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Skyrizi 101: Uses, Dosing, Side Effects, Cost Concerns (Plus - Does It Really Cause Weight Loss?)
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- เผยแพร่เมื่อ 18 ส.ค. 2024
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Skyrizi is used to treat psoriasis.
It’s mechanism of action is that it's an interleukin blocker. What that means is that eventually it's going to decrease the number of cytokines and chemokines that are produced in your body.
These substances are basically signaling proteins that lead to inflammation in your body.
Dosage
Skyrizi has a unique dosing schedule.
First of all Skyrizi comes in a 75 mg strength that you inject subcutaneously. You give two injections or 150 mg on day one, then you give 150 mg 4 weeks later, then you start giving 150 mg every 12 weeks.
The first month of dosing is what's referred to as a “loading dose”. The idea is to get your blood levels up a little higher earlier on and then level you out with the every 12 week dosing
Side Effects
Skyrizi does have some side effects that you need to be aware of.
First of all you can develop antibodies to use in Skyizi. This means that your body begins to develop antibodies to the drug and it can become less effective the longer you use it. You can see this in up to 24% of people who use it.
About 14% of people who use it can develop neutralizing antibodies. These types of antibodies actually make the drug ineffective.
The other type of side effect you can see is higher infection rates.
Remember Skyrizi acts on chemokines and cytokines. While they are involved in the inflammatory process remember that inflammation isn't always a bad thing. Part of your immune response involves inflammation. So when you knock that down it can lead to more infections.
You can see higher infection rate in up to 22% of users. Some of the more common infections tend to be upper respiratory tract infections and fungal infections.
I also warn people that you can see headaches in a small group of users as well as fatigue. But again these are only 3% to 4% of users.
One of the other things I get asked is if Skyrizi can cause weight loss?
It's actually not listed as one of the potential side effects for the drug. But keep in mind if you find that you're losing weight pay attention to if you are getting any sort of infections. If you're not feeling well because of infection there can be weight loss. But as far as Skyrizi directly affecting weight loss I think it's a long shot.
Because the drug can affect your immune system your doctor is likely going to monitor your labs throughout your use. I'll also test you for tuberculosis and monitor that as well.
How Long Does It Take To Work?
Skyrizi takes 3 to 14 days to reach peak blood levels. That doesn't mean it will take that long to start working. You may notice changes sooner.
But as far as peak effectiveness you're probably going to be looking at giving yourself at least a week or two on the medication to notice a change.
One of the biggest issues you see with people who want to use Skyrizi is that it costs quite a bit of money.
Sometimes we don't have any issues getting it through insurance other times you will. If that's the case you may want to look into financial assistance.
Here's a link to Skyrizi’s financial assistance program check it out see if you qualify: www.abbvie.com...
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Been on Skyrizi for over 2 years. No side effects and clear skin with only 2 minor flare ups throughout that time. Monoclonal Antibodies are a game changer.
May I know if you are still using Skyrizi? Allen
@@allenjeng5887 Yup! Still works great.
I have several questions.
Please and please help me out.
1. Do i have to take the shots for lifelong , or there is a point where i need to stop this ?
2. Is there any chance that The treatment would stop working and inreturn it would increase the severity?
Please help me out.
Did you have it in your scalp and did you lose hair? IF so , did your hair regrow?
How old are you cause that makes a difference
To be honest, I feel not so tired anymore, because it feels, as if the inflammation is gone and so I feel even more vital
Isabel, Do you plan to use Skyrizi for the long term? Any thought?
@@allenjeng5887 Hi Allen,
I am still free from it except tiny bit on the head, and not allowd to eat lots of meat, because than my joints of the right hand start to inflame.
I took the last injection in Juli '22.
One ist still waiting in the fridge.
If I need it, I will use it, and also before it goes of, because it is so expensive.
@@isabeleckert1274 Thanks a lot for sharing. I am thinking to let my son try it. But, not sure if it is a long-term solution due to the cost. I don't see anybody saying that they already used it for 5 or 10 years. So, maybe many users already stopped to use it. Do you know? What is your plan?
I did creams, and pills, skyrizi is a game changer!!! My insurance it cost me 120 but with the medication that the manufacturer provided it’s only costing me 5 dollars 🎉
Thanks for the feedback Andrew
I’m just here because I keep seeing the TH-cam ad and SkyRizi sounds like a SoundCloud rapper name
That was good 👍🏻
If I'm not mistaken, Abbvie did a poll to choose the name for the drug and it was determined that people preferred the word "sky" and the letter "z".
Thanks a lot for this video! I took my 1st dose three days ago. Very informative.
Thanks Donovan. Keep me posted on your progress.
It helped me a lot.
Third dosis in 3 month.
Plaque almost gone.
Second dosis only one day tired, took it on saturday to have time to sleep.
After that no more side effects.
I am truly happy.
Thanks Isabel
Thank you doctor.. I’m starting the first dose soon.. i hope it will help reduce my situation
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Curtis, Do you know any patients used Skyrizi for a long time like 5-10 years? I am thinking to let my son try it and wish to know more about it. I was told that if the users stop the Skyrizi treatment, the problem may come back again.
Allen - unfortunately I don’t know anybody who has been on it that long
@@AskCurtis Thanks a lot for the response. Does this mean that the user can stop the injection when the situation improvement is satisfied? And, then, if the issue comes back, the user can do the injection again? I assume Skirizi can not cure Psoriasis permanently.
It really depends on the patient as far as wether it will come back or not
@@AskCurtis Thanks a lot for the response. Do you mean for some patients it may come back and for some patients it may not? I was told there is no permanent cure for psoriasis and assumed it will come back.
Im due to begin skyrizi soon it will be my fourth biologic. Im really hoping it works as this time my entire body is affected about 50% skin coverage. Im lucky living in uk with our NHS it’s free. Im hoping an IL 23 will work with me.
My husband is having his very first injection of Skyrizi on December 23. He has had all of his COVID Boosters so we will see if he suffers with any side effects. We started out with an ointment but the Psoriasis was spreading all over his body and very fast and not going away. We went to the doctor and she diagnosis Psoriasis and she gave us a brochure about Skyrizi so my husband will be getting his first injection December 23, 2022.
Keep us posted 👍🏻
How did it go?
@@charleeschannel4841 We were able to get on the Skyrizi plan (a lot of paper work involved). My husband has had 2 injections (December 23, 2022 & January 20, 2023) plus a follow up visit to the dermatology he is doing great no side effects and the infected areas started clearing up in about 2/3 weeks with the first injection. The injections are easy with instructions. He has about 3 more injections in 2023. 5 Stars for Skyrizi
@@gypsyrose4110 Do you plan to use Skyrizi for the long term? My son plans to take it. And, I am not sure about how long he should use it. If the user stops to use it, he/she may have to use another solution. Right?
我才看到你們的信息。現在怎樣了？時隔一年多，因為我剛注射第二针剂，當然看不出效果。
I used to pay about $95 per dose when I was on COBRA insurance. The moment I went to Social Security and Medicare, My deductible for each injection went to $30K
That's $120K a year. That's on top of 12K we pay to Medicare. I had no choice, but to give it up, and live with it.
I start Skyrizi tomorrow and found this video very helpful.
Thank you
Update please how have you been on skyrizi ?
@@clarkkentll5490 So far the results are nothing short of AMAZING! My psoriasis is completely gone! I took the starting dose in June then my second dose in July. I'm now on an every 3 month schedule, with the next shot in October. I've experienced no side effects. My psoriasis was not severe like some people have it, but it was pretty moderate at its worst. I spent 25 years having to use ointments to make it disappear temporarily. I truly consider this treatment a miracle.
@@jq2147 that’s great news I’m very happy for you
I have a condition similar to psoriasis (Pityriasis rubra Pilaris) and on humira but other who have my skin condition are having great response with skyrizi as well soo I’ll speak with my dermatology about a switch.
Thanks again
@@jq2147 I'm about 45% involved now up from 15% while on Taltz. Hoping for the similar results.
This was really helpful! Thank you
Is it possible to „avoid“ side effects? To protect the skin from getting fungus? Can I support my overall immune system while on Skyrizi? Any tips? Thank you!!!
Nadja - not possible to 'avoid' side effects in my experience. Some people have it worse than others but very patient dependent. As far as things to do pretty much the common sense stuff like eating a wide variety of natural foods that support your metabolism, getting good sleep, avoiding stressors (extreme diets, caloric restriction, work/life balance), etc.
Never tried these injections before, was some how managing with herbal treatments but the situation has got worse with it spreading in different areas. DOCTOR recommended to try skyrizi. My age is 34 and other than psoriasis never had any other health issues may be because of the high immunity. so Just worried by taking skyrizi to treat psoriasis will it lead to me getting other diseases.
I take vitamin d and b and go out in the forest a lot
I feel fit.
How are you doing now that its been a few years? Was your immunity weakened.
Skyrizi is causing weight gain for me even eating low calorie. Seems a common complaint in support groups too.
That's helpful to know. Thank you
New patient on this, thanks for the information.
Absolutely. Any other topics you want covered let me know
@@AskCurtis maybe some tips on how to stay healthy while on these meds. Like avoiding infection. Maybe natural supplements that should be taken or considered. Thanks again!
@@ct79 great suggestions. Thank you 👍🏻
Great content. I am going to get my first dose soon.
Any updates? Just took my first today
Thanks vineet
Almost killed me & still may the dosing for psoriasis is 150mg the dosing gor my chrones was 600mg every 4 weeks after my 3rd infusion my cortisol fell fron 400 to 11 i alnost died the drug attacked my adrenal system now ive got addison's disease & the very next day after my 3rd iv infusion my chrones came back the worst its ever been.
Im laying in a Bournemouth hospital bed waiting for a colonoscopy tomorrow.
Pituitary issues adrenal gland packed up terrible
I think it's Crohn's disease.
Thank you
If you were to get an upper respiratory infection does it or is it something that lasts forever or is it treated and it goes away. Along with the other side effects are they treated and they go away. Or is this something you will deal with for life because you took this medicine.
Generally speaking, they come and go
I was ordered with Skyrizi for my Chrons Disease. The first 3 doses were intravenous monthly. I noticed within that time, when I combed my hair so much would come out. I analyzed any changes that occurred within those 3 months, and all I could think of was starting this medication. Anyone else experienced this?
I’m about to start treatment for Crohn’s disease as well. I’ve been experiencing some hair loss/shedding for several months now, but I’m also menopausal. I’m a little bit hesitant now, because the last thing I need is something else contributing to more hair shed. How are you doing with subsequent treatments? Did the hair shedding slow down down or go away?
@abriyahyasha-rahla2656 I have actually started to think the hair loss was attributed to stress. I was actually diagnosed with crohn's during a very, very stressful period last year. I was doing full-time work and full-time school. I was working one weekend and had 2 big research papers due by Monday. That's when I started getting the horrible abdominal pain, diarrhea, and loss of appetite. 3 months in being newly diagnosed, I lost a lot of hair. I decided to go part-time for work and finish off my masters. Reading the symptoms of the medication, I found no side effects to be hair loss. Stress can play a huge factor in IBD and crohn's, which is why a lot of young adults get diagnosed. The hair loss stopped. I cut a large chunk of my hair, and I'm just trying to grow it out now. Stress causes hair loss also! Maybe you have a lot of stressors in your life. I was diagnosed last year at the age of 29 and was recovering from brain surgery I had earlier that year, plus I started school and was working full time. I was juggling a lot and never realized it until I got sick. Stress isn't worth it. It harms the body.
Doc wants to put my son on it in a few months when he turns 18. He has Crohn’s. I’d like to know your opinion on this. His age the med and side effects. Thx
It’s an option but if it was my son I’d start looking at potential root causes of the Crohns. For example, I did a video today on Vitamin D and gut health. Very important. Also, inflammation, etc.
YES, I was on meds for Crohns for many years and got off of them, and in remission for almost 10 years by changing my diet and increasing daily vitamin D intake.
A take skyrizi for 9 months and my skin turns close to normal ! But a ave one side effects a fil exosted 😴
I started taking vitamin b
No more tiredness
Completely gone
How can I order skyrizi injections from Iraq, please ??😔
as much as I would love to keep taking skyrizi I think I've been getting a bad reaction to it after coming off of humaria (for crohn's), my body built up resistance to that so we had to try something different. How long does Skyrizi usually stay in your body before wearing off I never could find anything about that
Hello Dr I’m considering switching from humira to skyrizi you think it’s worth the try been on humira for 6 months only 50% better but itching has never left thanks
Peace be upon you, I am from Algeria and psoriasis covered my whole body. I want to try Skyrise. How do I get it? I really need it. Who can help me?
Malek - I would maybe reach out to the manufacturer of Skyrizi. They can point you in the right direction for getting financial assistance in your country (if they have it).
Hello, I enjoyed your video. I have a question. Can I take Skyrizi and take the COVID vaccine? I think not because it could lower the effectiveness of the medicine
Thank you. This whole issue continues to be a moving target. In my experience most doctors still encourage folks to get the vaccine. Skyrizi is technically an immunosuppressant so our concern is that it can actually lower the effectiveness of the vaccine
@@AskCurtis Thank you! I still have not got the COVID vaccine yet. I am going towards the 5th dose of the Syriza next month
Do yourself a favor and don’t get the Covid vaccine. It led to my autoimmune issues spiraling out of control
How long does it take for skyrizi to get out of blood?
Ryan sorry for the late response. Skyrizi will take 4-5 months to get out of your system. Thanks
Hello...
I want to ask you if skyiri affect body parts like liver or kidneys, because I can't seem to find a good source about.
Hello...
I wanna ask is it safe to take the covid vaccine while on skyrizi?
@@moadbasel2244 My Doctor told me to wait 2 weeks after second COVID vaccination shot before starting Skyrizi.
@@jq2147 I started with skyrizi before vaccination*not vaccinated till now*, when I asked my doctor he said just take it without giving it a second thought, when I asked about interference between the two shots or side effects, he kept saying there is no research on the subject. I talked to other doctor who do the vaccination for advice, she advised its better to take it after completion of the course or the vaccine with the dead virus and take the vaccine in the period between the skyrizi ahots.
@@moadbasel2244 Thank you for that information!
Soy de peru como podria obtenerlo?
Ve al oficina de dermatoligo
Does skyrizi interfere with diabetes or ckd
Not that I am aware of. Please double check with your doctor though
Michelle Brooks it could do if you gain weight on biological drugs.
its sooo good to see this drug losing traction and for society rejecting it
Why do you feel that way? I've heard nothing but positive feedback from people
You're a dumbass i am on it and its great if you have psoriasis it helps me live an easy life
@@danielhuffman2571 glad it’s helping you brother I’m considering switching from humira to skyrizi hopefully it can clear me as well without risks or side effects
How long have you been on it
@@clarkkentll5490 been on it 2 months and it has 90% cleared up my severe psoriasis dont listen to this dumbass above
Basically if u want cancer take this medication
@@theworldisastage1984 Don't be angry you weren't aware of the side effects. The good thing is now you are aware and will question your doctor if he or she asks you to take another biologic and you will look at the side effects of the drug the doctor wants to give you and decide on that basis. Good luck.
I like at the end of this guy's lecture he mentions, if you need financial assistance there are plans out there to help you afford this drug! I for one would seek the help of a holistic doctor to tray natural therapies, this is just another sales pitch from big pharma to make millions on a drug that doesn't work, and that's loaded with side effects!
David - you obviously don’t know me very well.
Thanks for sharing 👍🏻
Yeah your holistic quacks will throw “cure” after “cure” at you-here drink this tea; cut this out of your diet, here buy this supplement. What a joke. I hope you don’t end up suffering with an autoimmune disorder to the extent of those of us who had to choose pharmaceuticals. I was severely
su/i/ci/da/l before I was prescribed a biologic and now I’m not. Which would you rather have-me k/i/l/l myself, or go on a pharmaceutical that has been researched and developed by immunologists? Hmmmm. Hopefully YOU won’t have to make that choice for yourself but I had to.
I am prescribed Skyrizi for Chrohn’s disease. Does it cause seizures? Never had seizure before . And have had them since taking skyrizi and want to know if it is causing this?