On thing I really find that helps is the visual diagrams which you did well! My favorite goto channel is AK lectures. The thing that separates him from others is the way he explains a concept multiple times before moving on. Similar to what you did alot here, it really helps. keep it up!
Amazing explanation of the carbonyl organic chemistry, molecular biology, and biochemistry. It is clear you have put a lot of effort into getting good at this.
I just wanted to make a simple clarification that vitamin D cholecalciferol is made not from cholesterol, but a cholesterol precursor in the KR pathway, called 7DHC, 7 dehydrocholesterol. This is a very important distinction because all further metabolites of this steroidal-compound 'vitamin D' umbrella term- are dependent on that preprohormone cholecalciferol and not on cholesterol. Many cells make 7DHC, but only in epidermal cells is there the ability for UVB + heat to mechanically change the configuration to cholecalciferol (no enzyme required) So, that does leave vitamin D as a nutrient status, (and indeed that is the correct term), it is not just a cholesterol-based compound for further metabolite conversions. 'Vitamin D' umbrella term- and all its further metabolites are not made from cholesterol, rather they are substrate-dependent, that parent compound being cholecalciferol, so one can easily become deficient.
I believe cholesterol is a precursor to 7dhc, which then is a precursor to vit d derivatives…? So technically cholesterol is still a precursor just not directly?
@@sciencesimplified3890 in the mevalonate pathway, you'll see the KR (kandutsch-Russell) pathway and Bloch pathways to cholesterol, in the KR you'll see 7DHC 7-dehydrocholesterol.
Awesome presentation. First video on TH-cam specific for cholesterol biosynthesis for the MCAT!
Thanks Jeremy! Those are the exact type of comments that motivate me to make more videos!
On thing I really find that helps is the visual diagrams which you did well! My favorite goto channel is AK lectures. The thing that separates him from others is the way he explains a concept multiple times before moving on. Similar to what you did alot here, it really helps. keep it up!
Amazing explanation of the carbonyl organic chemistry, molecular biology, and biochemistry. It is clear you have put a lot of effort into getting good at this.
this was perfectly helpful and concise, thank you so much!
I just wanted to make a simple clarification that vitamin D cholecalciferol is made not from cholesterol, but a cholesterol precursor in the KR pathway, called 7DHC, 7 dehydrocholesterol. This is a very important distinction because all further metabolites of this steroidal-compound 'vitamin D' umbrella term- are dependent on that preprohormone cholecalciferol and not on cholesterol. Many cells make 7DHC, but only in epidermal cells is there the ability for UVB + heat to mechanically change the configuration to cholecalciferol (no enzyme required) So, that does leave vitamin D as a nutrient status, (and indeed that is the correct term), it is not just a cholesterol-based compound for further metabolite conversions. 'Vitamin D' umbrella term- and all its further metabolites are not made from cholesterol, rather they are substrate-dependent, that parent compound being cholecalciferol, so one can easily become deficient.
I believe cholesterol is a precursor to 7dhc, which then is a precursor to vit d derivatives…? So technically cholesterol is still a precursor just not directly?
@@sciencesimplified3890 in the mevalonate pathway, you'll see the KR (kandutsch-Russell) pathway and Bloch pathways to cholesterol, in the KR you'll see 7DHC 7-dehydrocholesterol.
so can cholesterol be synthesized in both SER and mitochondrial membrane?