Great content. I am a Pharmacist from Kenya and I like the way you integrate pathophysiology, medicinal chemistry, pharmacology and pharmacognosy all into one simple video
my respects professor if you are reading it i just wanna suggest that you make content on 1 specific type of topic for a series of ep. and then change the topic. also you should keep thumbnail and title understandable, related to daily life, current trends at global level, and surprise the viewers making them feel knowledgeable. otherwise you are doing fabulous And by the way i am your subscriber from last 1 year. all the best
Thanks for your unique biology explanation! Really looking forward for Astrophysics explanation. Hope you make a video to calculate Luminosity of a star.
Methotrexate is such a potent immunosuppressive that long term therapy might also increase the risk of cancer. People who are given it against RA have to take an "antidote" 24 hrs later, as it completely wrecks the signaling and metabolism pathways associated with folic acid. My grandma had to take it once a week and those were always her difficult days. Side effects may include general signs of intoxication: Weakness, low blood pressure, sweating, nausea, feeling ill, vertigo,… These symptoms usually subside 24hrs after taking the antidote. Against RA it was very effective though.
It's not an 'antitode' per say, but you take folic acid supplements to offset the side-effects of the Methotrexate. My husband is on both but a low dose. He has fatigue with it but otherwise fine. He has had RA since he was 2, he's now 51. Dose (and therefore side effects) depend on the disease activity, it's not a given that all patients will suffer like your grandma (seems like hers was very severe and active).
I have a question.The orbitals of electrons are just their wave function right.Can they collapse when interacting in a certain way.If they do what causes them to collapse and what consequences this collapse have.
Informative as always, Professor Dave. Quick question: What RA symptoms typically present to a physician that might suggest going straight to a bDMARDS regimen? Based on this video, it sounds like going to bDMARDS is a fool's errand unless there are some very specific problems.
In Canada, you have to try different ones (non-biological DMARDS) and have an inadequate response, then move on to the next in the pyramid, until it is proven that nothing works except the bDMARDS. Only then would they be covered by your insurance. As for going straight to biologics, it might only be about the size of your wallet if a rich patient wanted to go straight to that.
I don't have RA, at least for now. The rheumatologist that is following up on me believes that my reactive arthritis is showing signs of early to moderate either psoriatic arthritis or ankylosing spondylitis. I am taking 1/4 of a Medrol 16mg pill for now and tomorrow I'll have my 3rd weekly injection of methotrexate. Will I be taking methotrexate for the rest of my life if symptoms disappear and my blood tests don't indicate anything pathlogical? Thank you in advance.
I've started getting you reccomened after watching flat world videos and now I'm a consistent watcher!
Me too!
Been fighting RA for 18 years now, thanks for this easy breakdown.
God bless you brother
Great content. I am a Pharmacist from Kenya and I like the way you integrate pathophysiology, medicinal chemistry, pharmacology and pharmacognosy all into one simple video
Thanks professor! I feel a little more prepared for my pharmacology class for my next semester thanks to all your videos :D
Me too. Dave has a great ability to break down these topics clearly and quickly. Great stuff.
my respects professor if you are reading it
i just wanna suggest that you make content on 1 specific type of topic for a series of ep. and then change the topic. also you should keep thumbnail and title understandable, related to daily life, current trends at global level, and surprise the viewers making them feel knowledgeable. otherwise you are doing fabulous
And by the way i am your subscriber from last 1 year.
all the best
Thanks for your unique biology explanation! Really looking forward for Astrophysics explanation. Hope you make a video to calculate Luminosity of a star.
Check my astronomy playlist.
Thanks, this is an important topic
Methotrexate is such a potent immunosuppressive that long term therapy might also increase the risk of cancer. People who are given it against RA have to take an "antidote" 24 hrs later, as it completely wrecks the signaling and metabolism pathways associated with folic acid. My grandma had to take it once a week and those were always her difficult days. Side effects may include general signs of intoxication: Weakness, low blood pressure, sweating, nausea, feeling ill, vertigo,… These symptoms usually subside 24hrs after taking the antidote. Against RA it was very effective though.
It's not an 'antitode' per say, but you take folic acid supplements to offset the side-effects of the Methotrexate. My husband is on both but a low dose. He has fatigue with it but otherwise fine. He has had RA since he was 2, he's now 51. Dose (and therefore side effects) depend on the disease activity, it's not a given that all patients will suffer like your grandma (seems like hers was very severe and active).
Thanks Dave!
intro animated part always makes me grin 😅😍
Sinus infections are the most common side effect from those taking bDMARDs. Speaking from experience.
Excellent video 👌
Just great. Thank you so much. ❤
Can you please post a video about hydroxychloroquine for RA?
Thank you so much ❤
I have a question.The orbitals of electrons are just their wave function right.Can they collapse when interacting in a certain way.If they do what causes them to collapse and what consequences this collapse have.
hooray, pharmacology!
fascinating
Informative as always, Professor Dave. Quick question: What RA symptoms typically present to a physician that might suggest going straight to a bDMARDS regimen? Based on this video, it sounds like going to bDMARDS is a fool's errand unless there are some very specific problems.
In Canada, you have to try different ones (non-biological DMARDS) and have an inadequate response, then move on to the next in the pyramid, until it is proven that nothing works except the bDMARDS. Only then would they be covered by your insurance. As for going straight to biologics, it might only be about the size of your wallet if a rich patient wanted to go straight to that.
I don't have RA, at least for now. The rheumatologist that is following up on me believes that my reactive arthritis is showing signs of early to moderate either psoriatic arthritis or ankylosing spondylitis. I am taking 1/4 of a Medrol 16mg pill for now and tomorrow I'll have my 3rd weekly injection of methotrexate. Will I be taking methotrexate for the rest of my life if symptoms disappear and my blood tests don't indicate anything pathlogical? Thank you in advance.
So helpful 👍💯
Speaking of psoriasis, when the tubes of leo wher out of stock and stopt qpleing it, my spo whend away. Its like libbalm but more expensif.
Interesting
You an expert in mathematics? I really need help
His particular fields are chemistry and science education. He has other experts write many of his scripts. I suggest you find a math-centric channel.
Anyone else read the title as "Introduction to Antimemetics"?
Hello there
Are you pharmacist ?
Vincent trocheck I know it’s you
👍👏
Te amo
I hope I get to meet you one day I really wanna fight you I hope you see this..lets make this happen Im willing to travel
❤️❤️❤️🇵🇭
First 🥇
1t person