We get "Significantly Older" Twice in our Lives, according to massive new Study
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- เผยแพร่เมื่อ 15 ก.ย. 2024
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Reference [Copy & Paste DOI into Search Engine]
[1] doi:10.1038/s43587-024-00692-2
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#agingresearch #agingwell #aginggracefully
![These Molecules Reversed Aging by... YEARS! [TRIIM Study Explained - Study 216]](/img/n.gif)
So, apparently, we don’t age like a fine wine, but more like avocados.
fine avocadoes...
Well, maybe we do, try tasting a 44 years old wine...very likely not so fine anymore :)
Brilliant. 👌
Or pears
And much like a walnut as well. Both the shell and the meat inside is going to age with time. And, there is no turning back the clock for the most part, unless we thrown in the freezer.
This study is SO FLAWED if you actually read it (you can find it online).
First of all, 108 people participated in the study... but not really. The average is actually around 90 people aged between 25-75, and if you look at the chart, you'll see that 90% of them are between age 48-61. At the mentioned age of 44, there are 2 (!) people.
The average BMI (also shown on the chart) is 28.2 so most of them were obesse to start with. This is also reflected in the insulin resistance, where about a third are (pre)diabetic (insulin resistant). They all live in California, so hardly representing even the US.
They were followed for a total of ONLY 1.7 years on average. There is one person who was followed for nearly seven years, so some were only followed for a few weeks in exchange. It also mentions that, for example, only 78 people took the "gut microbiome" test, and even fewer for some other tests.
This is statistically a completely worthless study, even considering the USA.
Good points! I just want to add that 28.2 is not Obese, but it is Overweight. Obese starts at 30 BMI.
what makes the study worthless?
@@jonyngvesyland5461 I explained that just above. Totally insignificant number of people, just 1-2 for each age group (years), so possibly one man and one woman. Limited to badly overweight people from one geographical region, following probably the same diet, etc. Anyone who knows anything about statistical analysis, and especially in the medical field would not take this seriously. These reseachers got some funding and had to come up with some paper that showed some result. Total waste of money IMHO.
the first acceleration is somewhere between 40 and 46.
To me, this signifies strong life events happen at this time. Kids getting old and leaving the house? Retiring from work? Sounds about the right timing.
I have no such factors in my life and have aged significantly at 44
I don't know where you live, but where I live this doesn't add up at all. The average age here when people get children is about 30, so we would expect kids to leave the home around age 50. People also don't retire at 60 here - more like around 67-70.
So 44 is adolescent kids? Very traumatizing 😂
And at 55 is around when your kids get married? Making you feel how old you really are. The next generation is settled: your biological imperative fullfilled.
Yes I expect these things to be heavily affacted by (evolutionary) psychology.
@@abramjones9091 same 😂
I'm 58, fairly fit and in shape, but I'm conscious of this, It's only now I realise how young I was at 40,
I'm not going "gently into that goodnight" I'm taking the advice of this channel and some books I've read, I've changed my diet to less processed shyte, and more wholesome food, I've taken up weight training, power walking, meditation, creatine supplement and a multivit drink in the morning. I've just to get my sleep right which is proving to be the most challenging.
I'll see I suppose.
At 88 you will think you were young at 55
Respect Sir. Hope you invest in pre-hab for joint and tendon health?
@@frv6610 LOL, I know what you say will be true, I'm hoping to get to 88 and still be active as in still walking and exercising daily, I'm lucky in that I enjoy exercising and always did, BUT not everyone does.
A neighbour of mine is approaching 90, and every morning, she walks about 2 miles to the shops with a wheely shopping bag and back at a fair pace. That is what I aspire to at her age.
Good luck with your health sir
@@DrRussell I do a few of these exercises, I'm practicing balance, I stand on each foot with my eyes closed, I got past 2 minutes, I'm aiming for 3. I am also considering a yoga class, which I think I will enjoy, for flexibility.... Great channel by the way...
@@johnPaul-qn3dg glad to hear. I’m sorry if I created confusion, I’m not part of this channel. Certain yoga manoeuvres such as locust position are excellent for back pain. All the very best.
I turned 62 and all hell broke loose in my body ... eyesight , inflammation , everything. Fighting back with a long fast right now
maybe you dont eat enough vegetables
Low grade inflamation leads to cancer. Magnesiun is anti inflamatory and its needed for the body to funcion correctly reasons to eay vegetables loaded with magnesium and other minerals
My mother fell one day hitting her head. After that day she is never been the same. Suddenly her good white teeth started to look yellow and the teeth developed gaps. She got weaker and started getting illnesses. Whatever happened, that fall invoked something bad.
I have the personal belief that when we reach a certain age, even if we look okay, our body is in a delicate balance that once it's tipped over it's very hard to regain again, while I have a degree in health-related science I'm not expert in health advice like physicians, much less in geriartry, but I would suggest taking her to a nutriologist and doing specific blood work to see if she lacks any micronutrient or macronutrient in her diet first and foremost, and if your family is able to, taking her to a health profesional who can give her a routine to gain her strenght back, I would hope that would improve her quality of life at least
I must say that I didn't notice anything in my forties, but now I am 60, and I can feel the differences. 60 years for me have been a turning point.
What difference do you feel at 60? Some at 60 say they feel more energetic than in their 40s because I think it depends on the health of the person
I became diabetic at age 60. Coincidence?
At 67 l don’t feel any difference that when I was 20, maybe because I don’t think about it.
@@ramonmuniz8439 interesting
@@DrFunFongI think that's just life choices homie 😂
Theory. Peak average stress for many adults. First, when kids become teens. Second, when body starts to fall apart - prompting most to finally do something about it - as well as chill out more in general at this age as retirement no so far off. I'm 54 and see these stress patterns a lot in friends. Just a theory.
Love your channel. At 61, I need to make some changes regarding my health, and your information has given me a great road map to follow and what dirt roads to avoid. My sincere gratitude and appreciation to you!
Have you looked into Bryan Johnson stack and channel on TH-cam? That guy spends millions to age backwards
@@theancientsancients1769 I've watched a few of his videos. His entire life is geared towards longevity. He is a little over the top for my liking. I live as healthy as I can on my income. Getting old sucks, and I will keep trying to make it to tomorrow. 🙏
Check out High Intensity Health.
I also gone deep diving into health after stress burnout.
I very much noticed relatively sudden bursts in ageing from my early 30s onwards (such as the inability to run as fast as I could at 19, for example). Now in my 70s, it seems to me to be a decadal thing. I notice, for example, that my skin is ageing quite noticeably recently so there could be a list of other signs that point to ageing bursts.
Are you trying anything for your skin aging? Collagen supplements, Tretinoin cream, using a dermaroller, for example?
I wear a sunhat outdoors during summer@@gsomethingsomething2658
Aha! No wonder I have felt significantly older in the last 5 years. I'm 75. I have been aware that I have to keep doing more and more to stay in the same place. Tighter parameters on diet, more exercise, etc.
Have you looked into Bryan Johnson Blueprint protocol? He has a supplements stack now too. It's that guy who spends millions on himself to stay younger. He has a TH-cam channel. I think health is what gives energy
@@theancientsancients1769 I have. I do a lot of well considered supplementation, but of course I can't afford his protocol. I take it you aren't in your 70's?
@@barbarashirland9078 Michael Lustgarten is great. His regime is cheap.
Barabara, have you tried +NAD and NAC supplements yet? Not that expensive if you comparison shop. Nick has a lot up on those. They DO work. Direct effects on the mitochondria in the cells. Restacks the deck - might help you get past those diminishing returns. I take a lot of stuff, but then I experiment on myself.
@@barbarashirland9078 I'm not in the 70s, but agree it's expensive! More affordable is Xtend life and the owner in his mid 70s started his protocol in his 50s and used their supplements for 20s . He started this way before than others and they still are at the cutting of this industry in terms of products and set standards.
What I noticed at approximately age 40 and 60 is that in my 20s and 30s I wasn't very interested in working hard physically doing things like yard work, etc. But my will power and interest to do this work increased drastically as I aged (about 40 and another bigger spurt at 60) so that I do much more now in my 70s than I did in my 20s and 30s. I started eating vegetarian at age 23 and have continued for 53 years. I was into right eating and meditation, but not gym workouts. I do have a rowing machine and I do 200 rows five days a week. At 75 I have never been hospitalized or had surgery or even broken a bone.
Sounds like you're doing good. Good for you!
Maybe you can wear a sunhat during summer to protect face from uv light
@@frv6610 I wear sunscreen. Sometimes I wear a hat if it doesn't get in the way of working under trees.
It sounds like you're doing pretty good. I've seen healthy people deteriorate rapidly after a fall, and the best way to avoid falls is to work on muscular strength and quickness. This means at least some resistance exercise. I find the easiest way to do it is in a gym, but it can also be done at home. Sauna is another thing I'd look at.
@@incognitotorpedo42 Two years ago we were painting our eaves as quickly as we could because new eaves were going to be installed in a couple of days. I was getting off the ladder thinking I was on the ground but I was on the last step. I fell on my bottom, rolled on my back on cement and hollered to my husband to help me up. I still had the paint brush in my hand. I got up and nothing hurt. So I moved the ladder and resumed painting. It never hurt even later. I was lucky. I try to do 200 rows on the days I'm not doing other heavy work or cleaning the house. We have it at home. Also for 44 years I've done a 15 minute series of exercises twice a day never missing. It is to prepare for meditation. (Yogananda designed these in the 1930s.) It is mostly tensing and relaxing parts of the body.
I hit a brick wall at 30, had to stop drinking, smoking, and really start watching my diet. Before that there were no consequences
33 for me
Its funny i feel these at 21 ,body isnt invincible anymore and i easily feel anything harmful,also big mental differences i feel calmer like an old person. Lol. All cause of lifelong horrible mental health . Cant even drink alcohol anymore ,enough to get tipsy leaves me unfunctional for 3 days
Ye like at 33 i knew i wasnt gonna be like 15 year old again
This, I have no choice but to listen to my body and watch diet, exercise, stress, ect.
@@rayven6704make sure you try and keep you stress down and stay active. I resonated with you as at 22 I had a whole muscle group collapse from stress. My pelvic muscles to be specifics now I must do stretches regularly , take a pill and sleep 8hrs else feel some sort of discomfort it’s more common in woman but I am man who got it just saying to you because you said you were 21 and I always spread stay active , stretch and managed stress if you can
Why worry about it? Live your life, aim to be as healthy as you can.
Thats it, now go back to your joys
The study, which I also read, mentioned that there are a 6% of events/molecules that do not follow the biphasic changes observed in the more than 80% that do. Interestingly, they mentioned that this 6% follows a linear pattern of "decay" through the years. I do not understand why no event/molecule follows a linear change that instead of going down goes up. However, let's say most of that 6% suffer a "decay". Notably, that is the case of the gut microbiome and perhaps the lipidome. Moreover, many independent studies have pinpointed the significant role the microbiome has in maintaining the healthy functions of the mitochondria.
Another thing that got my attention is that they did not discuss this, neither an alternative theory that incremental changes may have an accumulative effect were going pass a threshold (two of them) may cause those biphasic changes observed in the 80%. This is interesting and provides a source for identification of changes in key events/molecules such as changes in the microbiome and lipidome, for example. Consequently, that may signal key events/molecules that might be suitable targets for clinical interventions.
Pedro O Flores-Villanueva, MD, PhD, MMSc
It's going to take quite a few studies to reach a conclusion, but you have to be at least partially (probably mostly) correct. It's going to be a trickle down effect. When it reaches a certain point it causes observable change. Like when muscles degrade to the point where movement really goes down, they atrophy due to the lack of movement. They can say root cause is lack of movement but more likely mitochondrial decay due to microbiome like you theorized.
Seems to me that the study shows that people born in different years/decades have different blood levels - for whatever reason.
It's unclear whether the difference is caused by age or by being born in a different generation.
Did they seperate out by gender? Could women suddenly age when they run out of eggs (right age range) and men show different test results? Menopause and perimenopause cause huge changes in women.
I wonder this, also.
I'm 63 and I agree with this study.
Definitely hit a speedbump at 45, then again 62. The 62 was nasty. Almost ended up filing for disability. Got past the 62 with +NAD, NAC, Taurine, Ureolithin-A, TMG, and much more (thank you Dr. Nick). Also some occasional Methylene Blue (Bjain pharma, from New Delhi). Now I'm back to almost the 45 level (aging camera says I'm '54' in appearance at 64). I had already been using Astragalus and DHEA some 15+ years and that does have a definite effect too. I've just added Lutein for the anti-Interleukin 11 effects to see if that will give it a further kick. Nick, any research on Astragalus or Lutein up recently?
Thanks so much for your analysis, Dr. Nic! The media reporting on this study have lacked substantiative interpretation. Even anecdotally, I’ve already passed one of those peaks and I didn’t notice a “surge in aging.” Your takeaway (biological aging isn’t linear) adds so much more perspective.
I wonder if the peak at 44 has something to do with hormone changes that occur around that age
definitely
~44 is when you get marriage problems, college bills for kids, job layoffs, health-issues, realization that you are old…
60 is when society sees you as useless and/or ignores you…….and 60 is realization that you are going to die soon…
Hi, non-scientist here. It looks to me that the body is regulating itself albeit over years and decades. These molecule peaks are identified by the body (don't know how, not a scientist), considered excessive/abnormal/unwanted, and action taken to reduce those peaks. The first peak is 'spotted' and the body takes action to reduce the offending molecules then the second lesser peak is 'spotted' earlier (the body learning) and action taken sooner. In another decade or two, assuming life continues, another peak will form and action taken again by the 'regulating' body. But like I say, I'm not a scientist, so I'm probably talking rubbish.
The amount of confounders in studies like this is so enormous that renders these no different than . . . crap!
The title is relatable. we see this kind of things in our lives. I can tell her from my life experience I saw my uncle at about age 40 becomes older his face shape changes and my mother at age 60 she become like grandmother with a white hair and the fallen smaller face. And even myself about the age 35 I became looking much older non-linearly
The ageing in your 40's is almost certainly due to having teenagers
100%
Thank you for this detailed explanation, Dr Verhoeven. I saw the news reports on this study, and wondered what it was all about. In good health at 76, I’m now very curious to see what the peak you mentioned at 78 will involve. My personal layman’s theory is that there are numerous cycles that come into common phase at a 20 year interval, 40-60-80, so I’ll find out more in the next few years and later at 100!
That is, if you make it to 100. A disease could be brewing inside you without you knowing or you're involved in a motor vehicle accident and, at your age, an accident or a disease will set you back a decade or more which likely you will never recover from.
Anything is possible - think positively!
I noticed that the graphs were from 7,000 to 9,000 on the y-axis. If they had plotted them from 0 to 9,000 those peaks wouldn't appear as large.
But that said. I'm 58 currently. I didn't need to wear glasses until I was 45 and did feel that something changed about my mid-40s. Between 45 and 50 is when I transitioned from playing soccer to swimming as my main form of exercise. It wasn't a choice I made, my body made it for me.
My eleven old boy said we get significantly older during the infants phase and adolescent phase. I think he is more accurate.
Very interesting, At age 44 I really noticed a change in my vision, needing much more light to read. Now at 62 I do a good workout daily and not noticing any significant changes. My mother seemed to age more rapidly at 78, but I chalked it up to the Covid inactivity demands.
So glad you have reviewed this! I have not watched any of the other vids on this study, I was really hoping you would do a review 😊 I know these types of studies take a lot of work which means a lot of money. What would be interesting is if they continue to follow each individual to see how they age from 40 to 60. Perhaps it wouldn’t make much of a difference but each person has their own lifestyle, genetic makeup, I know there are too many variables.
I had some health issues in my 40s so I didn’t feel great. I was finally able to figure out what was causing the issues and made changes that helped me feel better in my mid 50s and beyond. I’m now 63 and feel great but I can tell I have experienced changes from my mid 50s.
I'm a 63 year old male. I noticed two short periods when it seemed like a step change in aging took place. Around 32 rapid recession of hairline (mpb). Mid forties a small patch of grey hair below lip but the rest remained brown until 58 when sudden change of remaining hair and beard to grey took place. Also at this time 58-60 skin changes loosening on face and neck and development of abdominal fat which had never been an issue before.
Leave it to Nicolas to look at some click bait story that’s been circulating -and give us the real story. Thank you for the quality content!🙏🏽
I’m 66 and agree that between 62 and 65 there seems to be rapid aging.
Thanks for the warning dude, I'm 61 1/2 years old.
I'm 57.
Around 54 I started to grow gray and coarser hair at an alarming rate, and last year I was diagnosed with psoriasis, which hadn't been a problem at any time prior.
I my mind, spurts of aging looks plausible.
Im going through the same. And trying with Collagen, Taurine, Hyalurronic, good protein intake, quite phisically active, but do need mor specific excersize. Still feeling a difference amd mot in the best way.
Grey hair I had since 30s and dandruff I had them since my teens haha So it's not age related always
Thank you for admitting this. I've read many comments here and old people posting are delusional. They mention they're in their 50s, 60s, and 70s and humbly brag they feel a decade or two younger. Bullshit. They're old; they just want to admit it. Or, they're just one bout of pneumonia away from feeling older than they actually are.
Haha, the classic graph with cropped Y-axis.
Funny that I got incredibly sick at 40 and then it finally turned around completely at 60.
It's old man puberty! I'm getting closer to my first one, I'm scared...
44 isn't old. Sorry stop whining. This is just one study and it's likely flawed on a few levels.
At age 46, I suddenly noticed smaller muscles & lost interest in consistent workouts. At 47, I broke up w/ my live-in gf & felt the least stressed in my life.
women age during and after menopause...it sucks the life right out of you.
Maybe there's an Inverse Molecular Catalyst at work here: where Wishful Thinking combined with the Urge to Relive A Second Childhood and Too many Old School Reunions Drops a Bundle of Reminders on the The System that has Trouble Recollecting our Younger Days and Just decides To Let it all hang out../Still They Say Life Begins at ??? Maybe it Peaks again at 80 something ?🕺
Every one of our bodies just happens to know that at 44 and 60 to turn on the ageing rocket. Surely not
OKAY. 100 people. Very impressive.
😂😂😂😂😂😂
There are also many other dimensions, like hormones, neurons, cardiovascular health, and others.
The standard error is not even over the whole of the average lines being wider at the point where it is claimed we age faster but this could just show greater error in measurements at this point for some reason. Before I accepted this claim I would want to know why this is
.
For me, it seems that you only get better at laughing what falls apart or even off, but it does beat all out death.
How can they show a graph with data covering aging over the course of 25 years if the study only took place 1,6 years ?
According to Perplexity I was asking, result based on (only) 100 participants is not significant, need more further and vast research
Then do a larger study.
@@MetalheadAndNerd brilliant input 👏
It is probably hard to find anyone to add to any study these days due to the amount of stress and turmoil. How much have you aged in the last 4 years would be easier.
Whether 40s or 60s n lives gone full circle, u chill n enjoy it thankfully..
looks like a y-axis issue to me, obviously if it went from 0-9000 instead of 7000-9000 then it would not look particularly significant
Great video! Our mind thinking aging matters makes us sick. If there is one thing all super agers have in common, it is that they do not think they are old and they carry on like they are young. Rupert Murdoch, Roger Penrose, William Shatner, Dick van Dyke, David Attenborough, Eric Kandel, Bruce Ames, etc, all have this in common. Interestingly they all eat very little and are mostly plant based.
The human diet in nature isn't plant based. Is mostly animal based with some plants and fruits. So it's simply impossible a vegan or vegetarian diet is good. Cope with it.
@@Trader7535 Source? If you compare our teeth with any other animal in the wild, we only have 2 teeth that are meant for tearing through flesh (canines), and the rest are more or less for plants. Also, look at the way different cultures eat around the world. There is a tribe in Africa that eats a ton of diary but doesn't have high blood pressure because they have adapted to their diet over thousands of years.
Italians and Greeks eat a mostly plant based diet, and they have some of the longest lifespans in the world. Japan too, but they eat more fish instead of red meat. I will agree with you that a vegan diet is problematic in that it misses vitamin b-12, choline, and a few other micronutrients. I'm mostly vegetarian, but eat eggs and cheese. Same with my parents. They are 60 and both look like they're in their 40s.
Also, fruits are plants.
I am a science teacher and my mom is an RD. Keep coping. This carnivore diet craze is nothing but insecure alpha male BS. Plants make you strong! I eat lots of nuts and olive oil. My vegetarian ass can deadlift 350 lbs at 170 bodyweight, after only about a year of training.
His vids are great.
I just wish so much he'd conjugate the word 'data' as plural; it'd make my year.
What about the social effects of a person's life at 40-45 (teenage children, parents possibly dying, reaching the top of an income bracket, classic mid-life crisis) as for 60 (which I have just reached (thinking about retirement, elderly parents, can't be bothered with competitive sport, ie got the t-shirts, fear of job loss as nobody will employ 60+ years old)etc. Stress from life causes huge physiological changes, both good and bad.
My only physical comment from sportspeople is that many have a dip at the end of each decade rather than a progressive linear loss throughout each decade.
Can you please analyze the studies that says caffeine slows down the production of collagen?
Need to do the same study on people who are athletic and do not eat the standard American diet.
I was hoping you’d pick this COMPLEX study up, Nic!
I am 49 and I feel like I aged 10 years during the pandemic. Mentally I don't feel like I have ever 100% recovered from the virus. Just not mentally as sharp. My working memory got so bad and then has slowly recovered to about 80% of what it used to be. Maybe it was because I was 45 when I got it.
I just turned 50 myself. It's not just you who feels different. I felt a difference 4 years ago. I used to consistently go to the gym and felt that "itch" to go everyday. Now, I have to really push myself to go. I've noticed I don't have that "spunk" I used to have before age 46. I work at a job where there are many young employees. Those that are about our age, including myself, look older, have less muscle volume, and don't have that spontaneous, spunky attitude that the younger employees have.
We are just getting older. Some older guys are delusional and post a comment saying they've never felt younger (!). Bullshit. We're getting old.
Is this connected to sexual activity? Women lose interest at 44 and men at 60? Hormonal changes?
6:39 I don't understand why the graphs go up at all .. the body attempts of fighting aging? "oh no im getting older, send in the stems !"
p.s. shrinkified is a spell from Harry Potter. I'm pretty sure about this. watch them all again and let me know.
Luckily I got really serious about health at 55 and reversed to 44, I'll just hang out there.
😂🙌
You're 55. We all want to wish we were young again, but, you're 55. You may be a "young" 55, but you're still 55. One car accident or one bout of pneumonia, at your age, will likely advance your body by 10 years. That's because you're recovery rate is very slow compared to a guy in their 40s. I understand you want to feel young again, but face it: you're old. Sorry guy.
@joebeta1837 I was just joking around man. I'm actually 59.5 years old. I said I got serious about my health at 55. I can do 100 push-ups no problem. I'm not a typical person my age do to my proactive health focus.
Well, the underlying question here is how "aging" should be defined at all. You seem to be of the mind that molecule differentials could possibly be the CAUSE of aging, but might also not be. Other people would say that any time-linked difference CONSTITUTE aging.
My sister and I, both physicians, have seen great improvements from taking taurine. She's 72 yo and I'm 67 yo. I know that this is anecdotal information but it's backed by some legitimate science. Please reply with your taurine experience.
What kind of improvements?
Like this channel a lot. I'm 71 and did not notice any significant physical changes at 40 nor 60 other than not being able to run a quarter mile as fast as I used to. I still work out hard 7 days a week; running one day, weight lifting the next. MWF one hour of weights with 2 minute breaks, 16 exercises in all, heavy, (ex. dumbbell bench press 15 X @ 45lb.) finish up with 6 full extension pull ups, 10 dips and a 1.5 minute hang. TuThS one hour of ab work, stretching and balance exercises, finish up with step box and 1.5 minute hang. Tuesdays and Saturdays, 3 mile run (about 20 minutes); Thursdays and Sundays, HIIT: 8 X all out run up 60 yd long12% grade asphalt road hill. Lots of supplements from whey powder to Creatine. I still work part time, but make working out a priority. "Don't let the Old Man In"!
I believe, it is "shrunk" but "shruinkified" definitely has a ring to it...🤔 We should find a meaning for it bc it is to good a word to let it go to waste!
100 participants? WOW! just WOW! 😂😂😂😂
proteomic, biomics....what abouth the F'ing mirror!
My friends personal journey supports this study and in his case it is not externally related. His appearance remained pretty much the same from his 50's to his 70's until suddenly he looked a lot older. Scary
I wonder why researchers don't do multidimensional probability analysis. Like there are many combinations of the variable measurements in the population sample. I currently have been working to visualise a kernel density estimation of weather dimensions. Like day-hour, year-day, and temperature from 2003 to now from the hourly weather station readings. And use opacity to plot a 3d volume and show the high probability regions. In the Julia programming language.
Does that mean (hypothetically) that protocols to reduce aging would be most beneficial around those two peaks?
In other words if I'm 41 now then would rapamycin help me more in the next few years versus during slower aging?
Curious about this as well.
maybe that is why some of these clocks are having inconsistencies. They are always drawing a straight line in the scatterplot matrix and maybe they shouldnt
I think this idea is driven by people's experience, you are ageing at a steady pace and then pow you age faster over a few years which then stabilise before pow. I have heard many people describe how they experienced this
Cellular machinery just gradually wears down over time. The idea of two seemingly programmed jumps is outrageous.
I'm finally noticing middle age at 48. So I beat the odds by a couple of years.
Yes, the data looks unconvincing. Yes, there is something happening at two times in our lives, but am sure it is aging. I don't think you can get such data from just over 100 people that too in various groups.
I'm a fan of Electron Microscopy - so what is the subject of the photo on the wall behind you?
Rabbit poop 💩
It appears to be "Foetal Blood Stem Cells, Sem #7" by Science Photo Library 🤓
I really expected this to be looking at epigenetic aging clocks. I'm not really sure how to evaluate all the omics data, but I heard ages ago about a late life slowing in the rate of aging.
What about with heightened or boosted NAD+ levels?
That's very depressing but interesting at the same time.
This should go straight to Calico Labs... They were trying to be very academic about studying aging from the ground up (as opposed to focusing on quick interventions)
There is a traditional teaching that the body undergoes a significant change every seven years after the age of 21, I have to say so far I feel it is quite accurate 21, 28, 35, 42, 49, 56, 63, 70, 77, 84
Yes I felt the sudden aging at 56, not before
Did they separate the data of men/women? Women have significantly more changes physiologically than men. Especially between 45 and 60 - specifically.
Good looking young Man, I admire your brilliance...
Get back to me when you're 40, 45 and 50 as you watch everything turns grey and wrinkly.
LOL
This is from a popular, current statistical analysis: the two ages of greatest aging. It may be helpful in treating aging as a curable disease.
It is "they shrank," or "they have shrunk."
Time is nonlinear. gravity effects time, and they have detected gravity waves
Read about this last week and decided to wait for your take on it because it sounded like it might be some internet bait claims.
I wonder if these will become points at which we encourage epigenetic treatments more aggressively or if targeting treatments in these points will have a greater/lesser effect.
That may have been true over the past decades, however, now with most of the population genetically engineered to systemically express the pro-inflammatory spike protein, physiological aging is chronically accelerated across all age groups for at least the next few decades. Accordingly, we are going to see a "great surge" in aging-related morbidity and mortality and infertility in the coming decade that will be unprecedented, the results of which will be mass population collapses..... unless we create and adopt interventions that prevent and reverse biological aging.
Drink/drank , sink / sank , shrink/ shrank
If you think about it, this idea shouldn’t be as suprising as it may seem. I mean we develop non linearly, so makes sense there may be non linearity to aging. I wonder how much of a link there is between peaks/changes in development and early adulthood (
Love the new set. More light and less distracting depth and objects, helps to keep focus on you.
Also loved the flowers arrangement in the painting on wall
Errm...gut micro biome??
@@gsismaet5385 yeah, I knew. It was an attempt at Nick's kind of humour. Should've typed /s
@@gsismaet5385 Looks like "Foetal Blood Stem Cells, Sem #7" by Science Photo Library ;-)
I saw a couple of article's about this topic. Thanks
n is too small. Culture, geography, socio-economic status, education levels could all be confounding variables.
I can say that at 44, I'm in better shape than I was at 24. I do weight training and running, and I have more energy now than I did 20 years ago.
I'm 44 too & I cycle everywhere.
Been powerlifting since I was 18 back in 2001
I would say 65, for me. But that might also because of when Covid hit.
Did this study include women going through menopause? Perimenopause at 43? “Retirement” for the second bump?Are there studies that explore the possible deleterious effects of men being exposed to menopausal women via pheromones and or crash in sexual activity? General degradation of well-being with a newly antagonistic partner?
Amazing questions - they did not go into that granularity. An excellent point!
_"Are there studies that explore the possible deleterious effects of men being exposed to menopausal women via pheromones and or crash in sexual activity"_
- Interesting.
pheromones don't exist in humans
@@engine07 🤣
Probably rather the influence on the man through the swing of the woman's moods. Why should pheromones work on a husband but not on children and grandchildren, especially adult children? It may be unthinkable in America, but multigenerational homes are common in the world.
I'm 48. I work outside, doing a pretty hard job... Something definitely happened in the last few years when it comes to recovery time from minor injuries and even recovering from a particularly hard day at work.
David goggins in nearly 50
Believing all "science" stuff comming from social media, news papers and TV can significantly lead to increased brain aging.
But the study itself is very intressting!
This study reminds me of another study from a few years ago, "Undulating changes in human plasma proteome across the lifespan" (PMC7062043) in which they identified 3 peaks: at ages 34, 60 and 78. It seems more robust due to the cohort size (n=4263) but I wouldn't dare make any strong assertions.
It makes me wonder, how do the results of one study relate to the results of the other?
How much do the results (specifically the age peaks found) depend on the methodology, criteria, markers measured, cohort, etc.?
Still, both studies at least suggest sudden aging around specific ages.
Why did this remind me of: I am your father's brother's nephew's cousin's former roommate. Lone Starr: What's that make us? Dark Helmet: Absolutely nothing!