Thank you so much, Matthew. That's a great idea. I think it'll be a very famous channel in the future. unfortunately, such useful videos about organic synthesis are very rare on TH-cam.
This is perfect! I'm starting my 7 year journey on becoming a psychopharmacologist in a couple of weeks, and I have a lot of O-Chem ahead of me. Thank you so much for your hard work. I'll be watching intently.
Hey man, I really like the idea for these videos, very useful for people in our fields. One small thing I would say specifically about this video is you show the mechanism for this reaction using hypobromite, but all of the examples you showed used hypervalent iodine reagents, so it might have been good to show the mechanism using those reagents as well. Either way, great video, clearly explained and I love that you show examples from the literature, something that I feel university teaching often lacks.
Thank you very much for your support, Sandwich Ninja; that's a fair point. For the mechanism with PhI(OAc)2 and related iodine-based reagents we can imagine the same electron flow where the nitrogen of the amide displaces an OAc group by attacking I, which triggers the same rearrangement. This video ended up being more of the exception than the rule in the sense that hypochlorite/hypobromite are most often used to introduce the reaction, although many modern variants employ PhI(OAc)2 and variants thereof.
Nice videos, Doc! I'd like to ask you something: do you use directly ChemDraw for your slides or PowerPoint? And then, which stylesheet/typeface do you use in chemdraw for your molecules? I see they are bolder than ACS stylesheet and I like it very much! Hope in a Reply. Alessio Bianchi, University of Pavia
Hi there, thank you for the kind words! I paste ChemDraws into PowerPoint. If you send me an email at SynthesisWorkshopVideos@gmail.com I can send you the template if you like (it's custom).
New subscriber here and I wanna khow how chemist khow all the complex steps towards the target they can't solve them within a glimpse of the target I mean can they?
Welcome to the channel! Indeed when chemists see a complex target it's almost never immediately obvious what the best approach will be. Some molecules demand a lot of retro synthetic analysis, repeated and revised after each failed synthetic route. The judgment for what types of reactions are likely to work in a given system is something that develops slowly over time and eventually allows chemists to make more informed decisions about which route to prioritize in their workflow.
I like the vid! Great commentary and visuals! The one suggestion I might have could be to have discussed the Curtius rearrangement as well with their similarities.
Thank you very much for your kind comments and suggestion! I look forward to covering related rearrangements in the future and explaining the differences.
Thank you so much, Matthew.
That's a great idea. I think it'll be a very famous channel in the future.
unfortunately, such useful videos about organic synthesis are very rare on TH-cam.
Hi Ehsan, thank you very much for your support! I appreciate your kind words!
@@SynthesisWorkshopVideos . .. . . . . . ..
This is perfect! I'm starting my 7 year journey on becoming a psychopharmacologist in a couple of weeks, and I have a lot of O-Chem ahead of me.
Thank you so much for your hard work. I'll be watching intently.
Wow! That's very exciting! Good luck on your journey! It will be long but I'm sure it will have its rewards.
this is great, you have a great niche here
Thank you very much for your support Samuel! Stay safe :)
My only question (out of jest) - whats an amid vs an amide?
When to us Hofmann and when to use Curtius? They look to have similar outcome?
Hey man, I really like the idea for these videos, very useful for people in our fields. One small thing I would say specifically about this video is you show the mechanism for this reaction using hypobromite, but all of the examples you showed used hypervalent iodine reagents, so it might have been good to show the mechanism using those reagents as well. Either way, great video, clearly explained and I love that you show examples from the literature, something that I feel university teaching often lacks.
Thank you very much for your support, Sandwich Ninja; that's a fair point. For the mechanism with PhI(OAc)2 and related iodine-based reagents we can imagine the same electron flow where the nitrogen of the amide displaces an OAc group by attacking I, which triggers the same rearrangement. This video ended up being more of the exception than the rule in the sense that hypochlorite/hypobromite are most often used to introduce the reaction, although many modern variants employ PhI(OAc)2 and variants thereof.
Nice videos, Doc! I'd like to ask you something: do you use directly ChemDraw for your slides or PowerPoint? And then, which stylesheet/typeface do you use in chemdraw for your molecules? I see they are bolder than ACS stylesheet and I like it very much! Hope in a Reply.
Alessio Bianchi, University of Pavia
Hi there, thank you for the kind words! I paste ChemDraws into PowerPoint. If you send me an email at SynthesisWorkshopVideos@gmail.com I can send you the template if you like (it's custom).
Thank you so much! I surely will!
New subscriber here and I wanna khow how chemist khow all the complex steps towards the target they can't solve them within a glimpse of the target I mean can they?
Welcome to the channel! Indeed when chemists see a complex target it's almost never immediately obvious what the best approach will be. Some molecules demand a lot of retro synthetic analysis, repeated and revised after each failed synthetic route. The judgment for what types of reactions are likely to work in a given system is something that develops slowly over time and eventually allows chemists to make more informed decisions about which route to prioritize in their workflow.
Thanks!
I like the vid! Great commentary and visuals! The one suggestion I might have could be to have discussed the Curtius rearrangement as well with their similarities.
Thank you very much for your kind comments and suggestion! I look forward to covering related rearrangements in the future and explaining the differences.