I am lost a bit here.On type IV hypersensitive reaction,you said APC present antigens to CD8+ T cells.How is this possible?Maybe I am making a mistake but your earlier videos say CD8+ T cell is restricted to MHC 1 and CD4+ is restricted to type II MHC .Isn’t it that APC have MHC type II?
Thanks for your question student. Acc to Robbins 10th E, page 199, class 2 MHC are mainly expressed expressed on cells that present ingested antigens and respond to T cell help(APCs mainly Macrophages, B-lymphocyted, and DC) See they have said Mainly(Not Only) Your doubt is justified. See the figure 6.18 in Robbins 10th E page 213, in that diagram APCs are presenting AG's to both CD 4 as well as CD 8 cells. But remember APCs mainly present Ag to CD 4 cells. Here in the diagram APCs presenting AG to CD 8 plus T cells are NOT APCs in the true sense. These are cells which are infected with virus / are Tumour cells. Viral /Tumour AG's present on the surface of the cells which as you know are class 1 MHC are being referred to as APCs, which is being presented to CD 8 plus T cells. Hope this clears your doubt.
@@DrJIBRANAHMED Thanks for your reply, I got the point,the cells depicted as APC’s are in fact any cell with MHC I ie any nucleated cell and platelets not necessarily APC’s in the true sense of the word.
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You haven’t complete the book(robbins)!!
Please kindly upload all remaining lectures.
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I am lost a bit here.On type IV hypersensitive reaction,you said APC present antigens to CD8+ T cells.How is this possible?Maybe I am making a mistake but your earlier videos say CD8+ T cell is restricted to MHC 1 and CD4+ is restricted to type II MHC .Isn’t it that APC have MHC type II?
Thanks for your question student.
Acc to Robbins 10th E, page 199, class 2 MHC are mainly expressed expressed on cells that present ingested antigens and respond to T cell help(APCs mainly Macrophages, B-lymphocyted, and DC)
See they have said Mainly(Not Only)
Your doubt is justified.
See the figure 6.18 in Robbins 10th E page 213, in that diagram APCs are presenting AG's to both CD 4 as well as CD 8 cells. But remember APCs mainly present Ag to CD 4 cells.
Here in the diagram APCs presenting AG to CD 8 plus T cells are NOT APCs in the true sense. These are cells which are infected with virus / are Tumour cells. Viral /Tumour AG's present on the surface of the cells which as you know are class 1 MHC are being referred to as APCs, which is being presented to CD 8 plus T cells. Hope this clears your doubt.
@@DrJIBRANAHMED Thanks for your reply, I got the point,the cells depicted as APC’s are in fact any cell with MHC I ie any nucleated cell and platelets not necessarily APC’s in the true sense of the word.
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Sir please make a separate video seris on robbins 10th edition updates and new topics explaination
YES!! AS OF NOW THERE ARE FEW CHANGES WITH REGARD TO TISSUE REPAIR!!
MOSTLY THEY HAVE SHORTENED THE BOOK A BIT MAKING IT MORE CONCISE!!