Translucent Water in Oil Nanoemulsion Prepared by High-Intensity Ultrasound, Batch Mode.
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- เผยแพร่เมื่อ 14 ธ.ค. 2009
- Nano-emulsification of water in mineral oil has been carried out using a bench-scale ultrasonic liquid processor, BSP-1200, manufactured by Industrial Sonomechanics, LLC. A common converging ultrasonic horn (tip diameter 15.6 mm) was used in the first part of the video, producing 40 ml of the nano-emulsion. A Full-wave Barbell horn (tip diameter 35 mm) was used in the second part of the video, allowing to scale up the volume of the formulation by a factor of 5, thereby producing 200 ml of the nano-emulsion in the same amount of time. The ultrasonic amplitude delivered by both horns was 65 microns. More information is available at www.sonomechanics.com
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Ahhhhh, that's so cool! It looks like a science fiction movie! THANK YOUU!
Thanks for the post!
Yes, we have, here is a link to the tests we have done:
good one...but have you done this NE on the pharmaceutical based...
@bobbledill Yes, with our equipment you can make permanently stable oil-in-water emulsion. Which tween to use depends on the oil type. A little Span also helps if you want to make translucent nanoemulsions.
How do we get this device, what is the price, and is there a phone number for communication
@@user-vg1no1yl1t Yes, our phone number is +1-786-233-9255. To configure one of our ultrasonic processors and get instant pricing, please visit: www.sonomechanics.com/sales/
What are the surfactants?
In Venezuela, ¿Where can purchase this equipment? and.. ¿What is about the cost?
Will it do the same to one's blood if he puts his finger there?
You state that droplet size is 50 nm based on the clarity of the fluid. Have you done any testing to support this claim?
Is it possible to make mayonnaise like that so it becomes translucent? I imagine that the result as a yellow translucent liquid
Thanks
Forgive this question if it seems obvious, but would you achieve the same result at a lower amplitude with greater time (assuming the bar's surface area remains constant)? I ask out of curiosity. Thank you!
No, it is the amplitude (directly related to the intensity of cavitation-induced shear forces) that defines the final droplet size you are going to achieve given sufficient time. Additional processing time does not result in further droplet size reduction if the amplitude remains the same.
@@IndustrialSonomechanics The higher the amplitude the smaller the dropplet size.
Does that mean the smaller the HORN (tip) the better for smaller dropplet size or is the size of the horn not important?
@@Earthbound64 Barbell horns can generate very high ultrasonic amplitudes even when their tip diameters are large. Therefore, when a Barbell horn is used, the tip diameter does not matter in terms of the resulting droplet size. See this for further information:
th-cam.com/video/IAc-glwNAto/w-d-xo.html
@@alexeypeshkovsky1614 In the given video ,it says that the bigger horn has 100mykro metres of amplitude. But isnt a lower amplitude better for generating smaller droplets? I am now confused. In the given video it says that with the bigger horn you get bigger amplitude. Excuse my confusion!
@@Earthbound64 Higher ultrasonic amplitudes are better for making smaller nanoemulsion droplets. This is because at higher amplitudes, the intensity of cavitation and the associated shear forces are greater. The size of a Barbell horn is not correlated to the maximum amplitude it can provide - they are independent variables. For further information, please see this video: th-cam.com/video/IAc-glwNAto/w-d-xo.html
How do you account for or filter out the probe particles contaminating the emulsion ? Have you done any research on this and have you figured out best strategy to avoid it ?
Dear Gaurav. Thank you for your comment. We have done studies on the subject and there is a simple solution. Please see the following article: blog.sonomechanics.com/blog/should-i-filter-my-water-soluble-cannabis-nanoemulsion
Also, page 7 of this document: drive.google.com/file/d/0ByOwF3Ss6pqoa0ZzVFNPN1hSVlE/view
Do you have a method to have a stable Oil in water emulsion ? I have tween 20, tween 80, alginate, pva, pvp... thanks !
that was quick
I would like to do the reverse. Demulsification? Is this possible? Subsonics?
centrifuge
Can you achieve nano emulsification with a stator rotor homogenizer with small stator holes? Also if you dont mind me asking. What is the main difference when emulsifying ans creating nano emulsification vs micron emulsification? Will one last long without separating? Like say nano stays together for 2 years vs micron only staying together and separating after 1 year?
We do not have experience with stator rotor homogenizers for the production of nanoemulsions, unfortunately. Nano-emulsification, however, is one of the most common applications of our ultrasonic equipment (aka. soncators). For the difference between nano-emulsification and micro-emulsification, please see the following blog article: blog.sonomechanics.com/blog/water-soluble-cannabis-oil-microemulsion-liposomes-or-nanoemulsion. Correctly prepared nanoemulsions remain stable indefinitely.
@bobbledill There is more information on sonomechanics web page in -> applications -> cosmetic and dermatological -> translucent nanoemulsions
is all Nanoemulsions require surfactant? thx for reply me best regards
Hi Dyyari, yes, the process of nano-emulsification requires surfactant. Please see the following blog post for more information: blog.sonomechanics.com/blog/water-soluble-cannabis-oil-microemulsion-liposomes-or-nanoemulsion
I saw another video and I tried myself where 50% was vegetable oil and 50% water without tensides, the final product was just milky and not translucent. (Our experiment was 30 minutes at max amplitude) (Amplitude from max to MIN was 84microns in my experiment with a 14mm sonotrode)
How comes you had a better emulsification result with even a way higher oil percentage + lower amplitude and a bigger sonotrode?
I would love to receive a reply, thanks in advance and best regards!
This is a water-in-oil emulsion, not oil-in-water. The dispersed phase (water) concentration is much less than 50%.
@@alexeypeshkovsky1614 Shouldnt the emulsion with a higher oil concentration be less translucent than an emulsion where you just have few oil concentration?
In my experiment with 5-7% oil concentration and 95% water I did not achieve any translucent emulsion although my settings had a better environment (higher micron amplitude, less volume, same diameter of sonotrode)
Could you please clarify your answer regarding the O/W and W/O emulsion?
Generally, the median droplet size in a nanoemulsion is smaller and its stability is greater when the dispersed phase concentration is diminished. For an O/W nanoemulsion, that's the concentration of the oil phase, for a W/O, the aqueous phase. In this experiment, it's the latter. Additionally, an optimized surfactant mixture is always required for translucency.
@bobbledill Tween 80 and Span 80, approximately 50%/50%
somebody help me how to break the mayonnaise emulsion?
Is this the same process to obtain solid lipid nanoparticles? Should it also be translucid?
It's a similar process, the main difference would be the formulation components. The result will be translucent if all particles are smaller than about 100 nm, which is what's typically desired.
being you know and use all these cool machines with cool functions,,,,
do you believe a ultrasonic jewelry cleaner can actually make encapsulated liposomes,,,, that's the claim being made,,,, anywhere from 30% to 90% encapsulation of vitamin c
would love to hear your take on that
also,,,to do that, make vitamin related liposomes,,,, what would a decent machine with a horn cost,,,, a cheap one for maybe home, hobbyist use???any suggestions?
Geez no one replied.. You wouldnt happen to own a lab or have access to funding. I have 10 Solid Terpene infused Organic Flavors I have perfected. Sold 50K packages so far throughout the US..
yes, we have, here is a link:
Which surfactant you have used in this video
Tween 80 and Span 80
What if we want to have drug nanoparticles??!! for example if we have drug powder or drug syrup , can we do ultrasonic to have nanoparticles?? how?
S nowadays they’re using this exact technology to create marijuana edibles using distillate oil and dose edibles correctly and precisely. Wild!
Hello admin. I think this is a good video. I just want to asking for permission to screenshoot it for my assigment. Thanks a lot..
Hi Siti, yes, you can take a screenshot for your assignment.
Could this be done the other way around? oil in water?
Hi Martin, yes you can make oil-in-water nanoemulsions. Please see the following blog article for more information:
blog.sonomechanics.com/blog/achieving-stability-of-oil-in-water-and-water-in-oil-emulsion-products
Assuming you're going to use this in an engine, why would you need to use ultrasound? Surely a good shake and a milky mix works fine.
N1H1L9 this is more of an application to use in pharmaceuticals, cosmetics, food, etc.
there are other methods to do this
+Miguel Alvarez i want to prepare w/o microemulsion but which surfactant n oil is better for formulation
polyglycerol polyricinoleate It is one of those that have shown better results
Please contact us through our website and we will provide all necessary information and pricing. The website link is in the video description at the bottom.
isn't nano scale emulsions supposed to be transparent ???
+alok johnson
No. Most nanoemulsions are milky white. When their droplets are smaller than 100 nm in dameter, however, they become translucent. Nanoemulsions with droplet sizes below about 30 nm are near-transparent.
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