showed the amount of electrical signal in the muscle of his calf was what you would expect to see in someone running a marathon.
interesting
Really fascinating stuff! Thanks for your hard work, donation made 🫡