Approach to Diagnosing Generalized Lymphadenopathy

clinical lymphadenopathy in 2 or more non-contiguous areas. Generalized adenopathy may be indicative of systemic illness, and the workup is typically more laboratory and imaging-intensive and pursued more rapidly
include infections, autoimmune diseases, malignancies, histiocytoses, storage diseases, benign hyperplasia, and drug reactions. Generalized lymphadenopathy is most often associated with systemic viral infections. Infectious mononucleosis results in widespread adenopathy
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