Great video, quite detailed surprisingly, except for at 11:12 - the mechanism of one-hit vulnerability of TP53 is NOT a 'not fully understood mechanism'. It is due to hetero-oligomerization of the wild type p53 protein with the mutant p53 protein that results in the dominant negative effect of a single mutation in this tumour suppressor gene. I understand it might be difficult to include this aspect in the video but it is a well known phenomenon, so saying otherwise seems misleading. References: Lane DP. p53, guardian of the genome. Nature. 1992;358(6381):15-16. doi:10.1038/358015a0. Brosh R, Rotter V. When mutants gain new powers: News from the mutant p53 field. Nat Rev Cancer. 2009;9(10):701-713. doi:10.1038/nrc2693
One thing I don't get though, is why at 12:38 he pushes away meat... That doesn't really fly with me as being particularly cancerous. I saw my mother get permanent iron deficiency because she gave up eating meat. Now she sometimes needs an iron infused shot. What should've been on his plate was something loaded with chemicals like fried fastfood, not some pristine piece of lean steak.
@@Yezpahr maybe it was cured pork or even just overly red meat? The salts used for curing pork are really bad for us. In most of Europe there's now labeling on pork products that show the curing process hasn't made use of these bad salts.
Your body is actually pretty good at finding and eliminating cancer. It's the ones that your body doesn't detect, that spread fast enough to be harmful but slow enough to not burn out, that jump between different types of cells, that are dangerous. And yet, all these minuscule on minuscule on minuscule chances cancel out with the number of cells just right so that it's on a human scale.
@@jtgd It's not your cell if it's aberrant it's your immunity that is too much sickened for not being able to understand the difference between them.. Or to restore a non Aberrant Genetical patterns..
@@antoniopacelli ok wtf man stop spewing bs. You try to sound smart but you aren’t. You really just googled big words and shoved them in there. First guy is right.
How can a simple educational channel be soooo good!! This is mindblowingly unboring! I just love the animantions! And the topics will always keep me hooked. This channel deserves 1 million subs :)
Great video! But using the paper at 1:52 to claim that we go from 500 mutations per cell as an infant to 3000 per cell as an adult is confounded by the fact that they only looked at B cells. B cells are unique immune cells because they are able to select themselves to detect antigen by mutagenizing themselves, and the B cell receptor locus goes through 10k to 100k times more mutation than normal...so it's probably not the best cell type to use to make this claim.
Man you are one of the channels I click immediately no matter what the upload is about! Your explanatory and animation skills are off the charts and I can listen to you all day long! you deserve a billion subscribers, everyone should go through at least a couple of your vids, the content is so rich and diverse!
all those tiny molecular robots grinding a way day after day just so I can watch this video and not have cancer. thanks tiny robots :) awesome video as always!
I really love the style and content of your work. Please don't stop if you can comfortably keep it up, I'm sure the rest of your audience feels exactly the same.
Absolutely breathtaking Your videos are the best on TH-cam The attention to detail, the lack of watering down, your examples, everything makes these videos beautiful
I love these videos. Your clear and concise explanations paired with the very fun yet amazingly detailed animations make these videos a pleasure to watch. I can’t wait until the next one!
I learned about the P53 gene from Metal Gear Solid. In the game, if you make Snake smoke, he'll get a call warning him about cancer while mentioning the gene.
You should have millions of subscribers. Keep up the good work because "But Why?" Is one of the most important channels on TH-cam. The animations make understanding the subject so much easier.
Just found your channel and very happy I did! I'm just binge watching all your videos right now and really enjoying it. Thank you keep up the exceptional work!
9:27 Another unexpected Fermi Paradox, life is inherently subject to mutation which is probably what kickstarted life in the first place, but it could have just as easily killed itself off before it mutated a mutation that unmutates mutated mutations.
2:35 it is such a mind blowing and humbling realisation that such a remarkable cellular machine appeared in nature on its own just through nature processes although not 100% accurate. You always wish had there been some more "error correction" mechanisms, may be in future there could be a way that human intelligence could improve the cellular machinery but for now I will suggest lifestyle modification like fasting which will trigger autophagy in your cells which have any DNA damage preventing chances of cancer. Also try to avoid processed meat
That relocation mutation thing feels like it'd happen more if you shake the cell during it happening. And oh boy it feels like misreprecenting the scales at which it happens at but i cannot not feel like it would. Life pro tip. When you feel your cells doing a division, sit really still so it happens correctly...
It makes sense TP 53 is one hit vulnerable: its activity is entirely determined by the concentration of the ATM, that means that if one half of the synthesized TP 53 proteins is nonfunctional, you'll need twice the concentration of ATM to reach the threshold for apoptosis, and ATM probably never reaches twice that concentration because it didn't evolve to be effective at such wide ranges of concentrations, so the regulatory sequences won't ever allow such accelerated production.
What a great video! Thank you so much for your hard work. There are definitely many people that your videos helped and inspired, like myself. Please keep making such wholesome videos!
Brilliant, as I have come to expect from you. Highly impressive. One question: The bit about "only a little over 8% of our DNA has useful information" ( 03:10 ish). I thought that was a myth? Or at least a miscommunication, as in "only bits get expressed in each cell, so overall only a small amount (~8%) of the total DNA in your body is actually expressed -> useful? I know that evolution is far, far from being a perfectionist, but are we really carrying that much baggage? Best regards!
Great question. Basically the old much higher estimate was about protein activity on the DNA. Here's a quote "[The ENCODE project] counted all pieces of DNA on which some protein activity occurred, whether or not that activity was useful to the cell," Ponting told Live Science. "The difficulty is that protein activity occurs on all DNA, such as when it is replicated just before cell division." A better method is just comparing our DNA with similar species and observing the similarities. Essential DNA won't change much since our last common ancestor but we expect junk to freely mutate without much recourse. That method yields the ~8% that's important figure.
@Yooless ENCODE noted that 8% of our DNA are for functionally for proteins, which counts the cDNA (1.8%), and proximal transcription(cis)-regulation sequences, but it doesn't include distal (trans)-regulation sequences and mechanisms for DNA expression (e.g., RITS via miRNA, lncRNA) as well as regulation sequences for what is known as jumping genes in our genome. Jumping genes are sequences that can induce translocation and mutations to other regions in the human genomes and in some cases cause cancer. Arguably, the 8% better represents our knowledge about sequences that has a direct downstream effect on gene expression, but doesn't account the numberous upstream regulators. Indeed, when ENCODE reaccount for these sequences in 2012, 80% human genome seemed to be biochemically active and might therefore be functional/have molecular effects on a given cell. (www.pnas.org/content/111/17/6131)
@@jerrywang8945 Thank you for the response, and this interesting link :) I'm not sure if I understand the "upstream/downstream" part of your comment though. Could you explain this further? Reading through the publication you linked, I am surprised to find no mention of a statistical approach to finding out which parts of the genome are "functional". Since it was my first idea, I assume that there's a reason they are not doing it, but I don't see it. My idea would be to compare genomes of different species at varying distance from each other, genetically speaking. I believe that certain test organisms like mice, fungi, tube worms, etc. are well sequenced. Commonalities between these should indicate either convergent "junk", or relevant sequences. The distance from us in relation to the likelihood of occurrence per sequence could also be insightful, especially if one has more understanding of some of the sequences in question, allowing further inference. This could at least help to constrain the possibility space they are working with. But perhaps this is so commonly in use that they didn't consider mentioning it^^ Or do you see a problem I missed? Have a great day ;)
@@EliasMheart So when I talk about downstream gene regulations, we are talking about the protein mechanisms that regulate initiation/continuation of transcription (so promotors, transcription factors, enhancers, silencers, etc.). Downstream regulations tend to be restricted to a limited number of genes and protein products and occur in all forms of life Further upstream gene regulation utilize non-coding regions that regulate can many genes simultaneously, and generally invoke RITS mechanism and/or epigenetic histone-coiling of whole regions of DNA. It only occurs in linear-DNA organisms, so eukaryotes and archaea, but not prokaryotes (they have circular-DNA), contrasting that of downstream regulation. For instance, X-silencing is controlled by upstream gene regulation mechanisms via Xist lncDNA Also @But Why? Comparative genomics to look for functional genes is a good approach, but limitation includes that fact that upstream gene regulation mechanism also tend to be non-specific, so non-conservation doesn't necessarily imply that the section of DNA is useless. To quote the paper below, "More generally, alignment methods are not well suited to capture substitutions that preserve function, such as compensatory changes preserving RNA structure, affinity-preserving substitutions within regulatory motifs, or mutations whose effect is buffered by redundancy or epistatic effects. Thus, absence of conservation cannot be interpreted as evidence for the lack of function." www.pnas.org/content/111/17/6131
There are even the cellular elimination mechanism of cancer (e.g., cytotoxic immune cells) even after the molecular mechanism in a given cell fails. Indeed, chances are there are cancerous cells in your body right now. But you will never hear from them simply because they will be removed swiftly automatically and without issue. Even when some are not removed, most are benign cancers. Only when all of the above is surpassed can a cell line become dangerous at the organ and human scale.
Could a treatment consist in making the cells more likely to kill themselves when they detect mutations rather than try to fix themselves? I suppose Its not as simple as that but surely some medicine can put to sleep the medium fixer proteins or make the killer proteins more agresive/abundant/whatever. Other issue could be more cell division which in term leads to more mutations, but It wouldnt be hard to calculate if this treatment is beneficial or not in the net amount of mutations. The base idea is that in nature is useful to try to rescue every cell because we need to save up resources but now thats not an issue. There are probably many systems that take place in our bodies with the idea of saving resources for the sort term at the expenses of long term performance.
Wow, fascinating. The amazing complexity of these analogue molecules almost make me believe creationism. Alas no, science is my true religion. So please tell us some of the less obvious nasty habits we have that speed up the mutations. Great channel. Subscribed!
In the outro you say "Cut down on those guilty pleasures" while showing a steak. Is eating a steak correlated with DNA mutations? I'm not sure how this relates to the topic, otherwise a great insightful and educational video! Thanks :)
The right transcription of DNA by Polimerase, the right Homeostatic balance, the Perfect Innate Immunity bringing to a perfect DNA's damage response, and Symbiosis among every body's cells.. This is something that can be applied to everyone.. but not with a Warfare tipe of Healthcare like nowadays public standards.. [Cannabinoids Receptors activations from Natural Compouds and consequential increase in CBr Expression would naturally leading to at least 2 of this predetermined conditions]
@@iseriver3982 Conspiracy theorists talking about Conspiracies to others putatively chosen conspirators... A Classic. Read again.. you might have missed something. I stated that it's applicable not that is provided nor that isn't forbidden in the majority of the world. If Real Science it's banned by people like you all that is left (as you yourself are making noticing) It's our nowadays HeLacare standards.. You sad just because you fighting me instead to fighting the problem.. Let do like this I add a specific Information that might gonna make you understand better.
Did you really showed an mRNA at 4:39 to 4:43 double stranded!!!! plus polymerases don't do protein synthesis, the entire animation between 4:39 to 4:43 is wrong, this is a glaring mistake in this video. I don't think it's rectifiable now. But otherwise the entire video is well made and highly informative. I am giving this video a like nonetheless. [DiowE]
"This is bad news bears..." 3:30 I had to replay that a couple times trying to figure out WTF you were talking about. Try to keep the cuteness to a minimum.
“Loci” is pronounced with an S sound. The 92% of dna that supposedly does nothing does a lot of something. There might not be any “junk dna”, but rather it is non protein coding epigenetic control dna. So those mutations might be very significant.
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Great video, quite detailed surprisingly, except for at 11:12 - the mechanism of one-hit vulnerability of TP53 is NOT a 'not fully understood mechanism'. It is due to hetero-oligomerization of the wild type p53 protein with the mutant p53 protein that results in the dominant negative effect of a single mutation in this tumour suppressor gene. I understand it might be difficult to include this aspect in the video but it is a well known phenomenon, so saying otherwise seems misleading.
References:
Lane DP. p53, guardian of the genome. Nature. 1992;358(6381):15-16. doi:10.1038/358015a0.
Brosh R, Rotter V. When mutants gain new powers: News from the mutant p53 field. Nat Rev Cancer. 2009;9(10):701-713. doi:10.1038/nrc2693
Thanks for the correction.
Correcting science videos on youtube with references?
That's sciencing! 👍
@@ButWhySci But why? Makes me big smart.
@@SukacitaYeremia Tbh, with that level of vocabulary, I would've trusted it to be true as it's not my field of expertise anyway 😅.
@@louisrobitaille5810 Ah... I usually deny everything that's not my field of expertise. Interesting take Sir.
(just kidding heh heh)
can't believe you used the real protein structures, that's astonishing attention to detail
He usually does, he deserves over a million subs!
This dude doesn’t take shortcuts!
One thing I don't get though, is why at 12:38 he pushes away meat... That doesn't really fly with me as being particularly cancerous. I saw my mother get permanent iron deficiency because she gave up eating meat. Now she sometimes needs an iron infused shot.
What should've been on his plate was something loaded with chemicals like fried fastfood, not some pristine piece of lean steak.
@@Yezpahr maybe it was cured pork or even just overly red meat? The salts used for curing pork are really bad for us. In most of Europe there's now labeling on pork products that show the curing process hasn't made use of these bad salts.
@@Aristocrafied Ah, that could be it.
Your body is actually pretty good at finding and eliminating cancer. It's the ones that your body doesn't detect, that spread fast enough to be harmful but slow enough to not burn out, that jump between different types of cells, that are dangerous. And yet, all these minuscule on minuscule on minuscule chances cancel out with the number of cells just right so that it's on a human scale.
And cancer is good enough to evade destruction because it’s your own cells just trying to do it’s thing, not realizing it’s wonky
@@jtgd
It's not your cell if it's aberrant it's your immunity that is too much sickened for not being able to understand the difference between them..
Or to restore a non Aberrant Genetical patterns..
@@antoniopacelli ok wtf man stop spewing bs. You try to sound smart but you aren’t. You really just googled big words and shoved them in there. First guy is right.
@@antoniopacelli also do you even English? Nothing you said makes sense
@@Njadmessi Rude
these videos are huge, like the production level is insane as always, keep up the good work!
again thank you for these and have a great one!
How can a simple educational channel be soooo good!! This is mindblowingly unboring!
I just love the animantions! And the topics will always keep me hooked. This channel deserves 1 million subs :)
Its astounding to see the quality of these videos. The sheer amount of detail is incredible. Thank very much for all of your hard work.
Really enjoyed working with you on this video, thank you for the opportunity!
Great video! But using the paper at 1:52 to claim that we go from 500 mutations per cell as an infant to 3000 per cell as an adult is confounded by the fact that they only looked at B cells. B cells are unique immune cells because they are able to select themselves to detect antigen by mutagenizing themselves, and the B cell receptor locus goes through 10k to 100k times more mutation than normal...so it's probably not the best cell type to use to make this claim.
I can't believe people don't know this were smart 🤔🤔
Man you are one of the channels I click immediately no matter what the upload is about! Your explanatory and animation skills are off the charts and I can listen to you all day long! you deserve a billion subscribers, everyone should go through at least a couple of your vids, the content is so rich and diverse!
This channel is criminally undersubed
It feels like he has a doctorate in every subject, and still is very happy to teach.
all those tiny molecular robots grinding a way day after day just so I can watch this video and not have cancer. thanks tiny robots :) awesome video as always!
Thank god evolution has made it so that we don't have to consciously think about doing all our bodily processes. Cuz that would be a pain.
@@WanderTheNomad Ahem ahem: By reading this, you are now manually breathing, manually blinking, and you are aware of your toes. You're welcome.
@@WanderTheNomad "thank god evolution..." hmmmmmmmmmm
@@hardikb15 thank evolution god? 🤔
I really love the style and content of your work. Please don't stop if you can comfortably keep it up, I'm sure the rest of your audience feels exactly the same.
This channel is an undiscovered treasure. If you create a Patreon, I am in for sure.
Incredibly well summarized in less than 13 minutes without oversimplification, thanks
The longer the video goes on the more DNA starts to look like a long running software project with patch after patch to fix unforseen bugs
That's basically evolution in a nutshell.
such an underrated channel :(
dont stop producing such content and i promise you you will explode one day!
Absolutely incredible video, love your channel
Always makes my day when a new But Why video comes out. Thanks for the awesome content.
Love how comprehensible your vids are even with my small knowledge of biology
Absolutely breathtaking
Your videos are the best on TH-cam
The attention to detail, the lack of watering down, your examples, everything makes these videos beautiful
Great video, as always. Thank you for uour work!
I love these videos. Your clear and concise explanations paired with the very fun yet amazingly detailed animations make these videos a pleasure to watch. I can’t wait until the next one!
Your videos are amazing and my students will greatly benefit from them. Please continue doing what you're doing!
Why? cuz that damn radioactive spider 🕷
"Chemistry is simply the interaction of charges." Wow
I learned about the P53 gene from Metal Gear Solid.
In the game, if you make Snake smoke, he'll get a call warning him about cancer while mentioning the gene.
I genuinely find your elucidating skills commendable and the animations are neat as well. My fav videos remain the one on light !!!!
You should have millions of subscribers. Keep up the good work because "But Why?" Is one of the most important channels on TH-cam. The animations make understanding the subject so much easier.
Just found your channel and very happy I did! I'm just binge watching all your videos right now and really enjoying it. Thank you keep up the exceptional work!
9:27 Another unexpected Fermi Paradox, life is inherently subject to mutation which is probably what kickstarted life in the first place, but it could have just as easily killed itself off before it mutated a mutation that unmutates mutated mutations.
Could a mutation survive after killing off it's origin? If so, would that surviving mutation be considered life?
gonna add some engagment for this man here, good work deserves to be seen by more people
Thank you so, so much for the casual "bad news bears" you slipped in at 3:31.
Thank you to all the scientists that research the why behind cancer. I hope we one day find a cure.
Great as usual, your quality always amazes me every time.
excellent visual and verbal explanations. Loved the Natural Cell Division part especially
Time to do a any% cancer speedrun!!! let's goooo!! uranium -235 tablets here I come!
I'm trying Aflatoxin. Let the best man win
Cancer is the closest example of entropy in action
2:35 it is such a mind blowing and humbling realisation that such a remarkable cellular machine appeared in nature on its own just through nature processes although not 100% accurate. You always wish had there been some more "error correction" mechanisms, may be in future there could be a way that human intelligence could improve the cellular machinery but for now I will suggest lifestyle modification like fasting which will trigger autophagy in your cells which have any DNA damage preventing chances of cancer. Also try to avoid processed meat
This channel is just too good
Ey dude love your channel keep up the good work
This channel needs a patron
11:40 You might regret it, but I (and I'm sure others) appreciate it alot 😁!
That relocation mutation thing feels like it'd happen more if you shake the cell during it happening. And oh boy it feels like misreprecenting the scales at which it happens at but i cannot not feel like it would.
Life pro tip. When you feel your cells doing a division, sit really still so it happens correctly...
My new favorite TH-cam channel :)
It's just amazing to realize how complex our body is!
It makes sense TP 53 is one hit vulnerable: its activity is entirely determined by the concentration of the ATM, that means that if one half of the synthesized TP 53 proteins is nonfunctional, you'll need twice the concentration of ATM to reach the threshold for apoptosis, and ATM probably never reaches twice that concentration because it didn't evolve to be effective at such wide ranges of concentrations, so the regulatory sequences won't ever allow such accelerated production.
What a great video! Thank you so much for your hard work. There are definitely many people that your videos helped and inspired, like myself. Please keep making such wholesome videos!
i am mad that this channel does not have more views and subscribers
Brilliant, as I have come to expect from you. Highly impressive.
One question: The bit about "only a little over 8% of our DNA has useful information" ( 03:10 ish).
I thought that was a myth? Or at least a miscommunication, as in "only bits get expressed in each cell, so overall only a small amount (~8%) of the total DNA in your body is actually expressed -> useful?
I know that evolution is far, far from being a perfectionist, but are we really carrying that much baggage?
Best regards!
Great question. Basically the old much higher estimate was about protein activity on the DNA. Here's a quote
"[The ENCODE project] counted all pieces of DNA on which some protein activity occurred, whether or not that activity was useful to the cell," Ponting told Live Science. "The difficulty is that protein activity occurs on all DNA, such as when it is replicated just before cell division."
A better method is just comparing our DNA with similar species and observing the similarities. Essential DNA won't change much since our last common ancestor but we expect junk to freely mutate without much recourse.
That method yields the ~8% that's important figure.
@@ButWhySci Thank you, that makes a lot of sense :D
@Yooless ENCODE noted that 8% of our DNA are for functionally for proteins, which counts the cDNA (1.8%), and proximal transcription(cis)-regulation sequences, but it doesn't include distal (trans)-regulation sequences and mechanisms for DNA expression (e.g., RITS via miRNA, lncRNA) as well as regulation sequences for what is known as jumping genes in our genome. Jumping genes are sequences that can induce translocation and mutations to other regions in the human genomes and in some cases cause cancer. Arguably, the 8% better represents our knowledge about sequences that has a direct downstream effect on gene expression, but doesn't account the numberous upstream regulators. Indeed, when ENCODE reaccount for these sequences in 2012, 80% human genome seemed to be biochemically active and might therefore be functional/have molecular effects on a given cell. (www.pnas.org/content/111/17/6131)
@@jerrywang8945 Thank you for the response, and this interesting link :)
I'm not sure if I understand the "upstream/downstream" part of your comment though. Could you explain this further?
Reading through the publication you linked, I am surprised to find no mention of a statistical approach to finding out which parts of the genome are "functional". Since it was my first idea, I assume that there's a reason they are not doing it, but I don't see it.
My idea would be to compare genomes of different species at varying distance from each other, genetically speaking. I believe that certain test organisms like mice, fungi, tube worms, etc. are well sequenced. Commonalities between these should indicate either convergent "junk", or relevant sequences. The distance from us in relation to the likelihood of occurrence per sequence could also be insightful, especially if one has more understanding of some of the sequences in question, allowing further inference. This could at least help to constrain the possibility space they are working with. But perhaps this is so commonly in use that they didn't consider mentioning it^^ Or do you see a problem I missed?
Have a great day ;)
@@EliasMheart So when I talk about downstream gene regulations, we are talking about the protein mechanisms that regulate initiation/continuation of transcription (so promotors, transcription factors, enhancers, silencers, etc.). Downstream regulations tend to be restricted to a limited number of genes and protein products and occur in all forms of life
Further upstream gene regulation utilize non-coding regions that regulate can many genes simultaneously, and generally invoke RITS mechanism and/or epigenetic histone-coiling of whole regions of DNA. It only occurs in linear-DNA organisms, so eukaryotes and archaea, but not prokaryotes (they have circular-DNA), contrasting that of downstream regulation. For instance, X-silencing is controlled by upstream gene regulation mechanisms via Xist lncDNA
Also @But Why? Comparative genomics to look for functional genes is a good approach, but limitation includes that fact that upstream gene regulation mechanism also tend to be non-specific, so non-conservation doesn't necessarily imply that the section of DNA is useless. To quote the paper below, "More generally, alignment methods are not well suited to capture substitutions that preserve function, such as compensatory changes preserving RNA structure, affinity-preserving substitutions within regulatory motifs, or mutations whose effect is buffered by redundancy or epistatic effects. Thus, absence of conservation cannot be interpreted as evidence for the lack of function." www.pnas.org/content/111/17/6131
Dude I love this videos. You could have just used a 2d picture available but decided to fully animated it in 3d. The effect in this videos is amazing.
Every time I see a new video from but why I drop everything I am doing and watch it!
Transposons are also a source of mutation, although not point mutations, I guess that might fall under cell cycle mutations though
Your videos should be included in the curriculum of med schools...
High quality, informative,detailed, brilliant stuff. 👏
I think I’ll have a stern talking to with all my chromosomes and DNA polymerase and tell them be be more careful from here on out
awesome, very clear and easy to understand!
Don't forget all the cancer we are surrounded by!
the animations are great !
I learned a bit from this and I'm glad I watched it but man it kinda stresses me out haha
Just glad I can function and prevent most of these issues
I love your videos please make more
Dude, these videos are amazing! How do you even start doing them?
There are even the cellular elimination mechanism of cancer (e.g., cytotoxic immune cells) even after the molecular mechanism in a given cell fails. Indeed, chances are there are cancerous cells in your body right now. But you will never hear from them simply because they will be removed swiftly automatically and without issue. Even when some are not removed, most are benign cancers. Only when all of the above is surpassed can a cell line become dangerous at the organ and human scale.
Your animations are the best. And videos, like someone said in the newest one are magical. Very cute. And soo interesting. Have you studied physics? 🤔
Could a treatment consist in making the cells more likely to kill themselves when they detect mutations rather than try to fix themselves?
I suppose Its not as simple as that but surely some medicine can put to sleep the medium fixer proteins or make the killer proteins more agresive/abundant/whatever.
Other issue could be more cell division which in term leads to more mutations, but It wouldnt be hard to calculate if this treatment is beneficial or not in the net amount of mutations.
The base idea is that in nature is useful to try to rescue every cell because we need to save up resources but now thats not an issue. There are probably many systems that take place in our bodies with the idea of saving resources for the sort term at the expenses of long term performance.
Excellent quality and interesting content.
This is some surprisingly detailed information about cancer. Really amazing video quality.
Hey mate, did you monetize your channel? I'd love to watch ads to support you!
he was forced to do it by YT. he has minimized them as much as possible.
@@celiapearls7910well I have premium so I don't really know.
Wow, fascinating. The amazing complexity of these analogue molecules almost make me believe creationism. Alas no, science is my true religion. So please tell us some of the less obvious nasty habits we have that speed up the mutations. Great channel. Subscribed!
Love your videos!
awesome! looking forward to that anti cancer episode. Thank you for doing this.
What if we used genetic engineering to breed people with extra copies of genes such as TP-53 or DNA repair genes?🤔
In the outro you say "Cut down on those guilty pleasures" while showing a steak. Is eating a steak correlated with DNA mutations? I'm not sure how this relates to the topic, otherwise a great insightful and educational video! Thanks :)
Excellent
needs more chad protons
Your videos are awesome
This channel is simply amazing 🤩🤩🤩 Moar plz
Interesting!
my best
how did you create a marker pen effect using grease pencil?
Hey! Hey mr but why,
*please reply*
What do you use to animate
I am intrested in animation. And i want to learn this artstyle or software.
www.blender.org/
But do we know the mechanisms that help other animals like the blue whale to seemingly be immune to cancer?
can you share the blend files?
nice
9:50 🤣😂🤣😂🤣😂
omg im done
ThIs ViDeO iS tRaNsPhObIc!!!!!!!
Third but I haven't watched it yet
MORE
Cut down on red meat
Idk how you do it, this must’ve been a female dog to make n edit. Tremendous.
👀👄👀
The right transcription of DNA by Polimerase, the right Homeostatic balance, the Perfect Innate Immunity bringing to a perfect DNA's damage response, and Symbiosis among every body's cells..
This is something that can be applied to everyone.. but not with a Warfare tipe of Healthcare like nowadays public standards..
[Cannabinoids Receptors activations from Natural Compouds and consequential increase in CBr Expression would naturally leading to at least 2 of this predetermined conditions]
Ever wondered why other countries that don't have your healthcare conspiracy also don't have the perfect cancer treatment?
@@iseriver3982 Conspiracy theorists talking about Conspiracies to others putatively chosen conspirators...
A Classic. Read again.. you might have missed something.
I stated that it's applicable not that is provided nor that isn't forbidden in the majority of the world.
If Real Science it's banned by people like you all that is left (as you yourself are making noticing)
It's our nowadays HeLacare standards..
You sad just because you fighting me instead to fighting the problem..
Let do like this I add a specific Information that might gonna make you understand better.
@@antoniopacelli now we're going down the conspiracy rabbit hole.
Who's banned real science?
@@iseriver3982
Feel like bot here.
Nevermind I still acculturated the algorithm a bit.
Thanks for your help.
@@antoniopacelli you've changed the culture of the algorithm?
I think you need to take your meds.
mind blowing!! the biggest question is that who is the engineer behind all of this
Did you really showed an mRNA at 4:39 to 4:43 double stranded!!!! plus polymerases don't do protein synthesis, the entire animation between 4:39 to 4:43 is wrong, this is a glaring mistake in this video. I don't think it's rectifiable now. But otherwise the entire video is well made and highly informative. I am giving this video a like nonetheless. [DiowE]
Check the lower right corner at that scene
Second
Does medicine make u mutate as well?
Only if that medicine is gene editing, which some people with sickle cell get. Though that's not exactly a mutation.
"This is bad news bears..." 3:30 I had to replay that a couple times trying to figure out WTF you were talking about. Try to keep the cuteness to a minimum.
“Loci” is pronounced with an S sound.
The 92% of dna that supposedly does nothing does a lot of something. There might not be any “junk dna”, but rather it is non protein coding epigenetic control dna. So those mutations might be very significant.
Apparently it's lo-sai in American english and lo-kai in British english. At least, according to Google, and the Cambridge Dictionary
First.
Your body is always mutating if you eat like a slop and don't pay attention to it. Otherwise you aren't exactly mutating all the time.